trifluoperazine

A Drug Study Presented to

Lendell Kelly B. Ytac, RN
Faculty, INAHS BSN-Program
Davao Oriental State University

_____________________________________________

In Partial Fulfillment
of the requirements for
NCM 117
Care of Clients with Maladaptive Patterns of Behavior
(Acute and Chronic)

By

Clint S. Ancog
Student Nurse, BSN-3A

March 18, 2022

 Name of Drug Dosage/ Mechanism of Indication Contraindicatio Side Effects/ Nursing
Frequency/ Action n Adverse Effects Responsibilitie
Time/ Route s
Generic Name: Route: P.O., Trifluoperazine For people Patients with: SIDE EFFECTS: • Explain risks
trifluoperazine I.M. exerts its who has of dystonic
hydrochloride Onset: antipsychotic Anxiety -Coma ● blurred vision reactions,
Unknown effect by blocking States, ● difficulty akathisia, and
Brand Name: Peak: 2-4 hr central dopamine Schizophreni -CNS or bone urinating tardive
Stelazine Duration: 4-6 hr receptors, thereby a and other marrow ● constipation dyskinesia, and
preventing effects psychotic depression ● dizziness tell patient to
Drug ➣Anxiety such as delusions disorders. ● changes in report abnormal
Classification: States and hallucinations -Blood appetite body
antipsychotic, ADULTS: 1 to 2 caused by an dyscrasias ● nausea movements.
antiemetic mg P.O. b.i.d. excess of • Explain that
Increase dosage, dopamine. This -Liver disease. ADVERSE many drug
Chemical make- p.r.n., but don’t EFFECTS:
agent also interactions are
up and effect: exceed 6 mg
functions as a possible. Tell
Trifluoperazine daily. CNS: neuroleptic
calmodulin patient to seek
Hydrochloride is inhibitor, thereby malignant medical
➣
the hydrochloride Schizophrenia leading to syndrome, approval before
salt of and other elevation of extrapyramidal taking other
trifluoperazine, a psychotic cytosolic calcium. reactions, tardive medications.
phenothiazine disorders dyskinesia, • Warn patient
derivative and a ADULTS: For pseudoparkinsonis against
dopamine, alpha- outpatients, 1 to Pharmacokinetics m, dizziness, hazardous
adrenergic, and 2 mg P.O. b.i.d., : drowsiness, activities that
anticholinergic increased p.r.n. Absorption: insomnia, fatigue, require
antagonist with For hospitalized Absorption varies headache. alertness until
antipsychotic, patients, 2 to 5 with route of CV: orthostatic the effect of
anxiolytic, and mg P.O. b.i.d.; administration: hypotension, drug is
antiemetic may increase Oral tablet tachycardia, ECG established.
activities. gradually to 40 absorption is changes. • Tell patient to
Trifluoperazine mg daily. For erratic and EENT: ocular avoid sun
blocks central changes, blurred
dopamine I.M. injection, 1
variable, with vision. exposure and to
receptors, which to 2 mg q 4 to 6onset of action GI: dry mouth, avoid exposure
may prevent or hours, p.r.n. ranging from 1/2 constipation, to temperature
mitigate delusions to 1 hour; oral nausea. extremes
and hallucinations CHILDREN concentrate GU: urine because drug
caused by an AGES 6 TO 12 absorption is much retention, may cause
excess of (HOSPITALIZ more predictable. menstrual thermoregulator
dopamine; ED OR I.M. drug is irregularities. y changes.
dopamine UNDER absorbed rapidly. Hematologic: • Tell patient to
blockade in the CLOSE Distribution: transient take drug
chemoreceptor SUPERVISIO Distributed widely leukopenia, exactly as
trigger zone N): 1 mg P.O. throughout the agranulocytosis. prescribed and
(CTZ) may result daily or b.i.d. body, including Hepatic: cholestatic to avoid alcohol
in an antiemetic May increase breast milk. Drug jaundice. and medications
effect. This agent dosage is 91% to 99% Metabolic: weight that may cause
binds to central gradually to 15 protein-bound; gain. excessive
adrenergic mg daily. Or, steady state serum Skin: sedation.
receptors, which give 1 mg I.M. levels are achieved photosensitivity,
may result in once or twice within 4 to 7 days. allergic reactions,
anxiolytic effects. daily. Metabolism: pain at I.M.
Trifluoperazine Metabolized injection site,
also functions as a extensively by the sterile abscess,
calmodulin liver, but no active rash.
inhibitor, metabolites are Other:
elevating formed. gynecomastia,
cytosolic calcium. Excretion: Mostly inhibited lactation.
excreted in urine
via the kidneys;
some is excreted in
feces by way of the
biliary tract.

Pharmacodynami
cs: Trifluoperazine
is thought to exert
its antipsychotic
effects by
postsynaptic
blockade of CNS
dopamine
receptors,
inhibiting
dopamine-
mediated effects;
antiemetic effects
are attributed to
dopamine receptor
blockade in the
medullary
chemoreceptor
trigger zone.
Trifluoperazine
has many other
central and
peripheral effects;
it produces alpha
and ganglionic
blockade and
counteracts
histamine- and
serotonin-mediated
activity. Its most
common adverse
reactions are
extrapyramidal; it
has less sedative
 and autonomic
activity than
aliphatic and
piperidine
phenothiazines.

References:

Schull, P. (2013). McGraw-Hill Nurse’s Drug Handbook Seventh Edition. McGraw-Hill Companies, Inc.

Skidmore-Roth, L. (2021). Mosby’s 2021 Nursing Drug Reference, 3251 Riverport Lane St. Louis, Missouri 63043

Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for
in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.