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Pa Tho Physiology of Cushing
Pa Tho Physiology of Cushing
Precipitating factors
Predisposing factors
Manifestations Management
Increase levels of Mineralocorticoids Renin is secreted from the kidneys to stimulate the production of Angiotensin; angiotensin stimulates the secretion of aldosterone. If renin-angiotensin mechanism is
Increase levels of androgen sex hormone Can cause virilization of the female Development of low self-esteem
A
Increase sodium potassium exchange in the late distal and cortical collecting tubules of the Hypokale mia, increase urine output Potassiu m supplem ents
Excess sodium is transported back to the blood Water follows where sodium goes
Cardiac dysrhythmia
B G
Increase protein catabolism
E
Mobilization of fatty acids to form glucose for energy
Buffalo hump, moon face, truncal obesity, ecchymoses, thinning of the skin, acne
Collagen supplements, avoid scratching
Diet modificatio n
F
Diet modification, administer insulin
Suicidal attempt
G F &D
H H
B
Increased pressure in the capillaries/ blood vessels Decrease protein (albumin) in the blood which holds the fluids
G
Altered Calcium metabolism
Edem a
Muscle weakness and atrophy, cardiac irregularities, bone weakness and osteoporosis
C C,F,D, I
Surgical Surgical removal removal of of the the 02 dead dead 02 intubati part part inhalatio on n
Black Decrease in discoloration of O2 saturation, Greenish-black the affected cyanotic , of the color Cyanotic part, no pain tachypnic affected part events sensorium
C, F, D, I
Poor blood circulation Gangrene Poor tissue perfusion Septicemi Cell death/ necrosis DEATH