ОПИОИДНИ АНАЛГЕТИЦИ

I. Агонисти на опиоидните рецептори

Morphine (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol)
Dolcontin, Morphina

HO

O CH3
N

HO

Codeine (5α,6α)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol)
Codyl

H3CO

O CH3
N

HO

Diacetylmorphine (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate)

Heroin

H3C O

O
O CH3
O N

H3C O

Ethylmorphine (7,8-Didehydro-4,5α-epoxy-3-ethoxy-17-methylmorphinan-6-α-ol)
Codethyline, Dionine

C2H5O

O CH3
N

HO

Pholcodine (7,8-Didehydro-4,5α-epoxy-17-methyl-3-[2-(morpholin-4-yl)ethoxy]morphinan-
6α-ol)
Ethnine, Galenphol
 O
N
O
O CH3
N

HO

Hydromorphone (4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one)
Palladone, Dilaudid

HO

O CH3
N

Hydrocodone (4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one)
Dicodid

H3CO

O CH3
N

Levorphanol ( (-)-17-Methylmorphinan-3-ol)
Levo-Dromoran

HO

CH3
N

Pethidine (1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester)

Meperidine, Dolantin, Demerol, Lydol

COOC2H5

N
CH3
Hydroxypethidine (4-(3-Hydroxyphenyl)-1-Methylpiperidine-4-carboxylic acid ethyl ester)
Bemidone

HO
COOC2H5

N
CH3

Promedol (1,2,5-Trimethyl-4-phenyl-4-propionyloxypiperidine)
Trimeperidine

OCOC2H5
CH3

H3C N
CH3

Fentanyl (N-(1-(2-Phenylethyl)-4-piperidinyl)-N-phenylpropanamide)
Fentanest, Leprofen

COC2H5
N

Sufentanil (N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide)
Sufenta

H3CO N COC2H5

Methadone ( (R,S)-6-Dimethylamino-4,4-diphenyl-3-heptanone)
Symoron, Dolophine, Amidone, Methadose, Heptadon

COC2H5

CH2CHN(CH3)2
CH3
Dextromoramide (3S)-3-Methyl-4-morpholin-4-yl-2,2-diphenyl-1-pyrrolidin-1-yl-butan-1-one)
Palfium, Palphium, Dimorlin

O
N

CHCH2 N O
CH3

Tilidine (Ethyl (1R,2S; 1S, 2R)-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate)

Tilidin, Valoron, Valtran

COOC2H5
N(CH3)2

Tramadol (2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol)
Ultram

H3CO
OH

N(CH3)2

II. Агонист-антагонисти на опиоидните рецептори

Nalorphine (5α,6α)-17-Allyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol)
Nalline

HO

O CH2CH=CH2
N

HO

Nalbuphine (–)-17-Cyclobutylmethyl-4,5α-epoxymorphinan-3,6α,14-triol)
Nubaine

HO

O OH
N

HO
Buprenorphine (5α,7α(S)]-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-
dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol)
Buprenex, Temgesic, Norspan, Butrans

HO

O
N

H3CO
HO CH3
H3C CH3
CH3

Pentazocine (2α,6α,11R*)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-
methano-3-benzazocin-8-ol)
Fortral, Pentagin, Sosegon

HO
CH2CH=C(CH3)2
N
CH3
HO
H3C N
H3C CH2CH=C(CH3)2
CH3

Phenazocine (2R,6R,11R)-6,11-Dimethyl-3-(2-phenylethyl)-1,2,3,4,5,6-hexahydro-2,6-
methano-3-benzazocin-8-ol)
Prinadol, Narphen

HO
CH2CH2
N
CH3
HO
H3C N
H3C CH2CH2
CH3

Metazocine (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]-
azocin-8-ol)

HO
CH3
N
CH3
HO
H3C N
H3C CH3
CH3
II. Антагонисти на опиоидните рецептори

Naloxone (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one)
Nalone, Narcan

HO

O OH CH2CH=CH2
N