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    tk2 20210320080245

    Uploaded by

    Tuong Vo

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    © All Rights Reserved
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    DE THI KET TH 5 UC MON HOC MON THI THONG KEY HOC BOL TUONG DY THI:HQC VIEN SAU DAL HOC gly thi: 3. ‘D6 kha di (likelihood) 1a suat xay ra s6 ligu véi m6 hinh va tham s6 da cho b. Mite d6 phi hop cita 2 mé hinh ¢. Khong tin ey 95% cita xéc sudt xiy ramé hinh d. Xéec sudt xay ra mé hinh 4. Cho day sé ligu x: 10,4; 12,1; 13,7; 12,45 14,6; 12,1; 10,9; 12,5; 10,7; 13,5. Hay tinh trung binh va d6 léch cia sé ligu trén 2,20; 5= 1,37 12,29 ; 8= 1,37 ©. 812,29; s= 1,44 4. 912,205 8= 144 5. Trong dan sé A, huyét ép tim thu cé trung binh la 120 mmHg va 46 Igch chudin 10 mmHg. ‘Chon mét ngudi trong dain 36 A, tinh xée sudt nyudi niy 66 huyét dp tim thu >130: P¢huyét ap ‘4m thu> 130 mmHg)= P(e>1)= ‘Thoi gian tim bai: 90 phit . MiGE th2DIS A cD 1. Bién sd nao sau day la bién 36 a. 0,3085 dinh long 05,1587 a. Cé bi suy dinh dudng hay khong c. 0,1762 b. Tén giéo 4. 0,0668 tam lugng hemoglobin d. Din thc Dé tinh xéc sudt c6 2 bénh ahan tir vong do sét rét khi digu tri 200 2. Déxéc dinh te dgng ota bién # bénh nhin sét rét 6 thé sir dung cong 80 d6c lip (dinh lugng) lén bién sé phy thite cba phan phéi thude ld nbj gid c6 thé si dung: 2 Poisson A a. Hi quy tuyén tinh b. Chudn b. Hdi quy Cox cc. Nhj thie * SCHBi quy logistic d. Binh thudng 4, Hoi quy tuyén tinh hay hdi quy Cox i 1u duge . Dd thi thich hgp dé trinh bay phan b6 giGi tinh trong nhimg bénh en Tas b, Da gide tin sudt ¢, Bidu dd hinh chung & Biéu 48 hinh thanh Bang s6 ligu sau day cho biét sy dt edn do dé mé h6i trong ha dudmg ‘buyét do insulin ob 12’bénh niin duge diéu trj bing propranolol va i) bénh nhn tong nhém chimg, Trong nh6m diéu tri bing propranolol mit edn trung binh la 120 gram véi 46 Iéch chudnld 10 gram. Trong nhém chimg, mat cfn trung bin 14,70 gram vei d6 lech chudn 188 gram. Gid trt tinh urge las a. 13,16 b. 11,16 ¢ ©. 13,60 4. 13,60 Biét logit(p)=-2, p= 013s FY b.-0,119 0,119 0,135 10. Biét logit(p)=2, p = a2 b.05 ©.7,39 p88 11. Détinh xdc sudt chita khoi 8 bénb nhan trong trong tong s6 10 bénh hin duge digu tri (khi biét duge xe suat chia khdi cho mét béah nhfn) thé ding céng thite cia phan phdi das Nhj thire ». Poisson c. Binh thusng d. Chuan 12, 86 bién o6 xay ra trong mot don vj thdi gian chia cho dan sé nguy co trung binh duge goi la: a. Tile hién mac b. Nguy eo c. Nguy co ‘Ti sudt mac méi 13, 10 bénh nhén bi suyén duge do long FEVI (thé tich thé ra ging sire trong m6t gidy) trude va sau khi diéu tri bing Salbutamol. Bé kiém dinh gid thuyét Ho: salbutamol khdng lim thay i FEV1, test théng ké phi hgp la: Kiém djnh t bit cip iém dinh ANOVA ¢. Kiém dinh t khong bat cap 4d. Kiém dinh chi binh phuong 14. H@ 86 b cid phuong trinh hii quy logistic cia mét bién nhj gid theo mot bién nhj gia khéc o6 gid tri (véi OR 1a ti sé s6 chénh cia 2 bién s6 46) a. b-OR b. b=exp(OR) c. b=In(OR) 4. b 16m hon exp(OR) me di sy khiéc bigt khong 06 y nghia vé y té cdng cng 15. Nghién ciru 8 bénh nhén bi suy hd hap min tinh truée va sau ché d6 diéu tj gidm can, gidm him Iugng carbonhydrate trong khdu phin an, Tirlapur va Mir (Am J Med 1984;77:987) ghi nhin két qua vé 4p ue CO2 trong mau dng mach nhw sau. Phin ép CO2 trude va sau didu tri ‘cia timg 46 twong nhur sau: (49 - 45); (68 ~ 54); (65 ~ 60); (57-60); (76-59); (62-54); (49-47); (53-50). Bé lech chun cita higu s6 dp hue PCO2 dong ‘mach I8 6,54. Khodng tin cy 95% cha ‘tung binh ciia thay d6i ap lire CO2 la: 2,80 dén 9,72 0,80 dén 11,72 ¢. 5,80 dén 6,72 4. -0,20 dén 12,72 16. Ham Iugng cholesterol (mg%) cha 7 ngudi bj r6i loan lipid mau di truyén 1a: 320; 390; 420; 490; 460; 520; 530. Trung binh cua day sé ligu trén 1a 447.14 489.21 ©. 449.23 4.490 17, Trung binh 6 Phép hang nim c6 3 trudmg hop bénh CID durge phat hign, Tinh xéc suat trong nim 1995 c6 7 trang hgp bénh CID duge phat hign: a, 0.43 b.0.05 ©. 0.07 34. 0.02 18. _M@t Kho sét so sénh nhip tim Ide nghi eta van déng vign va hoe sinh phd théng. Trén 34 vén déng vién nhip tim hic nghi 66 va d6 Iéch chudn 5. ‘Trén 36 hge sinh nhip tim Ie nghi la__ 72 v6i dé léch chuan 1a 8. Gid tri thing ké dé so sanh nhip tim trung binh cia 2 nhém 1a aea4,5 b.ip=0.005 ©. = 20,25 &K t=3,74 19. Mt nghién citu tim durge phuong trinh héi quy tign dodn sé lugng bat thudng nhiém sic thé (trén 100 t6 bao) theo luong chi trong mau : Bat thug NST = 0,14 + 0,90 x Iugng, chi mau (tinh bing (g/100ml). Mat ngudi bj nhiém chi v6i ndng 46.0 (g/100m! duge tién doan 6 56 bat thutng NST/100 té bao la 46,2 b. 1,04 ©. 0,14 4. 0,90 20. Néwhé sé trong quan gitta ning 6 cholesterol va luong lipid trong Khdu phiin din 18 0,20, ta c6 thé két luan: a. Lipid trong, phan an giai thich cho 20% sy thay déi cia néng do ‘cholesterol b. Lipid trong khdu phan an giai thich cho 64% sy thay ddi cia nong d3 cholesterol ¢. Lipid trong khdu phin an giai thich cho 96% su thay déi ca ning 46 cholesterol . d. Lipid trong khdu phan &n gidi thich cho 4% su thay d6i cia ning do cholesterol 21. Tinh trung binh eda day sé ligu: 145+; 112; 158 ; 134; 124 2. 135,6 b, 136,6 ©. 134,6 4. 133,6 22, Xe suit bj bénh lao bing w a. P(lao hay hut thudc 14) + P(lao hay Khong hiit thuée 14) b. P(lao va hat thudc lt) + P(lao va Khong hut thudc Ia) c. P(lao va huit thudc la) x P(lao va khong hit thuéc 14) d. P(lao hay hit thuéc I) x P(lao hay khéng hit thudc 1a) 23, M@tnghién eitu tim duge _ phuong trinh hdi quy tién doan sé lugng bat thung nhiém sdc thé (trén 100 té bao) theo Iugng chi trong méu : Bat thudng NST = 0,14 + 0,90 x lugng chi méu (tinh bing (g/100ml). Mot nguisi bj nhiém chi voi néng 46 10 (g/100ml duge tién oan cé sé bat thurng NST/100 té bao 1a a. 9,14 b. 0,14 ©. 6,2 d. 0,90 24. Oba nhdm phy nd, nhém A co chdng bj ung ther di c&n, nhém Bcd chéng bj ttr vong do ung thur trong 6 thang truée va nhém C ¢6 chéng khée menh ngudi ta ghi nhan diém tram cém Hamilton (Hamilton depression score) nhu sau: Nhém A: Sé nguis : 13, ‘Trung binh: 5.3” 6 Iéch chuin: 5.2. Nhém B: $6 nguoi : 12 , Trung binh: 14,7, D6 léch chuin: 7.5. Nhom_ C: S6 nguoi : 12, Trung binh: 12.0, DG lech chudn: 6.8. Néu E=6,8, Gid tr} p value trong (rong ting véi gi tri F nay 1a a. >0,05 b. <0,001 ©. <0,01 4. <0,05 25. COméu cn thiét d8 ude long ti J suy dinh duémg véi sai s6. cho phép 3% 6 mite d6 tin cay 95% néu biét ring. 118 suy dinh dudng xdp xi 30% a.225 b. 897 ©. 384 d. 3586 26. Dé so sinh lugng corticoid 24h ‘tong nuée tiéu cia phy nit béo phé vi phy ni binh thuimg , ngudi ta thu duge : Nhém phy nit béo phé: n} = 120 ; lugng corticoid trung binh 24h : 6.3mg/24h , 46 léch chudn =1.7mg/24h vénnhom phy hr bintrtreag a= 148 , long corticoid tng ‘bin 724h : 4.5 mg/24h , d6 léch chu =1.5mg/24h. V6i a =0.05, igudi ta ‘imidn Biét ligng corticoid ‘trung binh 24h cia hai nhém cé khéc nhau hong, Gid tri €6 1gch chudn g6p (sp) a. sp= 14 b. sp= 16 c. sp= 1.57 4d. sp= 1.65 27. _ Tinh d6 léch chudn ota day sé ligu s6 ligu: 25; 28; 26; 38; 40, 7,05 b. 11,05 ©, 13,05 4.9,05 28. Cho 2 day sé ligu A: 10; 20; 30; 40; 50 va day s6 ligu B: 30; 40; 50; 60; 70. Dy s6 ligu no c6 dé léch chun Ién hon: a. d6 Iéch chudn bing nhau b.s6 ligua ¢. Khong tinh duge 46 Iéch chun 4.6 liguB 29, MOtkhdo sét nhim nghién ctu sy lién quan ca udng vitamin A va bénh tiéu chay 6 tré em. Nha nghién ctu phan chia 100 tré m6t céch ngfu nhién thinh 2 nhém: 50 tré dugc uéng, dé sung vitamin A va 50 tré khéng 8 duge udng Vitamin A. Két qui sau 3 ; théng sau quan sét duge 06 16 tr8 bj: tiéu chay trong nh6m bé sung Vitamin Ava 26 tré bj tiéu chay trong nhém | Khéng bé sung. Gia thiét Ho cia nghién cinu nay 1a: ; a. C6 sy lién hé gitta tinh trang thiéu | Vitamin A va mic tiéu chay 6 tré em b. THe tidu chay & hai nh6m tré 06 bd sung va khong bé sung vitamin A bing hau ¢. Tré khong duge bé sung Vitamin A! 8 bj tiéu chay hon tré 6 duge bé sung 4. Thiéu Vitamin A 1A yéu tb nguy co cla tieu chay &tré em, ‘Tinh trung binh ca day sé ligu| 86 ligu: 1; 3; 4; 7; 6; 8; 9, asd b7 31, _ Néuba me bj nhiém HIV, xc suit dia tr bj nhiém ti trong tir va trong khi chuyén da Ia 0,2. xée sult {é bi nhiém do bi sita me 1A 0,1. Tink] xée sudt dita tré dng thd bi nbiém IV trong ti cung va bj nhiém HIV ‘rong Khi bi me (néu hai xéc sudt nay 18 dg lp) - 40,3 7: b.0,02 ©. 0.28 4. 0,15 32, M6t loai thuéc trj phong chiét xudt ti v8 tm méi duge sin xudt ‘rong nuée ¢6 tén Chitosan duge dem ma ditu tr phong dé so sénh véi Silver. sulfadiazine (mt ché phim ngoai nhép). Trong 50 tring hop diéu tr] v64 Chitosan e6 40 truimg hop lanh. Trong 50 trudng hop diéu trj v6i Sulfadiazin bao-e6 38-trudng hop link: Gist} chi | - binh phuong (2): a.0,32 b.3,20 ©.2,32 4.0,23 33. Trong dan sé tinh X, xéc suit hat thude la = P (hit thude 14) = 0,3, Biét ring xéc sudt ung thu. phi & ngudi hit thuse 1418 0,4% va xdo sudt ung thu phéi 6 nguési khong hilt thude 14 1a 0,04%, Tinh P(ung thir phéi a. 30,4% b.0,148% ©, 0,120% 4. 0,440% oy 34, Phan sé nguy co quy tréch din 86 cila ung thu phdi gay nén do hit ‘trong Id trong nhiing ngudi dan éng la 95.4%. Néu trong tuong lai, ching ta 6 thé van dong dé khéng con ai hit thude ld nffa, so véi hign tai, sé béah nan nam bj ung thu phdi sé gidm: 2..95.4% b. 4.6% 2.5% 4. Khong tinh durge boi vi ching ta cin phai do biét duge nguy co tuong déi ciia ung thu phdi trong nhing ngudi ht thude la. 35. Cho day sé ligu x: 10,4; 12,1; 13,75 11,45 14,6; 11,15 10,9; 12,5; 10,7; 13,5. Hy tinh trung binh va d6 léch chudn cla sé ligu trén a. 12,09 ;s= 1,44 - b.X=12,20;8= 1.44 ©. 312,20; s= 144 4, 12,09 ; s= 2,23, 36. _ Phép bién adi log dugc ding cho 86 ligu 6: a. Phin bé Iéch trai b. Phan bd chuén . Phan bé léch am. 4, Phan bé léch durong 1 19 37. Trong khoa chéin thyong c6 25 bénh nhan nam va 15 bénh nhan nit. Chon mét bénh nhan bat ki, xéc sudt bénh nan d6 1a nor a a. 0,25 b.0,375 ©.0,60 4.0,15 38, - Motnghién eiru muén so sinh diém thai d9 cia céc diéu during truée ‘va sau khi tham dy m6t khod hoe. Biét ring diém thai d6 khng cé phn phéi binh thudng. Kiém dinh phi hgp cho nghién ciru nay 1a: a. Kiém dinh chi binh phuong b. Kiém dinh ANOVA ©. Hé 6 twomg quan Spearman d. Kiém dinh sip hang cé déu Wilcoxon. 39. Déso sénh tilé suy dinh dudng cea hai nhém tré: mét nhém durge ain kkhdu phin PAM va mét nhém: khéng duge ain khdu phan PAM, test théng ké thich hop dé sir dung 1a: a, Kiém dinh t bit cip ~b. Kiém dinh ANOVA . Kiém dink chi binh phurong 4d. Kiem dinh t khéng bat cap 40, Theo doi mét dan sé gém 100 ngudi ding ma tay theo duémg tiém chich: trong 46 ¢6 90 ngudiied HIV am tinh va 10 ngudi cd HIV duong tinh, Sau 2 nim, ngudi ta phat hign trong dan s6 nay c6 thém 9 ngudi nhiém HIV (do do tong s6 HIV duong tinh 1a 19). ‘Neuy co nhiém HIV sau 2 nam & mhiing d6i tugng ding ma tuy theo dubng tiém chich la; a, Cac s6 trén déu sai b.9% ©. 19% d. 10% Le 41. Do thj mé té méi quan hé gita hai bién s6 cin nang va chiéu cao duge oi la: a. T6 chite 4 b. Da giac tan sudt . Phan tan 48 4, Bigu dé hinh bénh 42, Néu cholesterol c6 trung binh Ia 200 mg% va d6 Igch chudn la 40 me%, Ly ngdu nhién mot ngudi, tinh xée suat cholesterol cia ngudi d6 lén hon 220 mg% (tuong tmg P(z>0,5) la: a. 0,1762 b. 0,3050 ©. 0,1587 4. 0,3085 43. Trong dan sé tinh X, xée sudt ht thude la = P (hit thudc 4) = 0,3. Biét ring xéc sudt ung thu phdi 6 ngudi hiit thudc 14 la 0,4% va xée sudt ung thu phdi & nguéi khong hit thudc 14 1a 0,04%. Tinh xdc suat m6t ngudi la hit thudc Ié néu nguvsi 46 bj ung thu phdi = P(hitt thude Id | ung thu phi): 2.81% oo b. 64% ©. 30% a Mita Ee 4. 60% 44. Ba td sinh vién (mdi td 06 12 sinh vién) tham gia the tap véi diém trung binh va phyong sai ciia timg td lan lurgt la (7,6 — 2,25) (8,2 - 4) (8,5 — 1). MS gitta cdc nhém (MSB) ciia diém thik a. 5,04 b. 2,42 ©.2,52 4.79.75 45. Baté sinh sinh vién) tham gia thye tp voi diém ‘trung binh va phirong sai cha ting t6 Tan lugt 1a (7,6 ~ 2,25) (8,2 - 4) (8,5 1). Bé kiém dinh Ho: Diém trung binh iia 3 16 sinh vign bing nhau, cdn tra bang F voi a. 2, 33 d6 ty do b. 3,39 d6 tudo ©. 3,36 dé tudo d. 2,36 46 tudo 46. So sinh hai mé hinh hdi quy logistic, ta duge sur khéc biét cia — 2log(likelihood)=10.2 vai 3 d6 ty do, gid tri p= 0,017. Ve mat théng ké ta nén chon: . a, Chua di thong tin dé két Ign +b. M6 hinh phite tap hon c. M@ hinh don gién hon 4, Can bé sung mé hinh phite tap mét sé bién sé khéc 47. So sdnh hai mé hinh héi quy logistic, ta duge sur khac bigt ciia — 2log(likelihood)=3.84 véi 3 46 ty do, gid tri p = 0,721. Ve mat théng ké ta nén chon: a. Mé hinh phitc tap hon b. M6 hinh don gian hon , Can bd sung mé hinh phitc tap mot sé bién sé khéc . . Chua di théng tin dé két ludn do sy khdc bigt cia —2log(likelihood)=3.84 48. Mt khdo sat so sinh nip tim le nghi ca van dng vign va hoc sinh phé théng. Trén 34 van déng vign nhip tim lic nghi 66 va d6 léch chudn 5. Trén 36 hoe sinh nhip tim lic nghi la 72 véi d6 léch chuan la 8. C6 thé so ip trung binh 6 2 nhém sir dung phép kiém: a. chi binh phuong b. tbit cap ~ c. tkhéng bat c&p 4d. tong quan 49. Phuong trink héi quy ciia thé tich huyét tong véi trong lung la thé tich huyét wong = 0,0857 + 0,0436 x trong Iugng, Mgt ngudi cé trong lung 65 kg sé 06 thé tich huyét tuong, la: a2. 92 lit b. 3.10 lit 2,50 lit . 2.90 lit 50. Trong mé hinh hdi quy logistic cia m@t bién nbj gid (phy thude) theo mot bién danh dinh: a. Khong bao gid str dung bién gia b. Chi str dung bién gid néu can xe inh tinh Khuynh huéng cia tic d6ng ¢. Chi sir dung bién gid khi bién danh dinh chi 6 2 gia tr sit dung bién gia 51. Dé thi thich hop aé trinh bay phan bé cia giéi tinh té so sinh la: a. Da gidc tan sudt b. T6 chite dd iéu 46 hinh thanh d. Biéu dé hinh chuéng 52. Trong'sé tré em méi sinh tai hhuy@n X, 1118 i sinh nhe cin= P (sinh nhe cAn) = 0,1. Biét ring xdc suét tir ‘Vong trong nam dau tién 6 tré sinh nhe clin 18.0,8% va xde suat tit vong & tré sinh di can 14 0,3%. Tinh P(tir vong va sinh nhe cén): 2.008% b.0,12% ©. 027% 4. 0,03% 53. Néuhé s6 tuong quan r= két Inn: 7 a. Tuong quan manh, thudn b. Twong quan yéu, thuan ©. Tuong quan manh, nghich 4. Tuong quan vira phai, thug 25 ta Ea 34. Him long cholesterol (mg?) iia 7 ngudi bi di loan lipid mau di truyén la: 320; 390; 420; 490; 460; 520; 530. D6 Iéch chuan cia dy sé ligu trén la: a. 447.14 ». 76,55 ©. 75,66 4.5630 35. Néu he s6 tuong quan cia céin ning va thang tudi J4 0,6 - d6 Iéch chudn cia thing tudi 18 10 thang va a6 - ech chudn cia can nang [& 2500 g. Phuong trinh héi quy ca cn ning (Y) theo thing tdi (X) s& 06 hé s6 g6c bang a. 6900 b.150 c. Khéng tinh duge. 4.10 56. Dé dénh gid higu qua cita thude ni N, thoi gian ngu méi dém cia 8 bénh nin duge ghi nhan trade vi trong khi sir dung thudc nga, $6 ligu urge ghi niin nhur sau: (7,0 - 8,0), (7,0 9.0), (3,0- 6,0), (6,0 - 5,0), (6,0 - 8,0), (4,0 -5,0), (8,0 8,0), (5,0 - 7,0), Gia tr t tinh duge la 2,76, Két lun cia nghién cin trén Ia: a. CO su khée bigt thoi gian ngu truée va trong Khi sir dung thuée nga p> 0,05 : b. Khong o6 sy khéc bigt vé thoi gian ngil truée va trong khi sit dung thuéc ‘nga v6i p < 0,05 ©. Cé sy khée bigt thoi gian ng true ‘va trong khi str dung thuée ng: p< 0,05 4. Khong c6 sy khc biét vé thoi gian ngu trudc va trong khi sir dung thuéc gui véi p> 0,05 57. Nhiing bién ¢6 nao sau day la ac lap a. Tiém chiing bnh séi - mic bénh séi b. Tudi tinh theo can-chi -méc bénh than c. Nhiém sin (dai) bd — Nhiém san (ai) héo 4. Uéng nugu - xo gan 58. $6 ligu vé thoi gian chiéu cao va ‘trong hugmg cia 6 sinh vig lin lugt 1a (150, 60), (155,55), (160, 58), (162,80), 165, 66), (170, 75). Tinh trung binh va 6 Iéch chuan ctia chiéu cao: 59, Dé thj thich hop dé trinh bay ién sé dinh Inong la: a. Té chite 3 b. Bigu dé hinh thanh ¢. Biéu d6 hinh chuéng 4. Biéu d6 hinh banh 60. MOt nghién cimu hdi tién cin cha 19 nguoi bj phong 6 7 ngudi cé ching BCG va trong 11 ngudi khéng bj phong 06 9 ngudi chiing BCG. So véi ngudi khéng chiing, nguy co mae phong cia ngudi ching BCG la: a, 0,51 B77 ¢. 0,13 d. 1,96 61. BO thi mé té méi quan hé gitta hai bin s6 a b. Phan tén 43 ¢. Bé thi tong quan 4. Da gide tin suit 62. Trong khoa néi B cé 20 bénh thin nam (10 bj bénh khép vi 10 bj bénh tim) vi 30 bénb nhan not (10 bj bénh khép va 20 bj bénh tim), Chon ‘mot bénh nhan bj bénh khép, xéc sudt bénh nhén nay fi nit = Poi | bénh khép): a. 0,50 b.07 ©. 0,75 d. 0,60 63. Phuong trinh hdi quy: cin ning: Iie sinh(gram) = -3800 + 200 x (tun tuéi thai) + 150 x (hoc van). Lf gidi sau Li hop li: a. V6i cing can nang, khi tudi thai ting Tén 1 tan can ning lic sinh ting 200 gram b. Khi tuéi thai ting thi cn ning lic sinh ting . c. Khi tudi thai ting lén 1 tun can ‘ing lt sinh tng 200 gram 4. Véi cling trinh 46 hoc van, khi tudi thai ting Jén 1 tudn can ngng lie sinh tng 200 gram 64, Néu ba me bj nhiém HIV, xée sult dia tré bj nhigm tirtrong ti cung ‘va trong khi chuyén da la 0,2, x4c sudt tré bj nhiém do bi sta me ld 0,1. Tink xée sudt dita tré bj nhiém HIV do bi. nhiém HIV trong tir cung hay bj nhiém HIV trong khi bi me (néu hai xéc suét nay 1a dc lip) a. 0,02 b.03 ©.0.28 d. 0,15 65. Dé so sinh tié tiém ching di cia hai x8 (m6t x duge ean thigp gido duc site khée va m@t xd chim), kiém dinh nto sau day 06 thé duge ding: a. Phan tich phuong sai b. t bit cap. 7 et 4. chi binh phyong, 66. Bién sé ndo sau day 1a bién 56 inh tinh a. C6 hit thude li hay khong b. Tudi ©. Chiéu cao 4. Can nang 67. Didutra cit ngang trén 250 tre g6m 200 tré trong gia dinh it con va 50 ‘é trong gia dinh nhidu con. G cdc gia dinh it con e6 20 trudng hop wé bi dinh dung va 6 cdc gia dinh ¢6 hi con e6 8 tring hyp suy dinh dudng, Xée sudt bj suy dinh dong & tré cua dinh it con P(suy dinh dudng| gia dinh it con) = a 0,112 b.o10 ©, 0,16 4.014 68. Sai tém loai I 18 sai Lim a. chép nhan gia thuyét Ho la ding khi gid thuyét Ho sai b.= 1- Iye nghién ctu (power) c. khOng bac ba gid thuyét Ho khi gid thuyét Ho sau . fi d. bac bé gia thuyét Ho khi gid thuyét Ho ding 69. Bien ethnic (dan tdc) la bién dank dinh 06 4 gid tri, Bé dura bién ethnio lim bién sé dc Ip cca mé hinh hii quy, c&n dura bao nhigu bién gia vio m6 hinh: 70. Digu tra efit ngang trén 250 tré 26m 200 tré trong gia dinh it con va $0 tré trong gia dinh nhiéu con, 6 ede gia a din it con 06 20 truimg hop tré bj suy dinh duéng va 6 céc gia dinh cé nhida con cé 8 trudng hop suy dinh duéng, Xée sudt bj suy dinh duéng 6 tré cia gia dinh ft con P(suy dinh duéng| gia dinh nhiéu con) = a. 0,14 b.0,16 ©. 0,112 4.010 71. Tisuat xdp xi véi nguy co mic bénh trong mgt don vj thei gian khi a. Bénh la bénh it phé bién va méi nguéi bénh chi mic bénh t6i da 1 lan . Bénh 1 bénb it phé bién c. Bénh la bénh phé bién va mdi nguoi bénh chi mic bénh (6i da 1 lan 4. Bénh fa bénh phd bién 2, 86 72. Til hit thude la p= chénb cia hit thude lé la: 8. Khong thé tinh duge vi chua di sé ligu bs ©. 0.25 40,2 73. MGtnghién ci so sinh trong long cita 14 tré so sinh con cia nhing DA mg hiit thude [4 va trong hong cia 15 té so sinh von cia ahiimg ba my khOng hiit thuée la. Nha nghién ctu ny xép hang trong luong ede dita tre fr nhé dén ton (iré nhe nbit dite xép trong luomg 1 va tré ning nhdt duge xép hang 29) va tinh tang hang cia tré so sinh con cia ba me nhe can véi két qua bing 163. Kiém dinh nay duge goi 1a kiém dink: a. T-test khong bat cap b. Kiém dinh téng sip hang Wilcoxon (con goi la kiém dinh Man Whitney) ¢. kiém dinh sip hang c6 déu Wileoxon 4. kiém dinh kruskal-wallis 74. e3= a. 0,4521 . 0,0201 ©. 0,0497 4. 0,3219 75. _ Xéc suit bi dj img véi penicillin 180,03 va xéc suat bj dj img voi streptomycin la 0,02. Tinh xe suét mot ngudi bj dj tmg véi penicillin hotc bi di tg voi streptomycin = P(dj img voi penicillin hay dij img véi streptomycin) (néu hai xe sudt nay 14 d6c lip) a. 0,0494 b.04 ©. 0,05 d. 0,0006 76. Sai Lim loai 2 la sai im a. chap nbn gid thuyét Ho la ding khi gia thuyét Ho sai b.= L-Iye nghién cin (pow ¢. bac bé gia thuyét Ho khi Ho dang 4. khéng bac bé gid thuyét Ho hi gia ‘thuyét Ho sau thayét 77. Phuong trinh hdi quy: cin ning le sinh(gram) = -3800 + 200 x (tuan tudi thai) . Hé 86 géc cia phuog trinh hdi quy 1a: a. 4000 b. 2000 20 d. 200 78. Ngudi ta lam tréc nghiém tam Ii van d6ng @ 3 nhém (mdi nhém 10 tré) duge huan luyén theo 3 edich khée nhau va ghi nhdn sé lan mic sai Lim trung binh (D6 Iéch chun) trong mi nhém. $6 ligu lin lugt a 7,4 3) - 8,3 (2,5) ~ 10,6 (3,5). Gia tri F = 2,97. Gid tri p value trong tuong img v6i gid tri F nay ia = 2.<0,01 b, <0,001 ©. 0,05, 4. <0,05 79. M@t nghién eiru duge tién hanh "trong d6 gui ta sit dung artesunate 48 igu trj cho 1200 bénh nhan bj s6t rét do P. falciparum. C6 990 bénli nhan duge edt sot trong vong 48 giv. Xéc sudt artesunate cét s6t trong vong 48 itv cho bénh nhan bj sot rét 1d: a, 80% b. 92.5% ©. 82,5% 4.99% 80. Bién sé nao la bién sé nhj gid a. Tinh trang hén nhan b. Nam hay no ¢. Tudi man kinh, . Tuoi ¢é kinh lin du 81. Nghién ci 8 bénh nhdn bj suy hi hap man tinh trude va sau ché 46 diéu tr giém cén, gidm him lung carbonhydrate trong khdu phan an, Tirlapur va Mir (Am J Med 1984;77:987) ghi nh§n két qua vé ap Ie CO2 trong méu dong mach nh sau. Phin ép CO2 trude va sau digu tr} cia timg dBi twomg nhs (49-45); (68 ~ 54); (65 - 60); (57-60); (76-59); (62-54); (49-47); (53-50). BE bic bd gid thuyét Ho v6i mite ¥ nghia 0,05, gia trj thong ké t (v6i 7 d6 ty do) phi a. >1,895 b.> 2,365 ©. <2,365 4. < 1,895 82. _ Chon m6t vj tri bat ki trong bing 86 ngdu nhién, Biét con s6 duge chon 1a con s6 nhd hon hay bang 7. Tinh xéc suai con s6 dé IA con 6 2 hay 4 hay 6, a..0,375 pa 5 b.0,324 ©. 0,676 4. 0,625 83. Néu xéc suit bj bénh lao la 0,1 ya xée suét bj bénh thurong han la 0,01, ‘Tinh xée suét mot ngudi bj bénh lao hay bj bénh thuong han - P(lao hay thuong han) all .0,001 ©.0,109 409 84. Néunguy co tuong déi cia hiit thude Id trong nam gigi 1a 22. Phan sé guy co quy tréch (trong nhém tip xtc) sé la: a. 21/22 b. 22/23 ©, Kh6ng tinh duge boi vi cin phai c6 86 ligu ve ti 18 dan s6 cé hit thuée la, 4.122 Bai béo "Prednisone duimg udng tren, bénh nhan ngoai tri sau khi diéu tri edp ctru bénh phéi te nghén man tinh (COPD)" cia Aaron va cng sy. Day 18 ‘mt thir nghiém lm sing ngiu nghién cétu e6 nhém chimg (RCT) ten 74 bénh nhan duge dura vio nhém prednisone (trong 46 c6 4 bénh nhén bd ‘cue va 70 bénih nhan theo dai dit 30 ngiy) va 73 bénh nhin vio nhém placebo (trong 46 c6 3 bénh nhin bé cuge va 70 bénh nhan theo di di 30 ngay). Két cude chinh ciia nghién ecru Ja phai di Khdm bénh do khé thé trong, ‘vong 30 ngay sau nhap vién Aaron SD, Vandemheen KL, Hebert P, Dales R, Stiell IG, Ahuja J, et a Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N Engl I Med. 2003 Jun 26;348(26):2618-25, Cac cu hdi sau dura trén bai bio trén: n 26 85. Doan vin ban edu 6 3-B & trang 3 etia bai béo la: (Chit thich: Values for FEVI, the transitional dyspnea index, and the Chronic Respiratory Disease Index Questionnaire were compared between groups with - Gié tri cia FEVI, chi sé khé thé chuyén tiép va B6 cau hdi chi sé bénh hé hdp man duge so sinh gitta cée nhém véi) a. if test, ba tiest ¢. Jog rank 4. Kaplan-Meier ». Bién nhi gia ¢. Bién dinh Iugng 4. Bién danh dinh 87. Gid tri cla 6 6-C 6 trang 6 cia bai béo (P value so sinh ti Ig nhip vién do COPD gitta 2 nhém Placebo va Prednisone) 2.011 b.<0.001 ©. 0.04 0.02 88. Gid tricia 6 6-B 6 trang 6 cia bai béo (P value so sénh thoi gian dén. ‘ic tai phat gitta 2 nhém Placebo vi Prednisone) la: a. <0,001 6.0.08 ¢. 0.30 4.0.11 89. Gid ti ctia 6 4-A d trang 4 cia bai bdo la: 90. oan vain ban cia 63-A 6 trang 3 eiia bai béo la: (Ch thich: The primary comparison of the 30 day Telapse rates was performed with use of an - So sdnh chinh cita ti tai phat trong 30 ngiy duge tién hanh véi sit dung) a, Kaplan-Meier b. equal variance ttest ©. Pearson chi-square test log rank 91. Cau dau tién c¥a phan ban luén (Wiscussion) 6 trang 6 (Our findings indicate that prednisone the risk of felapse for at least 30 days after resentation to the emergency department for an exacerbation of COPD: Phat rang prednisone nguy co tai Phétcho it nhat 30 ngay sau khi nhap phong cép ciru vi con kich phat cia COPD) cé hp 6D. Doan van bin trong hop 6D li: a. ting b. giim «. ting manh . khong gidm cia 6 4-B G trang 4 cla 26 6.0.30 4.0.90 93. Doan vin ban trong hop GE la treated with a 10 day course of prednisone, one relapse in 30 days is prevented: diéu trj véi ligu trinh prednisone 10 ngay, phang ngira duge 1ndt trutmg hop tai phat trong 30 ngay) a. every ten outpatients (mdi 10 bénh nan ngoai tril) b. every eight outpatients (mdi 8 bénh hin ngogi tra) . ¢. every six outpatients (méi 6 bénh nnhan ngoai tri) . 4, every tweleve outpatients (mai 12 bénh nhain ngoai tra) 94. Gid tj cla 6 1-A Strang J cia bai bio la: a.0.14 b. <0.001 ©. 0.04 4.0.02 95. Gid tri cia 6 6-A 6 trang 6 cia bai béo (P value so san tig tai phat trong vong 30 ngay gitta 2 nhém Placebo va Prednisone) la: a. 0.06 Bb. 0.04 ©. 0.05 4.0.10 Frome Depanara fate (2A, PH RD) ard Emery Metin (GS, Ji.) whe Otay Mea eter teste (RLV. EW, CW), Uneriyaf ‘teva, Otsu, Or te Dparnen of Energeny Medion, Queens Uses, Kogan Om (Rte Drone er ‘gy Modi Urey of Aa E> Fonton, Ala (2H), the Gepaiment sh ergeny Med, Lender Hes Sornees Cert, andor Or JO and Se Micha Hosa ont (00) — Min Cana Ader pit request esi, Otews Hovpal Genel bux tr BL, $1 Sry Rs Osea, ON KIN Me, Gnade or a sarong) otavahospealones, Neng Mea 2003248261825. Downlossed tom neimanton Oiober 10,2 an Shavin D. Aaron, M.D., Katherine L Yacwlernhien, BSc.N., Paul Hebert, M.O. Robert Dales, M.O., lan G, Stell, M.D, Jan Ahuja, M.0., Garth Dickinson, MD, Robert Brison. MD. M.P.M,, Brian M, Rowe, M.D jonathan Oreyer, M.D. Elizabeth Yetisr. Sc, Danvel Cass, MD , and George Wells, Ph.D ABSTRACT Inthis eandomiced, double-blind, placebe-controled rial, we studied the effectiveness ‘of prednisone in reducing the risk of relapse after outpatient exacerbations of chronic ‘obstructive pulmonary disease (COPD), ‘Weenrolled 147 patients who were being discharge from the emergency deparunentaf- tecan exacerbation of COPD and randomly assigned them to 10 days of treatment with 40 mg of oral prednisone once daly or dentical-appearing placebo. allpatients received ‘oral antibiotics for 10 days, plus inhaled bronchodilators. The primary end point was e- lapse definedas an unscheduled visio physician's office ora return to theemergency department because uf worsening dyspaca, within 30 days after randomization. “The overall ate ofrelapse at 30 days was lover inthe prednisone group than inthe pla- ceebo group 27 percents 43 percent, P=), andthe imeto elapse was prolonged ia those taking prednisone (P= MB. After 10 days of therapy, patients in the prednisone _group had greater improvements in forced expiratory volume in one second than did patients in te placebo group (mean (48D) increase from baseline, 34842 percents. 15431 percent; P=0,007). Patients inthe prednisone group also had significant im- provementsin dyspnez, as measured by the transitional dyspaeaindex the dyspnea domain ofthe Chronie Resp: Dbutnotin health-related quality offi ( (Outpatient reatment with oral prednisone offers a small advantage over placebo in teat ing patents who are discharged from the emergency department with an exacerbation, of corp. sewat mt0 34826 wirnseinone sum 26,2003 ‘The New England Jour of Meine Forpecoral se nly No ote se witout permis. Copyright ©2003 Masnehsets Metis Sec. Allih eared 7 (200pg per dose) fourtimes daily, anduhree puffs of inhaled ipratropium bromide (20 yg perdose) four times daly for 30 days. Patients were provided with spacer devices and were taught correct inhalation technique before discharge. Inhaled corticosteroids andall other meditations used by the patients atthe time of enrollment vere costinued throughout the: studyin both groups." ‘The primary outcome was defined as an unsched ‘led visit to a physician's office or a return to the emergency department because of worsening dysp- rea within 30 days after tandomization.19 We as- sessed patients 3,10, and 30 days after randomiza- tion to determine whether a relapse had occurred. For every suspected relapse we contacted both the patientand the physician to ensure thatthe vsithad ‘been prompted by dyspneaand ad been urgentand ‘unscheduled, and we obtained acopy ofthewritten medical record ofthe encounter. An adjudication ‘committee whose members were unaware of the patients’ teatmentassignments confirmed thatall relapses met he study definiion of elapse. ‘Secondary outcomes included a change from day Ltoday 10 in FEV, measured aftertheadminis- tration of a bronchodilator, the severity of dyspnea, and disease-specific quality oflife. These outcomes were assessed on the day of randomization (day 3) ‘and on study day 10, and changes were expressed asthe difference in values (day 10 values minus day Lvalues) foreach patient. Patents who relapsed before day 10 were assessed within 24 hours after relapse, and this observation was cartied forward today10. FEV, was measured after the administration of a bronchodilator, according to established extecia of the Americen Thoracic Society."* Dyspnea was evaluated with use of the base-line dyspnea index, land the transitional dyspnea index was used trate changes in dyspnea from base line. Ratings from the tensitional dyspnea index were added to yield a total score (range, -9 to 9, with higher positive scores indieating greater improvement in dyspnea) ‘Achange of one unitis considered clinically siguif- Disease-specific quality oflife was evaluated with use ofthe Chronic Respiratory Disease Index Ques- tionnaire, Scores on the questionnaire range from 1 to 7, with higher scores indicating beter self reported, disease-specific quality of ie. A change

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