Benha University Benha Faculty of Medicine

Medical Biochemistry Department

Courses codes (SURG601-UROL601-ORTH602)
Exam for M.SC&Diploma (Surgery)
Medical Biochemistry Date: 27/4/2014
Important Instructions For All Students: Please Read Carefully
Allocated time minutes including MCQ 60
Total allocated marks )marks 25(
Number of papers )papers, including MCQ 3(
Number of questions )questions including MCQ 6(
How to answer choose the correct answer for MCQ& write the
answers for the questions below
Attention All questions are to be answered

GENERAL AND SPECIAL SURGERY

case: (4 marks)-1
A 46-year-old male presents to the emergency department with severe
right toe pain and renal colic .The patient was in usual state of health until
early in the morning when he woke up with severe pain in his right big toe.
The patient denies any trauma to the toe and no previous history of such pain
in other joints. On examination, he was found to have a temperature of 38.2°C
(100.8°F) and in moderate distress secondary to the pain in his right toe and
also the renal colic. The right big toe was swollen, warm, red, and exquisitely
tender. The remainder of the examination was normal. His doctor refereed
him for laboratory investigations.
A-What is the likely diagnosis? How would you make a definite
diagnosis? (one mark)

B- Explain the different causes of this disorder? (3 marks)

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 2- Define ketosis-mention its causes –how to diagnose –and management
for ketoacidosis? (4marks)

3-Define mutation? List causes & types of mutation?

Explain in details two of them. (4marks)

4-Define apoptosis. Mention the functions, principal mediators and

diseases caused by excessive &insufficient apoptosis (4 marks)

: General Surgery
5- Define tumor markers &list some clinically important tumor markers.
(4 marks)
: Urology
.Discus the laboratory investigations used in diagnosis of cancer prostate -5
(4 marks)
:Orthopedic

5-Glycosaminoglycans (GAGs) have unique properties; explain these

properties. Describe the functions and role of hyaluronic acid in diseases
(4 marks)

6-MCQ. (5 marks)

Oral exam will be held on Tuesday 27/5/2014 at 10 AM in medical biochemistry

department.

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 Msc 1st part general &special surgery MCQ
Choose the correct answer : (5 marks each 0.5 mark)-6
The risk factors for type 2 diabetes include all -1 8- In carcinoid syndrome the argentaffin
:of the following except tissue of the abdominal cavity overproduce:
(A) Advanced age. (B) Obesity (A) Serotonin (B) Histamine
(C ) Smoking. (D) Physical inactivity (C) Tryptamine (D) Tyrosine

2- Acholuric jaundice is caused by: 9- Proto-oncogene could be activated to

(A) Obstructive jaundice oncogenes by EXCEPT:
(B) Hemolytic jaundice (A) Viral promoter.
(C) Infective jaundice     (B) Chromosomal translocation.
(D) All of the above (C) Gene amplification.
(D) Point mutation.
3-Splicing is associated with:
(A) mRNA            (B) Sn RNA 10- In humans, NH3(ammonia) is detoxified
(C) r RNA            (D) t RNA in liver as:
(A) Creatinine (B) Uric acid
4-All are true statements about p53 except: (C) Glutamine. (D) Uronic acid
(A) Protein coded by a tumour suppressor gene
(B) It suppresses mitosis
(C)It is important regulators of apoptosis
(D)Its presence in the serum indicate colonic cancer

5- Dietary cholesterol is transported to

extrahepatic tissue by :
(A) Chylomicrons           (B) VLDL
(C) LDL.                         (D) HDL.

6-Polymerase chain Reaction is :

(A) Enzymatic amplification of gene Medical biochemistry department
(B) Genetic engineering mediated gene
amplification Good luck
(C) Duplication of gene
(D) Cleavage of gene

7-All are true with regards to

glycohemoglobin,except:
(A)Seen as high levels in sickle cell anemia.
(B)Otherwise known as HbA1 c.
(C)Useful index of long term control of blood
glucose level.
(D)About 4-6% of hemoglobin in normal cases.

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 Model answers
Msc 1st part general &special surgery MCQ
Choose the correct answer : (5 marks each 0.5 mark)-6
The risk factors for type 2 diabetes include all -1 8- In carcinoid syndrome the argentaffin
of the following except: C tissue of the abdominal cavity overproduce:A
(A) Advanced age. (B) Obesity (A) Serotonin (B) Histamine
(C ) Smoking. (D) Physical inactivity (C) Tryptamine (D) Tyrosine

2- Acholuric jaundice is caused by: B 9- Proto-oncogene could be activated to

(A) Obstructive jaundice oncogenes by EXCEPT: C
(B) Hemolytic jaundice (A) Viral promoter.
(C) Infective jaundice     (B) Chromosomal translocation.
(D) All of the above (C) Gene amplification.
(D) Point mutation.
3-Splicing is associated with: B
(A) mRNA           (B) Sn RNA 10- In humans, NH3(ammonia) is detoxified
(C) r RNA            (D) t RNA in liver as: C
(A) Creatinine (B) Uric acid
4-All are true statements about p53 except: D (C) Glutamine. (D) Uronic acid
(A) Protein coded by a tumour suppressor gene
(B) It suppresses mitosis
(C)It is important regulators of apoptosis
(D)Its presence in the serum indicate colonic cancer

5- Dietary cholesterol is transported to

extrahepatic tissue by : C
(A) Chylomicrons           (B) VLDL
(C) LDL.                         (D) HDL.

6-Polymerase chain Reaction is : A

(A) Enzymatic amplification of gene Medical biochemistry department
(B) Genetic engineering mediated gene
amplification Good luck
(C) Duplication of gene
(D) Cleavage of gene

7-All are true with regards to

glycohemoglobin,except:A
(A)Seen as high levels in sickle cell anemia.
(B)Otherwise known as HbA1 c.
(C)Useful index of long term control of blood
glucose level.
(D)About 4-6% of hemoglobin in normal cases.

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58.  Familial hypercholesterolemia is A

(A) Deficient LDL receptors

(B) Deficient HDL receptors

(C) HMG CoA reductase deficiency

(D) Deficient VLDL receptors

59.  Dietary cholesterol is transported to extrahepatic tissue by C

(A) Chylomicrons           (B) VLDL

(C) LDL                         (D) HDL

71. Polymerase chain Reaction is A

(A) Enzymatic amplification of gene

(B) Genetic engineering mediated gene amplification

(C) Duplication of gene

(D) Cleavage of gene

75. Which of the following amino acids is associated with increased risk of Myocardial Infarction. B

(A) Methionine               (B) Homocysteine

(C) Ornithine                  (D) Valine

76. Which is a denaturing agent       A 

(A) Guanidine                (B) Glutamate

(C) Glycine                    (D) Guanosine

79. In Hartnup’s disease the following is excreted in the urine:        C 

(A) Ornithine                  (B) Glycine

(C) Tryptophan              (D) Cystine

80. Protein synthesis occurs in; A

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A. Rough endoplasmic reticulum

B. Smooth endoplasmic reticulum

C. Mitochondria

D. Golgi apparatus

90. Which of the following RNA contains thymidine A

(A) tRNA                       (B) Ribosomal RNA

(C) mRNA                     (D) Eukaryotic RNA

91. A promoter site on DNA: B

A. Codes for RNA polymerase

B. Initiates transcription

C. Regulates termination

D. Transcribes repressor

92. Acholuric jaundice is caused by B

(A) Obstructive jaundice (B) Hemolytic jaundice

(C) Infective jaundice     (D) All of the above

93. All are true of the genetic code except: C

(A) Degenerate              (B) Universal

(C) Punctuation             (D) Non overlapping