Anticoagulant Comparison Chart

Which anticoagulant is right for your patient?

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Brand name
Warfarin*
*Coumadin® was
discontinued in
April 2020. Dabigatran Rivaroxaban Apixaban Edoxaban Betrixaban
Generic Yes No No No* No No
*The FDA approved
a generic in
December 2019, but
it’s not available yet.

FDA-approved Stroke prevention Stroke prevention Stroke prevention Stroke prevention Stroke prevention VTE prevention
indications in Afib in nonvalvular in nonvalvular in nonvalvular in nonvalvular in hospitalized
Stroke prevention Afib Afib Afib Afib acute medically ill
in those with VTE treatment VTE treatment VTE treatment VTE treatment patients
heart valve VTE prevention in VTE prevention in VTE prevention in
replacements patients already patients already patients already
VTE treatment treated for a treated for a treated for a
VTE prevention blood clot blood clot blood clot
VTE prevention VTE prevention VTE prevention
after hip after hip and after hip and
replacement knee replacement knee replacement
surgery surgery surgery
VTE prevention
during
hospitalization
and after
discharge in
adults with acute
medical illness
Prevention of
major CV events
in patients with
CAD and PAD*
*In combination with
aspirin

Drug image and Doses vary 75 mg, 110 mg, 2.5 mg, 10 mg, 2.5 mg or 5 mg 15 mg, 30 mg, or 40 mg or 80 mg
available dosages or 150 mg capsule 15 mg, or 20 mg tablet 60 mg tablet capsule
tablet

Onset Slow: Fast: Fast: Fast: Fast: Fast:

Several days A few hours A few hours A few hours A few hours A few hours

Renal effects No Yes Yes Yes Yes Yes

Kidney function Kidney function Kidney function Kidney function Kidney function
affects the dosage affects the dosage affects the dosage affects the dosage affects the dosage

Food effects Yes No Yes No No Yes

Vitamin K The 15 and 20 mg Bevyxxa should be
interactions doses of Xarelto taken at the same
should be taken with time each day with
food food
Drug interactions Many Few Few Few Few Few

Routine lab Yes No No No No No

monitoring
Reversal agents Yes Yes Yes Yes Not yet Not yet
Vitamin K, fresh Praxbind Andexxa Andexxa Reversal agents are Reversal agents are
frozen plasma, (idarucizumab) (andexanet alfa) (andexanet alfa) being investigated being investigated
prothrombin
complex concentrate

Acute medical illness: Conditions such as pneumonia, stroke, heart failure, CAD: Coronary artery disease
infection, or inflammatory disease Major cardiovascular (CV) events: CV death, heart attack, and stroke
Afib: Atrial fibrillation (nonvalvular Afib refers to Afib in patients without PAD: Peripheral artery disease
mechanical heart valves)
VTE: Venous thromboembolism

This chart is for informational purposes only.

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