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Physiology
Physiology
Physiology
HUMANS
Have several advantages over other
animals as experimental subject in
biopsychological research:
o They can follow instructions
o They can report their subjective
experiences
o They have human brains
NONHUMANS
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
o Mitochondria
o Golgi bodies
o Cytoplasm
Glia
Neuroglia
Other components of nervous system
that performs many functions
From Greek word means glue
NERVE CELLS
Like a glue that held the neurons
together
Almost no human life is truly
independent Glia outnumbers neurons in cerebral cortex
People can do an enormous amount Neurons outnumbers glia in several other
together, but very little by themselves brain areas especially the cerebellum
The Cells of the Nervous System Astrocytes
Two Kinds of Cells: Star-shaped
Neurons Wrapped around the synapses of
o Receives information and functionally related axons
transmit it to other cells By surrounding a connection between
Glia neurons, astrocytes shield it from
o Are non-neuronal cells of the chemicals circulating in the surround
nervous system with various
types Microglia
o Not nerves Act as a part of immune system
Removes virus and fungi in the brain
Santiago Ramon y Cajal They proliferate after brain damage,
A pioneer of Neuroscience removing dead or damaged neurons
An outstanding anatomical researcher
and illustrator Oligondendrocytes & Schwann Cells
Draws the details of nervous system Build the myelin sheaths that surrounds
Receives a Nobel prize for research on and insulates certain vertebrate axons.
the stricture of the nervous system in They also supply an axon with nutrients
1906 with Camillo Golgi necessary for proper functioning
o Oligondendrocytes
The Structure if a Neuron in the brain, spinal cord or
in central nervous system
Neuron o Schwann Cells
Nerve cell that is the basic building In periphery of the body
blocks of the nervous system
Specialized to transmit information Radial Glia
throughout the body Guide the migration of neurons and their
Contain a nucleus axons and dendrites during embryonic
o Hold genetic information development
Surrounded by a membrane
o Protects the cell
Organelles that support the life of the
cells:
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
Active Transport
The brain uses for certain other
chemicals
A protein mediated process that
expands energy to pump chemicals from
the blood into the brain
Cell Body
metabolic center of the neurons
the soma Golgi Complex
Cell Membrane a connected system of membranes that
semipermeable membrane that packages molecules in vesicles
encloses the neurons Nucleus
Dendrites The spherical DNA-containing structure
the short processes emanating from the of the cell body
cell body Mitochondria
receive most of the synaptic contacts Sites of aerobic (oxygen-consuming)
from other neurons energy release
Axon Hillocks Microtubules
cone-shaped region at the junction Tubules responsible for the rapid
between the axons and cell body transport of material throughout neurons
Axons Synaptic Vesicles
the long, narrow process that projects Spherical membrane packages that
from the body cells store neurotransmitter molecules ready
Myelin for release near synapses.
The fatty insulation around the axons Neurotransmitters
Nodes of Ranvier Molecules that are released from active
Ran-vee-yay neurons and influence the activity of
The gaps between sections of myelin other cells
Buttons
The button-like endings of the axon The diverse shapes of Neurons
branches Purkinje Cells
Release chemicals into synapses o A cell type found only in
Synapses cerebellum
Sensory neurons from skin to spinal
cord
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
Pyramidal cell of the motor area of the It maintains an electrical
cerebral cortex gradient/polarization
Bipolar cell of retina of the eye All parts of a neuron are covered by a
Kenyon cells membrane with about 8
o From a honeybee nanometers(nm) thick.
o The membrane is composed of 2
layers that is free to float relative
to each other:
Phospholipid Molecules
Contains chains of
fatty acids and a
phosphate group
Protein Molecules
Cylindrical
Which certain
chemicals can pass
Protein channels
that permit ions to
cross through the
NERVE IMPULSES membrane at a
controlled rate
Axons
produce action potential
Convey information from the touch
receptors in hands or feet toward your Forces Acting on Sodium and Potassium
spinal cord and brain Ions
Instead of conducting electrical impulse,
the axons regenerate an impulse at If charged ions could flow freely across
each point the membrane, the membrane would
o Example depolarize
A long line of people o Eliminating the negative potential
holding hands inside
If the first person The membrane has selective
squeezes the permeability
second’s person’s o That is, some chemicals pass
hand, who then through it more freely than others
squeeze the third’s do.
person’s hand, and Oxygen, carbon dioxide, urea and
so forth. water cross freely through channels that
Axons transmit information at only are always open.
moderate speeds The several biologically important ions
o less that 1meter/second to about that cross through membrane channels
100m/s or gates that are sometimes open and
sometimes close are:
The Resting Potential of the Neuron o Sodium
Resting Potential o Potassium
Messages in a neuron develop from o Calcium
disturbances of the resting potential o Chloride
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
When a channel opens,
o It permits some type of ion to The Action Potential
cross the membrane Messages sent by axons
When a channel closes
o It prevents passage of that ion Negative Potential
It is when an axon’s membrane is at
When the neuron is at rest; rest
o Two forces act on sodium -mV
Both tending to push it into
the cells Hyperpolarization
o Consider the electrical gradient The change when a different electrode
Sodium is positively was used to apply a negative charge
charged When the negative charge increases
The inside of the cell is inside the neurons
negatively charged Increased polarization
o Opposite electrical charges Increased of resting potential
attract
So, the electrical gradient To depolarize neuron:
tends to pull sodium into Apply a current to the neuron that is
the cell. reduce/decreased its polarization (RP)
toward zero.
Chemical Synapses
They take more than time to be received
and read
But used more often
Are much easier to control
Sending signals to only certain
recipients
More precise
Use neurotransmitters, or chemical
signals
Synaptic Transmission
Advantage of Chemical over Electrical
Synapse Synapses
Meeting point between two neurons They can effectively convert the signals
From the Greek word to clasp or join in steps,
When an action potential sends an o From electrical to chemical back
electrical message to the end of an to electrical which allows for
axon, different ways to control that
o that message hits a synapse that impulse.
then translate or converts it into This sort of long-term translation could be the
different type of signal and flings result of:
it over to another neurons. Potentiation
Are numerous o the strengthening of a synapse
The brain has 100 billion neurons and through like, classical
each of those has 1000 to 10000 conditioning
synapses Habituation
Able to change and adapt in response to o When a synapse decreases its
neuron firing patterns response to a common stimulus
Allows you to learn and remember Sensitization
Roots of psychiatric disorders o When a reaction to one stimulus
Reason why drug and addiction exist causes other synapses to be
more sensitive to reactions
Electrical Synapses
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
In synapse, immediately or over longer periods These results in unidirectional or one-
of time, that signal can be: sided communication between neurons.
Modified
Amplified When an action potential races along
Inhibited the axon of a neuron, activating sodium
Split and potassium channels in a wave,
o It eventually comes down to the
This set-up has two principal parts: presynaptic terminal,
Presynaptic Neurons o and activates the voltage-gated
o The cell that’s sending the signals calcium(Ca2+) channels there
o Presynaptic Terminal to open and release the calcium
Transmitted or receives into the neuron’s cytoplasm.
the signals from This flow of positively-charged
presynaptic neurons calcium ions causes all those tiny
Knoblike structure synaptic vesicles:
Usually the axon terminal o to fuse with the cell membrane
Holds a whole bunch of o and purge their chemical
tiny synaptic vesicles messages
sacs it’s these neurotransmitters
Loaded with that act like couriers
thousands of diffusing across the
molecules of a synaptic gap and binding
given to receptor sites on the
neurotransmitter. postsynaptic neurons.
Postsynaptic Neurons
o The receiving cell
o Accepts neurotransmitters in its
receptor region (usually on the
dendrite or just o the cell body
itself)
Synaptic cleft
Tiny gap between presynaptic and
postsynaptic neurons
The first neuron has managed to
Less than five millionths of a centimeter convert the electrical signal into a
apart. chemical one.
But for it to become an action potential
Messages that travel via chemical again in the receiving neuron, it has to
synapses are technically not be converted back to electrical.
transmitted directly between neurons, It happens once a neurotransmitter
like they are in electrical synapses. binds to a receptor.
There’s a whole chemical event that That causes the ion channels to open.
involves the: Depending on which particular
o Release neurotransmitter binds to which
o Diffusion receptor, the neuron might either get
o Receptions excited or inhibited
Of neurotransmitters in order to
transmits signals. Excitatory Neurotransmitters
Depolarize the postsynaptic neuron by
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
o making the inside of it more
positive and Cocaine
o bringing it closer to its action Once it hits the bloodstream, it targets
potential threshold three major neurotransmitters:
o making it more likely to fire that o Serotonin
message on to the next neuron. o Dopamine
o Norepinephrine
Inhibitory Neurotransmitters
hyperpolarized the postsynaptic neuron Three Major Neurotransmitters
by Serotonin
o making the inside more negative, o Mainly inhibitory
o driving its charge down away o Plays an important role in
from its threshold regulating
o the message would not get Mood
passed along Appetite
o it’s harder to excite that portion of Circadian
neurons Rhythm
Sleep
Any region of a single neuron may have o Some antidepressants can help
hundreds of synapses stabilize moods by stabilizing
o Each with different inhibitory or serotonin levels
excitatory neurotransmitters Dopamine
Post-synaptic neuron developing an o Released during pleasurable
action potential depends on the sum of activities
all of the excitations and inhibitions in o Influences emotion and attention
that area o Makes you feel awesome
Norepinephrine
o Amps you up by triggering your
fight or flight response
o Increase the heart rate
o Priming muscles to engage
o While an undersupply of the
chemical can depress a mood.
After neurotransmitter deliver their
messages:
o They just sort of pop back out,
During the sober state, these
and
neurotransmitter does their thing in the
o Then either degrade or get
body
recycled. But once they’ve delivered their
o Some kinds diffuse back across chemicals payloads,
the synapse and are immediately o They usually diffused right back
re-absorbed by the sending out across the synapse to be
neuron, in a process called absorbed by the neuron that sent
reuptake. them
o Others are broken down by Cocaine blocks that reuptake,
enzymes in the synaptic cleft or especially of dopamine, allowing these
sent away from the synapses by powerful chemicals to float around and
diffusion. accumulate
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
o Making the user feel euphoric for
a time, paranoid and jittery.
When cocaine and drugs adapted by the
targeted neurotransmitters, synapses wil
remember how great those extra
chemical feels.
As a result, the receptors will start to
lose and takes even more dopamine, or
cocaine to function normally.
Brain
Most complex and sensitive organ
Responsible for all the functions of the
body
Coordinating center for all:
o Sensations
o Mobility
o Emotions
o Intellect
NEUROANATOMY Nervous
System
Peripheral
Central
nervous
nervous system
system
Somatic Autonomic
Brain Spinal cord nervous nervous
system systen
Sympathetic Parasympa
nervous system nervous s
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY
Meninges
o 3 layered membrane that
surrounds the brain
Dura Mater
Meningeal layer
closest to bones
Tough mother or
durable
Arachnoid Mater
Below dura mater
Spider-like mother 3 Main Parts of the Brain
Pia Mater
1. Cerebrum
Innermost
a. Largest part of the brain
meningeal layer
b. Composed of right and left
Delicate membrane
hemisphere
Tender mother c. Performs higher functions like
Firmly adheres to interpreting touch, vision, and
the convoluted hearing, as well as speech,
surface of the brain reasoning, emotions, learning,
Subarachnoid Space and fine control of movements
o Between arachnoid and pia mater 2. Cerebellum
o Filled with Cerebrospinal fluid a. Located under cerebrum
(CSF) b. To coordinate muscle
Watery fluid that is movements, maintain posture
produced by cells of and balance
choroid plexus 3. Brainstem
Deliver nutrients a. Relay center
Remove wastes from b. Connecting cerebrum and
neural/ brain tissues cerebellum to the spinal cord
c. Performs automatic functions
such as breathing, heart rate,
body temperature, wake and
sleep cycles, digestions,
sneezing, coughing, vomiting,
and swallowing.
PHYSIOLOGICAL AND BIOLOGICAL PSYCHOLOGY