Cefazolin

A Drug Study Presented to

Lendell Kelly B. Ytac, RN
Faculty, INAHS BSN-Program
Davao Oriental State University

_____________________________________________

In Partial Fulfillment
of the requirements for
NCM 118
Care of Clients with Life Threatening Conditions, Acutely Ill / Multi-Organ Problems,
High Acuity and Emergency Situations

By

Clint S. Ancog
Student Nurse, BSN-4

October 12, 2022

 Name of Drug Dosage/ Mechanism of Indication Contraindication Side Effects/ Nursing
Frequency/ Action Adverse Effects Responsibilities
Time/ Route
Generic Name: Usual Dosage Binds to bacterial Cefazolin History of SIDE EFFECTS: BASELINE
Cefazolin Range cell membranes, injection is hypersensitivity/ Frequent: ASSESSMENT
inhibits cell wall used to treat anaphylactic Discomfort with IM Obtain CBC,
Brand Name: IV, IM: synthesis. certain reaction to administration, oral renal function
 Kefzol ADULTS: 1–1.5 Therapeutic infections ceFAZolin, candidiasis (thrush), tests. Question for
 Ancef g q6–12h Effect: caused by cephalosporins. mild diarrhea, mild history of
(usually q8h). Bactericidal. bacteria abdominal allergies,
Drug Maximum: 12 including Cautions: Severe cramping, vaginal particularly
Classification: g/day. Pharmacokinetics: skin, bone, renal impairment, candidiasis. cephalosporins,
 Cefazolin Widely distributed. joint, genital, history of Occasional: Nausea, penicillins.
belongs to the CHILDREN Protein binding: blood, heart penicillin allergy, serum sickness–like
class of OLDER THAN 85%. Primarily valve, history of reaction (fever, jointINTERVENTIO
medicines 1 MO: 25–100 excreted unchanged respiratory seizures. pain; usually occurs N/
known as mg/kg/day in urine. tract after second course EVALUATION
cephalosporin divided q6–8h. Moderately (including of therapy and Evaluate IM site
antibiotics. It Maximum: 6 removed by pneumonia), resolves after drug isfor induration and
works by g/day. hemodialysis. biliary tract, discontinued). tenderness.
killing bacteria and urinary Rare: Allergic Assess oral cavity
or preventing NEONATES: Pharmacodynamic tract reaction (rash, for white patches
their growth. 25 mg/kg/dose s: infections. pruritus, urticaria), on mucous
q8–12h. Cefazolin (also thrombophlebitis membranes,
Chemical make-up known as (pain, redness, tongue (thrush).
and effect: Dosage in Renal cefazoline or swelling at injection Monitor daily
Impairment cephazolin) is a site). pattern of bowel
A semisynthetic Dosing semi-synthetic first- activity, stool
cephalosporin frequency is generation ADVERSE consistency. Mild
analog with broad modified based cephalosporin for EFFECTS: GI effects may be
spectrum antibiotic on creatinine parenteral Antibiotic- tolerable
action due to clearance. administration. associated colitis, (increasing
inhibition of Cefazolin has other superinfections severity may
bacterial cell wall broad-spectrum (abdominal cramps, indicate onset of
synthesis. It attains antibiotic action severe watery antibiotic
high serum levels due to inhibition of diarrhea, fever) may associated
and is excreted bacterial cell wall result from altered colitis). Monitor
quickly via the synthesis. It attains bacterial balance in I&O, renal
urine. high serum levels GI tract. function tests for
and is excreted Nephrotoxicity may nephrotoxicity.
quickly via the occur, esp. in pts Be alert for
urine. with preexisting superinfection:
renal disease. Pts fever, vomiting,
with history of diarrhea, anal/
penicillin allergy are genital pruritus,
at increased risk for oral mucosal
developing severe changes
hypersensitivity (ulceration, pain,
reaction (severe erythema).
pruritus,
angioedema, PATIENT/
bronchospasm, FAMILY
anaphylaxis). TEACHING
Discomfort may
occur with IM
injection.

References:

Carone S., & Bornsrtein M. (n.d). Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral
Administration. DrugBank Online. Retrieved from: https://go.drugbank.com/drugs/DB01327#references-header
Kizior R. J., & Hodgson K. J. (2021). Saunders Nursing Drug Handbook 2021. Elsevier. 3251 Riverport Lane. St. Louis, Missouri
63043.