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Diabetis Mellitus
Diabetis Mellitus
INTRODUCTION: Diabetes mellitus is a common disease in man. A predisposition to the disease is probably inherited as an autosomal recessive trait. About 25% of relatives of diabetics show abnormal glucose tolerance curves as compared to 1% in the general population. Definition: A chronic disease due primarily to a disorder of carbohydrate metabolism, cause of which is deficiency or diminished effectiveness of insulin, resulting in hyperglycemia and glycosuria. Secondary changes may occur in the metabolism of protein, fats, water and electrolytes and in tissues/ organs sometimes with grave consequences.
Secondary: Constitute minor group. Where it can be secondary to some disease process.
Primary (Idiopathic) Two clinical types: Juvenile- onset diabetes: Now called as Type-I(Insulin dependent)- IDDM. Maturity onset diabetes: Type-II NIDDM- (Non Insulin Dependent).
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Dehydration. Keto acidosis produces increasing drowsiness, leading to diabetic coma in untreated cases.
decrease in acetyl COA form carbohydrates, ATP, NADPH and glycerol-(p) in all tissues. Stored lipids are hydrolyzed by increased Lipolysis liberating free fatty acids (FFA). Increased FFA interferes at several steps of carbohydrates phosphorylation in muscles, further contributing to hyperglycemia.
5. Effect on Glycogen synthesis : Glycogen synthesis is depressed as a result of : Decreased glycogen synthesis activity due to deficiency of Insulin. By activation of phosphorylase production glycogenolysis through the action of epinephrine and or glucagons (antagonistic) hormones. By increased ADP: ATP Ratio.