&# 
##################################(
'#  
##########)

(#
###########################################+
)# #############################,


*# 

###############&)

+#  
#######################&+
,# 

##########&-
-# ###############################'&
 








,
1%
'$)1,-'
%1-+1.'
+'
)'+
#
#'+-'+'
-#4,,
%
,)&
*1
'%.%
%
,1
'$)',(%
'#'#$%-',:
$%'',:
2-$%,
4
-'-+)',;



+%%<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<DF:F
$

#% <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<H:B
$
'
,(+'<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<BA
$

+%.%<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<BH:H
$
1#-'

5%<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<G
$

%-'-%-'

#'<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<B
$
'
(#'<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<DD
$

3-+-'

+%%'<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<DEF
$
'
1$+'<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<F:F
$

3-+-'

#1<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<
BFC
$
=+%.%<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<DF:F
$

=,- %<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<BE:C
$

.#)+%'
,('<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<A:DD
$

+'3#<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<A:DD
$
%''#$%<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<A:BG
$

,-',
%+%-,
%
,'
,'$.',

1%
)+','

.2(%
$'#1#+
*1
1$%-
,1


'+$
3)'%%#<

.2(%
$'#1#+
,
1%
)+','
%'$%'


>



 
?

-+2,
#
1#
#,
$'#1#,
,'%
').$5,
+,

1%
$-''#' 
,1+-
)'+
#
+<
%-'%'

+/%
'%5#5:
#
'%,"'
1)+'+

%2,.'%,
%/,
>?

,)&:
4
,++'##
)',-+'+$%-
)'+
#
'+-'+'
-#4,,<B

%-
,-
)+',':
#,
$'#1#,
%.'3%-,
4
'-+,
$'#1#,
+','#1#,
*1
'%.%%
+1)',
+'3#'
%
,1
,-+1-1+
,
3)'%%

+1%,
#-+'$%.,
)+%,
*1
$)#+%
'%,+#$%-
,1
.2
'#(
,%
#-++
,1
,-+1-1+
$'#1#+<B

,-
$"'+
'-%
$%-
#


.%
#
)

$1#.)#+
#',
-',
-+)1.',

#,
,1,-%,
,'$.,

#
.2(%
$'#1#+:
'$'
#
.2
%.2+#
#
'
#++ %':
,-
BA<AAA
2,<B

-+'
,)-'
*1

,-+
,
*1:
$,

$)#+
,1,
-',
-+)1.',:
#


').$5
#
,%+
%-+$'#1#+:
'$'
,
',+2
%
#
%1-+1.'
:
'$'
,.$1#%-
%$1%'#('
4
'$'
%.'3%-:
#$%%'
#',
+#,
#+,:
*1
'$%-%
#
,-+,
'3.2'
4
*1
.2%
4
)+'$12%
#
+)#(%
2+#<B

%
1%
,-1'
*1
2#1(
#

%.'3%-
#
%1-+1.'
1,
,'$.'

.2(%
$'#1#+
>
?:
,
'$)+'(
*1
#
(%
%.'3%-
,
2'
$)#
,-
%
H<AAA
2,:
#'
*1
#'

$14
)'-%-<
,-',
+,1#-',
$1,-+%
*1
#
 

  
>
?
,
$)+,%#
4
%,+
)+
'%,1+
$4'+
.2
'#(
4:
)'+
#'
-%-':
$4'+
.2
%
#
-+-$%-'

#,
%+$,
*1:
+-
'
%+-$%-:
)+'1%
+#,
#+,<C
)'#
"#
&-
(
#*"
#"


(

#%*!0$"

%'#%(
)'%-*(
&-
(- "
%('
(%'(3
"
#"")'#"(
"#'! (3
"
(-()"(
#"
$"
)'%-*
#"#4
"
!% #

()
'%-()
(

#('.#
"
-"
()-#
' 0#
%#'
#"%$"
'0
'+"
)
 4
&-

!#()'#

(-%'#'
)'%-*


 -#(!"
(#!*



6")'#'.*.
#
5 -#(!"/'# #'
5

59973
"
#!%'$"
#"

 -#(!"
"#
*.
6 #'')#

5 -#(!"
5

73
 #.'
67
/
% #
"

)')!")#


&-'**(
'%*
"-
"
#"#(4:9





 




!
#&


 






 
  &







 
 
"



#


#
! 

 

 
 &
 
"
 '(&)


 
()
"#
-"#
(
"('
-"
$"
%# -!3
/
(
#!#
!#"#)'%
#
(##

#)'#(
!!")#(3
"

)')!")#


)(
*%#
9
/
:3

("'#!
!)$ #
/
"
()-#"(
&-
%'(")"
'(()"
%''


"(- "3
#!#

("'#!

#.'#(
%# &-(*#(
6 74;
 







# "
 #'"
"
'
"!

 # !!
 
 #
"

"
!
!#"0
"
!""
+
"
!# "0
'"
!

'" 

" ! 

"'

!

! '


" "


) 
 '!3
"#
'

'
'"
 '

"
!
!#"
6'"70


"' #
 !' 3=



# "
$
:
'"
'
! 
!

 "
+
"
!'



+

 " 3

!# !,
!

 "#!'

"
'"

#

"
"# "

 !"0
'
"
!'#!"

"'0






$' !"
" "
#!
"3

!
"#"
'"0

)'
+

!'
"'0
 

#!

'"

"
'"0

'
!)
 !' 0
'
'"
' !""
 #"
 !' "
!

!"3>



# "
 #'"
$
;
"
'
 ! 
 #

 
'
 #
! #

 !""
+! "

<9
"
+
"
!# !,
!

"'


" ! 

"'
! $0


"'





"'


'0

!

! ""# 


"'
 !!0

'

'!

 !' 
+
'#*3

# ""


"
$"
"#
! 

#! "
 $"
+

 # "0


! ""# 


"'
 !!
+



"3
'
 
+



' #0
)!$"

'

"
 !  "
 "
! ' # "


'3>


'#*
"
! ""


 
"#!"
*$)
!

) 

"
# "
+
 "  
'
 
!##


 ""

"
 "
!"



# "0
' '

)  "
"

 $!
' 

"
 ""
"#"
! 


 # 3>0?



# "
 #'"
$
;
"
"

'
+!
!#
+

'
#
! "

 "!!!
 "
!
+
!)"'! "0
"

 '!%"1
  "0
' 
!)!
 ' !0
"' 
! 
+
'#

 
!"3>












"!
 #

"$#'+
'
'!

!# !,
!

!'

#! "

! "

 !  "
!)"'! "0


 !# "0

" 0


"
)" !
+
"
 "# "

"'
# 3

"

'
+!
! "
!)"'!

!
,0
"



! "

 "!!!

# "
 #'"
$
;3

! " 

! ""# 


"'
"

" !
'
!##
#!
"#
!

!

"#
"! 3
!
#!
!# 0
#!"
#! "


"#!"0

#

$)
"0

#
 '"
+
'
 #
 '
#

"# 
! "

"'
"#3

"#
"!
#


"


4 ""# 
 !!


"'5
+
"

 ! 
 #

 "
(0
  "

" !

!
'"

""
!)"'! "


#'3:9


"!
 #

"
!# !,
!




'
"
)'

#! "

"
"' # "
#! "2
" 0

# "
 #'"
$
;

# !


'"0
 !# "
+
"
!  "
'

"3

 !
(

"#"

"
 #
"
"

'(()!


!(,!
:%'!(,! ;5
(
'5

$!


!(,!
!
#(
)#(
(
!#'
05
%#'
)!)#5
, !)
(,
!.
!

(!'8G


(!'# 
)$#
(
%,
%'(!)'
!
!.,#(
(!#(
#!
,!
%(#
!#' 
0
)#'!


,#(8
()
(!'# 5
# #

0#'5
*!
.'#(
# %#!!)(
0
!#
(
!('#
&,
)##(
#(
(
!()!
%'
%#'
(*!,'#8E


(!'# 
)$#
:;
(
,!
)'()#'!#
# %#
')'1#
%#'
,!
#!,!)#

)#'(

'(#
'#.(,'5
!' !)
'#!#(
#!

 ! !)#
!'

'(
0

'(()!


!(,!8E


 

 
 



(!'# 

#.'#
%#&,(*#
: ;
(
,!
)'()#'!#
)'#!#
')'1#
%#'

!#.,$!
'$!
0

%'!'#!( #8??5?@
/()
,!
)
!!


!
(
,'(
#!
)(
),(
*%#
@5
0
(

# %'##
&,

'(()!
%''


!(,!
0

%'!(,! 
# %!()#'
(#
( %"!
,!
%%
,! !)
!

%)#!((


 !!#8?A5?B


%'!(,! 
0

'(()!


!(,!
(#!
(
# ,!(
!)'
(
,'(
#!

&,
!)'
(
,'(
(!
()
)'$!5
!%!!) !)

(
(#!
#((
#
!#8??5?D

#(
(%)#(
)$#(

()
(!'# 
!,0!

'(()!


!(,!5

#(5
!# (
%(
0
,!
0#'
'(#

!)#'!


,#(
0

)(
),(
*%#
@8?B5?C


%'!(,! 
(* ,

('$!
!'#!
%#'
#(
#.'#(
0
(
!,(
(,%'''!(5
0
(,%' 

%'#,$!
%*


#,!
#'

#' #!(
(/,(

:
!(

 




;5
#
&,
%'#.#
,!
, !)#

!'$!#(
'(
#$ !)
*.#(8

/(#
#

!'$!#(
#.'#(
#


%'!(,! 
,(
)'(
%' ),'

#(
#,#(
#.'#(5
#' !#
%&,"#(
&,()(
0
!#.,$!8?F5@@

-!
')#(
(),#(5

%'!'#!( #
0

'(()!


!(,!
(
!()!
!
,!
)%
) %'!


.
0
%,!
!,(#
#'!'(
!

(
!)',)'!
0
))'(
! !)
!)(


%,')8?C5?E


!.
!)'5

, !)#


!(,!
) !
(
'#!
#!

('$!
!#' 


8

!.
%''#5
(* ,

('$!
#.'

!'$!#(
!)

, !)#


/%'($!

!
 ?E
:!1 
#' #'

!'$!#(
!
(
!,(
(,%'''!(
0
#(
#.'#(;
0


*.

)#'# #
BC>?E5
 (

)!'
,!
$!
(!'
#!

#' #!



#' 
')
0

(* ,'

('$!

)#'

' !)#
!(,!#
*%#
?
: 9?;
&,
(
!,!)'!
!

)#
#.'#8?G5@>5@?

!
'(, !5

'(()!


!(,!
#!)',0


%'$!

%'!'#!( #
'#!7
%#'
,!
#5

!.
!)'5
0
&,

!(,!
(
'#!
#!

('$!
!#' 


6
0
%#'
#)'#
#5

!.
%''#5

, !)'

('$!
#.'

!'$!#(5
!)

, !)#


/%'($!

!
 ?E
:!1 
#' #'

!'$!#(
!
(
!,(
(,%'''!(

#(
#.'#(;
0

*.

)#'# #
BC>?E8?G5@>5@?

  

 

(
,!
# %,()#
!,)',*#
'#
%#'

#')#'#
)0((
!
(%"
&,

#!*!
!
(,
# %#($!
## !)#(6
 !##(6
.) !(
0
)#)'%#(7



'!!88888888888888888888888888888888888888888888888888888888888888888888888888888@B6B


!
D6>

#
($'#888888888888888888888888888888888888888888888888888888888888888888>=


'!*!888888888888888888888888888888888888888888888888888888888888888888888888888888>D6D

,)#

1!8888888888888888888888888888888888888888888888888888888888888888888C


!)#)!)#

#88888888888888888888888888888888888888888888888888888888>

#
$#888888888888888888888888888888888888888888888888888888888888888888888888@@


/)')#

'!!#88888888888888888888888888888888888888888888888888888888@AB

#
, '#888888888888888888888888888888888888888888888888888888888888888888B6B


/)')#

,88888888888888888888888888888888888888888888888888888888888>B?


9'!*!88888888888888888888888888888888888888888888888888888888888888888888888888@B6B


9()!8888888888888888888888888888888888888888888888888888888888888888888888888888>A6?

*%'!#
($#88888888888888888888888888888888888888888888888888888888=6@@


'#/88888888888888888888888888888888888888888888888888888888888888888888888888888=6@@

!## !888888888888888888888888888888888888888888888888888888888888888=6>C







'!!
(
,!
 !##
(#
0
(

%'!%
%#')#'

!)'$!#
!
, !#(
0
! (8

(
# #
,!
 !##
( (!
#
#!#! !)
(!
!
#(
('(
, !#(6
0
&,
%,
('
(!)*1#
!$! !)
!
,!
!*
(,!)
%'
(*('
(
!((6
!#
(!#
!('#
!

)

#(
,)#(
(!#(8
(
 %#')!)
%'
!)!'

'(%,()
! ,!#$
0

)'1$!

(
'(8?@


'!!
%#(
,!
$!
(')#6
 (

!,'

'$!

(# )#)'#%!
0
%'#*!
%#'

!,
%),)'
0

'$!

!(,!
%!'*8
 !
(* ,

('$!

)#'

' !)#
!(,!#
: ;
0

'$!

#' #!(
!*!(,!(
# #

,$!6

(# )#()*!
0
(
)# !(8?A





!
(

(
( %

#(
 !##(6
0
&,
()
# %,()#
%#'
,!
(#
 !
0
,!

',%#
'#/#
#(

)# #

'#!#6
0
( %"
,!
%%
,! !)
!
!,()'#
(() 
(*.#
0
!'.#(#6
 (

('
!*#/!)
0
0,'

%'#%#'#!'
!'

#(
-(,#(8
(

%'!%
!,'#)'!( (#'
!#'
!

)'#!#
''
0
!

,
(%!8
 !
%,
#()''
,!
# %#') !)#
/))#'#7

''(

'%)#'
6

!
, !)

(!(

()

,) )#8


!6

'!

#)'#(
 !##(
!,'#)'!( (#'(6
!#
(
(!)*1
!

,'%#
(!#
&,
(
#*!


)8?B6?C


!
*!
.'(
,!#!(
!

#'!( #6
!)'
(
&,
()


%','(#'
#(!)*#8
(
'6
&,

!
%'*%
*. !)
!

# %#($!

#)'(
(,()!(
-*(
# #
(
%#''!(
:#' 

',%#
 #

(
 ##!(;6
(
%,'!(
:(
!)'#!
,*1
!

#' $!


!

;
0
(
#(#'*!(8?B6?C



&
&*
 
)$ &$%% $
 $1
"$"&


$'1


)
%"
-


&$ 
$$2
%
%
"$
#)
%
"$ ).

$

" &


)
-1
%1

")%
$+ %
")
$
$

 $!
%$

%
%'&%
"$&%

)$" 28;18<

 %

%&%
) %1


&*
&
 
&
%&$)&)$

+$%
%)%&%
-1

"$')$1

   2

)&'!1
)
' ,&
%
"$

#)$


,!
)$
)%1
"$"&1
" $

!

 %
$%
$%28;18<

 

%&
%
)
 

%
#)
")
 &$$%

 $
&)$


- $

"$ &%2
%
)
" $&&
"$)$% $

' ,&
)&'!1
 " &


&3#)$'
-
 %&$)& $
"$ &2

3%&
%
 &
 +$'

3%'


$%
&
$!

$)!3 ,!2

)&
 


-

)&& 1

%&
 $

)&'!1
)
" $ %
' ,&
#)
-)

"$ &$

$%
 &$
 %
$%
$%2
%
"$ "%


' ,&
&
-)

"$ &$

$$
-

 1

& ,%1
 
% 

  1

& 1

 &!

 %
& %1
&$
&$ %2
 %1

)&'!
&
 &$ 

!

&$ %
' ,&%
 

+&

-

+&
2;9


%&
-

' 
% 
" $&&%


%&%%


" 
"$ &


  2


" 
")
$)$

%

%)1

#)
$%)&
 %
"$

&%2;91;:1;;


 

3 $'
%
)
 
"$ &

%
"$

) &

$% 2
%
$1

$%
%&'.
'%
%)&%

3 $'

"$'$

&$ %
  %
)
 %
%&28=18>


)!


3 $'


)$"
%
"$'"$





)$1
" $

)

)$
%
,&$

 %
  %
-
%

" $

$%

&$+%


$2

3 $'
%
&
*'
 
"$ && $
" '2
)&
 

$'
-

$1
%
)'.
"$
 +.$
%
$%%

)$" 2
-)

%')$

%%&
) !
-
'
)
$
" $&


$

)$" 1
 %

-)$

$$$
%
)%

 28=18>


&%
 %%1

3 $'
")
%')$

 )
"&)&$
"$
#)
$

 $ 

$& 1
")
"$%&$
'+
!
-
 $$
%

$&
%

 %
&&%2

%&&1
 %
%&) %

 %&$
#)

3 $'
'
)
- $
&
!
)
%
%&$

% !
 

3$2

$'
&
%
$%" %

)&

 %
+%


 $ 

$&
45
-


%)28=18>


 

$'
%
)

)&$$
 
)
)!
)&


$!

$
" $
"$&


)1
-
#)
&*

%
$ %

&$%$

 %
 %
$% %
$%


$

& % 

%
&  $%1
&
%)
,!
-

$!

 %
&$ %&
4
52

$'
&
%

)'.
 
$)
 
 "&


&$&&

%"%1
-
#)
&*
 
)
" $&&
 -)+&


,!

 %
 %
$% %


$1

#)
)&

)%

&$$ %
"$

%)%&$

$28?


()-#

(-% !)$!
#!

<'!*!
%#'
(-(
%#((
)#(
!*#1!)(9
)!)#
!
!/-#(
(!#(
# #
!
&-#(
#!
!((
(%(9
!)'
#(
&-
(
!-!)'!
(
%'(#!(
#!
!' (
(&- (
2
#!
!-'#%+
*;CI

.!
#
()-#9DD


<'!*!
%#'
('
-!
 %#')!)
)#'

%'#)$!
!
(#(

!-'#%+
(''#
!
%'(#!(
*(9
- !)!#

%'-($!
!#!-'
2
(* -!#

'!'$!

(
'(
!'/#((;
!
()
()-#9
#(
)#(


(-% !)$!
#!
*<
<'!*!
(
#('/'#!
.! !)
!
%'(#!(
&-
%'(!)!
.!
(!)# 
!#9
# #

##';DA

 

 

%'#-
!

#'!( #
- !#9
!

#

'(9
2
(
#'!
%#'

#1$!

(-!)#

)'/(

-!
'$!
)3
%#'

!3 
(-!)#
('#!(;

-(#
!#

#
- '#
2
(-(
'/#(
(
' #!)

BIEI9
-!#

&- #
 !
0!
#' -$

%$)((

&-

%(#'((
()
-(
!
%')
%#'
-!
)'()#'!#

#

'(;DB


!( #

$!

#(
()'(

#
- '#
)#/
!#
(
# %'!
%! !)9
%'#
#(
()-#(
%'!#(
2
!#(
!
 #()'#
%'#%(
!*! )#'(9
! -!# #-#'(
2
!*%'#'*/(;

(%-
&-
#(
)#(
!*! )#'#(
()!
#!#!#(
%#'
!( #(
&-
!!
!
(
/(

)'!(-$!

(
("(
%'#! )#'(

)'/(


#-$!

(() 
'#1
!)'-';

#(
 #(
!
()
(() 
#!-!

-!
( !-$!


)'!(#$!

)#'

)'!('%$!
<
!

!.#
-'9
&-
!

1%'($!

)#&-!(
%'#! )#'(
= 79

<H


<B8>;DB






%'#1
#
/) !
F
()
%'(!)
!
#(
 !)#(
!

#' 

)'(
# %-()#(
(*!)#(:
%'#1!9
%'#1
2
%'#1 !;

#
&-
#(
'!
(

!)-'3

'-%#
-!#!
#

!#;


#' 
*/9

%'#1<E<#()#9
()
#' 
%#'

#(#'$!


%'#1!;DC

-!#!
# #
-!
#!3 
%'
-(
!3 (;
-
-!$!
%' '
# #
#!3 
!
/'((
'#!(
&- (
()
'#!
%'!% !)
#!

)#( #

(
%'#)!(;DC


/) !
F
).
# #
#!3 
!

(# %#($!
2

%'#/ !)#

#(
')#(

'#!#9
(
'((
2
(
%'#)!(9
2
!

%'#-$!

!-'#)'!( (#'(9
(-'!#
&-
#(
%'#(#(
)$#(9
# #

)#( #

(
'((
2

(
%'#)!(9
-!#!!
#'') !);DC


/) !
F
(
(-
-*3'
%'
# *'
#(
!/(
/#(

# #()!
-!)#
#!


#
$#
2

/) !
BC;


%'

 #'9

)(9
#(
)&-(

( 9

)'()#'!#
%#'
)

)!$!

%'*/
= >9
#(
-#(
'!(9

!'

%- $!9

!
2

)'#('#((
) !
%-!
)')'(
2
#''(
!)

 !()'$!

(-% !)#(

/) !
F;DC


()-#


 
 9
!

&-
%'*%'#!
(

HA;AAA
-'(9
'/$
-!
2#'
!!

!' (

(
')'(
#'#!'(
!
%'(#!(
#!
!/(
(
#(

/) !
F
!
# %'$!
#!
%'(#!(
#!
!/(
(
)#(; DG


!

*%


<
$

$ 


$
#
&*$


$
(
$
%


$
$%$


#
$
,
(

%#
 


#





( $
1 :=
$

#0
(
$(!%

!#+

#$%
 
$%

%#
 
2:>

  
 



$#
(

&



 



+ ($*
%

(%$

%
#
$

#


0


#0
(*$
,
 0
,

"(
$
$%&-

+ ($*
%
!#

%#
$2


*%


89
#"(#
!
#

$(

$#  


%#
%#$ 0
(

!#%

$ #%


!#

$
(
$
!
#%
$



( $

$%#
2::0:;



*%


89
,


%
$
(
%
$
!
#



$%$$

0

"(


$(
*-

 %




(#
 

$
#%# %$2


$
 $
#

!
#



#
 
,

%%




!



2


"(


$%$$





!#
!
#%


$

%#
$
%$&
$
$
$( %0

!#!# 
#$


%#
*$



%
2::0:;

#
 
%0


  


*%


89
$



$ 








!# $
0
(

  

#
%#-


!#
(
$
$
(
$
#
$

#
 
!#
,
!#


$-
 




!


(
$
#*$
$2
+$%
*$&
$
# %$
"(

$ 



  







(

,#
#$


%#$ #$$
,

#
$
(##
&*
$2::0:;

 

  
 




*%



3 

$ # 4
 


$$%

(  


%#
*$



$&(
 




&*

(  %
#
0



!#(  

%## 0



%#



$
#

$
,



!
 

 %$2::0:;



*%




%)


(
!%%

&+
%
$(


(
0

$

$#
(

%
#( %#0
,

"(


 %#$2;7
$0
$
(
!%%
#




 


$
!#%
$0
!#$%

 (
$

$
!$0

$
!#%
$
,

0
"(
%#(,



!
%$$




%$0


$

,
%#
$
#
$
# 
$

#
&*
$2;9

($
$%($
$(#
"(


$
!#%
$



$(

!(
$(##

 
,0
!#
$(%0
!#$%
#
(


&*

 

#( 
0

"(
%#(,


$
##

%#
$%#$
#

$


%
$



$(
2

$%
%+%0

($



*%



$
*#%

(
!#$


0
,

"(


!#*  




 



$(
0
,

$



! #
$



%##%
$
(0

#

(
#


(

#

$

&*

 
%0
#

!
#%#$



$$





$(
0


!#( 

,


%#
 





( $
2;9



*%


0
#

$


$(
!#

&+
%0
$
!#$%

%


!#% %#


$
#
$
 #$0


&#$0
#%



%$
% + $


#
%%#
*
%2
$$0
!
# 
#( #
$
*$



#

#&$
(


(#!
$
$%

$%#$0


#0
%#
(
$
$ $0
#
%(#
$0
"(
(#
$0
% 2;9



!#$ 


 

$ # 
$
$! 
%
#*
%

$
(  %$0




$
$! $
#
&*
$


+
3#

$
#$4
"(
$
#

(#
%



 %$$
,


&*
 
(%#
2
$%$
#

$
#$
$%

$ 
$


 $
,


$%#$


%#2::0:;
 !
$&'!(
$&"$'
!)"/!('
0
'
'",
!
,5
!
'(,"
&!(

 "'(&"
%,
"'
!"'
&".',&'


.( !

!
$!('
'$)"'
$,!
&'

',
!#!

#/"
!(&"
'!('
!,
7
85::4:;


"
'#&"
,!"!
" "
,!
!)"/!(4
!
.(&"4
 !!"
'
'$'
&).'

"/!"
0
%,'
&).'

!(&#!"
7&'
&'84
 $!"'
(&

"'(&"
5::4:;

 
 




"
#"4
"!""
( !
" "
.( !
 =
"
.( !
4
'
,!
.( !
&"'",
%,
$&(!

&,$"
4
!'&
$&

"& #!

$&"(!'
'(&,(,&'
0
 ""!4
0
',
,!(
'
/,'. !(
/#!5
'(
$&'!(
!
 !("'
" "
, &'4
.&,&'

"
"',&4
&,('4
&'
0
$&",("'
("'5::4:;4:<

!
"'
'!&" '


'"&#!4

!"&$"&#!

"'
"("'


(
' !,05
,

,!#!

'
$&"(!'
'
/(!'
0
'
 !
!
&!
$&"$"&#!
!

"4
"!
( !
'
("15
!

"
0
!

$' 4
!
$&'!

"
'#&"4

"
#"
'
"!.&(
!
',
"& 
(# !(
).
7"
((&&"#"8

(&.'


!1 
&""("
&,('5

 !
$"&
.
&!
0
$"&
 "''5::4:;4:<>


"
#"
'
 $"&(!(
$&
'
&"!'

)#!

"
'"/&&"!,"4


$&.!#!


$&" "'(! 5
 '4
(-
" "
!)"/!(4
0
',
'("
"/)."
'

'""
"!

&''(!


!',!4
"
%,
"!(&,0

'&&""

'!&" 
(#"
0

('
(,'
)$"
95

,
!
(


&'$,'(
,&
7$&",#!
0
!"("'

0
8
0
, "&

7! ,!"",!'84
$&(

'(&
&( !(
&"!
"!

&&

(,"
!,&5::4:;4:<





 



"!"
( !
" "
"
$!("(!"4

.( !
 <
'
,!
"!1 
%,
$&)$
!

("' "
!&)"
0
!

'!(''

"'(&"4
"'"$"'4
"& "!'
'(&"'
0
$"&&!
$&

 ""!5

"
$!("(!"
'(
" $,'("
$"&

"
$!(""
"

,!
',,!
(6!!4
$"&
!
$$*"5;:


"
$!("(!"
'
,!
" $"!!(


"!1 

7"84
', !"
,!
$$
!(&

!
'
&"!'

&#!

!&

$&)&

"'
&"&("'5
'(
$&'!(
!
&!'4
,."'4
4
&!"'
!(&'
0
!(&"'4
,(4
.,&4
.&,&'
7&#"84
,!'
&,('
7,(84
,.'

$'"

,
&4

&5;:

 $ !(
$&'!(
!
"'
 !("'4

.( !
<
$&
" "
("&
"!')(,0!(



"!1 
4
%,
'
'!
!
.&'
($'

("' "
,&
0
!

"(!#!

!&5;:

,
 !'(&#!
!
(& !"'

',$ !(#!
'(
!
!
!.,"'
"!
!''

!,(&"!'4
("/# !"'4
,&'
 &1'
"
(!('4
$&'"!'
%,
&1!
).'

&!
',&1"
'"4
$!('
$"'(%,&-&"'
"
'" )"'

'(&'
$&""!"5;:

 




-

"% 



#
*
#
$

#
!(
 "


#$##

"$
#1

$
#


""
$#1
 #
,
 #
(  #2
#$
"

#


"





$"

$"

#
"
#
,
#(#
"  $"#1

#


(

"


#
#&(#
#"  $"29<


-
#
(


$"
-% 

#

877
$
 "$
#
,
#

;7
-
#1
!(
# 

(

( 

$
%
1
#$"( $("

,
"(
"



#
$
-
#2:8

#$
 "($"$
$

$"*



#




#(

,
+#$
(

#$" 

"

#$"( $("

,
( 

$"
#2
(!(

" 
!(

 
#(
3-

#
$$
$
 #
"

"





"
1





$


 
 
"( 



%*




#(




#

#



#$"( $("


#$

"
2
#
(#1
#
#( $#

-

#

"

,

($




$(



(



"



"  $"1
#
!(
$




"





#(

"


1
,

#


 


  2

-
$

(

$"
#

#



#(

"

#


#
#&(#



 ##

#

  $#1

#"




"
2:8


#
 $"
#

-

#
#$#

 "% #
#$
"


#



#$##1




$
,


# " 

"
#2
#1

-

" 
#"
(
(
"
# 



$"
#( 



#


#(
1
,


 



"$

%"#

#
$
#

#
(

#

##
"
#
!(

($"$
" 
(
 $
% 
#"


"
2:8






"
1
$

 

"%1
#
(

"($

(,
"
& 
#
  



1
,
#
(



#
($#

$("
#
#
"
#


$ 

#2

#

$ 

#
#
" #
$

#
"# #
#

"

-(


"

,

#
!(

"
(

$
"

%+
$2
$"

#
"($
#
!(


#
$

#$(#
#

*
-
#1


"

#
(



#
#
"
#


%+
$#2
"#$

(
$
#  
$
*


#
4
$ 

#51

!(

" " 

(

 "$
$



%+
$
,
#
"
!(

#

$ 

#
#

" 


%*
"# #


#
 #

"



#
(2::



$"(,



"

)% #
" 
#
$"
(%
#



 ( 
$1
  
$1

%

$"

,

%+
$1
$"
$"
#2





 ( 
$


"



#
#$(


"
("##
*#%
"#
,


#  






#
%



(



#

$
#

%
%
#
#
" 

#2:;


(
#$(
"
-

"

"%
(:<
#





 (#

!(
#
+$"
$#

#$


$

$

" 
#
#
"#



#



#(

,

#
$
-
#1

#

(


%*

$ "$ $"
2


(
#$(

"

$
#

$

#


$
#
##

"
#

,
$"
$

#

+$"
$


"

4
  51
("
:=
(#


#$
(

#( 



"##$ 





#(
1
(

"( 



("$


  $#
,


#
# (
#


$"
#


"



#
"
$
#

$

#
#

(

$


$


"
#
#2




!$79
!

 


$ 

$

 $


 

"'
1
 
2

$



!
 

 

!
"
6
 


 



 $




$

!0
 !
 $!
$  
$


 
 
$ !




$ 


$

!'

$
  
   !


 $0




 

$!
!$


$"*
 

"& 

 


!! !

%"
   0

!
"/

!
 
  
$
 
$ !


$

!

 !07:


!*
 

/

$ !

 $/

!
$
'  /


$"*

  
 



00
$
$ 
 
 !

$
$!$


/

/

/
!
! 084


 $

$
!
 

 


$! !
)

$
 !
$
'

$)


)
"
"'

! 
1"(! 2/
 

!
   !
1 


*/



)

 20

$!


'! /
 !

 

'!

)
/
)


 
1 

*$ /
 /
 /

)
20

$
!
! 


' !

$
$ !
 !
 $!*

 /

  


 
 


 */




!$ 0

 $
" 

$

*
)
 !(/
  !

/
)
$



$
)

)$

!
*

' 

*%


 0

 

$

 !(!
)
*


!!
 !! "/

 $
" 
$
$
!!


!


$ 
$
 $
$



' 
 !! "07/85
  




 

=+!3**8
*'$>
*
/#
#/+)/-%
(/
%#-#
#
*/
%"'%*&#
%!%!"#+%*8
"#%%*8
1+"#*8
2+)+%

!/
3
2+)+%

)##%:

!
"%-1%
')
*%)
*+*
*/*+#*
/
!
')%'
#-%2#+

'%!/"#+
"%*+)
'%)

/#

!!*8
+#+%




%"%



:

*+
%"'%*&#
*%"-

-1&#
"%!/!) @8A

%"%
)*/!+%
/#
#/+)/-%
!+"#+
-1%8
3
(/
!

%'-"4
!*
')%'*
+)'/-*
3
"'!
!
*#)*"%
#+)
!!*8
#%
(/
 

*+
#%
')
+)+)
*+%*
')!/"%*
%

)**+#

!
#*/!#8
+/#%
#
!
"+%!*"%

!
!/%*8

!
14
(/
)/
!
*+)*
%2-1%:

)*

*/
%"'%*&#8
 

*-"/!
!*
/#%#*

!*
!/!*
+
'#)-*
3
1%)
%#*
#
!
**+"
*-1%
%#
!
#

)/)
!
*%)&#
*+)%#+*-#!

!/%*
=2+)+%

!/>8
"*

 ))
/#
&#
')%++%)8
+#+%
#+)!/!)
%"%
2+)!/!)8

!%*
+%*
') /!*

*+
'+%!%
=')!/"
3;%
)**+#

!
#*/!#>:

0#
*+/%*
)!4%*
#
'#+*
-%*
%#
)**+#

!
#*/!#8
*
%+/1)%#
)*/!+%*
1%)!*
#
!
*"#/&#

!%*
#1!*

+)!)%*
3
*
%*)1&
/#
/"#+%

%!*+)%!

8
*
%"%
!
" %)

!%*
#*
< 
3
<
#
/#
')%%

D
"**:B8D


/#(/
+%1
3
"/%
*%#%"#+%
)

!
*%'+%!%
!
 8
/#
%)"

)**+#

!
#*/!#
#+)#*
!
*#)%"
')
*)
/#
+%)
"'%)+#+
#
*/
*))%!!%:
/#%
*
')*#+
#
'#+*
%#
%*8
!
)**+#

!
#*/!#
%*)1
*
2'!
#
')+
'%)
!
2*%

+ %
)*%9
*#
")%8
*

%#*++%
(/
#!/*%
!*
"/ )*
!*
%#

-##
/#
"3%)
)**+#

!
#*/!#
#
%"')&#
%#
!*
"/ )*
%#
!
"*"%
#

"*
%)'%)!
*#
 :CC


')#*/!#"
*-"/!
!
*)&#
#)%#
'%)
!%*
%1)%*
3
!*
!#/!*
*/')))#!*8
3
*/')"
!
')%/&#
'-

!
!%/!#
 %)

%)"%#*
*2/!*

=!
#!*

 




>8
!%
(/
')%1%
/#
/"#+%

#)&#%*
!)*
%!&"#+
-1%*:
!
2*%
!%!

#)&#%*
%1)%*
%

!
')#*/!#"
/*
+)*
')"+/)

!%*
%!/!%*
%1)%*8
%)"#%
'(/$%*
(/*+*
3
#%1/!&#:CC

#+"#+8
*
#
)%"#%
)"%*
*#*!4%)*

#*/!#
%"%
!+)#-1
+)'/-

!)%
'!4%
#
!
+)+"#+%
!
 :

!
"'%)+#

!
')#*/!#"
#
!
*))%!!%
!
')#)%#*"%
3
#
!
')+/)&#

!
%!/!%#**8
')
)4%#!
*/'%#)
(/
*%*
)"%*
'/#
*)
0-!*
')
)*+!)
!%*
')"+)%*
!#%*
3
#%)#%*
!

!
+#/)
!
2*%

#*/!#:

*
#
%
#*3%*
%#
1)*
*/*+#*8
%"%
!
",%)"#8
!
+)%!+4%#8
!
)%*!+4%#8
!
'%!+4%#
3
!
<
)%<#%*+%!8
%#
/#%*
)*/!+%*:CC
 
'
+
$&"+("
+.
" ""
""
+(&+)"3
 "
$&

(&( ("

"'
'("'
$&+"'
.

&''( 


 '+ 4
'3

-'(

'('
 " '3
'

$&"$+'("
""
"$#
(&$+)
$&
'(
' &"3
.
%+
(,

 &
'&

"(&"'
&"'
' '/"&'

 '+ 
'
"'
("'
'+ &"'
+'"'
$"&
"'4

&  /5&"
.
""&';<
&/&"
+
'(+"
(&$
"
"
:=
$ ('
"

4

'!#
+
 '."
 "
(&$
"


%+
'
"$&#

'+$ ("
 )"

6
&'

'
"&/
"

"&

 7
"
+
$"3
.
'

&/#
'+ ("
+& (
<
''
 (
-+#
 
.
"%+4;<


"'&-#
+ 
' +#




5
 

"$&#
"


5
 3


-/
%+
'
&'(&#
+ 
"&
' )-


&''( 


 '+ 4

&'$+'(
 '(&+
+
."&


&+$"
%+
&#

.
+"
9
&/"'

'(
&+$"4;<


" +'#

'(+"
+
%+

' +.

&''( 


 '+ 
"
+ 
"&

' '

'(
"&" 

+&'
"

3
.
"&
"'
-'


.
('("'(&" 4;<
  


$0
."*$
%)'%),%$
$+)$,%$"

%.)$"
%
$%)$%"%1
%".#
A?@A5
),"

BFAE@G5
E
'*
%7@?8@@CC9A?@A9BFAE@G

Clinical Study
D i a m e l Th e r ap y i n Po l y c y s t i c O v a r y Sy n d rom e Re d u c e s
Hyperinsulinaemia, Insulin Resistance, and Hyperandrogenaemia
)+.)%
)$$2:)%5
"'
$+$
)25
*"
/*
)""%
1
.)%
)):
%


)$$2:)%
1
%"%)*CD
)"2)%$
.$
*+.%
+)'"
%
%$
BE
'$+*
%$
 8

')%1+&
.$
$*1%
"$%
+)'"
%
$
"
(.
"
*.'"#$+%
$.+)%$"
#"
;$
.)%'
 
*
%#)"2
%#%
#"<
*
%#')&
%$
.$
'"%8

*
#.!)*
$

)')%.,/
.)%$
*+).*
"+%)#$+
$
%*
).'%*

@F
1
@G
#.!)*5
)*',/#$+6
))%$
#"
%
'"%
1
*
"*
)"2&
.$
*.#$+%
.)$+
D
#**
#$+
/".&$
"$
1
%(.#8


%*)/&
.$
*#$.&$
*$,/
$
"
 : 

"%*
**
#**
%$
)*'+%
"
/"%)

$"8

*$*"

"
$*."$
#!%)&
%$*)"#$+
$
*+
).'%8

+*

).')&$
#$*+)."
.
#1%)
$
"
).'%
%$
#"5
1
%*
'$+*

%
).'%
(.)%$
#)2*8

Tabla 5: Evolución del índice de resitencia a la insulina (HOMA-IR) en pacientes con síndrome
de ovario poliquístico
n Diamel n Placebo
HOMA-IR inicio 18 4,3 ± 2,4* 19 4,6 ± 2,5*
HOMA-IR 3 meses 17 2,6 ± 1,3* 16 3,3 ± 2,0*
HOMA-IR 6 meses 16 2,4 ± 1,2* 16 3,3 ± 2,1*
* p = 0,04
Datos en media ± DE

Tabla 8: Evolución de los niveles hormonales en pacientes con SOP durante el

periodo de seguimiento
Seguimiento Diamel Placebo
Inicio
FSH (UI/L) 6,7 ± 2,6 6,1 ±1,5
LH (UI/L) 11,0 ± 6,1* 9,7 ± 5,3
Testosterona (nmol/L) 2,9 ± 1,5 2,6 ± 1,6
3 meses
FSH (UI/L) 6,8 ± 2,3 5,8 ± 1,9
LH (UI/L) 9,9 ± 5,9 9,2 ± 5,4
Testosterona (nmol/L) 2,6 ± 1,3* 3,7 ± 3,2*
6 meses
FSH (UI/L) 5,8 ± 1,8 5,7 ± 1,9
LH (UI/L) 7,6 ± 4,9* 8,8 ± 4,2
Testosterona (nmol/L) 2,3 ± 1,6 2,4 ± 1,8
* p = 0,05
Datos en media ± DE


"
*((-
*+$)%!
*.,#*/(

Utility of Diamel in patients with type 2 diabetes

mellitus receiving combination therapy with
glibenclamide
J.A. Hernández Yero, D. Vargas González

!

&*#'!
*'%!

7
%&

&
!%/
!!
 
83
!#*&'!
#!%
!!&3
,'&3
!!'!&3
-'%'!

*
.
-'%'!

%!3
(,!
'
#%!&!

(,"
!*%3
!
!&

,
#%(!
.
&'%!&'&(3
#!%
&%
*
'%(,
'%#*(
#%

'&
(#!
>
7>85


 4
,*%
*%'
*
#%!!

B
&&

!'%!
'"!3

&&


&*
.

*"

&
*&
'

#'&
!
>
'!!

&
5

   

4

&!%!
'!%'
B<
#'&
!
>

>
%*#!&
#%

%%

&

7%*#!
3
G?<83
!
&!'

7%*#!
3
G?<85


#!&!!


*

>
#&*&
?<
*'!&
'&

&.*!3


!
.


5




!&
#'&
&'
'%
!&
@<
.
!&
BA
 !&3
.

(#!

,!*"


%3
'%
!&
<
.
!&
=<
 !&5

-*."

!&
#'&
!
!!

7=8
&*#%!%

=<F
!
!
!#!&
%"&
!%&
!
%,&5
*%!
'%'!&
*%'
B
&&
!
,*"

.
!$*
7&*

.*&3
*!&
&
.
*!&
#!&'#%

!&
!%&3
=3
!&'%!3
'%%!&3
!&'%!


9
:3
&
6
.
68

#%#!3
.

!

?
.
B
&&5

  !

"
*




&!%#&!
.
*
(#!
#%!!

,!*"



'&

A3?
 !&
7%*#!
8
.

?3C
 !&
7%*#!
85

!&
!&


!'%!
'"!
*%!
&(,'
!%&


%*#!
!
3
!
&*"


!&&
%



!&
&&
&&5
!&
%*#!&
!&'%%!
%&&'


&*
76 83
!
*
'

&*%


%*#!
3
*$*
*!
!#%!&
!&
%*#!&
&'
%
!
*
&'&('
&(,5


&%"

&*
768
*'"
&(,'


%*#!
!


!#%"
!

%*#!

!'%!3


$*

&%"

&*
&*."5

 !
&'
&

#%%
&'*!
!'%!!
!

!#'!
5
*$*
!
&

/!
!
*
& !
!
!3

#%
&%
+(
#%
!%%

!'%!
'"!
.

*"

&
*&
'

!&
*%'
!&
&&
&&

&*'!5
 Tabla 4. Cambios en el control glucémico en el grupo A y en el grupo B
durante el seguimiento
Variables Evolución Grupo A Grupo B p
Glucemia ayunas Inicio 7,6 ± 2,2 7,4 ± 1,7 0,6
(mmol/L) 3 meses 6,8 ± 1,9 7,2 ± 1,3 0,35
6 meses 6,7 ± 1,5 7,6 ± 1,3 0,03
Glucemia Inicio 10,0 ± 2,5 9,4 ± 2,1 0,39
pospandrial de 2
horas 3 meses 8,9 ± 2,0 9,5 ± 2,1 0,27
(mmol/L) 6 meses 8,7 ± 2,6 10,1 ± 2,0 0,03
Hemoglobina Inicio 7,7 ± 0,8 7,4 ± 0,8 0,32
glucosilada 3 meses 6,8 ± 0,7 7,1 ± 0,6 0,05
(HbA1c) % 6 meses 6,8 ± 0,6 7,6 ± 0,9 0,001
Datos en media ± DE.

Tabla 5. Niveles de lípidos en el grupo A y en el grupo B durante el

seguimiento
Variables Evolución Grupo A Grupo B p
Colesterol Inicio 5,02 ± 0,96 5,2 ± 1,0 0,47
(mmol/L) 3 meses 4,7 ± 0,95 5,1 ± 0,99 0,08
6 meses 4,9 ± 0,82 5,4 ± 0,92 0,04
Triglicéridos Inicio 1,78 ± 0,52 1,89 ± 0,55 0,44
(mmol/L) 3 meses 1,64 ± 0,59 2,07 ± 0,62 0,008
6 meses 1,76 ± 0,63 2,12 ± 0,50 0,02
Inicio 1,11 ± 0,21 1,04 ± 0,16 0,15
cHDL (mmol/L)
3 meses 1,17 ± 0,32 1,04 ± 0,19 0,08
6 meses 1,06 ± 0,13 0,95 ± 0,09 0,001
Datos en media ± DE.

Tabla 6. Evolución del grado de resistencia insulínica (HOMA-S) y función

de las células beta (HOMA-B) en los grupos A y B
Variables Evolución Grupo A Grupo B p
HOMA-S (%) Inicio 7,5 ± 0,89 7,6 ± 0,7 0,87
3 meses 5,6 ± 0,73 6,6 ± 0,69 0,32
6 meses 6,4 ± 0,79 7,2 ± 0,46 0,46
HOMA-B (%) Inicio 128,6 ± 16,8 174,1 ± 35,1 0,24
3 meses 133,9 ± 26,2 116,8 ± 11,8 0,55
6 meses 156,1 ± 8,6 105,1 ± 8,6 0,03
Datos en media ± DE.
 


  




  




 

))'



#

  
(

 
 

 

 
 
$  "
 

  %#











 
 
 
  

   #

 

 
aQ 434*8(

W
 48:58,4
:1D9,9
bQ @#4
%!3,!4N
W
8@39B,!0
 48:48,$9
W
261$
#$3<(!<43P
W
:!+
]P
WadbfgF
W


]P
adW`dbe
W$9!8,6<43P
,@9,#
81
41@<43N
,7@,#N
fadF
W
`gVahVb`ad
W
b``
@836,0$
#
4@:+ 484@*+N

`aggbN


cQ 
Q
QN
$:
1
T3<A,81
!<A,:D
4&

W*1@!492,3$
#$8,A<A$
*,39:
+$86$<!
@1!$89
Z

:D6$
b[
,3
8 ,:
!583$U
,89:
6@ 1,9+$#P
$ 8@8D
aihi
W
+?69PVV#4,Q48*Va`QaaaaV/QageeW
cgfhQaihiQ: ``gbcQC

dQ


Q
QQN
$:
1Q
R<1,:D
4&
,2$1
,3
6<$3:9
B,:+
:D6$
b
#, $:$9
2$11,:@9
8$!$,A,3*
!42 ,3<43
:+$86D
B,:+
*1, $3!12,#$S
A
, $:41Q
b``fO
bcZa[P
bhdWbi`
eQ 
N


Q
R41$
4&
4C,#<A$
9:8$99
,3
#, $<!
!4261,!<439Q

3$B
6$896$!<A$
43
3
41#
68#,*2SQ
, $:$9Q
aiiiOdhPaWiQ
fQ 

N
$:
1Q
,2$1
994!,:$#
B,:+
,39@1,3
48

48
9

6+82!414*,!1
2434:+$86DQ
A,1 1$
:P
+?6PVVBBBQ!:1D9,9@9Q3$:V9:@#Y,2$1Q+:21Q
!!$94
#$1
f
#$
*49:4
#$
b``f
gQ N
Q
Q
O
N
Q
Q
3!8$9Q
3P
N
Q
Q
O
N
Q
O
N
Q
:414*,
$9:8@:@81
$
&@3!,431Q
fQ
$#Q
,4
#$
3$,84P
@3 8
44*3Q
b```Q
6Q
b`Q
hQ N
Q
Q
O
N
Q
Q

,9:58,!4
$
:8:2$3:4
#$
6!,$3:$9
!42
#, $:$9
2$11,:@9Q
3P
8:#4
#$
$3&$82*$2
2%#,!4W!,8@8*,!Q
iF
$#Q
,4
#$
3$,84P
@3 8
44*3N
b``bQ
6Q
cgQ
iQ N
Q
Q
O

N
Q
Q
39@1,3N
*1@!*43
$
#, $:$9
2$11,:@9Q
3P
YYYYYYQ
8:#4
#$
(9,414*,
2%#,!Q
a`Q
$#Q
,4
#$
3$,84P
@3 8
44*3Q
b``bQ
6Q
hbgWhd`Q
a`Q N
Q

Q
#$
O
N

Q
Q
#$
O
N
Q
#$
Q
82$:849
3:84642%:8,!49
$
9-3#842$
2$: 51,!
$2
#, $:$9
<64
bQ
87Q
89Q
#$
3#4!8,341Q
$: Q
AQ
e`
3Q
c
4
@14
/@3Q
b``fQ

aaQ 
N
Q
$:
1QN
T96$!:84
&$34=6,!4
#$1
9-3#842$
#$
4A8,49
641,7@-.9<!49NU
$A,9:
+,1$3
#$
 9:$:8,!,
D
,3$!414*G.N
A41Q
geN
34Q
bN
66Q
abdXacbN
b`a`Q
abQ 
QQ
$:
1QN
T
4B
!42243
8$
641D!D9<!
4A8,$9
,3
34821
B42$3
3#
B+:
,9
:+$,8
9,*3,(!3!$
&48
:+$
&$8<1,:D
4&
:+$
646@1<43MU
1,3,!1
3#4!8,3414*DN
A41Q
cgN
34Q
bN
66Q
abgX
acdN
aiibQ
acQ 

QN
$:
1QNT+$
6:+46+D9,414*D
4&
641D!D9<!
4A8D
9D3#842$NU
1,3,!13#4!8,3414*DN
A41Q
f`N
34Q
aN
66Q
aXagN
b``dQ
adQ

QQN
T39@1,3
8$9,9:3!$
,3
641D!D9<!
4A8D
9D3#842$NU@88$3:
6,3,43
,3
 9:$:8,!9
3#
D3$!414*DN
A41Q
iN
34Q
cN
66Q
aicXb`aN
aiigQ
aeQ 
QN
$:
1QN
T41D!D9<!
4A8D
9D3#842$
)$8
68$!4!,4@9
6@ 8!+$P
43:4*$3D
4&
:+$
14BW
,8:+
B$,*+:
$'$!:NU
1,3,!1
3#4!8,3414*DN
A41Q
eeN
34Q
eN
66Q
ffgXfgbN
b``aQ
afQ 
QN
$:
1
T$&$!:9
,3
,39@1,3
8$!$6:48
9,*31,3*
,3
A,A4
,3
:+$
641D!D9<!
4A8D
9D3#842$
Z[NU
2$8,!3
4@831
4&
+D9,414*DN
A41Q
bhaN
34Q
bN
66Q
cibXciiN
b``aQ
agQ 
QQN
$:
1
T41D!D9<!
4A8,$9
3#
994!,:$#
2$: 41,!
 34821,<$9
,3
3#,3
9@ !43<3$3:
9,3
B42$3NU
1,3,!1
3#4!8,3414*DNA41Q
diN
34Q
aN
66Q
iaXiiN
aiihQ
ahQ NQQ
$:
1Q
R94
#$
1
2$;482,3
$2
6!,$3:$9
!42
$1
9-#842$
#$1
4A8,4
641,7@-9<!4SQ
!:
%#,!
49:88,!$39$N
AQdiN
3Q
cN
b``gQ
,96 43,A$1
$2P
+?6PVVBBBQ8$#1D!Q48*V8<!@14Q4M,#jdcddic`dQ
!$994
$2P
`a
2,Q
b`aeQ
aiQ N
Q Q
$:
1Q
R-3#842$
#49
A8,49
41,!-9<!49N
-3#842$
$: 51,!N
,9!4
8#,4A9!@18
$
4
6$1
#49
*$3:$9
$39, ,1,E#48$9
#
39@1,3SQ
87@,A49
89,1$,849
#$
3#4!8,3414*,
$
$: 414*,Q
4
@14N
AQ
e`N
3Q
bN
b``fQ
,9 643-A$1
$2P+?6PVVBBBQ9!,$14Q 8V9!,$14Q6+6M9!8,6:j9!,Y8?$C:\6,#j```dWbgc`b``f```b```adQ
!$994
$2P
`a
2,Q
b`aeQ
b`Q N
Q
Q
$:
1Q

@<1,E"4
#$
*$3:$9
+,64*1,!$2,3:$9
34
:8:2$3:4
#$
6!,$3:$9
!42
9-3#842$
#49
4A8,49
641,!-9<!49Q
$A,9:
Q
,4
#$
3$,84N
AQ
cfN
3Q
abN
b``hQ
,9643-A$1
$2P
+?6PVVBBBQ&$ 89*4Q48*Q 8V9,:$VB6W!43:$3:V@614#9Vb`acV`eV$2,3Y#$E$2 84b``hW
gcaQ6#&Q
!$994
$2P
`a
/3Q
b`aeQ
]\N K
NN
#8
.N

"/*0*786 *20
"#
/#916/*0
#0
#.
7+0"61/#
"#
1?6*1
41.*5=+7: 1N#?*78
#A* 0
"#
#"* *0
"#
.
#461"= *20N
$A* 1K
?N_K
0N
_K
][\]N
*7410+?#.
#/M
)<4MQQ@@@N/#"*(64)* N 1/Q4"&7Q6#461"= *10Q/6S][\]Q/6\]_N4"&N
 #771
#/M
]`
6N
][\`N
]]N 
NNNK
#8
.
O+0"61/#
"1
1?6*1
41.* +7: 1
#
/#916/*0M
6#?*71
7#"
#/
#?*"%0 *7P

R
1?#/61
][[d
R
?1.
^b
R
0E
\\
]^N  0 8 6  / # " * * 0 #
T
 6 1 & # 7 7 * 1 0  .
 1 0 1 ( 6  4 ) 7
T
 = 8 6  # = :  . 7
T
 6 ( * 0 * 0 #
U@@@N*086/#"* *0#N 1/VN
]_N 
K
#8
.N
//=0#S/1"=.816B
 :107
1&
6(*0*0#
*0
8)#
6*: ..B
*..N
6

=86N
][[]
0Lcb
=44.
\M\]\S^]
]`N 
K
#8
.N
#)0*0(#6
6*0 *4.#7
1&
*1 )#/*786B
_
#"N
WN.NXM
NN 6##/0N

dbcS[S
b\abS_^^dS]

]aN 
K
N
#8
.N
)#
&6##
6"* .
*0
4B6=?8#
&16/8#S.B7#
*7
.1 8#"
10
(.B *0#Sb^_N
cdU^VMddaS\[[[N
WN.NXM
61 N
8.N
 "N
 *N
NNN

]bN K
N
NN
=86*#08#7
#
#64#=: N
#.187QM
*71
68#7

6' 7K
][[dN

]cN K
NL
#8
.L

T

=*
1/4.#81
"#
107=.8
&6/ 18#64#=: N

6 #.10N
]D
"N
][[`

]dN 
N NNK
#8
.
O4.* !3#7
.+0* 7
"
7=4.#/#08!1
"#
S 60*:0P
#?N
=86N
?1.N\c
01N`
/4*07
#48NQ 8N
][[`
S
)<4MQQ"AN"1*N16(Q\[N\`d[Q\_\`S`]b^][[`[[[`[[[[c
^[N 


K
#8
.N
O #8B.SS 60*:0#
U.#? # 60*0#V
*0
86#8/#08
1&
"*#:
0#=6148)BN

.10(S8#6/K
60"1/*7#"K
"1=.#S.*0"K
4. #1S 10861..#"
78="BPN
6=(7

N
][[]L
^U_VM]]^S^\
^\N

.N.NK
#8
.NK
O78#6#7
"#
 *"1
&=/6* 1
0
4716+7#
#/
4. 7P
#?*78

b^U^V
][\`

^]N K
N
NK
#8
.N
*8/*0
a
T
6#?*71
8=.*C"
716#
7=7
4.* !3#7
.+0* 7N
#?*78
67*.#*6
"#
#"* *0
S
"#601
7=4.#/#086
"#

*0# 1.1(*
#
78#86+ *
`b
U][[[VN

^^N K
NL
#8N
.NK
O*8/*07
*"61771.>?#*7NP
0M
.*?#*6K
NKNKN
*%0 *7
=86* *10*7K
4N
\\N
1
=.1M
6?*#6K
\ddcN
44
\d\
T
][^

^_N 
N
U#"NVN
=86*!1
.+0* N
*1
"#
0#*61M

=06
11(0K
][[bN

^`N 
K
#8
.N
O *"1
&2.* 1NP
1
=.1K
M
08#60:10.
*&#
 *#0 #7
07:8=8#
"1
67*.L

][\[K
]_
4N
$6*#
"#
=.* !3#7

67*.M
&=0!3#7
4.#0/#08#
6# 10)# *"7
"#
0=86*#08#7L
?1.N\[


^aN 
NNK
#8
.N
O6: *4:10
1&
C*0
*0
*07=.*0
6#7*780 #P
65
67
0"1 6*01.
#8
?1.N_c
01N]
1
=.1
46N
][[_


^bN 
N
*8/*0
a
U4B6*"1A/*0#V
7=44.#/#08:10
0"
1/4.* :107
1&
"*#8#7N
#81.*7/N
][[bL
`aU]VM\acSb\N
^cN 
K
#8
.N
O)#
#0"1 6*0#
40 6#7
*0
4B6*"1A*0#
"#' *#08
687NP
1)1-=

A4
#"N
\dc\L
\^_U^VM^^\SaN
^dN 
 K
#8
.N
O/461?#/#08
1&
16.
(.= 17#
81.#60 #
*0
(#78:10.
"*#8#7
B
4B6*"1A*0#NP
6
#"
N
\db`L
^U`db_VM\^S`N
_[N K
NL
#8
.N
=4.#/#08!1
=0 *10.
(*786.M
"17
0=86*#08#7
17
1/417817
*1:?17N
\
#"*!1N
1
=.1M

"*816K
][[cN
_\N SK
#8
.NK
O*8/*0

=44.#/#08:10
# 6#7#7
07=.*0

.B :10
0"
/461?#7

.= 17#
1/#1787*7
*0
#7#
B4#6(.B #/*
U1Q1V
* #PN
#81.*7/L
`\
U_VM
`\_S`\bK
][[]N
_]N 
NK
O//=01S#0"1 6*01.1(BM
8)#
61.#
1&
/* 610=86*#087
*0
)16/10.
7*(0.*0(P
#?*78
67*.#*6
"#
=86*!1
=0 *10.
S
01
\^K
0E`aK
][\^
_^N K
NK
#8
.N
O*8/*07
*"61771.>?#*7NP
0M
.*?#*6K
NKNKN
*%0 *7
=86* *10*7K

4N
\\N
1
=.1M
6?*#6K
\ddcN
44
\d\
T
][^
\\K 4-5#/H
KH
#6
-K
TZXX_UK
/6)0 ?/*/5
*/)**6
/; -#4
& 604R,22
 8<80/
*/
.0/0 ?6#5
/"
4#"; #
2-5.
0/ #/6480/5
0&
240*/'..604?
.#"*6045
*/
)#-6)?
";-65K

;64H
Y[_H
22K
Ya]YRYa]\K
\]K
H
K
KH

K
TZXX[UK
0.248<#
56;"?
0/
6)#
.#"* */-
2-/65
.056
4# 0..#/"#"
?
64"*80/-
24 880/#45
*/
0440 0
/"
/"K

 



H
YXH
22K
Z]R\]K
\^K H
K
K
#6
-K
TZXX^UK
/8R"*#8
2402#48#5
0&
6)#
/"*/
-0=;5)
-;##44?
 */*;.
/(;58&0-*;.
*6K
)?60.#"* */#H
Y[H
22K
^YZR^Z[K
\_K H
K
#6
-K
TZXXaUK
*#64?
-;##44?
:#/;6#5
=)0-#R0"?
*/5;-*/
4#5*56/ #
*/
)*()
&6R&#"
.* #
?
4#"; */(
"*20 ?6#
"#6)
/"
*65
*/'..604?
5#3;#-#K

H
Y[aH
22K
Y]YXR
Y]Y^K
\`K H
K
K
#6
-K
TZXYXUK
*0 8<#5
*/
-;##44*#5
*.240<#
*/5;-*/
5#/5*8<*6?
*/
0#5#H
*/5;-*/R
4#5*56/6
.#/
/"
=0.#/K

H
Y\XH
22K
Y_^\RY_^`K
\aK 
 
H
#6
-KH
L





M
/"*/
0;4/-
0&
-*/* -
*0 )#.*564?
ZXXXH
Y]T;22
UH
Y^aRY__
]XK 
KH
#6
-KH
L-/65
.#"* */*5
/0
646.#/60
"0
*#6#5
#--*6;5O
#<*56
 H
/K`H
2K
`YRa_H
4KP+;/KZXX^
]YK 
KH
#6
-KH
N 6; >/8/
R
;.
206#/ *-
406#/1*"#
/8"*$8 0
"
-& #
T 6; 
58<U
*/*#

8<*""#
"
GR.*-5#
#
GR(-* 05*"5#
*/
<*640
#
#.
4605
"*$8 05MK
00"
;/ 6K
ZXY_
4
ZZI
`
T[UJ
YYZ\RYY[YK
"0*J
YXKYX[a
P
^&0XY^]]
]ZK H
KK
#6
-K
04.;-4*0
$"* 0
4. %;8 0RZ@
#"*!0K
0
;-0J
# /024#55H
ZXXZK
][K 

KKK
#6
-K
L






M
#<K
;64KH
.2*/5H
YZTZUJ
YZ[RY[XH
.*0P(0KH
Yaaa

]\K 
H
S
"* *5
*<4#5
#.
.#"* */K
;/"0
#"*604*-
 K
0
;-0
YaaZK
]]K 4*#
H
0/5# 
H
(.0-*
H
550-5
H
4 6
K
L0-? ?58
0<4?
5?/"40.#
/"
.#704.*/J
#<*"#/ #R5#"
4#<*#=M

Q
0<#.40
ZXXa
Q
<0-
[_
Q
/A
YY
]^K
R
H
#6
-KH
L*.#-
)#42?
*/
0-? ?58
<4?
?/"40.#
#"; #5

?2#4*/5;-*/#.*H
/5;-*/
#5*56/ #H
/"

?2#4/"40(#/#.*M
/6#4/80/-
0;4/-
0&
/"0 4*/0-0(?
0-;.#
ZXYZH
48 -#

[`Z_YaH
_
2(#5
"0*JYXKYY]]PZXYZP[`Z_Ya
CERRAR