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Presentation 1
Presentation 1
Thesearethefundamentalunitsofthebrainandnervoussystem.Thereare3typesmainlythereceptor,interneu
ronandeffector/
motor.Thecellsresponsibleforreceivingsensoryinputfromtheexternalworldforsendingmotordemandstoou
rmusclesandfortransformingandrelayingelectricalsignals.Itconsistsofdendrites,cellbody/somaandaxon.
Cellbody
Itistheneuronscore.Itcarriesgeneticmaterialitmaintainstheneuronsstructureandprovidesenergytodriveac
tivities.Ithasanucleusandspecializedorganellesthatareenclosedbythemembranethatprotectsitandallowsi
ttointeractwithitsimmediatesurrounding.
Itisresponsibleforthetransformationofglucosetohighenergyinthemitochondriaandproteinsynthesisbyribo
somes.Hasorganellesthatcarrynumerousfunctions.nucleusnucleolusendoplasmicreticulumGolgiapparatu
s
Dendrites
Theseareacontinuationofthecellbodythatbranchesdifferentlydependingonthefunctionperformedbythece
ll.Thethintreebranchinggreatlyincreasestheopportunityforsynapticconnectionsbetweentheextensionsoft
hecellbodyanddendrites.Theyhavedendriticspinesthatformthepostsynapticelementofsynapsesinthebrain
thedendriticspinesreachouttocontacttheaxons.
Axon
Itarisesfromthecellbodyandextendstotheregionofsynapticcontactastheyhaveexcitablemembranewhichis
capableofgenerating/propagatinganactionpotential.
Axonhillock–
itformsthebasisofthetransportationsystemforaxonsinaidingmovementofsubstancesfromcellbodytoendfe
et
Endfeet–
asaxonapproachessynaptictargetsitbranchesintoanumberofsmallerprocesses,eachterminatinginanendfo
ot.Endfeetcontainmitochondriaandsynapticvesselsthatcontainneurotransmittersubstancesreleasedintot
hesynapticcleftwhichisthespacebetweenthepresynapticandpostsynapticmembraneofreceivingcells.
Cellmembrane
Itseparatestheneuronsfromothercellsfromtheextracellularliquid.Itismadeupofphospholipids.Allmessages
receivedbyaneuronthatentersandpassesthroughthismembrane.Ithasintegralproteinsthatlinktheinteriora
ndexterior,andareinvolvedinthetransportandatsynapses.
Gilacellsoccupycellsbetweenneurons.Therearemacroandmicrogilia.Themacrogiliacanbefurtherdividedint
oastrocytesandoligodendrocytes.Theastrocytesregulatetheflowofionsinsynapsesandprovidingstructurals
upportofneuron.Theoligodendrocytesproducemyelin(insulatedcoating).
Theshwancellencirclestheaxon,wrapsitselfinmyelinandformsmyelinsheath.Myelinationincreasesspeedof
actionpotential.
Synapses
Itisthesiteoftransmissionfrompresynaptictopostsynapticneuron
1. Axodentic–itisanexcitatorysynapseformedbytheconnectionbetweenanaxonandadendrite.
2. Axosomatic–itisaninhibitorysynapsethatisdirectlyconnectedtoonecellbodytoanother.
3. Axoxonicterminalofoneaxontoanotherforregulation.
4. Electricalsynapse–signalspassdirectlyfromonenervetoanotherthroughgapjunctions.
Development
Neuronsinitiallydevelopfromtheembryonicneuraltubethathas3layer.
1. Ventricularzone
Surroundsthecentralcarnaloftubetoformependyma.
2. Intermediatezone
Formedbythedivisionoftheventricularzonetoformapiallayerstretchingfromtheouterpartofthevent
ricularzonetoneuraltube.
Willformgraymatter
3. Marginalzone
Extensionofnervecellsfromintermediatezone
Willmakewhitematterwhenmyelinated
Neuronsmustdifferentiate.Thelargerneuronsformthemotorsandthesmallerneuronaresensoryreceptorsfo
rmedfrombirth.
Gialcellsaidthedifferentiationofneuronsandfacilitategrowthinthedirectionoftargetlocation.Theyalsopartic
ipateinthereuptakeofexcessneurotransmitterinsynapticcleft.
Reference
Caire,Michael,Varacallo&Matthew(2018)Physiology,Synapse
https://www.researchgate.net/publication/329718026_Physiology_Synapse