Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING

INTERVENTION
1.Brand Name: Pharmacologic -Combines with -presence of CNS: Headache, -These drugs 1. Monitor pulse
(Questran) class: bile acid in GI allergy to any bile anxiety, fatigue, decrease or delay and blood
Generic: Bile acid tract to form acid sequestrant and drowsiness the absorption of pressure for
Cholestyramine sequestrant insoluble complex to prevent thiazide diuretics, changes related
excreted in feces. hypersensitivity GI: nausea, digoxin, warfarin to CAD risk
Therapeutic reactions. vomiting, factors.
DOSAGE: class: Lipid- constipation -Any of these
Adults: 4 g P.O. lowering agent drugs should be 2. Give the drug
once or twice taken 1 hour before meals to
daily. Pregnancy risk before or 4 to 6 ensure that the
category C hours after the drug is in the GI
bile acid tract with food.
sequestrant.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
 INTERVENTION
2.Brand Name: Pharmacologic -Inhibits hepatic 1. Presence of CNS: headache, - The risk of 1. Administer the
(Zocor ) Class: enzyme HMG- allergy to any of dizziness, blurred rhabdomyolysis drug at bedtime
Generic: Hmg-Coa CoA reductase, the statins or to vision, insomnia, increases if any of between midnight
Simvastatin reductase interrupting fungal byproducts fatigue these drugs is and 5 AM
inhibitors cholesterol or compounds to combined with
synthesis avoid GI:nausea, erythromycin, 2. Monitor serum

hypersensitivity vomiting, and cyclosporine, cholesterol and

Therapeutic constipation LDL levels
reactions. gemfibrozil,
class:
niacin, or
Antihyperlipidemic 2.Patients with antifungal drugs;
active liver such
Pregnancy risk disease or a combinations
category X history of should be
alcoholic liver avoided.
disease leading to
severe liver failure

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
 INTERVENTION
3..Brand Name: Pharmacologic -Drug that 1. Should not be -Adverse effect of 1.Increased 1.Evaluate the
(Heparin) Class: interfere with the used with any the anticoagulants bleeding can patient regularly
Generic: Anticoagulants normal conditions that is bleeding, occur if heparin is for any sign of
Heparin coagulation could be combined with blood loss
Therapeutic process by compromised by oral (petechiae,
class:
Antithrombin interfering with the increased anticoagulants, bleeding gums,
clotting cascade bleeding salicylates, bruises, dark-
and thrombin tendencies penicillins, or colored stools,
Pregnancy risk formation. cephalosporins. dark-colored
category B
2. Caution should urine).
be used in 2.Decreased
patients with heart anticoagulation 2.Provide
failure can occur if increased
heparin is precautions
combined with against bleeding
nitroglycerin. during invasive
procedures

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
 INTERVENTION
4.Brand Name: Pharmacologic -break down the 1.Should not be -Adverse effect 1.The risk of 1. Arrange to
(Streptase) class: thrombus that has used with any associated with hemorrhage administer
Generic: Group C been formed by condition that the use of increases if tenecteplase or
Streptokinase betahemolytic stimulating the could be thrombolytic thrombolytic streptokinase to
streptococcal plasmin system. worsened by the agents is agents are used reduce mortality
nonenzymatic dissolution of bleeding with any associated with
protein clots, including anticoagulant or acute MI as soon
Therapeutic recent surgery, antiplatelet drug. as possible
class: active internal
Thrombolytic bleeding, 2. Discontinue
heparin if it is

Pregnancy risk being given

category C before
administration of a
thrombolytic agent

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
5.Brand Name: Pharmacologic -Decrease the 1. Presence of -adverse effect 1.The risk of 1.Suggest safety
class:
(Pletal) formation of the any known seen with these excessive measures
Quinolone
Generic: derivative platelet plug by bleeding disorder drugs is bleeding bleeding
cilostazol Therapeutic decreasing the because of the increases if any of 2.Monitor platelet
class: responsiveness of risk of excessive these drugs is count if the patient
Antiplatelet agent
the platelets to blood loss like combined with
stimuli recent surgery another drug that 3.Provide
Pregnancy risk affects blood increased
category C precautions
clotting
against bleeding
during invasive
procedures

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
6.Brand Name: Pharmacologic -Decrease the - Presence of -adverse effect 1.The risk of 1.Suggest safety
(Plavix) class: formation of the any known seen with these excessive measures
Generic: Platelet platelet plug by bleeding disorder drugs is bleeding bleeding
clopidogrel aggregation decreasing the because of the increases if any of 2.Monitor platelet
inhibitor responsiveness of risk of excessive these drugs is count if the patient
Therapeutic the platelets to blood loss like combined with
class: stimuli recent surgery another drug that 3.Provide
Antiplatelet agent affects blood increased
clotting precautions
against bleeding
Pregnancy risk during invasive
category B
procedures

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
7.Brand Name: Pharmacologic -Decrease the 2. Presence of -adverse effect 1.The risk of 1.Suggest safety
(Coumadin) class: formation of the any known seen with these excessive measures
Generic: Coumarin platelet plug by bleeding disorder drugs is bleeding bleeding
warfarin derivative decreasing the because of the increases if any of 2.Monitor platelet
Therapeutic responsiveness of risk of excessive these drugs is count if the patient
class: the platelets to blood loss like combined with
Anticoagulant stimuli recent surgery another drug that 3.Provide
affects blood increased
clotting precautions
Pregnancy risk against bleeding
category B during invasive
procedures

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
 INTERVENTION
8.Brand Name: Pharmacologic -Decrease the - Presence of adverse effect .The risk of 1.Suggest safety
(Persantine) class: Platelet formation of the any known seen with these excessive measures
Generic: adhesion platelet plug by bleeding disorder drugs is bleeding bleeding
Dipyridamole inhibitor decreasing the because of the increases if any of 2.Monitor platelet
Therapeutic responsiveness of risk of excessive these drugs is count if the patient
class: Antiplatelet the platelets to blood loss like combined with
agent, stimuli recent surgery another drug that 3.Provide
affects blood increased
Pregnancy risk clotting precautions
category B against bleeding
during invasive
procedures

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
9.Brand Name: Pharmacologic -Buscopan exert - Patients who CNS: drowsiness, - Increase the risk 1.Administered
(Buscopan) class: spasmolytic action have dizziness, of side effects if with food or milk
Generic: Antimuscarinic on the smooth demonstrated confusion you take them at to minimize
Hyoscine muscle of the hypersensitivity to the same time as gastric irritation.
Therapeutic gastrointestinal, hyoscine or any GI: constipation, Buscopan,
class: biliary and genito- other components dry mouth including Codiene
Antipasmodic urinary tracts. of the products.
agents

Pregnancy risk
category C

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
10.Brand Name: Pharmacologic -These drugs are -These drugs are CNS: drowsiness, -There is a risk of 1Caution patient
to avoid driving
(Antivert) class: anticholinergics contraindicated dizziness, increased
and
Generic: Anticholinergic that act as with known allergy confusion sedation if these other hazardous
activities until he
Meclizine antihistamines to any component drugs are
knows how drug
Therapeutic and block the of the drug to GI: constipation, combined with affects
class: dry mouth concentration
transmission of prevent any other CNS
and alertness.
Antipasmodic impulses to the hypersensitivity depressants,
agents CTZ reactions including alcohol. 2. Advise patient
to relieve dry
mouth
Pregnancy risk with hard candy or
category B frequent sips of
fluids.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
11.Brand Name: Pharmacologic -Proton pump -Presence of CNS: dizziness -There is a risk of 1Administer drug
 class: inhibitors known allergy to and headache increased serum before meals to
(Nexium) Proton pump suppress the either the drug or levels and ensure that the
inhibitor
Generic: secretion of the drug GI: nausea, increased toxicity patient does not
esomeprazole Therapeutic hydrochloric acid components to vomiting, dry these are open, chew, or
class: into the lumen of prevent mouth combined with crush capsules
Antiulcer agent
the stomach hypersensitivity these drugs.
reactions. 2.Provide
appropriate safety
Pregnancy risk
category C and comfort
measures if CNS
effects occur to
prevent patient
injury.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
12.Brand Name: Pharmacologic -Blocks action of -The H2 CNS: dizziness -famotidine can 1Administer oral
histamine at antagonists slow the drug with or
(Pepcid) class: histamine2- should not be and headache metabolism of the before meals and
Generic: Histamine2- receptor sites in used with known following drugs, at bedtime.
famotidine receptor gastric parietal allergy to any GI: Diarrhea, leading to
antagonist cells, drugs of this class Constipation increased serum 2.Arrange for
to prevent levels and decreased dose in
Therapeutic hypersensitivity possible toxic cases of hepatic
class:
Antiulcer agent reactions reactions like or renal
warfarin dysfunction to

anticoagulants. prevent serious

Pregnancy risk toxicity.
category B

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
13. Brand Name: Pharmacologic -Inhibits -Hypersensitivity CNS: dizziness -Contraindicated 1. Monitor signs
(Penicillin G class: biosynthesis of cell- to penicillins and headache to drugs like of allergic
Benzathine) aspirin,
Generic: Penicillin wall sulfonamides, reaction.
Benzylpenicilin Therapeutic mucopeptide; kills GI: Nausea furosemide for it 2. Monitor every
class: Vomiting,
penicillinsusceptibl increases the hour for the
Antibiotics
e bacteria during Diarrhea half-life of effectiveness of
active penicillin. the drug.
Pregnancy risk multiplication stage
category B

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
14. Brand Name: Pharmacologic -It competitively -The only CNS: dizziness -Do not use 1. Aviod sexual
(Zovirax) class: inhibits viral DNA absolute and headache medications intercourse while
Generic: Acyclic purine polymerase by contraindication of containing visible lesions are
acyclovir nucleoside acting as an acyclovir is GI: Nausea valacyclovir while present while
analogue analog, stopping hypersensitivity Vomiting, using acyclovir. taking acyclovir.
the spread of the Diarrhea
Therapeutic herpes virus in the 2.Assess skin and
class:
body. mucosal lesions
Antiviral
to help determine
if drug therapy is
Pregnancy risk
category B successful.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
15.Brand Name: Pharmacologic -It competitively -The only CNS: dizziness -Do not use 2. Aviod sexual
(Mycostatin) class: inhibits viral DNA absolute and headache medications intercourse while
Anti-infective polymerase by contraindication of containing visible lesions are
Generic: acting as an acyclovir is valacyclovir while present while
nystatin Therapeutic analog, stopping hypersensitivity GI: Nausea using acyclovir. taking acyclovir.
class: the spread of the Vomiting,
Antifungal herpes virus in the Diarrhea 2.Assess skin and

body. mucosal lesions

Pregnancy risk to help determine
category A if drug therapy is
successful.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
15.Brand Name: Pharmacologic -acts by binding to -Paraben GI: Nausea -Topical 1.Advise patient
(Mycostatin) class: sterols in the hypersensitivity. Vomiting, corticosteroids: to continue taking
Generic: Anti-infective plasma Some Diarrhea increased for
nystatin memebranes of formulations of corticosteroid at least 48 hours
 Therapeutic funngi causing the nystatin, such as absorption after symptoms
class: cells to leak, oral suspension -No serious, resolve.
Antifungal eventually leading contain moderate or mild
to fungal cell methylparaben. inetractions with 2.If patient misses
Pregnancy risk death. -because nystatin other drugs. a dose, tell her to
category A suspension take dose as soon

contains as possible and

significant amout then

of sucrose, it resume her

should be used regular dosing

cautiously with schedule.

DM patients.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
16.Brand Name: Pharmacologic -The precise -Paraben CNS: dizziness -Opioids, alcohol, 1.Tell patient to
(Aralen) class: action is hypersensitivity. and headache antihistamines take drug with
Generic: 4-aminoquinolone unknown. Some and general food at
chloroquine derivative Chloroquine, may formulations of GI: Nausea anesthetics evenly spaced
exert its effect nystatin, such as Vomiting, should not be
phosphate Therapeutic against oral suspension Diarrhea taken together intervals.
class: plasmodium contain because of risk of
Antimalarial, species by methylparaben. RR: Slow slow down 2.As appropriate,
concentrating in -because nystatin breathing breathing review all other
Pregnancy risk the acid vesicles suspension significant and
category A of the parasite contains life-threatening

and by inhibiting significant amout adverse

polymerization of of sucrose, it reactions and

heme. should be used interactions,

cautiously with especially

DM patients. those related to

the drugs.

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
17.Brand Name: Pharmacologic -Piperacillin --Hypersensitivity CNS: dizziness -Hormonal 1.Tell patient to
(Zosyn) class: inhibits bacterial to penicillins and headache contraceptives: monitor urinary
Generic: Penicillin cellwall synthesis, decreased output and report
piperacillin resulting in cell GI: Nausea significant
sodium Therapeutic Vomiting, -Methotrexate:
Piptaz class: death. Diarrhea increased risk of changes.
Anti-infective methotrexate
toxicity 2.As appropriate,
Pregnancy risk review all other
category B significant and
life-threatening
adverse
reactions and
interactions,
especially
those related to
the drugs

Drug Name Classification MOA/INDICATIONS CONTRAINDICATION ADVERSE EFFECT D-D INTERACTIONS NURSING
INTERVENTION
18.Brand Name: Pharmacologic -Stops bacterial -Hypersensitivity CNS: dizziness -Antacids 1.Tell patient he
(Zithromax ) class: protein synthesis to drug, and headache containing may take tablets
Generic: Macrolide by inhibiting the erythromycin aluminum or with
azithromycin transpeptidation/ GI: Nausea magnesium: or without food.
Therapeutic Translocation step Vomiting,
class: of protein Diarrhea decreased peak 2.Advise patient
Anti-infective synthesis and by azithromycin to take
inhibiting the blood level suspension 1
Pregnancy risk assembly of the hour before or 2
category B 50S ribosomal hours after meals.
subunit.