PPT OUTLINE FOR AUBF REPORT:

SLIDE 1: TITLE

SLIDE 2: FLOW OF PRESENTATION

- Case Presentation
- Diagnosis
- Explanation

SLIDE 3: PATIENT PROFILE

- Gender
- Age

SLIDE 4: DISEASE MANIFESTATION

- Leg edema
- Abdominal discomfort
- Nausea
- Progressive ankles swelling
- 10kg weight gain

SLIDE 5: PATIENT HISTORY

- Received a second dose of Pfizer vaccine 7 days prior onset of symptoms

- No history of infections or malignancies
- Not taking any medication or supplement

SLIDE 6: PHYSICAL EXAMINATION

- Blood Pressure: 115/74 mmHg

- Pulse 99 bpm

SLIDE 7: PHYSICAL EXAMINATION

- Bilateral pitting edema

- Decreased breathing sounds on both lung bases
- Abdomen – slightly distended

SLIDE 8: INITIAL LABORATORY TESTS

- Table for Chem and UA

SLIDE 9: ADDTITONAL TESTS:

- Testing for antinuclear antibody, antineutrophil cytoplasmic antibody, C3, C4, hepatitis C
and B panels was all negative.
- Renal ultrasound revealed 11 cm kidneys bilaterally with slight increased echogenicity.
- Ascites and pleural effusion were noticed on the ultrasound
SLIDE 10: ADDTITONAL TESTS:

- Kidney biopsy
- Light then electron – picture
- Immunofluorescence studies were all negative.

SLIDE 11: INTERVENTION:

- Started on 60mg of oral prednisone along with furosemide and olmesartan

SLIDE 12: DIAGNOSIS

1. When looking at this group of signs and symptoms, what syndrome does it reflect?
- Nephrotic syndrome

SLIDE 13: DIANOSIS

2. What is the disease3 that have caused the nephrotic syndrome

- Minimal Change Disease

SLIDE 14: DIFFERENCE BETWEEN SYNDROME AND DISEASE

SLIDE 15: DISCUSSION

- Minimal Change Disease is one of the most common causes of nephrotic syndrome
especially in children where there is a disruption of podocytes.
- It is not associated with much damage in the cellular level.
- Patient typically responds to corticosteroid treatment within a month.
- It has more favorable prognosis than adult nephrotic syndrome
- Minimal Change Disease follows recent immunization, allergies, and infections.

SLIDE 16: ADDITIONAL INFFORMATION

- Electron microscopy was used as a confirmatory test

- Pfizer is the earliest vaccine administered to ages 12-17 years old
- T cell activation may be the main mechanism for MCD pathophysiology.

QUESTIONS:

1. What was the COVID-19 vaccine administered to the patient in this case? After what dose did
the patient developed sudden edema?
A. Pfizer; first primary dose
B. Pfizer; second primary dose
C. Pfizer; booster dose
D. None of the above
2. What was the confirmatory test used to identify the disease in this case study?
A. Light microscopy
B. Renal ultrasound
C. Electron microscopy
D. Immunofluorescence studies