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Case Study - Hiv
Case Study - Hiv
Case Study - Hiv
AIDS-related fatalities worldwide, which peaked at 2.4 million in 2005 and have
been progressively declining since then, were predicted to be 1.5 million in 2013.
(UNAIDS, 2014a). Despite the fact that Sub-Saharan Africa bears the brunt of HIV/AIDS,
HIV and AIDS have a substantial impact on nations in South and Southeast Asia,
Eastern Europe and Central Asia, and Latin America (CDC, 2014b; UNAIDS, 2014b).
I. PATHOMECHANICS
People who are HIV-positive are more likely to have risk factors for bone loss,
including smoking, drinking alcohol, use of opioids, low testosterone, and a lower intake
of calcium and vitamin D. The virus, which causes HIV/AIDS, itself make your bones
more likely to break. And some anti-HIV medications my raise your chances for bone
less. That can cause your bones to become fragile. If you lose too much bone mass, or
density, you doctor may diagnose you with osteoporosis, A smaller level of bone loss
called osteopenia. And the people with HIV will get osteoporosis or osteopenia, at least
II. PATHOPHYSIOLOGY
Immunodeficiency
Multiple Infections
range of opportunistic infections (OI) and tumors, as well as causing direct harm to
several organs. The incidence of latent and acquired infections, as well as the lifespan of
different areas of the world. As individuals relocate, their OD habits alter. Many of the
chemotherapy, but it also brings a wide range of toxic pathological damage. Longer
longevity allows new HIV-related illnesses to emerge (Lucas, 2002). Many important
cells in the human immune system combat infection and kill aberrant cells, including
lymphocytes known as T-cells, which control the immune system's response to foreign
antigens. HIV infects CD4 'helper' cells, which are a specific kind of T-cell. They're
termed so because they don't eliminate or neutralize foreign antigens themselves, but
HIV quickly seeks out and infects CD4 cells after entering a host's body. The virus
takes over the function of CD4 cells and transforms them into factories that create
multiple copies of the virus on a daily basis; between 10 million and 10 billion new virus
are eventually eliminated; their decreasing quantity in the host promotes immunological
failure and infection vulnerability. The course of HIV infection is sometimes classified
into phases, however it is difficult to exactly demarcate people into discrete, distinct
including genetics and comorbidities. Because HIV is genetically complex and frequently
mutates, viral variables such as viral gene deletions, viral subtype, and coreceptor use
can all influence the rate of HIV progression. As a result, the stages serve as a guide.
The symptoms of HIV vary depending on the stage of infection. Though people living
with HIV tend to be most infectious in the first few months after being infected, many are
unaware of their status until the later stages, the infection progressively weakens the
immune system, they can develop other signs and symptoms, such as swollen lymph
nodes, weight loss, fever, diarrhea, and cough. Without treatment, they could also
• headaches
• sore throat
• excessive fatigue
• chills
• muscle pain
IV. COURSE
The first noticeable stage is primary HIV infection. This stage is also called acute
symptoms, so it's possible for someone in this stage to think they have severe flu or
another viral illness rather than HIV. Fever is the most common symptom.
V. PROGNOSIS
within three years after onset of AIDS. With appropriate treatment, a 20-year-old with
HIV infection can expect to live to reach 71 years of age. This dramatic increase in
life expectancy emphasizes the need for early diagnosis and treatment. Moreover,
with newer treatment regimens and guidelines, there is every reason to think that life
expectancy will continue to increase in patients who are able to receive appropriate
treatment. There are some factors that decrease life expectancy, including use of
illicit drugs and the coexistence of other conditions like chronic hepatitis.
VI. DIAGNOSIS
The most frequent technique to diagnose HIV is through blood testing. These tests
check for antibodies to the virus that the body produces in an effort to combat it. People
antibodies to the virus can take anywhere from six weeks to a year.
ELISA Test The enzyme-linked immunosorbent assay (ELISA) test is used to identify
HIV infection. When an ELISA test results in a positive result, a Western blot test is used
to confirm the diagnosis. If you receive a negative ELISA test but suspect you have HIV,
you should be tested again in one to three months. Because antibodies aren't created
immediately after infection, you may test negative for a few weeks to a few months after
being infected, yet ELISA is highly sensitive in chronic HIV infection. Even if your test
results are negative during this time period, you may still have a high amount of the virus
The only home test that has been approved by the US government is the home test.
The Home Access Express Test, which is available at pharmacies, is approved by the
Food and Drug Administration. Saliva tests are taken using a cotton pad from the inside
of your cheek. The pad is placed in a vial and sent to be tested at a laboratory. In three
days, the results will be released. A blood test should be used to confirm positive
results. The quantity of HIV in your blood is measured by a viral load test. It's often used
to track treatment progress or diagnose HIV infection early on. The reverse transcription-
polymerase chain reaction (RT-PCR), branched DNA (bDNA), and nucleic acid
sequence-based amplification test is three methods for measuring HIV viral load in the
blood (NASBA). These exams are based on the same basic ideas. HIV is identified
utilizing DNA sequences that attach to the virus specifically. It's vital to keep in mind that
A 47-year-old woman presented with a chief complaint of fever of 103 �F, non-
productive cough, and dyspnea which has progressed over one week. She has tested
HIV-positive 5 years ago at which time her CD4 lymphocyte count was 583. Zidovudine
was started, but she stopped taking it after one month and did not return to her doctor for
follow-up. She has anorexia and lost 70 pounds over the last 3 months.
She used heroin and cocaine intravenously for a six-month period 6 years ago. She
does not smoke or drink, has no past STD's and is not sexually active. She has no
PAST HISTORY
She has bees diagnosed having a human Immunodeficiency Virus (HIV) in the
past 5 years ago and has no other past medications has been taken up by the patient
other than the Zidovudine that was started when she was diagnosed until she stopped
She has a history of using drugs such as heroine and cocaine. She does nto drink
alcoholic drinks, does not smoke, and did not even have any sexual intercourse in her
past. Moreover, she did not have any STDs as well. The case study does not explain her
social life
She was pale, diaphoretic, and had severe breathing problems. T 37.4 degrees
Celsius, P 96 beats per minute, R 30 beats per minute, BP 110/70. Oral thrush was
discovered. Poor inspiratory effort and bibasilar crackles were seen 2/3 of the way up
no murmurs in her heart. Her abdomen was not painful, and her liver and spleen were
not enlarged. Except for vaginal candidiasis, the pelvic exam was normal. The
IF ANY AS NEEDED)
WBC: 7,500/mm3
Platelets 248k/mm3
ABG: 7.48(pH)/32(pCO2)/51(pO2)/23(HCO3)
CD4: %=11.#=235/mm3
It has been shown in her laboratory, specifically in her induced septum that she may
CLINICAL PRESENTATION
which is a deadly illness. The majority of persons who have PCP have a medical
condition that weakens their immune system, such as HIV/AIDS, or are taking
and illness. Since the patient has been diagnosed with HIV last 5 years ago, it is not
impossible for her to have the said disease knowing that HIV attacks the immune system
Due to her immune deficiency which she attained last 5 years ago and diagnosed
deadly disease or illness due to the weakening of their immune system caused by
the immunodeficiency they have. The patient, according to her laboratory records
TREATMENT
PCP requires the use of a prescription medication. PCP can be fatal if left
trimoxazole and marketed under the trade names Bactrim, Septra, and Cotrim, is the
most commonly used therapy. This drug is taken orally or intravenously for three
weeks.
Side effects of TMP/SMX include redness and fever. If a patient is unable to take
PREVENTION
strongly suggest that isolating patients with known PCP from patients at high risk for
practice to prevent PCP. Adults and adolescents with HIV, including pregnant
People with a CD4 cell percentage of less than 14 percent should also be considered
for PCP prophylaxis (BII).12,13,41 If ART initiation is delayed and frequent CD4
References
Central, PubMed. 2013. "CASE STUDY OF A PATIENT WITH HIV-AIDS AND VISCERALLEISHMANIASIS CO-
INFECTION IN MULTIPLE EPISODES - PMC." www.ncbi.nlm.nih.gov.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105092/.
Contributor, N. (2020, June 15). HIV 1: epidemiology, pathophysiology and transmission | Nursing Times.
Nursing Times. 2020.
15-06-2020. Contributor, N. (2020, June 15). HIV 1: epidemiology, pathophysiology and transmission |
Nursing Times. Nursing Times; www.nursingtimes.net. .
2020, June 15. "HIV 1: epidemiology, pathophysiology and transmission Nursing Times. Nursing Times."
https://www.nursingtimes.net/clinical-archive/immunology/hiv-1-epidemiology-
pathophysiology-and-transmission-15-06-2020/.