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Week 2 Sex and Fert
Week 2 Sex and Fert
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Sex and Fertilization
SEX
Act of copulation / “coitus
SEXUAL RESPONSE CYCLE
4 Stages of Sexual Response:
1. EXCITEMENT PHASE
- Physical and psychological stimulus
- Arterial dilatation and venous constriction in the genital
area
Physiological changes in woman: Functional life of a spermatozoa is about 48h, possibly as
- clitoris increase in size long as 72h
- Lubrication - Ova about 24h possibly as long as 48h
- Vagina widens - The ovum is surrounded by a ring of mucopolysaccharide
- Breast nipples become erect fluid (zona pellucida) and a circle of cells (corona radiata) -
- Increase BP, HR, RR serve as protection from injury
Physiological changes in men:
- Erection
- Scrotal thickening
- Elevation of the testes
- Increase BP, HR, RR
2. PLATEAU PHASE
- Reached first before orgasm
- Women: formation of orgasmic platform, increased nipple
engorgement
- Men: full distention of the penis Fertilization usually occur in the outer 3rd of the Fallopian
3. ORGASM PHASE tube, the ampullae portion
- Discharge of accumulated sexual tension - Normally, an ejaculation of semen averages 2.5 ml of fluid
- Shortest stage containing 50M - 200 million spermatozoa per milliliter or an
4. RESOLUTION STAGE average of 400 million / ejaculation
- External and internal organs return to their uncrossed state - Spermatozoa deposited in the vagina during intercourse
Generally takes 30 min generally reach the cervix within 90 sec and the other end of
the Fallopian tube within 5 min after deposition
CAPACITATION
- Final process that sperm must undergo to be ready for
fertilization
- The sperm move toward the ovum
Changes in the plasma membrane of the sperm head, reveals
the sperm - binding receptor sites
FERTILIZATION
CONCEPTION / IMPREGNATION / FECUNDATION
- Union of ovum and spermatozoon
- Fertilized egg is called ZYGOTE
OVUM - from ovulation to fertilization
ZYGOTE - from fertilization to implantation HYALURONIDASE
EMBRYO - from implantation to 5-8 weeks - Proteolytic enzyme
FETUS - From 5-8 weeks until term Released by the spermatozoa and acts to dissolve the layer of
CONCEPTUS - developing embryo / fetus and placental cells protecting the ovum
structures throughout pregnancy
Normally, only one spermatozoon is able to penetrate the cell
membrane of the ovum. Once it penetrates the zona After implantation, the endometrium is called the DECIDUA
pellucida, the cell membrane becomes impervious to other Once implanted, the zygote is called an EMBRYO
spermatozoa.
After the spermatozoon penetrates the ovum, its nucleus is
released into the ovum, its tail degenerates and its head
enlarge and fuses with the nucleus of the ovum. This fusion
provides the fertilized ovum, called a zygote with 46
chromosomes. The spermatozoon and ovum each carried 23
chromosomes (22 autosomal and 1 sex chromosome)
DIAGNOSIS OF PREGNANCY
- Blastocyst; large cells collect at the periphery of the ball, SIGNS AND SYMPTOMS OF PREGNANCY
leaving a fluid space surrounding an inner cell mass PRESUMPTIVE
- this structure attaches to the uterine endometrium Presumptive means speculation or unconfirmed.
- the cells in the outer ring are known as trophoblasts which Presumptive signs and symptoms of pregnancy are those
will form into placenta and membranes signs and symptoms that are usually noted by the patient,
the inner cell mass (enclosed within the trophoblast will form which impel her to make an appointment with a physician.
the embryo) These signs and symptoms are not proof of pregnancy but
they will make the physician and woman suspicious of
pregnancy.
1. Amenorrhea (Cessation of Menstruation). (1) In early pregnancy, changes start with a slight, temporary
(1) Amenorrhea is one of the earliest clues of pregnancy. The enlargement of the breasts, causing a sensation of weight,
majority of patients have no periodic bleeding after the onset fullness, and mild tingling.
of pregnancy. However, at least 20 percent of women have Breast Changes during Pregnancy
some slight, painless spotting during early gestation for no (2) As pregnancy continues the patient may notice:
apparent reason and a large majority of these continue to (a) Darkening of the areola–the brown part around the
term and have normal infants. nipple.
(2) Other causes for amenorrhea must be ruled out, such as: (b) Enlargement of Montgomery glands–the tiny nodules or
(a) Menopause. sebaceous glands within the areola.
(b) Stress (severe emotional shock, tension, fear, or a strong (c) Increased firmness or tenderness of the breasts.
desire for a pregnancy). (d) More prominent and visible veins due to the increased
(c) Chronic illness (tuberculosis, endocrine disorders, or blood supply.
central nervous system abnormality). (e) Presence of colostrum (thin yellowish fluid that is the
(d) Anemia. precursor of breast milk). This can be expressed during the
(e) Excessive exercise. second trimester and may even leak out in the latter part of
1. Nausea and Vomiting (Morning Sickness). the pregnancy.
(1) Usually occurs in early morning during the first weeks of (3) These breast changes can be more positive if the patient
pregnancy. has not recently delivered and is not presently breastfeeding.
(2) Usually spontaneous and subsides in 6 to 8 weeks or by 1. Vaginal Changes.
the twelfth to sixteenth week of pregnancy. (1) Chadwick’s sign. The vaginal walls have taken on a deeper
(3) Hyperemesis gravidarum. This is referred to as nausea and color caused by the increased vascularity because of
vomiting that is severe and lasts beyond the fourth month of increased hormones. It is noted at the sixth week when
pregnancy. It causes weight loss and upsets fluid and associated with pregnancy. It may also be noted with a
electrolyte balance of the patient. rapidly growing uterine tumor or any cause of pelvic
(4) Nausea and vomiting are unreliable signs of pregnancy congestion.
since they may result from other conditions such as: (2) Leukorrhea. This is an increase in the white or slightly gray
(a) Gastrointestinal disorders (hiatal hernias, ulcers, and mucoid discharge that has a faint musty odor. It is due to
appendicitis). hyperplasia of vaginal epithelial cells of the cervix because of
(b) Infection (influenza and encephalitis). increased hormone level from the pregnancy. Leukorrhea is
(c) Emotional stress, upset (anxiety and anorexia nervosa). also present in vaginal infections.
(d) Indigestion. 1. Quickening (Feeling of Life).
MGT: Dry toast / crackers before arising in the morning; avoid (1) This is the first perception of fetal movement within the
greasy / fatty foods; avoid highly seasoned foods; eat small, uterus. It usually occurs toward the end of the fifth month
frequent meals because of spasmodic flutter.
1. Frequent Urination. (a) A multigravida can feel quickening as early as 16 weeks.
(1) Frequent urination is caused by pressure of the expanding (b) A primigravida usually cannot feel quickening until after
uterus on the bladder. 18 weeks.
(2) It subsides as pregnancy progresses and the uterus rises (2) Once quickening has been established, the patient should
out of the pelvic cavity. be instructed to report any instance in which fetal movement
(3) The uterus returns during the last weeks of pregnancy as is absent for a 24-hour period.
the head of the fetus presses against the bladder. (3) Fetal movement early in pregnancy is frequently thought
(4) Frequent urination is not a definite sign since other factors to be gas.
can be apparent (such as tension, diabetes, urinary tract 1. Skin Changes.
infection, or tumors). (1) Striae gravidarum (stretch marks). These are marks noted
MGT: Decrease fluid intake in the evening on the abdomen and/or buttocks.
Avoid caffeine and tea (a) These marks are caused by increased production or
Void as soon as the urge is felt sensitivity to adrenocortical hormones during pregnancy, not
Teach how to perform Kegel’s exercise just weight gain.
Report signs of UTI at once (b) These marks may be seen on a patient with Cushing’s
1. Breast Changes. disease or a patient with sudden weight gain.
(2) Linea nigra.
(a) This is a black line in the midline of the abdomen that may
run from the sternum or umbilicus to the symphysis pubis.
Video:
https://www.youtube.com/watch?v=sxEf_ddmpZk
14. AMNIOCENTESIS
- Refers to a needle insertion into the uterus trans
abdominally to aspirate amniotic fluid for analysis
- Can be performed as early as 12 - 13th week of gestation,
Video: placental grade
when uterus has moved into the abdominal cavity
https://www.youtube.com/watch?v=OCL9R4Lg8ow
- Requires only 1 ml of fluid for analysis
8. AMNIOTIC FLUID VOLUME ASSESSMENT
- Is indicated for women age 35 and older and women with
- Amount of amniotic fluid present is an important fetal
family history of chromosomal / neural tube defects or inborn
assessment measure because a portion of the fluid is formed
errors of metabolism
by fetal kidney output
USED FOR ASSESSMENT, DX, AND EVALUATION
9. ELECTROCARDIOGRAPHY
- Amniotic fluid color
- May be recorded as early as the 11th week of pregnancy
Normal - color water
10. MRI
Slightly yellow tinge - late in pregnancy
- Has the potential to replace or complement ultrasound as a
Strong yellow color - blood incompatibility
fetal assessment technique
Green color - meconium staining
- It may be most helpful in diagnosing complications such as
-Lecithin/Sphingomyelin ratio 2:1
ectopic pregnancy / trophoblasts disease
- Phosphatidyl glycerol & desaturated phosphatidyl - choline
11. MATERNAL SERUM ALPHA-FETOPROTEIN
(present only with mature lung function)
- Requires a blood sample obtained via venipuncture to
- Bilirubin determination - analyzed if a blood incompatibility
evaluate the level of alpha fetoprotein in the mother’s serum
is suspected
- Fetal liver produces alpha fetoprotein
- Chromosome analysis - few fetal skin cells are always
- This CHON crosses the placenta and appears in the mother’s
present in amniotic fluid. These cells many be cultured and
serum
stained for karyotyping
- Alpha-fetoprotein begins to rise at 11 weeks gestation, then
- Inborn errors of metabolism
steadily increases until term
- Alpha-fetoprotein
Video: amniocentesis vs. chorionic villi sampling
https://www.youtube.com/watch?v=bZcGpjyOXt0 anger and/or the age of the father
https://www.youtube.com/watch?v=GB0JkmMhGnQ • Planning pregnancy
15. PERCUTANEOUS UMBILICAL BLOOD SAMPLING (PUBS) - Good health and avoiding exposure to harmful substances
- Also called CORDOCENTESIS / FUNICENTESIS are significant contributing factors for a successful pregnancy
- Is an invasive procedure during which a needle is inserted and a healthy baby
through the mother’s abdomen and uterine wall into a vessel - Any woman of childbearing age should be aware of health
in the umbilical cord under direct ultrasound guidance problems or medication regimens that may
- Provides direct access to the fetal circulation to obtain fetal - adversely affect pregnancy and the birth of healthy baby
- It is recommended for women to optimize their intake of
blood samples or to transfuse the fetus in utero
folic acid several months before becoming pregnant
- Access to the fetal circulation allows for direct drug
- Regular aerobic exercise conditions the body systems
administration - Smoking cessation is an important consideration when
- Used when the fetus is at risk for congenital and planning for pregnancy
chromosomal abnormalities, congenital infection or anemia - Alcohol intake can affect the developing child especially in
- Also used to assess acid balance of fetuses with intrauterine the earliest weeks of pregnancy
growth retardation - A woman with chronic illness is at higher risk for poor
- Can be done anytime after 16 weeks gestation pregnancy outcome
16. AMNIOSCOPY • Preventing pregnancy
- Visual inspection of the amniotic fluid through the cervix - The best contraceptive method is the one that is most
and membranes with an amnioscopy (a small fetoscope) comfortable and natural for the partners, and the one that they
- Use to detect meconium staining will consistently use correctly
- Risk for membrane rupture Natural or Fertility Awareness Methods:
17. FETOSCOPY 1. Calendar (Rhythm method)
- Actual visualization of the fetus by inspection through a - Relies on abstinence from intercourse during fertile periods
fetoscope - Fertile periods are calculated by recording 12 consecutive
- Amniotic may occur; mother is placed on 10-day antibiotic menstrual cycles
- Subtract 18 days from the shortest cycle and 11 days from
therapy after the procedure
the longest cycle = fertile period
- Effectivity rate is 13%
Advantages:
SPECIAL ISSUES OF REPRODUCTION & - Inexpensive and convenient
WOMEN’S CARE - Encourages communication
• HEALTH SCREENING FOR WOMEN - No side effects
- Breast cancer screening - Ethically and morally non-controversial
- Pelvic examination and pap smear - Appropriate for sexual education programs
- Vulvar self-examination Disadvantages:
• COMMON DISORDERS OF THE FEMALE - Requires long periods of abstinence and control
REPRODUCTIVE TRACT - Requires correct calculations and regular menstruations to be
- Menstrual disturbances effective
> Amenorrhea - Confusing irregular uterine bleeding with a menstrual period
> Atypical uterine bleeding day lead to incorrect calculations
Menorrhagia - Effectiveness is unreliable and depends on many variables
Metrorrhagia Natural or Fertility Awareness Methods:
> Dysmenorrhea 2. Cervical Mucus method
> Post-menstruated syndrome - Relies on abstinence from intercourse during fertile periods
- Endometriosis - Cervical mucus in the ovulatory period is clear and slippery
- Infectious disorders and more abundant
- Pelvic Inflammatory disease - Pre-ovulatory and post-ovulatory periods, cervical mucus is
• COMMON DISORDERS OF THE UTERUS yellowish, less abundant, thick and sticky (inhibits sperm
& OVARIES motility)
- Cervical polyps - Effectivity is about 20%
- Uterine fibroids Advantages:
- Ovarian cysts - Inexpensive
REPRODUCTIVE LIFE CYCLE ISSUES - No side effects
FAMILY PLANNING - Ethically and morally non-controversial
- Family planning consists of two complementary Disadvantages:
components: - Not as effective as other methods
> Planning pregnancy
> Preventing pregnancy
- Family planning gives the woman control over the number of
children she wishes to have and allows her to determine when
births will occur in relation to each other and in relation to her
2. Intrauterine Device
- Flexible device inserted in the uterine cavity during
menstruation
- This alters uterine transport of sperm so fertilization don’t
occur
- Side effects:
> Dysmenorrhea
> Increased menstrual flow
> Uterine infection or perforation
> Ectopic pregnancy
- Danger signs to report
> Late or missed menstrual period
> Severe abdominal pain
> Fever and chills
3. Symptothermal method
> Foul vaginal discharge
- Couple makes use of the combination of calendar, basal body
>Spotting, bleeding, or heavy menstrual periods
temperature, and cervical mucus method to determine fertile
>Spontaneous expulsion occur in 2-10% of users in the first
period
year
- Effectivity can be as high as 13-20% among typical users
Advantages:
- Inexpensive
- No side effects
- Encourages communication
- Provides the couple with more information
Disadvantages:
- More complex and difficult to learn
- Requires regular and daily effort Advantages:
4. Lactation Amenorrhea Inexpensive for long term use
- As long as a woman is breastfeeding an infant, there is some - Reversible
natural suppression of ovulation - May be use with lactating women
- The woman may not be menstruating but may be ovulating; - Requires no attention other than checking that it is in place
the woman may still be fertile even if she has not had a period Disadvantages:
since childbirth - Available only through a health care provider
Artificial Methods: Barrier Methods - Contraindicated if woman has an active infection of pelvis,
1. Male Condom postpartum infection, endometrial hyperplasia or carcinoma,
- A latex or rubber sheath that fits over the erect penis and uterine anomalies, women who have an increased risk of
prevent sperm from entering the vagina STDs or women with multiple sexual partners
- Effectivity is 86% 3. Cervical cap
Advantages: - Is a reusable rubber cap that fits tightly over the cervix. The
- No side effects cervical cap is inserted into the vagina with spermicide before
- Helps prevent conception and STDs sex to prevent pregnancy.
- Available over the counter - For people who’ve never given birth, the cervical cap is 86%
- Condom helps maintain erection longer Advantages:
- Prevents sperm allergies - Convenient and give you control
- Discretely carried by men and women - Cervical caps don’t interrupt sex
Disadvantages: - Cervical caps don’t have hormones
- Decreases spontaneity and sensation - Lasts a long time > only need to be replaced every year with
Disadvantages: proper care
- Should be used with vaginal jelly if condom or vagina is dry
- Contraindicated to men and women with latex allergy
Disadvantages:
- Cervical caps don’t protect against sexually transmitted
infections spermatic cord
- You have to use it every time you have sex. Difficult / hard - Each vas deferens is lighted and cut
to use correctly for some people to do, also, spermicide can - May experience some pain, bruising, and swelling
have side effects - May apply ice pack, scrotal support, and a mild oral
- Changes in the body over time can mess up the fit of the analgesic
cervical cap. You have to get refitted for a new size if you 1-2 days moderate activities because of scrotal tenderness
have a baby, miscarriage, or abortion - Sutures are removed about 4-7 days
4. Cervical diaphragm - Must use another method of birth control for at least
- Is a shallow, bendable cup that you put inside your vagina. 1 month until a negative sperm count verifies sterility
It’s a shallow cup like a little saucer that’s made of soft - The man still has the ability to achieve and maintain erection
silicone. You bend it in half and insert it inside your vagina to or on the volume of ejaculate
cover your cervix Pharmacologic Methods
- Adding spermicide is used to make it more effective 1. Oral Contraceptives
- 88% effective - that means about 12 out of 100 people who - Used to prevent conception by inhibiting ovulation
use it will get pregnant each year - Causes atrophied changes of the endometrium to prevent
Advantages: implantation
- Convenient and give you control - Causes thickening of cervical mucus to inhibit sperm travel
- Don’t interrupt sex - Regulates menstrual cycle
- Lasts a long time up to 2 years with proper care - Combined estrogen and progesterone in table form
Disadvantages: - Effectivity is about 97-100% if properly used
- You have to use it correctly Side effects:
- Some people have trouble inserting the diaphragm - breakthrough bleeding
- Spermicide may have side effects - Nausea and vomiting
- Susceptibility to vaginal infections
- Thrombus formation
Edema and weight gain
- Irritability
- Missed periods
Advantages:
- Most reliable contraceptive method
- Convenient to use
- Tend to decrease menstrual cramps and pain
Disadvantages:
- Contraindicated to women who are smoking
Surgical Methods - Contraindicated to women with history of thrombophlebitis,
1. Tubal Ligation CVA, varicosities, DM, estrogen dependent carcinoma, liver
- The Fallopian tubes are surgically lighted or cauterized either disease, older than 35 years of age
through mini laparotomy or laparoscopy - Needs reassessment and re-evaluation every 6 months
- Effectivity is 100% - Does not offer protection against STDs
Advantages: 2. Contraceptive Implants
- Highly effective - Is a very small plastic rod about the size of a matchstick. A
- Usually permanent doctor inserts it into the upper arm, right under the skin. It
- Can be performed immediately postpartum releases progestin hormone into the body to prevent pregnancy
Disadvantages: - Prevents pregnancy by blocking the release of eggs. It also
- Invasive procedure thickens cervical mucus
- May be irreversible - Implants must be removed after 3 years. At that time, another
- High risk of ectopic pregnancy after reversal implant can be inserted
- No protection against STD Advantages:
- One of the highest levels of effectiveness of all
contraceptives
- No need to worry about birth control for 3 years
- Fertility returns as soon as the implant is removed
- Appropriate for women who can’t use birth control that
contains estrogen
Disadvantages:
- No protection against STIs
- High up-front cost
- Insertion requires a doctor’s visit
- Must be removed after 3 years
2. Vasectomy
- This procedure takes about 20 minutes
- Small incision is made on each side of the scrotum over the