11/30/21, 6:09 PM PhysioEx Exercise 2 Activity 4

PhysioEx Lab Report

Exercise 2: Skeletal Muscle Physiology

Activity 4: Tetanus in Isolated Skeletal Muscle

Name: ПАВЕЛ МИЛЕНКОВСКИ 153788

Date: 30 November 2021

Session ID: session-adddde33-22e1-078a-c29f-255515be3e41

Pre-lab Quiz Results

You scored 67% by answering 2 out of 3 questions correctly.

1 Stimulus frequency refers to

You correctly answered: the rate that stimulating voltage pulses are applied to an isolated
whole skeletal muscle.

2 Which of the following distinguishes a state of unfused tetanus from a state of complete
(fused) tetanus?

You correctly answered: Muscle tension increases and decreases during a state of unfused
tetanus.

3 When the stimulus frequency reaches a value beyond which no further increases in force
are generated by the muscle, the muscle has reached its

Your answer: unfused tetanic tension.

Correct answer: maximal tetanic tension.

Experiment Results
Predict Question
1 Predict Question: As the stimulus frequency increases further, what will happen to the
muscle tension and twitch appearance with each successive stimulus? Will there be a limit to
this response?

Your answer: As the stimulus frequency increases, the muscle tension generated by each
successive stimulus will increase. There will be a limit to this increase.

Stop & Think Questions

1 What begins to happen at around 80 msec?

You correctly answered: unfused tetanus develops.

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2 How does the trace at 130 stimuli/sec compare with the trace at 50 stimuli/sec?

You correctly answered: Fused tetanus develops at this greater stimulus frequency.

3 How do the traces with 146-150 stimuli per second compare with the trace at 130 stimuli per
second?

You correctly answered: Maximal tetanic tension develops with these very high stimulation
frequencies.

Experiment Data
Voltage (v) Length (mm) Stimuli/sec Act. Force Pass. Force Total Force
8.5 75 50 5.12 0 5.12
8.5 75 130 5.88 0 5.88
8.5 75 140 5.91 0 5.91
8.5 75 142 5.92 0 5.92
8.5 75 144 5.94 0 5.94
8.5 75 146 5.95 0 5.95
8.5 75 150 5.95 0 5.95

Stimuli/sec = 50 at 8.5 V

Stimuli/sec = 130 at 8.5 V

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Stimuli/sec = 140 at 8.5 V

Stimuli/sec = 142 at 8.5 V

Stimuli/sec = 144 at 8.5 V

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11/30/21, 6:09 PM PhysioEx Exercise 2 Activity 4

Stimuli/sec = 146 at 8.5 V

Stimuli/sec = 150 at 8.5 V

Post-lab Quiz Results

You scored 100% by answering 3 out of 3 questions correctly.

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11/30/21, 6:09 PM PhysioEx Exercise 2 Activity 4

1 The term tetanus refers to

You correctly answered: sustained muscle tension due to very frequent stimuli.

2 Which of the following distinguishes a state of unfused tetanus from a state of complete
(fused) tetanus?

You correctly answered: Muscle tension increases and decreases between different values
for an unfused tetanus.

3 When the stimulus frequency reaches a value beyond which no further increases in force
are generated by the muscle, the muscle has reached its

You correctly answered: maximal tetanic tension.

Review Sheet Results

1 Describe how increasing the stimulus frequency affected the force developed by the isolated
whole skeletal muscle in this activity. How well did the results compare with your prediction?

Your answer:

големувањето на фреквенцијата на стимулот ја зголемува мускулната тензија

генерирана од секоја наредна сила, но сепак ќе има плато.

2 Indicate what type of force was developed by the isolated skeletal muscle in this activity at
the following stimulus frequencies: at 50 stimuli/sec, at 140 stimuli/sec, and above 146
stimuli/sec.

Your answer:

При 50 стимули/сек, генерираната сила е во состојба т.н. нефузиран тетанус,

мускулната тензија се зголемува и намалува при различни вредности При 140
стимули/сек, генерираната сила е во состојба наречена целосен (споен) тетанус,
мускулната тензија повеќе не се колеба. При над 146 дразби/сек, генерираната сила е
во состојба наречена максимална тетанска напнатост што значи дека секоја поголема
фреквенција нема да ја промени генерираната сила.

3 Beyond what stimulus frequency is there no further increase in the peak force? What is the
muscle tension called at this frequency?

Your answer:

Над 146 дразби/сек, нема дополнително зголемување на максималната сила. Оваа

мускулна напнатост се нарекува максимална тетанска напнатост.

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