1. What is a synapse?

2. What is a neurotransmitter?
3. When is the neurotransmitter released?
4. How do neurotransmitters affect postsynaptic cells?
5. Describe the mechanism of synaptic transmission

Structure of Chemical Synapse

 Chemical synapses have a larger synaptic cleft (region between the pre and postsynaptic
neurons) than electrical synapses. The presence of tiny, membrane-bound structures called
synaptic vesicles within the presynaptic terminal is a key feature of all chemical synapses.
 The chemical signals generated by the presynaptic neuron are filled with one or more
neurotransmitters, and it is these chemical agents serving as messengers between the
connecting neurons that provides this synapse its name.
 There are many different types of neurotransmitters, with acetylcholine being the most well-
studied. It is used in peripheral neuromuscular synapses, autonomic ganglia, and some
central synapses.
 Synapses are asymmetrical in both structure and function. Only the presynaptic neuron
produces the neurotransmitter binding to receptors on the postsynaptic cell’s side of the
synapse.
 The presynaptic nerve terminal (also known as the synaptic button, bouton, or knob)
develops from the axon’s tip, whereas the postsynaptic target surface develops from a
dendrite, cell body, or another component of the cell.
Signaling across chemical synapses

The release of neurotransmitter is triggered by the arrival of a nerve impulse (or action potential) and occurs
through an unusually rapid process of cellular secretion, also known as exocytosis: Within the pre-synaptic
nerve terminal, vesicles containing neurotransmitter sit "docked" and ready at the synaptic membrane. The
arriving action potential produces an influx of calcium ions through voltage-dependent, calcium-selective ion
channels. Calcium ions then trigger a biochemical cascade which results in vesicles fusing with the
presynaptic-membrane and releasing their contents to the synaptic cleft. Vesicle fusion is driven by the action
of a set of proteins in the presynaptic terminal known as SNAREs. The membrane added by this fusion is later
retrieved by endocytosis and recycled for the formation of fresh neurotransmitter-filled vesicles. Receptors on
the opposite side of the synaptic gap bind neurotransmitter molecules and respond by opening nearby ion
channels in the post-synaptic cell membrane, causing ions to rush in or out and changing the
local transmembrane potential of the cell. The resulting change in voltage is called a postsynaptic potential. In
general, the result is excitatory, in the case of depolarizing currents, or inhibitory in the case of hyperpolarizing
currents. Whether a synapse is excitatory or inhibitory depends on what type(s) of ion channel conduct the
post-synaptic current display(s), which in turn is a function of the type of receptors and neurotransmitter
employed at the synapse.