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Yuritci Martinez

Dr. Sharity Nelson

ENGL 1302-101

5 December 2022

Covid-19 Vaccines effectiveness and safety toward the community

There have been millions of cases of the Coronavirus disease (Covid-19, often known as

SARS CoV-2) that have resulted in lethal circumstances. The government has authorized five to

eight vaccines to provide protection against Covid-19. Since multiple vaccinations have

demonstrated in clinical tests to have good safety profiles and significant efficacy against Covid-

19, determining the optimum vaccination for various age groups is necessary. As stated, “The

four vaccines, Covid-19 messenger RNA (mRNA) vaccine, Pfizer vaccine, Moderna vaccine,

AstraZeneca vaccine, and Sinovac vaccine, which have low safety risk and higher efficacies of

95%, 94%,70.4%, and 78%, respectively, were used in many countries because there is no

specific drug to treat Covid-19 virus worldwide” (Qamar et al. 355). The SARSCoV-2 was

prevented not only with the Covid-19 vaccines but also several booster shots, which have also

been reducing hospitalizations.

The researchers have shown that the more booster shots someone receives, the lower their

chance of being admitted to a hospital due to Covid-19. The Covid-19 vaccinations have shown

that doing so will assist the globe limit the spread of the virus and prevent further deaths from

occurring globally. As seen in the past with previous vaccines, “Vaccination is an effective way

to fight against Covid-19, which can help reduce the rate of serve illness and morality, to curb

further spread of the disease, and potentially to achieve herd immunity” (Tian et al. 4645). The

Covid-19 vaccines must be mandatory because is an efficient method of preventing the disease,
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which can assist to lower the risk of serious sickness and fatality, to stop the disease from

spreading, and perhaps to create herd immunity. The coronavirus vaccinations are intended to

assist the body in recognizing the spike proteins and fighting the coronavirus that contains them.

A successful vaccination will help prevent a person against serious disease, hospitalization, and

death.

Many people of all ages have been hospitalized in the Emergency Room and have been

affected by many health problems because of the Covid-19 virus. Covid-19 vaccines has been

beneficial to a lot of people preventing hospitalization or even death. Erazo et al. stated that their

“results support the vaccinations’ ability to protect against the risk of hospitalization across all

age groups” (4). Therefore, Pfizer, AstraZeneca, Johnson & Johnson, and boosters are among the

five anti-Covid-19 immunizations that have received official government approval. Each

vaccination has a unique set of responses and has helped people in different ways. Erazo et al.

recognize the fact that the Covid-19 vaccination is secure and lowers hospitalizations, thus

demonstrating their effectiveness. The results "affirm the protection offered by the

immunizations against the risks of hospitalization in all age categories," (Erazo et al. 4). The

second SARSCoV-2 was prevented with the Covid-19 vaccine and booster shots, which have

also been reducing hospitalizations. The Covid-19 vaccination has been shown to protect against

hospitalization, and studies have shown that the more booster shots a person receives, the lower

their chance of being admitted.

Due to a decrease in the number of persons who are infected with the virus, the Covid-19

vaccination has proven to be both safe and effective for all candidates “For these vaccines,

clinical trials have shown high vaccine efficacy against symptomatic infection and under real-

world circumstances, great vaccine efficacy has been established” (Veerle et al. 1). The booster
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shot has proven that these vaccinations may prevent people from getting the virus, which has

been a huge assistance for everyone. “A lower risk of a breakthrough infection was associated to

past Covid-19 infection, immunization history and booster vaccination” (Veerle et al. 9). For

individuals who had previously been infected and those who had gotten a booster shot, the risk

of a breakthrough infection was diminished significantly. All vaccinations are safe and effective;

like almost any medicine, they may have modest side effects, but this is sign that the

immunizations are influencing your body.

The Covid-19 immunizations have had a significant impact since they have prevented

people from needing hospitalization, re-infecting themselves with the virus, and maybe even

dying. Since many patients have reported that the Covid-19 immunizations have kept them

healthy, Chirico et al. believe that the vaccines are safe and effective. There are currently eight

vaccines against Covid-19 that have received emergency use authorization by the who that can

offer some protection to the world’s population during the Covid-19 pandemic (Chirico et al.

91). These vaccinations have showed significant efficiency against the virus and extremely high

levels of protection against illness, hospitalization, and morality/deaths (Chirico et al. 92). These

vaccinations demonstrated both a very high level of protection against sickness, hospitalization,

and mortality as well as great effectiveness against the infection. There are “three vaccines that

had higher efficacy against Covid-19 infection: Pfizer is 95% efficacy, Moderna is 94% and

Sputnik V is 92% effective” (Veerle et al. 92). Additionally, Moderna, Sputnik V, Janssen, and

Oxford-AstraZeneca vaccines have reduced the risks of severe symptoms of Covid-19.

The Covid-19 virus has spread tremendously and has caused a lot of people to get

infected, but the vaccines have helped restore people’s lives around the world. Therefore, it has

been established that these immunizations are both efficient and safe for everyone. Liu et al.
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evaluate the "Covid-19 vaccine's effectiveness and safety" in the real world. Vaccinations against

Covid-19 are safe and effective, according to Liu et al., and they will help avoid hospitalization,

infections, admission to the ICU or Emergency department, and mortalities. Worldwide,

coronavirus vaccines are extremely safe and have the potential to drastically reduce the number

of virus-related illnesses, infections, and fatalities” (1). The first dosage and the second dose

have demonstrated that they are highly helpful in treating individuals, preventing re-infection

The researchers found that while two doses of a vaccination might have moderate side effects,

they are more effective than other immunizations. They also discovered that those who are

completely immunized experience less infection or hospitalization. Every vaccination has been

shown to be both reliable and secure for everyone.

Chen et al., believes that the Covid-19 vaccinations are safe and could progressively

lower the number of infections, deaths, and the other Covid-19 related illnesses around the

world. Two doses of the Covid-19 vaccine had an effectiveness of 85% or higher (Chen et al. 9).

Although immunizations against strains of the SARS-CoV-2 virus were less effective than the

initial strain, they were still more than 50% effective in those who had received all available

vaccinations (Chen et al. 9). The results of the study showed that various immunization types are

usually safe and effective. These immunizations helped the virus spread less widely and

significantly reduced the number of mortalities among persons of all ages. These vaccines can

reduce deaths, severe cases, symptomatic cases, and infections from the Covid-19 virus.

Most of the vaccines showed a good safety profile and significant efficacy against Covid-

19. The researchers wanted to examine how efficacy each Covid-19 vaccine is and for every

vaccine they performed trials to test their safety. They first examined Moderna, AstraZeneca,

CoronaVac, Baharat, Sinopharm, Clover, Casino, CureVac, and ZyCov-D vaccines only. These
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vaccines tested to be more effective in preventing Covid-19 infection. Sinopharm and Sputnik

vaccines exhibited the highest safety profile and most effectiveness. Toubasi et.al stated that “In

the elderly population it is important to balance between the safety and efficacy for each

individual” (259). The researchers revealed that Pfizer was the most effective toward the elderly

population. In this article, they stated that these six vaccines are more effective than others and

have shown great improvement around the world. The elderly has benefited the most from these

vaccines because they are more vulnerable to get infected due to their weakened immune

systems. These vaccines have demonstrated a substantial level of protection against Covid-19

infection.

Numerous people have been afflicted by the Covid-19, which has spread quickly and

resulted in severe health issues or even death. The researchers wanted to examine four vaccines,

which are Pfizer, Moderna, AstraZeneca, and Sinovac. These four vaccines have lower risk and

have higher efficacy of 95%,44%,70% and 78% respectively. Although, these vaccines are

effective and save, they may cause some adverse effects. Most of the adverse effect were caused

by the second dose. The government banned the use of certain vaccines because they were

causing blood clots. The Sinopharm vaccine has been approved as a 2-dose vaccine for

prevention of Coronavirus and this vaccine has helped people from not getting infected. The

Pfizer vaccines is the most popular and has a 95% efficacy against the Covid-19 virus. The

Sputnik V vaccine has efficacy of 91.6% and has help a lot of people with lowering the side

effects.

The Covid-19 vaccine is an efficient method to preventing the disease, which can assist

to lower the risk of serious sickness and fatality, to stop the disease from spreading, and perhaps

to create herd immunity. These vaccines have been widely used on the adult population and trials
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have been done with some younger generations. The Covid-19 vaccines has helped children and

adolescents to be at less risk of getting infected or contracting another type of virus. The

vaccines have been shown to be efficient and safe for everyone. According to a study, “people

who received mRNA vaccinations in full or in part were protected against Covid-19 in 91% of

cases and in 81% of cases, respectively” (Tian et al. 4652). The researchers stated that all these

vaccines are efficient, but some of the vaccines cause mild effects on some people after getting

vaccinated. The researchers stated that these vaccines have helped by reducing the cases of

Covid-19 around the world.

Worldwide, the Covid-19 sickness claimed many lives and infected many more. Many

studies have demonstrated the safety and efficacy of the Covid-19 vaccines. The clinical trials

used to assess and approve Covid-19 vaccinations have shown that the vaccine considerably

lowers the risk of contracting the virus. Even if you contract the virus, the Covid-19 vaccination

may help prevent you from becoming extremely unwell, according to what has been

demonstrated concerning vaccines for other illnesses. Getting vaccinated may help protect

individuals close to you, especially those who are more susceptible to Covid-19's severe disease

such as elderly or immunocompromised people. Regardless of whether people have favorable or

unfavorable experiences and perspectives, they should get vaccinated for the safety of everyone.

These studies suggest that people should receive the recommended Covid-19 vaccines and

boosters to help prevent mortality or other diseases caused by the virus, allowing them to lead a

normal healthy long life.

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Works Cited

Chen, Yamin, et al. “Covid-19 Vaccine Research Focusses on Safety, Efficacy,

Immunoinformatics, and Vaccine Production and Delivery: A Bibliometric Analysis Based

on VOSviewer.” BioScience Trends, vol. 15, no. 2, 2021, pp. 64–73.,

https://doi.org/10.5582/bst.2021.01061. 

Chirico, Francesco, et al. “Safety & Effectiveness of COVID-19 Vaccines: A Narrative

Review.” Indian Journal of Medical Research, vol. 155, no. 1, Jan. 2022, pp. 91–104.,

https://doi.org/10.4103/ijmr.ijmr_474_21. 

Liu, Qiao, et al. “Effectiveness and Safety of SARS-COV-2 Vaccine in Real-World Studies: A

Systematic Review and Meta-Analysis.” Infectious Diseases of Poverty, vol. 10, no. 1, 14

Nov. 2021, pp. 1–15., https://doi.org/10.1186/s40249-021-00915-3. 

Erazo, Diana, et al. “Investigating Covid-19 Vaccine Impact on the Risk of Hospitalisation

through the Analysis of National Surveillance Data Collected in Belgium.” Viruses, vol.

14, no. 6, 16 June 2022, pp. 2–8., https://doi.org/10.3390/v14061315. 

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Tian, Fangyuan, et al. “Safety and Efficacy of Covid‐19 Vaccines in Children and Adolescents:

A Systematic Review of Randomized Controlled Trials.” Journal of Medical Virology, vol.

94, no. 10, 2022, pp. 4644–4653., https://doi.org/10.1002/jmv.27940. 

Qamar, Naila, et al. “Vaccines for Covid‐19: An Insight on Their Effectiveness and Adverse

Effects.” Journal of Medical Virology, vol. 94, no. 8, 2022, pp. 3554–3560.,

https://doi.org/10.1002/jmv.27810. 

Toubasi, Ahmad A., et al. “Efficacy and Safety of Covid‐19 Vaccines: A Network Meta‐

Analysis.” Journal of Evidence-Based Medicine, vol. 15, no. 3, 2022, pp. 245–262.,

https://doi.org/10.1111/jebm.12492. 

Yang, Bingyi, et al. “Immunogenicity, Efficacy, and Safety of SARS-COV-2 Vaccine Dose

Fractionation: A Systematic Review and Meta-Analysis.” BMC Medicine, vol. 20, no. 1,

2022, https://doi.org/10.1186/s12916-022-02600-0.