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Cell wall synthesis

Inhibitors
AfraTafreeh.com exclusive

Gm B B B B B B B B ponoeumopcocci

protozoa

Anaerobes X X X
vaginosis
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Neisseria Neisseria
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Antimicrobials

Antibacterial Antifungal Antiviral Antiparasitic

azotes Vir

NB Humans have a cell membrane but met a cell wall


Bacteria fungi have a cell wall
T
B lactam Bglucan
Antibacterials o.o

at ti k
ell wall synthesis inhibitors protein synthesis inhibitors Nudeicaadsynthes
inhibitors
ordisruptorsofcellmembrane
Interferewithcellwallsynthesis 30S inhibitors
Aminoglycosides GNATS IS A
Indirect
B lactams tetracyclines teeth
Direct
acting acting
Penicillins
Cephalosporins
Monobactam
505 inhibitors Transcriptionor Replication Folate
inhibitors inhibitors
Aztreonam Macrolides
Carbapenems
Lincosamide Quinolones flox TMP SM
Glycoproteins vancomycin Clindamycin anerobes DNA
Nitrofurantoincuth
Streptogramins pyrimethuqfaind.ee

Rifamycin Rifampin RNA


Bacitracin
on classified Quinupristin
Dalfopristin
Disruptorsof cellmembrane
Chloramphenicol
Daptomycin Linezolidresistant
lymyxinB MRSA.vrsaivre.pro
AfraTafreeh.com exclusive
5 Antibacterials
l I I
F V A
Cell wall synthesis Protein synthesis Ctranslation Nudeicaadsynthes
inhibitors
inhibitors inhibitors
ordisruptorsofcellmembrane
A
Indirect
Interferewithcellwallsynthesis 305 inhibitors Direct
acting
acting
Aminoglycosides Gnats
lactams
B
earasinusinteaion

Gentamicin
Folate
Pneumocystis

Transcriptionor Replication
oirorecii
Neomycin
Penicillins Amikacyin
inhibitors in inhibitors
pop
sensitive
penicillinpiaotamase Tobramycin pneumocystepneumonia
my lactamaseresistantpenicillins Habitationnaf
p TMP SM
streptomycin

B I in5idiiisitivepenicillins
Quinolones flox
ciprofloxacin
DNA
Tetracyclines Teeth
IiiaEEo
lacatmpq.pe spiactamase

11
toxoplasmosis

B penicillins
lactanticisseedomsonednsitive
Edm ahahibuitionisa
Nitrofurantoincuti pyrimethamine
piperacininaticarauincarbenicillin
subaa.am Tetracycline chlamydia sulfadia
i taobao.am
Doxycycline Rickettsia Rifamycin Rifampin RNA
Cephalosporins e X uymel
spirochetes side
effects

Monobactam s pg pseudomonas Minocydinefify.ggdasma


Tigercycline Brucella
ornate
deficiency

Hypersensitivity
isp
Aztreonam a pseudomonas
aupset
Carbapenemspseudomonas
impenemmeropenemertapenem
50 S inhibitors acute noon
hemolysis
deacieng

edfa
MAC.roidesu
typFcal
mycoplasmacnoceHwail
Glycoproteins mrsaovrsaninezoi.ae
cowiscoran
membranous pseudo
mycobacteria acid fast
histamine Erythromycin chlamydiaCGeimsa
redman
syndrome
Vancomycin Give
antihistaminic
diphenhydramine
Azithromycin Legionella silvercharcoalyeast
clarithromycin
Nonclassified
Bacitracin
Lincosamide
membranouscolitis
topicalysorskincgram clindamycin anerobes pseudo

Streptogramins
Disruptors ofcellmembrane Quinupristin
oRhabdomyolysis check kinase Dalfopristin
Daptomycin creatinine
poses
rinse

I Blood
side
make effects

p Mpo A Chlotramphenic
oolymyxin B
baby
Gray syndrome
d yscrasia

I res Linezolid resistant

Gram osmosis MRSA.vrsa.vre.pro


cellwallsynthesisinhibitors

JTterferwith
Daptomycin
Vancomycin

µt
Bacitracin B

1 4
f
144 Cell wall 11 111 1111 1 cell wall
B
acid
aminobenzoic
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aa
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cell membrane
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JFolicacidTynthhibilors InterferwithDNAstructure
andfunction inhibition RNA
of of
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synthesis synthesis

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itF

Nitrofurantoin
f i
Lincorosamides
clindamycin

it inhibitsmRNAsynthesis 501 fPat hran7


Entire
ieos
Quinolonesinhibit
DNAgyrase RNAsynthesis
inhibits Linezolid
l I i 1
Indirect Direct

protein synthesis
Nucleic acid synthesis inhibitors inhibitor

Bacterialribosomes are 7Os madeof 3058505


B
Human ribosomes are 805 so they are not affected
AfraTafreeh.com exclusive

Inthebeginning Blactamaseresistantpenicillin
Methicillin sensitive staphaureud
staph were sensitive to Methicillin
then we discovered that Methicillin causes interstitial nephritis
so we stoppedusing it and started using
OX clot didox
nqf.to staph I did

Then staph developed resistance Methicillin resistantstaphaureus MRSA


so we started using Vancomycin for MRSA
Then staph developed resistance vancomycin resistantstaph
aureus RSA
0 So we use linezolid daptomycin for VRSA
or telarancin or Ceftaroline
Antibacterials o.o

at ti k
ell wall synthesis inhibitors protein synthesis inhibitors Nudeicaadsynthes
inhibitors
ordisruptorsofcellmembrane
Interferewithcellwallsynthesis 30S inhibitors
Aminoglycosides GNATS IS A
Indirect
B lactams tetracyclines teeth
Direct
acting acting
Penicillins
Cephalosporins
Monobactam
505 inhibitors Transcriptionor Replication Folate
inhibitors inhibitors
Aztreonam Macrolides
Carbapenems
Lincosamide Quinolones flox TMP SM
Glycoproteins vancomycin Clindamycin anerobes DNA
Nitrofurantoincuth
Streptogramins pyrimethuqfaind.ee

Rifamycin Rifampin RNA


Bacitracin
on classified Quinupristin
Dalfopristin
Disruptorsof cellmembrane
Chloramphenicol
Daptomycin Linezolidresistant
lymyxinB MRSA.vrsaivreprsp
cephalosporins cannot coverLAME

1st generation 2nd generation 3rd generation 5thgeneration


Cefazolinicephaletin
4thgeneration
ceftriaxone ceftaroline
Go Influenzae Klebsiella
bacteroides gramtvelf.snns lactamase
resistant
EEdi strept
resistant
penicillin anaerobes
ngitis.p MRSA
Elebsiellapneumonia

Proteus so Aminoglycosides notpseudomon


MRSA
Cannot Listeria
cefazolin surgicalprophylaxis
0 latypicals
O
toprevent Saureus
woundinfections

HSN vitamin def


Adverseeffects
yk
I VII IX X as
y
Antibacterials o.o

at ti k
ell wall synthesis inhibitors protein synthesis inhibitors Nudeicaadsynthes
inhibitors
ordisruptorsofcellmembrane
Interferewithcellwallsynthesis 30S inhibitors
Aminoglycosides GNATS IS A
Indirect
B lactams tetracyclines teeth
Direct
acting acting
Penicillins
Cephalosporins 50 S inhibitors Transcriptionor Replication Folate
Monobactam inhibitors
Aztreonam inhibitors
Macrolides
Carbapenems
Lincosamide Quinolones flox TMP SM
Glycoproteins vancomycin Clindamycin anerobes DNA
Nitrofurantoincuth
Streptogramins pyrimethuqfaind.ee

Rifamycin Rifampin RNA


Bacitracin
on classified Quinupristin
Dalfopristin
Disruptorsof cellmembrane
Chloramphenicol
Daptomycin Linezolidresistant
lymyxinB MRSA.vrsaivre.PRO
Mostpotent Blactamascabapenems Broad spectrum plactamaseresistant
were
pseudomonas
kidney gm cocci
Nephrotic to N
mtoefiaboh.IE anaerobes E
tmipenemdehydwpeplidyase.is is gm rods

t.se ri

C Ef Cilastatin se
N
Enterobacter

Citrobacter
om rod

notfor GI Vg
pseudomonas pseudomonas
D Klebsiella
f
Meropenemodoripenemgertapenem Rash Eroteus
confusion pseudomonas
No need for cilastatinDHP
bctheyarenotdegradedby Il cµgf seizures serratia
Myoclonic
A lowerrisk ofseizure Pseudomembranous colitis
NOTMRSA gm cocci

N enterococci
gmtcocci
Monobactam
Blactamaseresistant
eg Aztreonam

No cross allergenicity withPCN or cephalosporins or anyother B


lactam
GT
Aztreonam covers
No coverageof gm t or anaerobes Klebsiella
Onlyforgrain rods especially if life threatening Iv

Denicillin allergy
y Actreonams E l
Do NOTgive Do give
Eandidiasis
T Otherpenicillins Monobacfams
membranous
Pseudo
Cephalosporins Macrolide Eolitis
Carbapenems Doxycycline i
L oh I

May cause rash phlebitis 94 Lets


Antibacterials o.o

at ti k
ell wall synthesis inhibitors protein synthesis inhibitors Nudeicaadsynthes
inhibitors
ordisruptorsofcellmembrane
Interferewithcellwallsynthesis 30S inhibitors
Aminoglycosides GNATS IS A
Indirect
B lactams tetracyclines teeth
Direct
acting acting
Penicillins
Cephalosporins
Monobactam
505 inhibitors Transcriptionor Replication Folate
inhibitors inhibitors
Aztreonam Macrolides
Carbapenems
Lincosamide Quinolones flox TMP SM
Glycoproteins vancomycin Clindamycin anerobes DNA
Nitrofurantoincuth
Streptogramins pyrimethuqfaind.ee

Rifamycin Rifampin RNA


Bacitracin
on classified Quinupristin
Dalfopristin
Disruptorsof cellmembrane
Chloramphenicol
Daptomycin Linezolidresistant
lymyxinB MRSA.vrsaivre.pro
Glycoproteins cellwall synthesisinhibitor
Vancomycin
Grampositivesonly

Binds D AtaD Ala Muramyl pentapeptide i Inhibittrans


glycosylation
to
preventelongation of
peptidoglycan
IV Enterococci
MRSA URSA Linezolid
oral pseudomembranous colitis

Eliminatedbykidney containsglomeruli

Red man syndrome histamine


Giveantihistaminicdiphenhydramine
Infuse slowly

Ototoxic nephrotoxic same as Aminoglycosides


AfraTafreeh.com exclusive
CoversMRSA p p
I
Aptomycin cellwall synthesisinhibitor
Alternative to Vancomycin
Similar
Daptomycin
Delocanoicacidlipid insertion intobacterial cell membrane Bactericidal
DA fb
Disruptsthe membrane Depolarization of cell membrane inhibitionofDNARNAptnsynt
sees Gram 1 endocarditis sepsis
imination Eliminatedby kidney Destroyedbypulmonary surfactant cannottreatpneumon

adverse
Dermatitis severeskinrash allergic
Effects
f Destroysmuscles
Myopathy
Rhabdomyolysis checkcreatininekinase

Mkt
pop
pin
Itcat12
DarkRedurinehematuria noRBCs
Antibacterials o.o

at ti k
ell wall synthesis inhibitors protein synthesis inhibitors Nudeicaadsynthes
inhibitors
ordisruptorsofcellmembrane
Interferewithcellwallsynthesis 30S inhibitors
Aminoglycosides GNATS IS A
Indirect
B lactams tetracyclines teeth
Direct
acting acting
Penicillins
Cephalosporins
Monobactam
505 inhibitors Transcriptionor Replication Folate
inhibitors inhibitors
Aztreonam Macrolides
Carbapenems
Lincosamide Quinolones flox TMP SM
Glycoproteins vancomycin Clindamycin anerobes DNA
Nitrofurantoincuth
Streptogramins pyrimethuqnfaind.ge

Rifamycin Rifampin RNA


Bacitracin
on classified Quinupristin
Dalfopristin
Disruptorsof cellmembrane
Chloramphenicol
Daptomycin Linezolidresistant
lymyxinB MRSA.vrsaivre.pro
subscribed 942 I latte
HfdBBBOB

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