Prepared By: Rizwan Naqvi

 Industrial Safety refers to reduce the risk of

injury or loss and danger to persons, property
from the industrial hazards.
 Toxic corrosive chemicals, fire explosions and
personnel falling into accident are major health
and safety hazards encountered in the
operations of pharmaceutical industries.
 Identification of hazards and employing
protective measures to control the hazards are
important to protect the people from their
consequences.
 Understand the harmful effects of industrial
hazards.
 Define the relationship between hazard and risk
 Explore the routes of exposure to industrial
hazards
 Shed lights on type of toxicity by industrial
hazards
 Know the most toxic environmental hazardous
substances.
 Hazard is the potential of a substance
to cause damage.
 Toxicity is the hazard of a substance which
can cause poisoning
 Risk is a measure of the probability that harm
will occur under defined conditions of
exposure to a chemical.
 Large exposures to chemicals can effect
human health directly or indirectly
 The release of chemicals into environment
can have global impacts
 All the changes that occur in
the environment affect people.
 There are 03 main routes by
which hazardous chemicals enter
the body;
1) Absorption through the respiratory tract
through inhalation.
2) Absorption or injection through the skin or
eyes.
3) Absorption through digestive tract. This may
occur with contaminated hands or in
contaminated works in areas.
 Acute Poisoning is characterized by rapid
absorption of the substance and the exposure
is sudden & severe. e.g. carbon monoxide
 Chronic Poisoning is characterized by
prolonged or repeated exposures of a
duration measured in days, months or years.
e.g. lead or mercury poisoning & pesticide
exposure.
 Fire Hazards
 Chemical Hazards
 Electrical Hazards
 Mechanical hazards
 Pharmaceutical Hazards
 The self-sustaining process of rapid oxidation
of fuel which produces heat and light.
 Three essential for combustion of fire are;
 Fuel (any combustible materials)
 Oxygen
 Temperature
 Well planned design and layout
 Proper ventilated system
 Chemical data sheet
 Proper training of personnel
 Fire fighting equipments
 Sprinkler systems
 Many chemicals can cause severe burns. If
these coming to contact with living tissues or
other routes like inhalation.
 Living tissues may be destroyed by chemical
reactions such as dehydration, digestion,
oxidation etc.
 Some common organic solvents like
chloroform & benzene.
 Application of barrier creams before
commenting the work
 Using the high vapor pressure solvents,
safety goggles, gloves and helmet.
 Electrical hazards occurs when a person come in
contact with the conductor carrying current and
simultaneously contacts with the ground,
usually known to be work hazards.
 Sources
 Short circuits
 Electrostatic hazard
 Arcs & Sparks hazard
 Improper wiring
 Insulation failure
 Proper maintenance of wiring and equipment
 High voltage equipment should be properly
enclosed
 Good house keeping
 Worker should avoid working in electrical
circuits or equipments in
wet clothing or shoes.
 These are associated with power-driven
machine, whether automated or manually
operated by steam, hydraulic and/or electric
power introduced new hazards into work
place.
 Its can be reduced by application of
appropriate safeguards such as;
 Prevent contact
 Protect against falling objects
 Do not create interference
 Allow safe maintenance
 Use types of safeguards i.e. fixed guards,
interlocked guards & adjustable guards.
 Hazards drugs that pose a potential health
risk to health care workers who may be
exposed during drug manufacturing.
 Dugs that meet one or more of the following
criteria should be hazardous
 Carcinogenicity
 Teratogenicity
 Reproductive toxicity
 Organ toxicity at lower doses.
 Use personnel protective equipments for
hazardous drug handling
 Proper treatment and disposal method for
effluents
 Awareness program
 Disposable gowns
 Powder free gloves
 Face & eye protection
 Approved respirator
 Gas release should be vented outside building
 Exhaust should be provided
 Prepare Drug Disaster Management plan
 Disease due to biological hazards are;
 Bruccellosis (dairy industry)
 Byssinosis (textile industry)
 Bagassosis (sugar-cane)
 Loco motor disorder
 Proper treatment and disposal method for
Biological hazards
 Periodic health checkup
 Personnel protection
 First Aid Facilities
 Facility vaccination
 Routine sanitization programme
 Initial examination
 Proper treatment and disposal method for effluents
 Standard operating procedures
 Handling of Hazardous materials
 Water supply and drainage
 Emergency Exists
 Back up plan if anything goes
wrong
 Health polices & insurance
 Safety Audits
 Risk Analysis
 Regular Monitoring of workplace
 Awareness and training Program
 Written documentations
 In short safety aspects
must be considered by the
pharmaceutical industry not
only in the interest of the
property but also in terms of employee.
 The source of possible hazards, risk analysis,
control procedures preventive measures and
contingency plan are the main five essentials for
ensuring a completed safe work atmosphere in
the industry.