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1.1 Sindrom Autisme (Bhs Inggris)
1.1 Sindrom Autisme (Bhs Inggris)
The purpose of this research is aimed at finding effective classical herbs prescriptions and providing
references for further research on the autism treatment by consulting modern literature, ancient books and
monographs. We took full advantage of CiteSeer, CNKI, PubMed, VIP and other literature databases as
the major methods in this study to review the modern literature of autism during 1989-2014 and
summarized them. We have also sorted out many prescriptions which used to treat autism in modern
literature. In the traditional Chinese medicine (TCM) terms, the highest frequency of symptoms used to
diagnose autism are "dullness", "mutistic", "soliloquy", "five kinds of retardation", "five weaknesses",
"fetal toxicity" and "infantile metopism". By consulting ancient books and monographs, we found TCM
associated with treatment of the aforementioned autism descriptors used by TCM. The results of this
research is as following: Collecting over 4,706 research articles about autism spanning approximately 26
years, we reviewed the research of autism with respect to TCM and western medicine regarding its etiology,
symptoms and treatment. We found the highest frequency TCM terms used to describe diagnostic
symptoms of autism are "dullness", "mutistic", "soliloquy", "five kinds of retardation", "five weaknesses",
"fetal toxicity" and "infantile metopism". Those descriptors were used as keywords to search related
prescriptions from ancient books and monographs. More than 300 prescriptions were obtained. Finally, we
verified clinical applications of these prescriptions, noting the frequency of use as a single medicine. We
also collated pharmacological effects of the prescriptions, and the frequency of usage in the treatment of
autism symptoms. The conclusion has been reached that TCM emphasizes a holistic treatment strategy
with comprehensive aftercare. In addition, ancient physicians recorded many prescriptions about
treatment of autism related symptoms in the ancient books and monographs, and some prescriptions are
still applied in clinical autism treatment in current practices. In conclusion, seeking effective prescriptions
and medicine from the perspective of TCM is of great importance.
[N A J Med Sci. 2015;8(1):20-30. DOI: 10.7156/najms.2015.0801020]
INTRODUCTION
Autism spectrum disorder (ASD) is a developmental sleep disorders. This is a lifelong disorder of increasing
disability which occurs before the age of three and is usually prevalence and community concern.1
diagnosed after one year old. The main symptoms are
language development disorders of different levels, Based on the community Report on Autism (March 2014)
interpersonal communication barriers, narrow interests and from the Center of Disease Control (CDC) in the USA, about
inflexible behavior patterns. Even to the extent that some 1 in 68 children were identified by the data from 11 Autism
children suffer from epilepsy, gastrointestinal diseases and and Developmental Disabilities Monitoring (ADDM) sites
__________________________________________________________________________________________________ and the data covering 2012.2 According to other data
Received: 06/15/2014; Revised: 11/17/2014; Accepted: 12/30/2014 published in 2014 from USA, the total number of global
*Corresponding Author: autism patients had reached 67 million.3 At present, the
[Jin-qing Lu] Medicinal Plant Research Center/Department, Hubei incidence of autism is rising, but the effect of treatment and
University of Traditional Chinese Medicine, Hubei Province, Wuhan, China
prognosis are still not satisfactory.
430065. Tel: 086-13871312439.
(Email: ljq59169@163.com)
[Gang Lu] American Chinese Medical Exchange Society, 15 New England The ancient time mentioned in this review refers to the period
Executive Park, Burlington, MA 01803 USA, Tel: 781-791-5066. before 1911 which was the end of year of last Chinese
(Email: ganglu888@hotmail.com)
North American Journal of Medicine and Science Jan 2015 Vol 8 No.1 21
dynasty of Qing. in that period, the TCM did not have a to environmental factors including exposure to certain toxic
disease called autism, however, it had the records of the substances during pregnancy.4 Infantile metopism is a
symptoms associated with autism, such as "dullness", congenital disfigurement of the forehead in which the frontal
"mutistic", "soliloquy", "five kinds of retardation", "five suture unclosed.
weaknesses", "fetal toxicity" and "infantile metopism".
Dullness, also known as dementia, is a result of abnormal TCM treats autism according to different pathological lesions,
digestive function of the spleen and stomach by TCM theory. time of the disease and place of morbidity. Chinese medicine
Spleen and stomach damages lead to inner sputum and prescriptions for treating autism stress the principle of
dampness, blinding the heart, and then impacting on "monarch, minister, assistant and guide" 5,130 that are the well-
intelligence. From model medicine perspectives, mutistic is known principles for the composition of prescriptions.
mainly caused by genetic predisposition. Symptoms of "Monarch drug" is the key ingredient in the prescription,
mutistic are unwillingness to speak and reply. Soliloquy "minister drug" promotes the "monarch drug" to exert
means absence of mind and muttering and its cause is curative effect, and "assistant drug" strengthens the effect of
deficiency of “heart qi” which meant the “state of mind” here the prescription or restrict toxin, and "guide drug" directs
and lack of physical recuperation. Five kinds of retardation other ingredients to work on the affected part. This principle
include slowness in standing, walking, hair growth, tooth could not only make reasonable use of each herb, but also
eruption and speech. These five kinds of retardation are make the prescription by appropriately adding and
caused by the parents’ unhealthy body which led to the subtracting in specific circumstances, which has important
congenital deficiency of infants. The Five weaknesses refer instructive significance for rational clinical use of medicines.
to flaccid head, flaccid nape, flaccid hands and feet, infantile Therefore, this article aims to find effective prescriptions and
flaccidity of muscle and flaccid mouth. Their causes are provide reference for better treatment of autism through
insufficiency of essence and blood. Fetal toxicity that refers collecting modern literature and ancient medical books.
Figure 1. PRISMA flow chart for the literature search and collection process. Figure 2. PRISMA flow chart for the ancient books search and collection process.
Figure 6. The summary data of 392 classic ancient herbs prescriptions that
used to treat the 7 symptoms of autism.
Figure 4. The summary data for the books that have the prescriptions to treat Some prescriptions, such as Hu Gu pill, Bu Zhong Yi Qi
the 7 symptoms of autism by Chinese dynasty. decoction, Chang Pu pill, Zuo Gui pill and so on were still
used in modern clinic to treat autism and its associated traits.
treated a variety of psychiatric disorders based on Zhi Zi Chi reading difficulties were improved obviously. Chen
decoction, the efficacy was satisfactory. Zhou Ronggen 61 Jianhong62 utilized Si Jun Zi decoction and Huang Lian Jie
treated 23 cases of patients with dementia by Bai Hu Du decoction to treat 30 cases of patients with dementia. The
decoction. Through this process of treatment, the symptoms curative effect was good and the total effective rate was
like memory loss, aphasia agnosia, abnormal behavior and 80.3%.
Use Frequency and Pharmacological Effects of Chinese pharmacological research results and showed that the
Medicine in Prescriptions pharmacological action of these Chinese medicines might
Frequency of use of Chinese medicine improve the treatment of autism and its associated symptoms
Filtering Chinese medicine of high frequency of use from based on the etiology that we have known so far. We thought
more than 300 prescriptions, we received 32 kinds of Chinese that the prescriptions and Chinese medicines of TCM could
medicines with high frequency of use, such as Acorus be as a breakthrough point to further research of autism for
gramineus Soland, Poria, Angelica, ginseng, etc. The results effective drug in treatment of autism, and we believed that it
are shown in Table 1. would be the most valuable work.
Pharmacological effects of Chinese medicine TCM has made it clear that autism occurs in the brain, and
We verified pharmacological effects of these 32 kinds of closely related with heart, spleen, liver and kidney. In TCM
Chinese medicines with high frequency of use through therapy of autism, Chinese medicine follows the overall
literature review, which were mainly improving the immune thoughts of Chinese medicine to treat autism by invigorating
system, calming the nerves, improving gastrointestinal tract, the spleen, eliminating phlegm, opening mind, tonifying the
enhancing memory, and so on. These pharmacological kidney, nourishing the heart, building the brain. Treating
effects were closely associated with the treating the cause of autism is mainly tonifying spleen, eliminating phlegm,
autism. The results were shown in Table 2. inducing resuscitation, tonifying kidney, nourishing heart,
and invigorating brain.
DISCUSSION AND CONCLUSION
We summarized symptoms and their targeted prescriptions Chinese herbal medicine compound takes effect with multi
related to autism in the ancient books, and have found some components, multi target, multi mechanism and multi-
of the prescriptions were still being used to treat autism in tache synthetically. It could adjust organism function and
modern times, such as Hu Gu pill, Bu Zhong Yi Qi decoction, change its usage when faced with different diseases, and its
Chang Pu pill, Zuo Gui pill and so on. In addition, we also side effects are slight. Hence, compound Chinese medicine in
consulted the Chinese medicines which have high frequency the treatment of autism has irreplaceable advantages
of use in the prescriptions and mapping with modern compared with Western medicine. Therefore, it is feasible
North American Journal of Medicine and Science Jan 2015 Vol 8 No.1 27
from the perspective of Chinese medicine to search the functions of improving immunity, protecting the brain
prescriptions and Chinese medicines to cure autism. Studies and nervous tissue, adjusting gastrointestinal, in a word, they
have shown that Chinese medicines we collated chiefly have can improve related symptoms of autism.
Note: A: Improve immune, B: Protect the nerve, C: anti-inflam-matory, D: Antiall-ergic, E: Calm down nerves, F: Improve the
gastrointestinal, G: Elimin-ating phlegm, H: Enhance memory, I: Protect liver
As we have learned from this review, recently biomarkers for 2. U.S. department of Health and Human Services, Centers for Disease
Control and Prevention. Prevalence of Autism Spectrum Disorder
the autism measurements have been extensively investigated
Among Children Aged 8 Years-Autism and Developmental Disabilities
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precisely diagnoses the autism, but also can be used to http://www.cdc.gov/mmwr/pdf/ss/ss6302.pdf. Accessed March 28,
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3. Congressional Record-House. Autism Collaboration, Accountability,
Research, Education, And support act of 2014.2014;H5688-5693.
However, the traditional prescriptions have disadvantages of Available at:https://www.congress.gov/crec/2014/06/24/CREC-2014-
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http://www.nytimes.com/2011/08/09/health/views/09klass.html?_r=1.
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CONFLICT OF INTEREST 7. Yuan Q, Wu ZF, Wang RC, et al. Analysis of Therapeutic Effect of
The authors declare no conflict of interest. Jin’S Three-Needling Therapy on Children Autism With Different
TCM Syndrome Types. Journal of Guangzhou University of
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