Adenoviridae

Characteristics
Double stranded DNA virus
Replicates in Nucleus
Non-enveloped
Icosahedral symmetry
Infectious canine hepatitis (Rubarth’s disease or Blue eye)
Etiology- caused by Canine adenovirus-1 (CAV-1)
Transmission- enters via ingestion
Pathogenesis- Following ingestion, virus initially replicates in
intestinal epithelium particularly peyer’s patches. As viremia
develops virus disseminates throughout the body. Virus also replicates
in the parenchymal cells of liver and kidney.
Clinical signs- Fever
Anorexia
Depression
Polydipsia
Vomiting
Diarrhoea
Abdominal pain
Jaundice
Corneal opacity (Blue eye)
Glomerulonephritis
PM examination- Hepatomegaly, haemorrhages in liver and kidney
Diagnosis-
On the basis of clinical signs (history of fever, abdominal pain,
vomiting)
On the basis of PM examination
Blood examination reveals marked reduction in neutrophils and
lymphocytes.
Presence of Intranuclear inclusion bodies in kupffer cells
ELISA
PCR
Egg Drop syndrome (EDS-76)
Etiology- caused by Fowl adenovirus
Transmission- enters through ingestion, vertical transmission.
Virus mainly replicates in the pouch shell glands
Clinical signs- Fever
Anorexia
Drop in egg production
Production of shell-less eggs
Soft- shelled eggs
PM examination- haemorrhages in the ovaries and oviduct
Diagnosis-
Production of pale, thin-shelled and shell-less eggs
Decreased egg production
PM examination
Virus cultivation-Duck kidney cell lines
Haemagglutination Inhibition test
Inclusion body hepatitis
Etiology- caused by Fowl adenovirus
Transmission- Horizontal and vertical transmission
Clinical signs- Fever
Anorexia
Anaemia
Ruffled feathers
Yellow mucoid droppings
PM examination- swollen liver
Haemorrhages and necrosis of liver
Hydropericardium Syndrome (Angara diasease or Leechi disease)
Etiology- caused by Fowl adenovirus
Transmission- Horizontal and vertical transmission
Clinical signs- Fever
Anorexia
Anaemia
10 ml of straw coloured transudate in the pericardial sac
PM examination-
Hydropericardium
Enlarged liver
Yellow discolouration of liver
Diagnosis-
On the basis of clinical signs
On the basis of PM lesions
Serological tests