PKSolver 2.

0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit mg/L Analyst ACER
Dose 80 Date 2022-12-28
Dose Unit mg Time 19:41:15

Time Conc ln(C) AUC AUMC R R_adj

0.25 3.4 1.22377543 0.425 0.10625
0.5 13 2.56494936 2.475 1.025
0.75 50 3.91202301 10.35 6.525
1 200 5.29831737 41.6 36.2125 -0.79913958 0.59345208
1.5 110 4.70048037 119.1 127.4625 -0.80456747 0.59694722
2 60 4.09434456 161.6 198.7125 -0.81858234 0.61508988
2.5 29.5 3.38439026 183.975 247.15 -0.85338805 0.6739254
3 15 2.7080502 195.1 276.8375 -0.90252956 0.76819951
4 10.5 2.35137526 207.85 320.3375 -0.91591065 0.78518975
6 6.2 1.82454929 224.55 399.5375 -0.99917434 0.99752405
10 5.2 1.64865863 247.35 577.9375 -0.99929224 0.99716995
14 4.4 1.48160454 266.55 805.1375
18 3.8 1.33500107 282.95 1065.1375

250

200
Concentration (mg/L)

150

100

50

0
0 2 4 6 8 10 12 14 16 18 20
Time (h)

1000

100
Concentration (mg/L)

10
 100

Concentration (mg/L)

10

1
0 2 4 6 8 10 12 14 16 18 20
Time (h)

1000

100
Concentration (mg/L)

10

1
0 2 4 6 8 10 12 14 16 18 20
Time (h)
vascular Input

Parameter Unit Value

Lambda_z 1/h 0.040892469
t1/2 h 16.950484949
Tmax h 1
Cmax mg/L 200
Tlag h 0
Clast_obs/Cmax 0.019
AUC 0-t mg/L*h 282.95
AUC 0-inf_obs mg/L*h 375.87664619
AUC 0-t/0-inf_obs 0.7527735571
AUMC 0-inf_obs mg/L*h^2 5010.280703
MRT 0-inf_obs h 13.329587655
Vz/F_obs (mg)/(mg/L) 5.204767218
Cl/F_obs (mg)/(mg/L)/h 0.2128357822
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit mg/L Analyst ACER
Dose 80 Date 2022-12-28
Dose Unit mg Time 19:43:30

Time Conc ln(Conc) Conc_pre Residual Weight Parameter

0.25 3.4 1.22377543 44.9819834 -41.5819834 1 A
0.5 13 2.56494936 71.0901559 -58.0901559 1 ka
0.75 50 3.91202301 84.26479 -34.26479 1 k10
1 200 5.29831737 88.7840276 111.215972 1
1.5 110 4.70048037 83.1648231 26.8351769 1 Parameter
2 60 4.09434456 69.2484655 -9.24846554 1 t1/2ka
2.5 29.5 3.38439026 54.0592602 -24.5592602 1 t1/2k10
3 15 2.7080502 40.5153366 -25.5153366 1 V/F
4 10.5 2.35137526 21.0740939 -10.5740939 1 CL/F
6 6.2 1.82454929 4.81326143 1.38673857 1 Tmax
10 5.2 1.64865863 0.18636132 5.01363868 1 Cmax
14 4.4 1.48160454 0.0060772 4.3939228 1 AUC 0-t
18 3.8 1.33500107 0.00018248 3.79981752 1 AUC 0-inf
AUMC
MRT
250
Observed
Diagnostics
Predicted r obs-pre
200 SS
WSS
R^2
Concentration (mg/L)

150 WR^2
SE
AIC
SC
100

50

0
0 2 4 6 8 Time10
(h) 12 14 16 18 20

1000

Observed
Predicted

100
Concentration (mg/L)

10
 100

Concentration (mg/L)

10

1
0 2 4 6 8 10 12 14 16 18 20
Time (h)

Residual Plot
150

100
Residual (mg/L)

50

0
0 2 4 6 8 10 12 14 16 18 20

-50

-100
Time (h)
 Unit Value Time Conc_Pre
mg/L 5078.5696318 0 0
1/h 0.9643219042 0.18181818 34.8839412
1/h 0.9194865238 0.36363636 58.7873539
0.54545455 74.3029313
Unit Value 0.72727273 83.4791204
h 0.7187923219 0.90909091 87.9272444
h 0.7538415872 1.09090909 88.9083805
(mg)/(mg/L) 0.3388049516 1.27272727 87.4037133
(mg)/(mg/L)/h 0.3115265872 1.45454545 84.1714155
h 1.0618796146 1.63636364 79.7925524
mg/L 88.941009944 1.81818182 74.7080596
mg/L*h 256.79970554 2 69.2484655
mg/L*h 256.79991143 2.18181818 63.6577277
mg/L*h^2 545.58724039 2.36363636 58.1122993
h 2.1245616377 2.54545455 52.7363377
2.72727273 47.6137972
Value 2.90909091 42.7980097
0.6974096184 3.09090909 38.3192452
20879.062653 3.27272727 34.1906507
20879.062653 3.45454545 30.4128907
0.6501810553 3.63636364 26.9777507
0.6501810553 3.81818182 23.8709157
45.69361296 4 21.0740939
135.30452794 4.18181818 18.5666227
136.99937601 4.36363636 16.3266681
4.54545455 14.3321049
4.72727273 12.5611489
4.90909091 10.9927975
5.09090909 9.60712277
5.27272727 8.38545344
5.45454545 7.31047257
5.63636364 6.36625356
5.81818182 5.53825125
6 4.81326143
6.18181818 4.17935883
6.36363636 3.62582145
6.54545455 3.14304713
6.72727273 2.72246643
6.90909091 2.35645536
7.09090909 2.03824992
7.27272727 1.76186414
7.45454545 1.52201268
7.63636364 1.31403849
7.81818182 1.13384587
8 0.97783912
8.18181818 0.84286651
8.36363636 0.72616959
8.54545455 0.62533741
8.72727273 0.53826546
8.90909091 0.46311885
9.09090909 0.3982996
9.27272727 0.34241747
9.45454545 0.29426414
9.63636364 0.25279036
9.81818182 0.21708581
10 0.18636132
10.1818182 0.1599333
10.3636364 0.13721004
10.5454545 0.11767971
10.7272727 0.10089985
10.9090909 0.08648824
11.0909091 0.07411487
11.2727273 0.06349496
11.4545455 0.05438292
11.6363636 0.04656705
11.8181818 0.03986496
12 0.03411956
12.1818182 0.02919566
12.3636364 0.02497691
12.5454545 0.02136326
12.7272727 0.01826869
12.9090909 0.01561928
13.0909091 0.01335153
13.2727273 0.01141089
13.4545455 0.00975054
13.6363636 0.00833031
13.8181818 0.00711572
14 0.0060772
14.1818182 0.0051894
14.3636364 0.0044306
14.5454545 0.00378216
14.7272727 0.00322813
14.9090909 0.00275486
15.0909091 0.00235064
15.2727273 0.00200545
15.4545455 0.00171071
15.6363636 0.0014591
15.8181818 0.00124433
16 0.00106105
16.1818182 0.00090464
16.3636364 0.0007712
16.5454545 0.00065737
16.7272727 0.00056027
16.9090909 0.00047746
17.0909091 0.00040685
17.2727273 0.00034664
17.4545455 0.00029531
17.6363636 0.00025155
17.8181818 0.00021426
18 0.00018248
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit mg/L Analyst ACER
Dose 80 Date 2022-12-28
Dose Unit mg Time 19:45:16

Time Conc ln(Conc) Conc_pre Residual Weight Parameter

0.25 3.4 1.22377543 44.9710446 -41.5710446 1 A
0.5 13 2.56494936 71.0778806 -58.0778806 1 Alpha
0.75 50 3.91202301 84.255954 -34.255954 1 B
1 200 5.29831737 88.7804992 111.219501 1 Beta
1.5 110 4.70048037 83.1716761 26.8283239 1 ka
2 60 4.09434456 69.2618831 -9.26188306 1
2.5 29.5 3.38439026 54.0751713 -24.5751713 1 Parameter
3 15 2.7080502 40.5308988 -25.5308988 1 k10
4 10.5 2.35137526 21.085291 -10.585291 1 k12
6 6.2 1.82454929 4.81661416 1.38338584 1 k21
10 5.2 1.64865863 0.18645734 5.01354266 1 t1/2Alpha
14 4.4 1.48160454 0.00607561 4.39392439 1 t1/2Beta
18 3.8 1.33500107 0.0001826 3.7998174 1 t1/2ka
V/F
CL/F
V2/F
250
CL2/F
Tmax
Observed
Cmax
200 Predicted
AUC 0-t
AUC 0-inf
AUMC
Concentration (mg/L)

150 MRT

Diagnostics
r obs-pre
100
SS
WSS
R^2
50 WR^2
SE
AIC
0 SC
0 2 4 6 8 10 12 14 16 18 20
Time (h)

1000

Observed
Predicted

100
Concentration (mg/L)

10
 100

Concentration (mg/L)

10

1
0 2 4 6 8 10 12 14 16 18 20
Time (h)

Residual Plot
150

100
Residual (mg/L)

50

0
0 2 4 6 8 10 12 14 16 18 20

-50

-100
Time (h)
 Unit Value Time Conc_Pre
mg/L 5894.0229267 0 0
1/h 0.9222958745 0.18181818 34.8747709
mg/L 1E-06 0.36363636 58.7749616
1/h 0.0425710529 0.54545455 74.2910322
1/h 0.9609159411 0.72727273 83.4698615
0.90909091 87.9216954
Unit Value 1.09090909 88.9068929
1/h 0.9222957976 1.27272727 87.4061799
1/h 7.334326E-08 1.45454545 84.1774543
1/h 0.0425710565 1.63636364 79.8016362
h 0.7515453552 1.81818182 74.719603
h 16.282124432 2 69.2618831
h 0.7213400786 2.18181818 63.6724694
(mg)/(mg/L) 0.3377151496 2.36363636 58.1278716
(mg)/(mg/L)/h 0.3114732632 2.54545455 52.7523134
(mg)/(mg/L) 5.818303E-07 2.72727273 47.629818
(mg)/(mg/L)/h 2.476913E-08 2.90909091 42.8137845
h 1.062164345 3.09090909 38.334545
mg/L 88.938874982 3.27272727 34.2053025
mg/L*h 256.84365906 3.45454545 30.4267702
mg/L*h 256.84387536 3.63636364 26.990775
mg/L*h^2 545.77434931 3.81818182 23.8830365
h 2.1249264696 4 21.085291
4.18181818 18.5768985
Value 4.36363636 16.3360423
0.6974278228 4.54545455 14.3406104
20878.589918 4.72727273 12.5688278
20878.589918 4.90909091 10.9996983
0.6501889757 5.09090909 9.61329802
0.6501889757 5.27272727 8.39095745
51.086434009 5.45454545 7.31535999
139.30423359 5.63636364 6.3705782
142.12898038 5.81818182 5.54206513
6 4.81661416
6.18181818 4.18229716
6.36363636 3.62838905
6.54545455 3.14528438
6.72727273 2.72441044
6.90909091 2.35813999
7.09090909 2.03970589
7.27272727 1.76311919
7.45454545 1.52309171
7.63636364 1.31496377
7.81818182 1.13463724
8 0.97851416
8.18181818 0.84344079
8.36363636 0.7266568
8.54545455 0.6257496
8.72727273 0.53861316
8.90909091 0.46341126
9.09090909 0.39854474
9.27272727 0.34262229
9.45454545 0.29443465
9.63636364 0.25293178
9.81818182 0.2172026
10 0.18645734
10.1818182 0.16001186
10.3636364 0.13727396
10.5454545 0.11773139
10.7272727 0.10094134
10.9090909 0.08652128
11.0909091 0.07414092
11.2727273 0.06351526
11.4545455 0.05439853
11.6363636 0.04657883
11.8181818 0.03987364
12 0.03412576
12.1818182 0.02919987
12.3636364 0.02497956
12.5454545 0.0213647
12.7272727 0.0182692
12.9090909 0.01561908
13.0909091 0.01335081
13.2727273 0.0114098
13.4545455 0.00974921
13.6363636 0.00832882
13.8181818 0.00711415
14 0.00607561
14.1818182 0.00518783
14.3636364 0.00442908
14.5454545 0.00378072
14.7272727 0.00322679
14.9090909 0.00275362
15.0909091 0.00234951
15.2727273 0.00200443
15.4545455 0.00170981
15.6363636 0.0014583
15.8181818 0.00124364
16 0.00106045
16.1818182 0.00090415
16.3636364 0.00077079
16.5454545 0.00065704
16.7272727 0.00056002
16.9090909 0.00047728
17.0909091 0.00040673
17.2727273 0.00034658
17.4545455 0.0002953
17.6363636 0.00025159
17.8181818 0.00021434
18 0.0001826
waktu (jam) kadar obat dalam darah (mg/L)
0.25 3.4
0.5 13
0.75 50
1 200
1.5 110
2 60
2.5 29.5
3 15
4 10.5
6 6.2
10 5.2
14 4.4
18 3.8