Trinilla, Jeshamae A.
BSN 2 – PENDER B March 25, 2022
NCM106PHR Drug Tabulation
Dr's order is to give a capsule every 12 hours, 9am-9pm.
Name of Drug Content Mechanism of Action
acetaminophen acetaminophen Therapeutic Class: Analgesic,
antipyretic
(Tylenol)
Drug Class: Synthetic non-
500mg/cap opioid p-aminophenol
derivative
1 cap
MOA:
P.O. Inhibits the enzyme
cyclooxygenase, block- ing
q12h prostaglandin production and
interfer- ing with pain
9:00 am – 9:00 pm impulse generation in the
peripheral nervous system.
Acetaminophen also acts
directly on temperature-
regulating center in the
hypothalamus by inhibiting
synthesis of prostaglandin E2.
Indication
Mild to moderate pain caused
by headache, muscle ache,
backache, minor arthritis,
common cold, toothache, or
menstrual cramps or fever.
Contraindication(s) Side Effects
Hypersensitivity to drug GI: Abdominal pain,
hepatotoxicity, nausea,
vomiting
Hematologic:
thrombocytopenia, hemolytic
anemia, neutropenia,
leukopenia, pancytopenia
Hepatic: hepatotoxicity
Metabolic: hypoglycemic
coma
Skin: rash, urticaria, jaundice
Other: hypersensitivity
reactions (such as fever),
angioedema
Nursing Considerations
1. Before and during long-
term therapy, monitor
liver function test results,
includ- ing AST, ALT,
bilirubin, and creatinine
lev- els, as ordered.
2. Monitor renal function in
patient on long- term
therapy. Keep in mind
that blood or albumin in
urine may indicate
nephritis; decreased
urine output may
indicate renal failure; and
dark brown urine may
indi- cate presence of the
metabolite phenacetin.
3. Expect to reduce dosage
for patients with renal
dysfunction.
4. Store suppositories
under 80° F (26.6° C).
5. Tell patient that tablets
may be crushed or
swallowed whole.
6. Instruct patient to read
manufacturer’s label and
follow dosage guidelines
precisely. Explain that
infants’ and children’s
acetaminophen liquid
aren’t equal in drug
concentration and aren’t
interchangeable.
7. Advise patient to use
manufacturer’s drop- per
 or dosage cup for
measuring liquid
acetaminophen.
8. Advise him to contact
prescriber before taking
other prescription or OTC
products because they
may contain
acetaminophen.
9. Teach patient to
recognize signs of
hepato- toxicity, such as
bleeding, easy bruising,
and malaise, which
commonly occurs with
chronic overdose.

References:

2011 Nurse’s Drug Handbook (Tenth Edition)

McGraw-Hill Nurse’s Drug Handbook (Seventh Edition)