PHATOPHYSIOLOGY OF ACUTE MYELOID LEUKEMIA

Predisposing factor Precipitating factor

 Gender  Smoking
 Age  Electromagnetic fields
 Family history  Workplace exposure to diesel
 Having genetic syndrome  Exposure to herbicides or pesticides

Sign and symptoms: Causes of AML:

Acute Myeloid
 Weight loss Leukemia  Smoking is proven
 Fatigue to cause AML
 Fever  Develop mutation
 Night sweats in bone marrow
 Loss of appetite
 Shortness of
breath
DNA Damage

Blood cell production

If left untreated: Develop immature blood cell

 Bleeding If treated:
 Long term of
 No bruising
survival Abnormalities of bone marrow
 No bleeding
 CBC
abnormalities  Having a chances
of survive
 Death
Cancer cell travel into the blood
stream

TREATMENT:
Spread to the other organ
 Chemotherapy
 Radiation therapy
 Stem cell transplant
 Targeted therapy
Develop complicated
 Other drugs