A.

Allopurinol

B. Dexamethasone

C. Cochicine

D. Indomethacin

Ans: D

Rational:

Due of their greater tolerability, NSAIDs such as indomethacin are the medicine of choice in

acute gout. Aspirin is not utilised since it might lead to hyperuricemia. • Colchicine is more

effective and faster acting than NSAIDs, although it is rarely used because to its high toxicity.

Dexamethasone is immunosuppressant. Allopurinol is the preferred treatment for chronic gout in

the intercritical phase (between two acute attacks). However, it is contraindicated in acute gout

because uric acid inhibits the production of cytokines and allopurinol may exacerbate

inflammation by lowering uric acid levels.

Q2. The following are side effects caused by bromocriptine:

A. Impotence

B. Nausea and/or vomiting

C. Contractions of the uterus

D. The secretion of prolactin

Ans: B

Rational: Initiation of bromocriptine therapy is defined by nausea, vomiting, and postural

hypotension, but extended usage might result in behavioural changes, hallucinations, and strange

movements.
Q3. Carbimazole is different from propylthiouracil in that:

A. It works less well from dose to dose.

B. It has a shorter half-life in the blood.

C. It doesn't make an active metabolite.

D. It doesn't stop the conversion of thyroxine to triiodothyronine at the edges of the body.

Ans: D

Rational: There are following are the following property of propylthiouracil:

• High plasma protein binding affinity

• Pregnancy safe (because less transfer across placenta due to high PPB).

• Is less powerful.

• The plasma half-life is shorter, necessitating multiple daily dosages.

• Also inhibits peripheral T4 to T3 conversion.

Q4. The insulin receptor is:

A. Ion channel regulating

B. Tyrosine protein kinase

C. G-protein coupled

D. None.

Ans: B

Rational:

Insulin, growth hormone, prolactin, and cytokines work via Tyrosine protein kinase receptor.

Q5. The following side effects are associated with imipramine, with the exception of:

A. Tachycardia

B. Euphoria
C. Lowering of seizure threshold

D. Dryness of mouth

Ans: B

Rational: Except the option B, all other three responses are due to anticholinergic property of

imipramine but euphoria is occur due to stimulation of dopamine release.