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First FRCR Examination – Clinical Pharmacology module

List of Anti-Cancer Drugs

This supporting document sets out a list of drugs expected to be covered during core clinical
oncology training and which may be included in the clinical pharmacology module of the
First FRCR examination. It is anticipated that this will be reviewed regularly to ensure current
practice is reflected.

List A contains drugs from all the major classes. Trainees are expected to demonstrate their
knowledge of these drugs in terms of their indications, and all aspects of these drugs as
defined in Appendix 2 of the specialty training curriculum - “Underpinning Scientific
Principles” (Appendix 2, sections 2.1-2.5 and 2.7).

List B drugs will not be examined in the First FRCR Examination but may feature in the Final
FRCR Examination as defined in Appendix 1 of the curriculum.

This version will apply to examinations held from Autumn 2016 until a further version is
published.

LIST A
Cytotoxic agents

Alkylating agents
• Cyclophosphamide
• Ifosfamide
• Temozolomide
Anti- Metabolites
• Capecitabine
• 5- Fluoro Uracil
• Methotrexate
• Gemcitabine
• Pemetrexed

Anti-Tumour Antibiotics
• Mitomycin
• Bleomycin
• Epirubicin
• Doxorubicin (pegylated liposomal)

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Plant Alkaloids/ Microtubule Inhibitors
• Etoposide
• Paclitaxel
• Irinotecan
• Docetaxel
• Vincristine

DNA Linking Agents


• Carboplatin
• Cisplatin
• Oxaliplatin

Biological agents
• Bevacizumab
• Cetuximab
• Gefitinib
• Imatinib
• Trastuzumab
• Denosumab
• Rituximab
• Sunitinib

Bisphosphonates
• Zoledronate

Hormones/other
• Abiraterone
• Anastrozole
• Bicalutamide
• Exemestane
• Goserelin
• Medroxyprogesterone
• Octreotide
• Tamoxifen

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LIST B
Cytotoxic agents

Alkylating agents
• Bendamustine
• Carmustine
• Chlorambucil
• Lomustine
• Melphalan
• Procarbazine
• Streptozocin
Anti- Metabolites
• Fludarabine
• Raltitrexed
Anti-Tumour Antibiotics
• Actinomycin D / Dactinomycin
• Doxorubicin
• Mitoxantrone

Plant Alkaloids/ Microtubule Inhibitors


• Eribulin
• Topotecan
• Vinblastine
• Vinorelbine

Biological agents
• Afatinib
• Aflibercept
• BCG
• Crizotinib
• Dabrafenib
• Interferon
• Ipilimumab
• Lapatinib
• Nivolumab
• Panitumumab

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• Pembrolizumab
• Pertuzumab
• Sorafenib
• Trastuzumab emtansine
• Temsirolimus
• Vemurafenib

Bisphosphonates
• Ibandronic acid
• Pamidronate

Hormones/other
• Bexarotene
• Buserelin
• Cyproterone
• Degarelix
• Folinic acid
• Fulvestrant
• Lanreotide
• Lenalidomide
• Letrozole
• Leuprorelin
• Megestrol
• Mesna
• Thalidomide

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