Lingüística de Corpus en Español The Routledge Handbook of Spanish Corpus Linguistics 1st Edition Giovanni Parodi Editor Pascual Cantos Gómez Editor Chad Howe Editor Full Chapter Download PDF
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Introduction Quality Control Specifications View Monograph
SPONGIA TOSTA 8114 SPNG Guidelines Starting Material: Guidelines for A. Macroscopic identification: To comply with monograph Description. Manufacturing B. General identification tests: Homeopathic Medicines Criteria for identification; starting material must meet all of the following Homeopathic Good identification tests: Manufacturing Practices Tests 1 and 2 Test 1: Homeopathic Drug Triturate 0.1 g of starting material with 3 ml of water. Filter. The filtrate Stability Guidelines complies with the identity test for chlorides as per European Pharmacopoeia 2.3.1. - Identification Reactions of Ions and Groups Expanded Labeling [Chlorides, Method (a)]. Guidelines Test 2: Table of Alcohol Strength, Extract 1 g of starting material with 10 ml of 70% alcohol. Filter. To 1 ml of Manufacturing Class and the filtrate, add 5 ml of water, 0.1 ml of sodium nitrite solution, and 0.5 ml of sulfuric acid. Shake with 5 ml of chloroform. In the chloroform phase, a Dispensing Potencies pink color is produced. Bibliography C. Assay: The starting material contains not less than 0.40% of iodine (I; a.w. 126.90). Standards & Controls Place 1.000 g of the starting material in a nickel crucible. Dissolve the residue in a few milliliters of water, and add 3 g of sodium hydroxide. Stir until it Published Monographs dissolves by slightly heating. Evaporate. Ignite, first carefully, then heat more intensely until completely incinerated, without attaining a red-hot Drug Data Tables temperature. The procedure requires about half an hour. Cool and dissolve the residue in boiling water. Filter through a sintered glass filter, and rinse Official Short Names the crucible and the filter with hot water so as to obtain a volume of about 75 ml. Add 0.5 ml of methyl orange solution. Neutralize by first adding 25% List of Synonyms sulfuric acid. Add dilute sulfuric acid until the solution starts turning pink, and add 3 more drops of dilute sulfuric acid. Add 15 ml of freshly prepared Search HPUS Monographs bromine water. Remove the bromine with a stream of steam. Continue this process for about 7 minutes after boiling begins. Allow to cool. Add 1 g of Archives potassium iodide to the perfectly clear solution. Allow to stand for about 1 minute. Add a few milliliters of starch solution, and titrate the released iodine with 0.1 N sodium thiosulfate solution. 1 ml of 0.1 N sodium thiosulfate solution is equivalent to 2.115 mg of iodine yielded by the starting material. Tincture (all quality control data is applicable to macerate tinctures only): 1. CHARACTERISTICS A. Color: amber-yellow B. Odor: burnt wood C. Taste: unpleasant 2. IDENTIFICATION Criteria for identification; tincture must meet all of the following tests: Tests 1, 2, 3, 4, and 5 (Procedures A and B) Test 1: When examined under ultraviolet light at 365 nm, the tincture shows a green-blue fluorescence. Test 2: To 2 ml of tincture, add a few drops of silver nitrate solution. A precipitate is produced, which is soluble in dilute ammonia solution and insoluble in dilute nitric acid. Test 3: To 1 ml of tincture, add 1 ml of ammoniacal silver nitrate solution. Bring to a boil. A brown color is produced. Test 4: To 1 ml of tincture, add 5 ml of water, 0.1 ml of sodium nitrite solution, and 0.5 ml of sulfuric acid. Extract with 10 ml of chloroform. In the chloroform phase, a pink color is produced. Test 5 (CHROMATOGRAPHY): Procedure A: Test Solution: tincture Reference Solution: none Plate: silica gel of suitable grade Application: 30 µl test solution in 10 mm band Mobile phase: acetone + isopropyl alcohol + strong ammonia solution (20+20+10) Development: 10 cm Drying: in air Detection 1: Examine under ultraviolet light at 365 nm. Result 1 Test Solution: · generally, a series of blue-tinted bands over the entire length Detection 2: Spray with ammoniacal silver nitrate solution, then heat at 100-105 °C for 20 minutes. Examine in daylight. Result 2 Test Solution: · a gray band haloed with a purple hue at about Rf 0.40 Procedure B: Test Solution: tincture Reference Solution: none Plate: silica gel of suitable grade Application: 30 µl test solution in 10 mm band Mobile phase: acetone + isopropyl alcohol + strong ammonia solution (20+20+10) Development: 10 cm Drying: in air Detection: Place in a tank saturated with hydrochloric acid fumes for 10 minutes, then spray with starch solution. Examine in daylight. Result Test Solution: · a purplish band at about Rf 0.85 3. ALCOHOL CONTENT: 65% v/v (±15%) as per S & C Section - Alcohol Determination. 4. DRY RESIDUE: not less than 0.3% w/w as per S & C Section - Dry Residue Determination. 5. ASSAY: The tincture contains not less than 0.015% w/w of iodine (I; a.w. 126.90). Place 20.0 g of the tincture in a nickel crucible, and evaporate on a water bath to dryness. Dissolve the residue in a few milliliters of water, and add 3 g of sodium hydroxide. Then follow the method described under Assay for the starting material.
Lingüística de Corpus en Español The Routledge Handbook of Spanish Corpus Linguistics 1st Edition Giovanni Parodi Editor Pascual Cantos Gómez Editor Chad Howe Editor Full Chapter Download PDF