TUGAS TERSTRUKTUR FARMAKOKINETIK KLINIK 1:

PADA PEMBERIAN OBAT PERORAL DENGAN DOSIS 50 MG DIPEROLEH HASIL KADAR OBAT DALAM DARAH
VERSUS WAKTU SBBSEPERTI TABEL DI BAWAH INI. 6 > Xd,Yd > 0.87 > HITUNGLAH:
ln 1. Cmax. 2. AUC °¯~.

WAKTU (JAM) PLASMA LEVEL (MG/L) Cextrapolated Cdifferent AUC

0 0
0.5 0.38 1.92 1.54 0.431782 0.10 -0.99948 1.54 0.5 0.4317824 -0.963319
1 0.6 1.78 1.18 0.165514 0.25 0.9824197 1.18 1 0.1655144 0.5825009
1.5 0.73 1.66 0.93 -0.072571 0.33 -1.416686 0.93 1.5 0.0725707 -0.359212
2 0.85 0.40
3 0.95 0.90 -0.99948 0.5 0.4317824 -0.99948
4 0.94 0.95 1.3464376 1 0.1655144 0.6792618
6 0.87 -0.139262067333508 1.81 -1.980676 1.5 -0.072571 -0.504353
8 0.66 -0.415515443961666 1.53
12 0.37 -0.994252273343867 2.06 -1.980676 -0.504353
8.31 0.6792618
Ke 0.143 1.973268
B 2.06
t½ 4.88
Ka 0.504 3.5244755 0.5470945
A 1.97
tmax 3.49 0.361 6.3795014
Cmax 0.91 tmax 3.4901901
AUC°¯¹² 8.31 8.31
AUC¹²¯~ 2.59 2.59
AUC°¯~ 10.9 10.90 -0.499097 0.6068871

-1.759056 0.1720161
2.587412587
LN PLASMA
6 0.87 -0.1392620673335 r2 -0.9999355 1.2501874 0.3388717 0.9113157 cmax
 8 0.66 -0.4155154439617 B -0.1428106
12 0.37 -0.9942522733439 A 0.7213489 2.72
ANTILN 2.0581441

ln 10 2.3025851
10 19.09 10 2.949165 -0.9970708
14 13.9 14 2.631889 3.8395481 24.606225 2.303 24.606225
20 7.97 20 2.075684 -0.0877706 22.161395
2.72
2.302585093 22.161395
3 2
24.606225
10 4.71654807760645 8 46.617416
112.11536339137
46.617416
2.9618421089376 2.08413614
19.3697706842366 8.048237029
3.83954807760645
6 23.01 3.13592890404727 -0.989009674 r2 C0 19.097065 2.303
10 19.09 2.94916463773766 3.535710874 A
14 13.9 2.63188884013665 -0.063005008 B
2.72