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    Selina Sun
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    1) The active site of an enzyme may not initially be complementary to its substrate. 2) When the substrate binds to the enzyme, the active site undergoes a conformational change to mold around the substrate and become complementary. 3) This stronger binding between the active site and substrate due to the conformational change makes the catalyst more efficient.

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    induced fit hypothesis

    Original Title

    Chapter 3 notes (1)

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    1) The active site of an enzyme may not initially be complementary to its substrate. 2) When the substrate binds to the enzyme, the active site undergoes a conformational change to mold around the substrate and become complementary. 3) This stronger binding between the active site and substrate due to the conformational change makes the catalyst more efficient.

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    9 views2 pages

    Chapter 3 Notes

    Uploaded by

    Selina Sun
    1) The active site of an enzyme may not initially be complementary to its substrate. 2) When the substrate binds to the enzyme, the active site undergoes a conformational change to mold around the substrate and become complementary. 3) This stronger binding between the active site and substrate due to the conformational change makes the catalyst more efficient.

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    © All Rights Reserved
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    of 2

    INDUCED FIT HYPOTHESIS

    active site of enzymesmaynot becomplementary totheactive site inthebeginning


    oncesubstratecontactenzyme activesite moldaroundsubstrate to become complementary
    strongerbinding betweenactive siteandsubstrate undergo conformational change
    makecatalystmoreefficient
    flexibility shape activesitewill
    of notchange

    when
    change
    conformational
    tosubstrate
    binding after
    becomescomplementaryonly binds
    substrate

    bind
    stronger

    of
    Efficiency

    COURSE OF CATALYSED REACTION


    rateslowsdown stop concofstarch substrate
    NOT
    cesschance for Rategthfaction
    substrate Esc
    GRADIENT

    lesssubstrate
    available

    cototsubstInterese Ytitemkalfose

    Haz Hot Oz starch 8 maltose


    iodine
    intensity ofcolour
    colorimeter

    TEMPERATURE AFFECT
    initialrate sub concare sameinallexp at timeO
    otherfactor keptthesame
    anydiff inratecaused bytemp
    catalase
    211202 21420 t 02
    biologicalreaction
    in cell

    Frandientoffatngeffgitty.gg

    slopeoftangenttothecurveattime0

    attimeo drawatangent

    COLORIMETER
    nearing absorption I transmission
    Lightso a absorption Mtransmission
    dark soI A absorbtion N transmission

    El Atilio
    2 1.6 1.0 0.5

    É
    to A standard calibrationcurve

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