E4U

CLASS XII
HUMAN HEALTH & DISEASE & BIOTECHNOLOGY II
91 Most accurate technique for the detection 4)In between N and C-terminal
of cancer 97 The use of vaccines and immunization
1)Radiography 2)CT Scan programmes have enabled us to
3)MRI 4)all of the above completely eradicated a disease like
92 From the following, how many diseases 1)Polio 2)Smallpox
are transmitted through contaminated
3)Diphtheria 4)Both (1) and (2)
food and water
98 Constipation, headache, loss of appetite,
i)Typhoid ii)Ringworm
stomach pain are the symptoms of
iii)Pneumonia iv)Ascariasis
1)Amoebiasis 2)Ascariasis
1)4 2)3 3)1 4)2
93 Which drug is abused by some sports 3)Typhoid 4)Pneumonia

persons these drugs are? 99 Match the column I with column II and

1)Opioids 2)Cannabinoids choose the correct option

3)Coca alkaloids 4)Both (2) and (3) Column-I Column-II

94 Which measure would not be particularly a. Typhoid 1. Fungal disease
useful for prevention and control of b. Common cold 2. Bacterial disease
alcohol and drugs abuse among c. Malaria 3. Viral disease

adolescents? d. Ringworm 4. Helminthic diseage

e. Filariasis 5. Protozoan disease
1)Looking for danger sign
1)a–1, b–2, c–4, d–3, e–5
2)Avoid undue peer pressure
2)a–5, b–1, c–3, d–4, e–2
3)Seeking benefits perceived of
3)a–2, b–3, c–5, d–1, e–4
drug/alcohol use
4)a–3, b–2, c–5, d–1, e–4
4)Education and counselling
100 Natural killer cells provides innate
95 Person showing in figure suffering from
immunity. These are a type of
1)Lymphocytes 2)Thrombocytes
3)Erythrocytes 4)Monocytes
101 Drugs used to quickly reduce the
symptoms of allergy
i)Histamine drugs ii)Adrenaline
iii)Steroids iv)alpha interferons
1)i, ii, iii 2)i, ii, iv
3)ii, iii 4)i, ii
102 A drug after administration causes
1)Ringworm 2)Amoebiasis depression and slows down body
3)Elephantiasis 4)Pneumonia functions. The receptors for this drug are
96 Antigen binding site is present on which present in the
terminal of peptide chain in antibodies 1)CMS and GIT 2)Brain
1)N-terminal 2)C-terminal 3)Cardiovascular system
3)Either N or C
 4)Spinal cord 3)a–3, b–4, c–2, d–1
103 A disease is characterised by muscular 4)a–3, b–4, c–1, d–2
pain and internal bleeding. Find the 108 In the adolescent male or female severe
incorrect statement about this disease. facial and body acne, and premature
1)Transmitted by common round worm. closure of the growth centres of the long
2)Healthy person acquires infection bone may result in
through contaminated water 1)Increased aggressiveness
3)Sometimes intestinal passage could be 2)Kidney and liver dysfunction
blocked. 3)Mood swings
4)Other symptoms are fever and anemia. 4)Stunted growth
104 The term 'Health' is defined in many ways. 109 Which is common between AIDs and
The most accurate definition of the health Hepatitis-B?
would be i)Both are viral diseases.
1)Health is the reflection of a smiling face ii)Both are transmitted by infected
2)Health is the state of body and mind in needles and syringes.
a balanced condition. iii)Both are infectious diseases
3)Health is the symbol of economic iv)Both are chronic diseases
prosperity. v)Both are ultimately fatal.
4)Health is a state of complete physical, 1)ii, iii, iv, v 2)i, ii, iii, v
mental and social well-being. 3)i, ii, iii, iv, v 4)ii, iii, v
105 The sporozoites that cause infection when 110 Which of the following component of the
a female Anopheles mosquito bite a immune system is not correctly matched?
human being are formed in 1)IgA present in colostrum in early days
1)Liver of human 2)RBCs of mosquito of lactation to protect infant from
3)Salivary glands of mosquito diseases.
4)Intestine of mosquito 2)Interferons–Secreted by Virus-infected
106 Psychological attachment to certain cells and protected non-infected cells from
effects (such as euphoria & temporary further viral infection
feeling of well-being) associated with 3)Macrophages–Mucus secreting cell that
drugs and alcohol is called trap microbes entering in the body
1)Addiction 2)Dependence 4)B-lymphocytes–Produces antibodies in
3)Withdrawal Syndrome response to pathogens into blood.
4)Both (1) and (2) 111 Select the correct combination of
107 Match the column I with column II and statements regarding of acquired
choose the correct option. immunity.
Column-I Column-II i)PMNL and Natural Killer Cells are

a. Innate immunity 1. Natural infection involved in acquired immunity

b. Acquired emmunity 2. Colostrum ii)Active and Passive immunity are types
of acquired immunity.
c. Active immunity 3. Interferons
d. Passive immunity 4. Anti bodies iii)CMI is responsible for acquired
immunity
1)a–4, b–3, c–2, d–1
iv)It produces a 1° response of low
2)a–4, b–3, c–1, d–2
 intensity. 1)Retrovirus 2)Rhinovirus
1)i, ii, iii 2)ii, iii, iv 3)Adenovirus 4)Bacteria
3)ii, iii 4)i, ii, iii, iv 117 Entamoeba histolytica is transmitted
112 Select the correct statement. ' through
1)Injection of snake antivenom is an 1)Insect bite 2)Bird dropping 3)Sweat
example of active immunisation. 4)Food or water contaminated with cysts
2)Certain protozoans have been used in 118 Which disease is caused by a nematode?
mass production of hepatitis-B vaccine. 1)Poliomyelitis 2)Leprosy
3)If due to some reason B & T 3)Filariasis 4)Amoebiasis
lymphocytes are damaged, the body will 119 Which is correctly matched?
not produce antibodies against a Disease Causative Mode of
pathogen. Organism Infection
1) Typhoid Salmonella with inspired
4)Injection of dead or inactivated
typhi air
pathogen cause passive immunity.
2) Pneumonia Streptococcus Droplet
113 Statement A: Morphine is sedative and
pneumonia infection
painkiller.
3) Elephantiasis Wuchereria Contaminated
Statement B: Barbiturates cause mental
bancrofti water and
retardation.
foot
1)Statement B is correct and statement A
4) Malaria Plasmodium Bite of male
is wrong
vivax Anopheles
2)Both the statement A and B are correct
3)Statement A is correct and statement B
120 Fever in malaria is due to
is wrong
1)Entry of cryptomerozoites into red blood
4)Both the statement A and B are wrong.
corpuscles
114 The organisms which causes diseases in
2)Entry of sporozoites into blood
plants and animals are called
capillaries
1)Pathogens 2)Vectors
3)Entry of merozoites from red blood
3)Insects 4)Worms
corpuscles
115 Match the column I with column II and
4)Release of merozoites from red blood
choose the correct option.
corpuscles
Column-I Column-II
121 A person preparing food like Mary Mallon
a) Auto-immunity 1. Rheumatoid arthritis
can be a major source of spread of disease
b) Allergic disease 2. Asthma
c) Contact inhibition 3. Normal cells 1)Pneumonia 2)Syphilis
3)Cancer 4)Typhoid
d) Metastasis 4. Malignant tumour
122 What is correct?
1)a−1, b−2, c−3, d−4
1)Malignant tumours may exhibit
2)a–1, b–2, c–4, d–3
metastasis.
3)a–2, b–1, c–3, d–4
2)Patients who have undergone surgery
4)a−2, b−1, c−4, d-3
are given cannabinoids to relieve pain.
3)Benign tumours show metastasis.
116 In severe cases lips and finger nails may
4)Heroin accelerates body functions.
turn gray to bluish in color due to
123 Which is related to CO content in blood?
 i)CO reduces the concentration of exhibit metastasis
haembound oxygen Statement B: Patients who have
ii)Smoking increases CO content in blood, undergone surgery are given cannabinoids
iii)CO causes cancer of lung, urinary to relieve pain
bladder and throat 1)Statement B is correct and statement A
iv)CO causes oxygen deficiency in body is wrong
1)i, iii 2)i, ii, iii, iv 2)Both the statement A and B are correct
3)ii, iii, iv 4)i, ii, iv 3)Statement A is correct and statement B
124 In the life cycle of Plasmodium, sexual is wrong
stages develop in 4)Both the statement A and B are wrong.
1)RBC of humans 2)RBC of mosquito 131 Cocaine interferes with transportation of
3)Stomach of mosquito neurotransmitter
4)Gut of mosquito 1)Serotonin 2)Dopamine
125 Which activates the immune system and 3)Epinephrine 4)Acetylcholine
helps in destroying the tumor?. 132 A factor responsible for cirrhosis of liver is
1)Amphetamines 2)-Interferon 1)Vitamins 2)Fats and oils
3)Benzodiazepines 4)Morphine 3)Alcoholism 4)Sugar
126 Chikungunya is transmitted in many parts 133.Type of immunoglobulin present in
of India, by Colostrum/only mother’s milk is
1)Aedes mosquito 2)Anopheles mosquito 1)IgA 2)IgG
3)Culex mosquito 4)Both (2) and (3) 3)IgD 4)IgE
127 In malignant tumors, the cells proliferate, 134 Which One of the following acts as
grow rapidly and move to other parts of physiological barrier to the entry of
the body of form new tumors. The stage microorganism in human body ?
of disease is called 1)Tears 2)Monocytes
1)Metagenesis 2)Metastasis 3)Skin 4)WBC
3)sporogenesis 4)Mitosis 135 Filariasis is due to
128 The antigen binding site is present in 1)Helminth 2)Protozoan
1)Constant region of both light and heavy 3)Bacterium 4) Virus
chains.
2)Variable region of both light and heavy 136 Which of the following is not a
chains. conventional method of diagnosis ?
3)Variable region of heavy chains i)PCR ii)Serum analysis
4)Variable region of light chains iii)ELISA iv)Urine analysis
129 Interferon suppresses the pathogenic v)r-DNA technology
activity of
1)i, iii, iv 2)ii, iii
1)Bacteria 2)Viruses
3)ii, iv 4)i, iii, v
3)Protozoans 4)Helminths
137 In probe the nucleic acid which is tagged
with a radioactive molecule could be-
1)A single stranded RNA
2)A single stranded DNA
130 Statement A: 'Malignant tumours may
3)A double stranded DNA
 4)Both 1 and 2 iii)The source of complementary RNA
138 Infection by pathogen can be detected by could be from an infection by viruses
the having RNA genome or transposons that

1)Presence of antigens replicate via an DNA intermediate. Select

2)Detecting the antibodies synthesized the incorrect statement.

1)i, iii 2)i, ii 3)ii, iii 4)i, ii, iii
against the pathogen
143 In the clinical gene the therapy for ADA
3)Detecting the antigens synthesized
deficiency, the ADA cDNA is introduced
against the pathogen.
into the blood cells by using a vector which
1)Both 1 and 2
would be
139 The term used to refer to the use of bio-
1)Agrobacterium
resources by multinational companies and 2)Bacillus thuringiensis
other organizations without proper 3)Retrovirus 4)Both 1 and 3
authorisation from the countries and 144 ELISA is based on the principle of
people concerned without compensatory 1)Polymerase chain reaction
payment is 2)r-DNA technology
1)Bioprospecting 2)Biopiracy 3)Autoradiography and probe
3)Biofortification 4)Bioinformatics 4)Antigen-antibody interaction

140 Match the column I with column II and 145 Statement A: Bt protein exists as active

choose the correct orjtion. toxin in the bacillus

Statement B: The activated toxin enters
Column-I Column-ll
the ovaries of the pest to sterilize it and
Gene Provide resistance
thus prevents its multiplication
a. Cry I Ac from
1. Cotton bollworms 1)Statement B is correct and statement A
b. Cry I Ab 2. Corn borer
is wrong
c. Cry II Ab 3. Meloidegyne 2)Both the statement A and B are correct

1)a—1,b—2, c—3 2)a—2, b—1,c—2 3)Statement A is correct and statement B

is wrong
3)a—1,b—2, c— 1 4)a—1,b—2, c—3
4)Both the statement A and B are wrong.
146. For the purpose of early diagnosis, which
141 To prevent the infection of a nematode
method is employed
Meloidegyne incognitia in the roots of
1)PCR 2)ELISA
tobacco plants, a novel strategy was
adopted which was based on the process 3)r-DNA technology 4)All of the above

of 147 Rosie produced human enriched milk

1)RNA interference (RNAi) containing the human ……
2)DNA interference (DNAi) 1)2.8 g/L, -1 antitrypsin
3)ds RNA interference 4)Both 1 and 3 2)2.8 g/L, -lactalburnin
142 Read the following statements. 3)2.4 g/L, -1 antitrypsin
i)RNAi involves silencing of specific mRNA 4)2.4 g/L, -lactalburnin
due to complementary ds RNA.
148 The site of production of ADA in the body
ii)RNAi takes place in all prokaryotic
is
organism as a method of cellular defense
1)Lymphocytes 2)Bone marrow
 3)Blood plasma 4)Both 1 and 2 binded to the
149 C-peptide of human insulin is 1)Foregut epithelial cells
1)Responsible for its biological activity 2)Midgut mesothelial cells
2)Removed during maturation of pro- 3)Midgut epithelial celis
insulin to insulin 4)Hindgut mesothelial cells
3)A part of mature insulin molecule 156 In the following figure cotton boll
4)Responsible for formation of disulphide destroyed by
bridges
150 If a radiolabel is used to tag a DNA
molecules, the techniques used to localise
would be
1)Agarose gel-electrophoresis
2)Polymerase-chain reaction 1)Corn borer

3)Autoradiography 4)Probe 2)Meloidegyne incognitia

151 The trigger for activation of toxin of 3)Bacillus thuringiensis 4)Insect

Bacillus thuringiensis is: 157 Match the column I with column II and
choose the correct option.
1)Acidic pH of stomach Column-l Column-II
2)High temperature 3)Alkaline pH of gut a. Bt toxin 1. Meloidogyne incognitia
4)Mechanical action in the insect gut b. RNAi 2. Insecticide
152 Crystals of Bt toxin produced by some c. Gene therapy 3. Routine test for AIDS
bacteria do not kill the bacteria d. PCR 4. ADA deficiency
themselves because 1)a—2, b—1, c—3, d-4

1)Toxin is inactive 2)Toxin is immature 2)a—2, b—1, c—4, d—3

3)Bacteria are resistant to the toxin 3)a—1,b—2, c—3, d—4

4)Bacteria encloses toxin in a special sac 4)a—1,b—2, c—4, d—3

158.Match the column I with column II and

153 The critical research areas of choose the correct option.

biotechnology are Column-l Column-II

1)Downstream processing technology a. First transgenic cow 1. m-RNA

2)Providing the best catalyst usually a silencing

microbe or pure enzyme b. Safety test of polio 2. Rice

3)Creating optimal condition for a catalyst vaccine
4)All of the above c. Resistance from 3. Rosie
154 Genetically modified (GM) plants have nematode
been useful in d. Vitamin 'A' enriched 4. Transgenic
1)Enhanced nutritional value of food crop mice
2)Helped to reduce post-harvest losses 1)a—1, b—3, c—4, d—2
3)Produced of pest resistant plants 2)a—3, b—2, c—1, d—4
4)All of the above 3)a—3, b—4, c—2, d—1
155 The insecticidal protein in Bt cotton is 4)a—3, b—4, c—1, d—2
159 The modification/usage of living 3)T-DNA 4)All of the above
organisms for public service (for example, 166 Which is a powerful technique to identify
as food and medicine sources) has also many genetic disorders?
created the problem with 1)PCR 2)ELISA
1)Piracy 2)Patents 3)Serum analysis 4)All of the above
3)GMO 4)Ethical issues 167 Which is based on antigen-antibody
160 Statement A: First transgenic buffalo interaction?
Rosie produced milk which was human 1)PCR 2)ELISA
alphalactalbumin enriched 3)r-DNA technology 4)All of the above
Statement B: Restriction enzymes are 168 Which organization will make decision
used in isolation of DNA from other regarding the validity of GM research &
macromolecules the safety of introducing GM-organisms
1)Statement B is correct and statement A for public services?
is wrong 1)EFB 2)GEAC
2)Both the statement A and B are correct 3)US patent and Trademark office
3)Statement A is correct and statement B 4)Indian parliament
is wrong 169 Vitamin-A rich transgenic plant is
4)Both the statement A and B are wrong. 1)Flavr Savr tomato
161 Biological products are useful for the 2)Golden Rice 3)Bt Cotton
treatment of 4)Vaccinated Potato
1)PKU 2)Emphysema 170. Cry II Ab and Cry I Ab produce toxins that
3)Cystic fibrosis 4)All of the above control
1)Cotton bollworms and corn borer
162 Which is the possible solution to minimize
respectively
the use of fertilisers and chemicals?
2)Corn borer and cotton bollworms
1)Genetically modified crops (GMO)
respectively
2)Organic farming 3)Tobacco budworms and nematodes
3)Bio- pesticides 4)All of the above respectively
163 The source of the complementary RNA 4)Nematodes and tobacco bollworms
during process of RNA interference respectively
171 Select the incorrect statement.
1)From an infection by viruses having RNA
1)Transgenic animals are used for study
genomes
of complex factors involved in growth such
2)Transposons 3)Both 1 and 2 as insulin-like growth factor.
4)None of the above 2)Transgenic animals are specially made
164 In insulin, A and B chains are combined by to serve as models for human diseases so
1)Diphosphate bonds 2)Dicyanide bonds that investigation of new treatments for
disease is made possible.
3)Disulphide bonds 4)Disulphate bonds
3)First transgenic cow, Rosie, produced
165 A functional ADA, DNA is introduced into
human protein-enriched milk containing
the lymphocytes using
the human alphalactglobulin.
1)Retroviral vector 4)Transgenic mice are being developed for
2)Agrobacterium tumefaciens vector use in testing the safety of vaccines before
 they are used on humans. 3)Either RNA or DNA
172 Match the column I with column II and 4)Can be ss DNA but not ss RNA
choose the correct option. 178 Choose the correct option regarding
Column-I Column-II retrovirus.
a. First clinical gene therapy 1. 1990 1)An RNA virus that can synthesise DNA
b. First transgenic cow produced 2. 1997 during infection
c. Eli Lily form human Insulin 3. 1983 2)A DNA virus that can synthesise RNA
d. American company got 4. 1980 during infection
patent rights on Basmati 3)Ass DNA virus 4)Ads RNA virus
rice 179 ADA is an enzyme which is deficient in a

1)a—3, b— 1, c—4, d—2 genetic disorder SCID. What is the full

2)a—2, b—4, c—1, d—3 form of ADA?

3)a—4, b—3, c—2, d—1 1)Adenosine deoxyaminase

4)a—1,b—2, c—3, d—2 2)Adenosine deaminase

173 Silencing of mRNA/RNA interference has 3)Aspartate deaminase

been used in development of plants 4)Arginine deaminase

resistant to 180 Silencing of a gene could be achieved

1)Viruses 2)Insects through the use of

3)Fungi 4)Nematodes 1)RNAi only 2)Antisense RNA only

174 The genetic defect adenosine deaminase 3)By both 4)None of the above

(ADA) deficiency may be cured

permanently by
1)Introducing bone marrow cells
producing (ADA) into cells at an early
embryonic stages
2)Administrating adenosine deaminase
activators
3)Periodic infusion of genetically
engineered lymphocytes having functional
ADA c-DNA
4)Enzyme replacement therapy
175 Which one is not used for early molecular
diagnosis?
1)Polymerase chain reaction
2)Gel electrophoresis
3)Recombinant DNA technology
4)Enzyme linked immunosorbent assay
176 Protein alpha 1 antitrypsin is used to treat
1)Cancer 2)Rheumatoid arthritis
3)Alzheimer's disease 4)Emphysema
177 A probe which is a molecule used to locate
specific sequences in a mixture of DNA or
RNA molecules could be
1)A single stranded RNA
2)A single stranded DNA