3i Hema 1 p2 Laboratory WBC Kinetics and Disorders

11/5/21, 11:11 AM 3i Hema 1 P2 LABORATORY - WBC KINETICS AND DISORDERS
3i Hema 1 P2 LABORATORY - WBC

KINETICS AND DISORDERS
Total points 90/100
You have 1 hour and 30 minutes to complete the examination. Read and answer carefully.
For problems regarding the form, please notify your instructor immediately. Best of luck and
God bless!
Email *
stda.asubar.swu@phinmaed.com
This is the last mitotically active WBC precursor * 2/2
Myeloblast
Promyelocyte
Myelocyte
Band
Metamyelocyte
What WBC count is preferred in determining whether the patient has too 1/1
many blood cell of certain type? *
Corrected WBC count
https://docs.google.com/forms/d/e/1FAIpQLSeGRw_FkjsOwO-FMt2B4_uzQ_DkWu7qwsvWYjhJgCshcOm5Tg/viewscore?viewscore=AE0zAgAuWURTufR… 1/24
Absolute count
200-cell differential
Relative count
What lymphocyte variant is seen in cases of Infectious Mononucleosis? * 1/1
Type I
Type II
Type III
Turk's irritation cell
Plasmacytoid lymphocyte
What dye is used in in staining if the diluting fluid used is Turk's solution? * 2/2
Methyl violet
Crystal violet
Gentian violet
What White Blood Cell precursor contains not more than 20 granules of ···/1
unknown function? *
Myeloblast
Myelocyte
Metamyelocyte
Promyelocyte
What is the allowable difference between 2 chamber counts for WBCs? * 2/2
15-16
12-14
10-12
6-10
These cells are counted in duplicate or triplicate in th RBC aperture booth * 1/1
Platelets
White Blood Cells
Leukocytes
Erythrocytes
The youngest neutrophil precursor in the maturation pool * 2/2
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band
What is the most common WBC diluting fluid used in Automation? * 2/2
Hayem's
2 % Glacial acetic acid
1 v/v Hydrochloric acid
Turk's solution
Monocyte is the most potent APC through co-stimulatory molecules * 2/2
True
False
Thesaurocyte is commonly seen in what disorder? * 1/1
Myeloma
Niemann's Pick Disorder
IgA myeloma
Infectious mononucleosis
Pan B-cell is designated as * 1/1
CD 2
CD 3
CD 19
CD 24
CD 45R
What are the inclusions found in russel bodies? * 2/2
Primary granules
Secondary granules
IgM
Altered primary granules
Plasma cell
What is the name of the macrophage found in the placenta? * 1/1
Histiocytes
Dust cell
Microglial cells
Mesangial cells
Mesangial cells
Hoffbauer cells
This light scattering determines the morphology an the surface 1/1

characteristics of the cell *
Forward angle light scatter
Zero degree forward angle
10 degree light scatter
90 degree light scatter
Encapsulated bacteria are directly phagocytosed through Primitive Pattern 1/1

Recognition Receptor attaching to the Pathogen Associated Molecular
Pattern. *
True
False
What is the specific counting chamber for eosinophil counting? * ···/1
Improved Neubauer counting Chamber
Fuch’sRosenthal
Hemocytometer
What is being produced by eosinophil to counteract the histamine produced 1/1

by basophil? *
Arginine-rich major alkaline protein
Peroxidase
Muramidase
Lysozyme
Amidine oxidase
Opsonins are of great help in phagocytosis if the bacteria does not contain a 2/2
capsule *
True
False
Blood-to-anticoagulant ratio is most critical for a specimen collected in this 2/2

tube *
Lavender top
Light green top
Light blue top
Serum Separator Tube
FAMILY NAME, GIVEN NAME, MIDDLE INITIAL *
ASUBAR, STELLA MARIS, D.
Considered to be the first phagocyte to reach an infected area * 1/1
Neutrophils
Eosinophils
Basophils
Monocytes
Lymphocytes
What needle is used in the collection of bone marrow samples? * 1/1
Jamshidi needle
Triphine needle
B5 needle
MayGrunwald needle
What is the significance of "4" in the WBC count formula? * 1/1
depth correction factor
dilution factor
area correction factor
standard number used in Manual WBC counting
What is the best criterion in staging white blood cells? * 1/1
Nucleus:Cytoplasmic ratio
Presence of non-specific and specific granules
Condensation of the chromatin
Cluster Differentiation Marker
A malignant bone marrow-based plasma cell neoplasm associated with 1/1

abnormal antibody production *
Multiple Myeloma
Waldenstrom’s Macroglobulinemia
Hyperimmunoglobulin E syndrome
Lazy Leukocyte Syndrome
Steroid therapy causes a shift in the marginating pool to circulatory pool 0/1
which causes an increase in WBC count *
True
False
LAP/NAP sample can be collected using purple tube * 1/1

True
False
Eosinophilia is seen in asthma attack * 2/2
True
False
200-cell differential is performed if: (check all that apply) * 0/2
Eosinophils are 10%
Monocytes are >11%
Basophils are >2%
WBC count is <1.0 x 10^9/L
These inclusions is described as crystals of coalesced nonspecific granules? * 1/1
Tart cell
Dohle bodies
Auer rods
May Hegglin cell
Toxic granulations
https://docs.google.com/forms/d/e/1FAIpQLSeGRw_FkjsOwO-FMt2B4_uzQ_DkWu7qwsvWYjhJgCshcOm5Tg/viewscore?viewscore=AE0zAgAuWURTuf… 10/24
Saline conducts electricity better tan cells do is the principle of * 1/1
Coulter
Radiofrequency conductivity
Optical Light scattering
Cytochemistry
Which chemical substances are responsible for differentiation and replication 2/2
of the pluripotent stem cell?
Erythropoietin
Cytokines
Insulin
Hypoxia
What are the cells seen in Chronic Lymphocytic Leukemia? * 2/2
Smudge cell
Flame cell
Hand mirror cell
Reider cell
Basket cell
Auer rods
What is the final stage of B cell maturation? * 1/1
Effector cell
Helper Cell
Plasma cell
Cytotoxic cell
What are the markings found in a WBC thoma pipet and its dilution factor? * 1/1
0.5, 1, 11 - 20
0.5, 1, 101 - 100
0.5, 1, 20 - 100
The drop of blood for smear preparation should be * 1/1
1-2 mm
2-3 mm
3-4 mm
4-5 mm
What are the CD markers present in the pathognomonic cell found in 2/2
lymphoma? *
CD 19, 24, 45R
CD 15, 30
CD, 19, 24, 45R, mu chain
CD 16, 56
What disorder is described as an autosomal recessive trait that lacks 1/1

lysosomal enzymes to break down mucopolysaccharides *
Pelger Huet Anomaly
May Hegglin Anomaly
Alder Reilly Anomaly
Chediak Higashi Syndrome
Lymphocyte is not an obligate end cell * 2/2
True
False
In the adult, the usual location for obtaining a bone marrow aspirate is the 2/2
Posterior superior sternum
Iliac crest
Long bones
anterior superior sternum
T cell and B cell can be differentiated through * ···/1
Morphological characteristics
Granules present
Cluster Differentiation Markers
Surface Immunoglobulins
B2-integrin and P-selectin enables the neutrophil to adhere to the 1/1

endothelium with a strong connection *
True
False
Conditions associated with monocytosis (check all that apply) * 2/2
Asthma
Tuberculosis
Eczema
Urticaria
Taeniasis
Listeria infection
Staphylococcal infection
This type of leukemia is considered to be the most aggressive type of 1/1

Leukemia with severe bleeding tendency *
AML-M1
AML-M2
AML-M3
AML-M4
What should be the dilution if the WBC count is 30, 000 per cubic millimeter? 2/2
*
1:10
1:20
1 100
1:100
1:200
What is the specific stain for Eosinophil? * 1/1
Gentian violet
Methyl violet
H&E stain
Feulgen stain
Hansel stain
Sudan Black
Stage where nuclear indentation is first recognizable using light microscope? 2/2
*
Promyelocyte
Myelocyte
Metamyelocyte
Myeloblast
Band
WBC anomaly associated with poor chemotaxis and random movement * 1/1
Lazy leukocyte syndrome
Job's syndrome
Jordan's anomaly
Chediak Higashi Syndrome
May Hegglin Anomaly
This type of leukemia is described as blasts with smoggy gray-blue cytoplasm 0/1
containing azure dust, and pseudopods are common *
AML-M3
AML-M4
AML-M5
AML-M6
What is considered to be the minimum angle in smear preparation in cases of 0/1

anemia? *
15’
20’
25’
30’
Alkaline phosphatase activity in chronic myelogenous leukemia is decreased * 2/2
True
False
Hand Mirror appearance of neutrophil means * 0/1
The patient is infected with EBV
The cell is about to phagocytose a pathogen
The patient has infectious mononucleosis
The cell is about to diapedese from circulation to the tissue
A deficiency of B-glucocerebrosidase leads to the accumulation of what 1/1

substance and what is its appearance in light microscopy? *
B-glucuceribroside, macrophage with fat droplets
B-glucocerebroside, crumpled tissue paper, neutrophil with eccentric nucleus
B-glucocerebroside, macrophage with mucopolysaccharide
B-glucocerebroside, macrophage with small eccentric nucleus and resembles a

crumpled paper
The anticoagulant present in gray top tube 2/2
EDTA
Oxalate
Thrombin
Sodium fluoride
What CD marker is added when the lymphocyte already encounters an 1/1

antigen? *
CD 25
CD 4
CD 8
CD 16
CD 15
CD 30
Myeloblast and Monoblast cannot be differentiated morphologically * 2/2
True
False
Epsteinn-Barr Virus attacks what type of specific lymphocyte? * 1/1
B cell
T cell
NK cell
What is the size of the predominant lymphocyte found in adult blood? * 1/1
7-10 um
10-12 um
11-25 um
What isoenzyme is responsible for the TRAP+ in Hairy cell leukemia? * 1/1
Isoenzyme 3a
Isoenzyme 3b
Isoenzyme 4
Isoenzyme 5
Iosenzyme 2
loosely woven chromatin pattern is described in what WBC? * 1/1
Eosinophil
Lymphocyte
Monocyte
Neutrophil
Basophil
Lymphocyte types can be differentiated morphologically * 2/2
True
False
Conditions associated with lymphocytosis (check all that apply) * 3/3
Trichinella infection
CLL
E. granulosus infection
Bordetella pertussis infection
Brucellosis
Streptococcal infection
What is the earliest recognizable precursor of Neutrophil? * 1/1
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
In the OPD, a doctor requested a CBC and urinalysis for a 3-year-old child. A 2/2
sample was taken and processed right away by the medical technologist. The
system detected a problem during processing: the lymphocyte count is
higher than the neutrophil count. How many WBC should be counted in
manual differential counting to correct the WBC count? *
50 WBCs
100 WBCs
300 WBCs
200 WBCs
What is the composition of charcot leyden crystals? * 2/2
Major basic protein
Lysophospholipase
Lysine
Argine
Melanin
If the WBC count is <1.0 x 10^9/L, the source of the smear should be * 2/2
Freshly collected blood using EDTA
Freshly collected and spun sample, specifically the third layer

Freshly collected blood using Citrated tube to avoid pseudoleukocytosis
Sample collected using EDTA and should be made within 2 hours
What is the angle used in smear preparation? * 1/1
15-30’
25-35’
30-45’
25-40’
What is the normal ratio of myeloid to erythroid precursors in bone maarrow? 3/3
1:1
1:3
6:1
4:1
This type of automated spun smear is used because of its consistency in the ···/1
preparation and fewer smudge cells are formed in patients with CLL *
Slie-to-slide
Miniprep
Centrifugal
Ehrlich’s Method
What parasite causes a markedly increased Eosinophil count? * 1/1
Diphylobothriocephalus latus
Echinococcus granulosus
Trichinella spiralis
Taenia saginata
Clonorchis sinensis
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11/5/21, 11:11 AM 3i Hema 1 P2 LABORATORY - WBC KINETICS AND DISORDERS

3i Hema 1 P2 LABORATORY - WBC

This is the last mitotically active WBC precursor * 2/2

Corrected WBC count

What lymphocyte variant is seen in cases of Infectious Mononucleosis? * 1/1

Turk's irritation cell

White Blood Cells

The youngest neutrophil precursor in the maturation pool * 2/2

2 % Glacial acetic acid

1 v/v Hydrochloric acid

Monocyte is the most potent APC through co-stimulatory molecules * 2/2

Thesaurocyte is commonly seen in what disorder? * 1/1

Niemann's Pick Disorder

Pan B-cell is designated as * 1/1

What are the inclusions found in russel bodies? * 2/2

Altered primary granules

What is the name of the macrophage found in the placenta? * 1/1

This light scattering determines the morphology an the surface 1/1

Forward angle light scatter

Zero degree forward angle

10 degree light scatter

90 degree light scatter

Encapsulated bacteria are directly phagocytosed through Primitive Pattern 1/1

What is the specific counting chamber for eosinophil counting? * ···/1

Improved Neubauer counting Chamber

What is being produced by eosinophil to counteract the histamine produced 1/1

Arginine-rich major alkaline protein

Blood-to-anticoagulant ratio is most critical for a specimen collected in this 2/2

Light green top

Light blue top

Serum Separator Tube

FAMILY NAME, GIVEN NAME, MIDDLE INITIAL *

ASUBAR, STELLA MARIS, D.

Considered to be the first phagocyte to reach an infected area * 1/1

What needle is used in the collection of bone marrow samples? * 1/1

What is the significance of "4" in the WBC count formula? * 1/1

depth correction factor

area correction factor

standard number used in Manual WBC counting

What is the best criterion in staging white blood cells? * 1/1

Presence of non-specific and specific granules

Condensation of the chromatin

Cluster Differentiation Marker

A malignant bone marrow-based plasma cell neoplasm associated with 1/1

Lazy Leukocyte Syndrome

LAP/NAP sample can be collected using purple tube * 1/1

Eosinophilia is seen in asthma attack * 2/2

200-cell differential is performed if: (check all that apply) * 0/2

Eosinophils are 10%

Monocytes are >11%

Basophils are >2%

WBC count is <1.0 x 10^9/L

These inclusions is described as crystals of coalesced nonspecific granules? * 1/1

May Hegglin cell

Saline conducts electricity better tan cells do is the principle of * 1/1

Optical Light scattering

What are the cells seen in Chronic Lymphocytic Leukemia? * 2/2

Hand mirror cell

What is the final stage of B cell maturation? * 1/1

0.5, 1, 101 - 100

The drop of blood for smear preparation should be * 1/1

CD 19, 24, 45R