Erytromycin

Presented By
Dr. Nayana Borah
 • Oto toxicity:-Ototoxicity is the property of being toxic to the ear (oto-), specifically
the cochlea or auditory nerve and sometimes the vestibular system.
• Tinnitus is when you experience ringing or other noises in one or both of your
ears. The noise you hear when you have tinnitus isn't caused by an external
sound, and other people usually can't hear it. Tinnitus is a common problem. It
affects about 15% to 20% of people, and is especially common in older adults.
• Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and
mucous membranes. It's usually a reaction to medication that starts with flu-like
symptoms, followed by a painful rash that spreads and blisters. Then the top layer
of affected skin dies, sheds and begins to heal after several days.
• QT interval prolongation is an irregularity of the electrical activity of the heart
that places patients at risk for ventricular arrhythmias. Serious complications of
drug-induced QT interval prolongation are rare; the identification of patients at
risk may help to prevent these events.
• Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some
substances, both toxic chemicals and medications, on kidney function. There
are various forms, and some drugs may affect kidney function in more than one
way. Nephrotoxins are substances displaying nephrotoxicity.
• The third type, cholestatic, or obstructive, jaundice, occurs when essentially
normal liver cells are unable to transport bilirubin either through the hepatic-
bile capillary membrane, because of damage in that area, or through the biliary
tract, because of anatomical obstructions such as gallstones or cancer.