PATHOPHYSIOLOGY

Modifiable:
Non- Modifiable:
 Occupation (Cooking class)
 Age: 70 years old  Lifestyle (typing, gardening and
 Female baking class)
 Genetic  Overweight
 History of hypertension  Medicine (hydrochlorothriaside)

Kidney disfunction

Accumulation of uric acid Decrease uric acid secretion

(Uric acid 7.9, normal <7)

S/s: Increase fighting mediator

 Stiffness of extremity
 Localized pain

Serotonin (vasoactive amine) Leukocytes: Prostagandin

 Neutrophils
 Eosinophils Chronic Pain
Inflammation  Basophils
(foreign body accumulation in the
joints)

Rheumatoid
arthritis