1-phenoxy 50.000-100.

000
unit/kg/ day
Ospen
→susp 400.000
For
prophylaxis in
methyl orally every 6-8hours unit/5ml RF
→tab 1.000.000 Its given
pencillin unit/tab every 12
Cliacil hour
→susp 300.000
unit/5ml
→tab 1.000.000
unit/tab

2- < 27 kg →1/2 vial

> 27 kg→1 vial
Depopen vial--
1.200.000unit
Mainly used
in prophylaxis
benzathine Or Lastipen vial-- of RF
< 3 years→1/4 vial 1.200.000unit Every 2
pencillin 3-6 year→1/2 vial ‫وكمان عندنا‬ weeks
>6 years→1 vial ‫الريتاربين والبنسيتارد‬ -sensitivity
I M every 2 weeks test must be
Done before
each injection
-can be
dissolved in
Lidocaine

B-broad Gram +ve→but

spectrum ‫االموكساسيللين احسن من‬ ‫معلومه هامه ان كل ادويه عائله‬ notantistaph
pencillins ‫االمبيسلن عشان بيمتص اسرع‬ ‫البنسيلين الحقن ال يتم تجزءتها‬ Gram-ve→but
NotAntipseudomonas
Not Antiklebiella

60-90mg/kg/day every -Epicocillin Main side effects are

Ampicillin 6-8 h(20-30mg/kg/dose) -Ampicillin :
In meningitis→ 150-200 susp→125- -diarrhea
mg/kg/ Day 250mg/5ml vial→500- -skin rash e
‫وفى الحاله دى يفضل‬ 1000mg/vial Infectious
‫السيفالوسبورن‬ - Mononucleosis
 unasyn,unictam,ampictam
oral→50 mg/kg/day susp 250 mg/ 5ml ‫من امن االدويه لمريض الكبد‬
Ampicillin+ i.e 1 cm/kg/day every 8 h -unasyn-unictam-sulbin
sulbactam parentral→150mg/kg/day vial ‫احسن من الكالفيولينك اسيد‬
375,750,1500,3000 ‫اصال‬ ‫علشان الكالفيولنك‬
mg / vial ‫بيعمل كوليستيتس‬

Amoxicillin -Drops
60-90 mg /kg /day every hiconcil 100mg/ml Less side effects
8h -Susp than
(20-30mg/kg/dose) Biomox 125-250 mg/
Ampicillin
Oral, iv, im 5ml Ibiamox 200-
‫وزى ما قولنا احسن من‬
400mg/5ml
-Vials
‫فى االمتصاص ومش‬
e-mox 250-500- ‫بيتأثر بوجود االكل‬
1gm/vial

Amoxicillin Orally every 8 h -Hibiotic-N susp Contraindicated

+Clavulinic 60-90 mg/kg/day 230 – 460 mg/5ml before 9 Months old
acid (20-30mg/kg/dose) -Megamox,deltaclave d.t GIT
susp troubles
Iv only every 12 h 228.5– 457 mg/5ml
30 mg/kg/day -Augmentin , curam susp
156–312 mg/5ml

-Augmintin ,magnabiotic
600 mg &1,2gm vial
C-Pencillin -Amox+flucloxacillin Oral preparation has
Combinations 100-200 mg/kg/day e.g flumox bad tast
susp 250 injection form very
vial 500mg &1gm painful
cap 250 ,500 mg
-amox+cloxacillin
-amox+dicloxacillin
A-first generation

1-cephalaxin
60-90 mg/kg/day Ceporex , ospexin 80% Gram
every ,keflex +ve
6-8 H Susp ….125 &250 20% Gram
(20- mg /5ml –ve
30mg/kg/dose) Ceporex tab 250 ,500
Oral ,iv, im ,1000 mg ‫دى تنطبق على كل‬
Ceporex vial 500 , ‫الجيل ده‬
1000 mg

2-cephradine Velosef ,cephradine

60-90 mg/kg/day ,cefadrine
every Susp…125 &250 mg
8H /5ml
(20- Cap…250 ,500
30mg/kg/dose) ,1000 mg
Oral ,iv, im Vial…250 ,500
,1000 mg
Farcocef vial only
250&500mg

50 mg /kg /day
3-cephadroxil every Duricef , biodroxil
12 H Susp…125 ,250
Orally ,500 mg/5ml
-In case of susp 250 cap….500mg
Dose=wt/2 every N.B…curisafe drops
12h 100mg/ml
B-second
Generation Oral →20- Zinnat 50% Gram
40mg/kg/day - Susp…..250mg/5ml +ve
Every 12 H - Vial….750 50% Gram -
1-Cefruxime
parentral→50- &1500mg ve
100mg/kg/day
every 12 H IV or
IM

2-Cefaclor 20-40mg /kg/day Bacticlor →60 ml

every 8 H -susp…125
(10 mg/kg/dose) &250mg/5ml
orally ceclor→75 ml -
125&250mg/5ml
In case of 250mg
susp
Dose=wt/5
every 8 H

20-40mg/kg/day
3-Cefprozil every 8H Cefzil susp
125&250mg/5ml

‫ابحث كل يوم عن معلومه تجعل منك افضل من غيرك وتأكد انه‬

‫سيأتى اليوم الذى سوف ترد فيها هذه المعلومات جميلك عليها‬

‫فسوف ترى نفسك اعلم من غيرك بما يراه االخرون سنين ضوئيه‬

‫الن الجهل سيطر على عقولهم‬

‫اسالم عيد‬
C-third 80% Gram –ve
generation Cefaxone vials 20% Gram +ve
50-75 250……8 ‫جنيه‬ &antipseudomonal
mg/kg/day single 500……14
ceftriaxone daily dose ‫جنيه‬ Active agaist
Iv→with water gram+ve&
IM→with
1000…..20 ‫جنيه‬ Gram –ve but not
lidocaine
Oframax vials Antipeudomonal
250….8 ‫جنيه‬
Available in to 500….22 ‫جنيه‬
forms Ceftriaxone
one for IM sandoz
injection& 250…..9 ‫جنيه‬
the other for 5000….18
IV injection ‫جنيه‬
1000….29
‫جنيه‬
Xorine vial ½
cefotaxime 100- &1gm
150mg/kg/day Cefotax ,
every 12 H claforan vial 1/4
IV oR IM , 1/2 & 1 gm

cefoperazone Limited use in

100- Cefobid & pediatrics →affect
150mg/kg/day cefazone vial spermatogenesis&can
every 1/2gm & 1 gm Cause testicular
12 H atrophy
IV oR IM

ceftazidime
100- Fortum vial Most potent against
150mg/kg/day 1/4 , 1/2 & pseudomonas
every 1gm
12H
IV oR IM
oral 3rd generation

cefixime 8 mg/kg/day single Ximacef Not antistaph

dose or &suprax Not
in 2 divided Susp antipseudomonal
doses √√ 100mg/5ml
cap Used mainly in ttt
200mg/cap of
Uti , typhoid
fever,
cefpodoxime OM& sinusitis
1o mg/kg/day in 2
Orelox
divided doses
susp
40mg/5ml
Tab 100mg
D-fourth generation 50-100mg/kg/day Wincef vial.. More extended
1-cefpime 1n 2divided dose spectrum than 3rd
1/2 gm(14) gen
1gm(21)

2-cefepime 50-100mg/kg/day Maxipime

1n 2divided dose 1/2&1 gm
Cefrom
1/2&1 gm
vials

‫خمتلف‬ ‫ فيجب ان تفعل شىء‬.... ‫ان اردت ان تكون شخص خمتلف‬

‫وان اردت ان حتقق هدفك فال تنظر اىل غريك اين يسري ولكن انظر لطريقك متى‬
!!‫يتنري؟؟‬

‫اسالم عيد‬
 mainly Gram-ve →
+
Antipseudomonal
gentamicin 5-7 mg/kg/day -Garamycin amp + Weak Anti
1n 2-3 divided 20 & 80 staph
Doses mg/2ml
IV oR 40 mg/ml Most
IM -Epigent amp nephrotoxic(reversible)
20 & 80 mg Especially:
/2 ml -When taken e other
-gentamycin nephrotoxic Drugs
amp -in renal patient
20 & 80
mg/2ml
40 mg/ml
amikacin 10- Amikin vial Widest spectrum
15mg/kg/day 100 , 250 ,500 Most
1n 2 divided mg/2ml ototoxic(irreversible)
Doses Both
IV oR IM auditory&vestibular

tobramycin 2.5- Nebcin vial Most active against

7.5mg/kg/day 20 &80 Pseudomonas
in 2-3 divided mg/2ml
Doses ‫مش هتشوفه اصال فى‬
IV oR IM ‫الصيدليه‬
‫هتالقيه فى قطرات العين بس‬

N.B

1-amnoglycosides should not be used more than one week

otherwise evaluation of renal function Must be carried out
2- amnoglycosides not used in ttt of meningitis as it do not cross
blood brain barrier
3-no oral form as no absorption from GIT
 Gram+ve mainly
macrolides Active against
atypical
Organisms(no cell
wall)
Erythromycin e.g
-Erythrin & erythrocin mycoplasma,
30- Susp… 200mg / 5ml Chlamydia
50mg/kg/d -Eryped susp 400mg/5ml
Every 6-8 H N.B→present in some campylobacter
Orally combination
e.g pedizole susp (+ SMX
600mg)
primomycin susp(+ TMP 50mg)

Clarithromycin 15mg/kg/day Klacid susp..125

Every 12 H &250mg/5ml
Orally Klarimix susp…125mg/5ml
After meal

Azithromycim 10mg/kg/day
Every 24 H Zisrocin susp (30ml) Although ttt for 3
…100mg/5m Xithrone
Orally days
susp(15ml). 200mg/5ml
On empty only it Remain in
Zithrodose(45ml)..100mg/5ml tissue in effective
Stamch
Concentration
In case of 100mg susp
for 10 days
Dose = wt ∕ 2 per day
In case of 200mg susp
Dose= wt ∕ 4 per day
 0ther antibiotics
25–50 Vibramycin -Contraindicated
Tetracycline
mg/kg/day in Doxy SR before 8 years old
2–4 divided Cap...100mg/ca -Mainly in…..
doses. p brucella, Chlamydia
&Mycoplasma
infection
N.B----may be used in
Sinusitis (ambrodoxy
cap)
chloramphenicol
50-100mg/kg/day Mephenicol -Contraindicated before
Oral IV IM Cidocetine
Vial--1gm 6 years old
Every 8 H
Susp--125mg (bone marrow
Supp-- depression)
‫فى حقن اسمها‬ 125&250 -Mainly in…..
thiophenicol
Meningitis
‫فى الصيدليه دى اللى‬
‫هتشوفها ودى زيها‬ Typhoid fever
‫بظبط‬

sulphamethoxazole 4mg tmp+20mg Septrin, Septazol Mainly in…..

Trimethoprim smx/kg/day & Sutrim susp
In 2 divided doses
-UTI
In susp form--- -GE
(200mgsmx+
1cm/kg/day every
12h 40mgTmp) ‫اوعى يتاخد مع اى حاجه فيها‬
‫هيكسامين او بيبرازين‬
‫بيعمل حصاوى ياسعاده البيه‬
clindamycin 20-40my/kg/day -Dalacin c Mainly in
Every 8-12 h Amp…150,300, anaerobic infection
Oral IV IM 600 &antistaph
Cap... 150 ,300
(e.g dental infections)
mg
-Clindam
Cap…150 ,
300mg
Quinolone -Ciprofloxacin
In neonates ?? Not recommended
10mg/kg/day before
Infant&children 16 years
15- N.B---topical
30mg/kg/day preparations are safe
- Ofloxacin In all ages
completely
Contraindicated
In pediatrics

Nitrofurantoin :
Dose----5-7mg/kg/day rvery 12 H after meals (food↑ its absorption by
40%)
Preparations------uvamin retard cap 100mg/cap
macrofuran&mepafuran cap 50 &100mg/cap
N.B- 1-mainly in uti
2-In long term use(uti prophylaxis) may cause peripheral neuritis
so Consider Vit B comp
3-Like other nitrofuran(nifruxazide(antinal)&furazolidon) is
contraindicated in favism ( ‫انيميا الفول اللى شرحناها المره اللى فاتت‬

- URTI
-amoxycillin , amoxicillin clavulinic acid ,ampicillin sulbactam
- 1st generation cephalosporin
-2nd generation cephalosporin
 -LRTI
-3rd generation cephalosporin
-2nd generation cephalosporin
- Amoxicillin clavulinic acid

-GIT INFECTIONS(GE)……only with:

- SMX-TMP patient looks toxic
-CEFTRIAXONE
salmonella,shigella,campylobacter
-CEFOTAXIME patient in shock(no
-XIMACEF parentral GE
-UTI
-Nitrofurantoin
-SMX-TMP
-3rd generation cephalosporin
-1st generation cephalosporin(cephadroxil)
-Aminoglycosides
-SKIN INFECTION
-Macrolides -2nd generation cephalosporin -3rd generation
cephalosporin
-OSTEOMYLITIS
-antistaph e.g Cloxacillin , Flucloxacillin(Flumox 200mg/kg/day)
or Vancomycin(Vancocin 40-80mg/kg/day)
+ Fortum ,Ceftriaxone or Cefotaxime

ANTIBIOTIC SELECTION BY AGE GROUPS

1-Amox-clav…………contraindicated before 9 months(GIT

troubles)
2-Chloramphenicol…. contraindicated before 5 years(bone
marrow depression)
3-Tetracyclin…………contraindicated before 8 years
 4-Ofloxacin………… contraindicated before 12
years(osteoarthropathy)

How to calculate dose of antibiotic?

In suspension form

- Required Dose in ml =
amount required in mg/kg/dose × body weight × 5(spoon)
Concentration of susp(125 or 250 …. etc )

Example :
Child 15kg weight how to calculate dose of bacticlor 250mg ?
Answer :
Required Dose in ml =
30(dose in mg/dose) ×(15)body weight×5(spoon) = 3 ml
250(Concentration of susp)

So the required dose = 3ml every 8 hours

In injection form

-Required dose in ml=

Amoun Required in mg/kg/dose×body weight×amount in which you dissolve

Concentration(250 or 500 or 1000 mg ….et
1- you can use 3rd generation parentral for 5 days then shift to
oral 3rd gen e.g ximacef

2--aminoglcosides are more potent than 3rd generation

Cephlosporine against grame –ve

3- 3rd generation Cephlosporine are more potent tha

Aminoglcosides against proteus, pseudomonas,
Klebseill

4-ceftazidime is the most potent against pseudomonas

5 -ceftriaxone -----is contraindicated in neonates with

Hyperbilirubinaemi

6-smx-tmp------not to be used before 2 months old

7-first generation cephalosporines e.g Cephadroxil(biodroxil-

duricef) 50mg/kg/day every 12 h Cephalexin 50-
100mg/kg/day
They are excreted unchanged in urine so effective in
Ttt of uti

8-case of uti not responding to AB therapy suspect

Presence of distant septic focus

9-Amikacin There is incompatibility with heparin, HCT,

phenytoin,
nitrofurantoin, warfarin, Vitamin B complex and vitamin C