Group: Group 01

Name: Miramonte, Kristine D. Activity: 1st Group Work

Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

ZERO-ORDER REACTION

1. Find the zero-order rate constant (mg/ml/min) if the initial concentration of the drugs is
500mg/mL and after 45 minutes is 69 mg/ml.
Given: Co = 500mg/ml
Ct = 69mg/ml
t = 45 mins
ko = x
!"#!
Formula: 𝑘𝑜 = $
%&&'(/'*#+,'(/'*
Solution: 𝑘𝑜 = -% '/01
-23'(/'*
𝑘𝑜 = -% '/01
Answer: 9.59mg/ml/min

2. If the final concentration of a drug is 600mg/ml at 60 minutes and has a zero-order rate
constant of 10 mg/mL/min. What would be the initial concentration?
Given: C = 600mg/ml
t = 60 mins
ko = 10mg/ml/min
Co = x
Formula: Co = C + Ko(t)
Solution: Co = 600mg/ml + 10mg/ml/min (60mins)
Co = 600mg/ml + `600mg/ml
Answer: 1,200mg/mL

3. Calculate the zero-order rate constant if the initial concentration of a drug is 2.2x10^-3 mg/ml
and later on becomes 4.5x10^-3 mg/ml at 4 hours. Express your answer in mg/ml/min.
Given: Co = 2.2𝑥10#2 𝑚𝑔/𝑚𝑙
C = 4.5𝑋10#2 𝑚𝑔/𝑚𝑙
t = 240 mins
ko = x
!"#!
Formula: 𝑘𝑜 = $
4.463&!" '(/'* # -.%63&!" '(/'*
Solution: 𝑘𝑜 = 4-& '/01
4.263&!" '(/'*
𝑘𝑜 = 4-& '/01
Answer: 0.00000958333mg/ml/mins
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

4. When does the concentration of the drug A (400mg/ml) decay at a rate constant of 1.25
mg/ml/hr. after 7 days?

Given: Co = 400mg/ml
ko = 1.25mg/ml/hr.
t = 168 hrs.
Formula: C = Co – ko (t)
Solution: C = 350 mg/ml – 1.25mg/ml/hrs. (168hrs)
C = 350 mg/ml – 210 mg/ml
Answer: 140mg/mL

5. Find the time when a drug X (500mg/ml) decomposes at a rate constant of 0.25 mg/ml/min
with initial concentration of 0.88mg/ml?

Given: C = 500mg/ml
Co = 0.88mg/ml
ko = 0/25mg/ml/min
t=x
!"#!
Formula: t = 7"
&.88'(/'*#%&&'(/'*
Solution: t = #$
&.4% /'/0
#%
-,,.34'(/'*
t= #$
&.4% /'/0
#%
Answer: 1996.48 mins
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

FIRST-ORDER REACTION

1. The initial concentration of Penicillin is said to be 84mg/mL. What would be the rate constant
if the amount of product remaining after 200 hours was 19mg/mL?
Given: lnCo = 84mg/mL
lnC = 19mg/mL
T = 200 hours
Formula: 𝑙𝑛𝐶 = 𝑙𝑛𝐶𝑜 − 𝑘𝑡
Derive: 𝑙𝑛𝐶 + 𝑘𝑡 = 𝑙𝑛𝐶𝑜
𝑘𝑡 = 𝑙𝑛𝐶𝑜 − 𝑙𝑛𝐶
7$ *0!"#*0!
$
= $
*0!"#*0!
𝑘= $
*0!"#*0!
Solution: 𝑘 = $
*084#*019
𝑘= 200
4.431#2.944
𝑘= 200
Answer: 0.007431ℎ𝑟 #1

2. A Zidovudine solution is said to have an initial potency of about 95mg/mL. When the solution
was stored in a refrigerator for 1.5 years, its potency declined by 50mg/mL. It is found out that
the main reason for the degradation of the product is due to its interaction with its container.
Find the rate constant of the product.
Given: lnC = Initial Concentration (a) - Declined Concentration (x)
lnCo = 95mg/mL
Concentration declined by = 50mg/mL
lnC = 95mg/mL - 50mg/mL = 45mg/mL
T = 1.5 years
Formula: 𝑙𝑛𝐶 = 𝑙𝑛𝐶𝑜 − 𝑘𝑡
Derive: 𝑙𝑛𝐶 + 𝑘𝑡 = 𝑙𝑛𝐶𝑜
𝑘𝑡 = 𝑙𝑛𝐶𝑜 − 𝑙𝑛𝐶
7$ *0!"#*0!
$
= $
*0!"#*0!
𝑘= $
*095#*045
Solution: 𝑘 = 1.5
4.554#3.807
𝑘= 1.5
Answer (k): 0.498𝑦𝑟 #1
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

3. The stability of Salbutamol was studied at pH 3.5 in aqueous solution. The starting
concentration of Salbutamol is 22 mg/mL. After 65 days, the concentration of Salbutamol in
the solution is 14.3 mg/mL. Calculate the rate constant and its half-life at pH 3.5.
Given: lnCo = 22mg.mL
lnC = 14.3mg/mL
T = 65 days
1 0.693
Formula (k): 𝑙𝑛𝐶 = 𝑙𝑛𝐶𝑜 − 𝑘𝑡 Formula: (𝑡 2) = 7
0.693
Derive: 𝑙𝑛𝐶 + 𝑘𝑡 = 𝑙𝑛𝐶𝑜 Solution: 𝑘 = 0.006631
𝑘𝑡 = 𝑙𝑛𝐶𝑜 − 𝑙𝑛𝐶 Answer: 104.5 days
7$ *0!"#*0!
$
= $
*0!"#*0!
𝑘= $
*0!"#*0!
Solution: 𝑘 = $
*022#*014.3
𝑘= 65
3.091#2.660
𝑘= 65
Answer (k): 0.006631𝑑𝑎𝑦𝑠 #1

4. A Digoxin oral solution containing 0.25mg/mL is said to have a half-life of 10 days in a plasma.
Find the concentration of the solution in 8 days.
Given: Co = 0.25mg/mL
1
𝑡 2 = 10 𝑑𝑎𝑦𝑠
T = 8 days
1 0.693
Formula: (𝑡 2) = 7
Formula: 𝐶 = 𝐶𝑜𝑒 9$
1 0.693 0.25
Derive: (𝑡 2) = 9
𝐶 = : 0.0693×8
1 0.25
(𝑟)(𝑡 2) = 0.693 𝐶 = 1.74
1
(9)($ ) 0.693
1
2
= 1 Answer: 0.144mg/mL
($ ) ($ )
2 2
0.693
𝑟= 1
$
2
0.693
Solution: 𝑘 = 10 =>?1
𝑘 = 0.0693 𝑑𝑎𝑦𝑠
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

5. A certain first order reaction is said to have a half-life of only 25 minutes. With this in mind,
we must find (a) The rate constant of the reaction; (b) How much time is required for this
reaction to be 85% complete.
1
(a) Given: 𝑡 2 = 40 𝑚𝑖𝑛𝑢𝑡𝑒𝑠
1 0.693
Formula: (𝑡 2) = 7
1 0.693
Derive: (𝑡 2) = 7
1
(𝑘)(𝑡 ) = 0.693
2
1
Solution: (𝑘)(𝑡 2) = 0.693
(k)(25min) = 0.693
0.693
𝑘= 25
Answer: 0.02772 𝑚𝑖𝑛#1

[A"]
(b) Formula: 𝑙𝑛( [A$] ) = 0.02772 𝑚𝑖𝑛#1 (𝑡)
Given: At time = 0
[Ao] = 100% → 1
Completion = 85%; Hence, 15% of A remains
[At] = 15% = 0.15
[A"]
Solution: 𝑙𝑛( [A$] ) = 0.02772 𝑚𝑖𝑛#1 (𝑡)
1
𝑙𝑛(0.15) = 0.02772 𝑚𝑖𝑛#1 (𝑡)
𝑙𝑛6.67 = 0.02772 𝑚𝑖𝑛#1 (𝑡)
*06.67
𝑡 = 0.02772'/0!1
Answer: 68.46 → 68 mins
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

SECOND-ORDER REACTION

1. Diethylacetate and KOH were at a concentration of 0.05M. KOH concentration was observed
to change by 0.0867 mol/L over a period of 60 mins. Determine the second rate constant.

Given: a = 0.05M
t = 60 mins.
x = 0.0867 mol/L
1 6
Formula: 𝑘 = >$ × >#6
1 0.0867'"*/D
Solution: 𝑘 = (0.05C)(60 '/01.) × 0.05C#0.0867'"*/D
1 0.0867'*/D
𝑘 = 3C/'/01. × 0.0367'"*/D
𝑘 = 0.333𝑀/𝑚𝑖𝑛𝑠.× 2.36𝑀
Answer: 0.79M/mins.

2. The decomposition of gaseous acetaldehyde having a rate constant of 0.12M/mins was at a

concentration of 0.5M. Determine its half-life.
Given: k = 0.12M/mins.
Aₒ = 0.5M
1 1
Formula: 𝑡 2 = 𝐴ₒ 𝑘
1 1
Solution: 𝑡 2 = (0.5C)(0.12C/'/01.)
1 1
𝑡 2 = 0.06 𝑀/𝑚𝑖𝑛𝑠.
Answer: t = 16.67 mins.

3. At 25ᐤC, hydrogen iodide breaks down very slowly to hydrogen and iodide. The rate constant
at 25ᐤC in 2.4 × 10#33 L/mol.s. If 0.0100 mol of HI(g) is placed in a 1.0L container, how long
will it take for the concentration of HI to reach 0.00900M?
Given: k = 2.4 × 10#11 L/mol.s
[HI]ₒ = 0.0100M
[HI] = 0.00900M
1 1
Formula: [%&] = 𝑘𝑡 + [%&]ₒ
1 1
Solution: 0.00900) = 2.4 × 10*11 𝐿/𝑚𝑜𝑙. 𝑠(𝑡) + 0.0100)
111.11 = 2.4 × 10*11 𝐿/𝑚𝑜𝑙. 𝑠(𝑡) + 100
111.11 − 100 = 2.4 × 10*11 𝐿/𝑚𝑜𝑙. 𝑠(𝑡)
111.11*100 2.4×10!11 ,/./0.1(3)
!11 =
2.4×10 ,/./0.1 2.4×10!11 ,/./0.1
11
Answer: t = 4.63 × 10 𝑠𝑒𝑐𝑠.
Group: Group 01
Name: Miramonte, Kristine D. Activity: 1st Group Work
Sabiniano, Decsyrae C.
Tomines, Cresencia Fidela D.
Department/Course: BS Pharmacy 3A Subject: PHR 121
Academic Year: 2022-2023 Teacher-in-Charge: Ms. R. Resuello
Date Submitted: November 23, 2022, Wednesday

4. If the concentration of reactant changes from 0.5M to 0.10M in 20 minutes. Calculate the rate
constant and time at which concentration of reactant becomes 0.02M.

Given: Aₒ = 0.10M
Aₜ = 0.5M
t = 20 mins.
1 1
Formula: 𝑘𝑡 = [5]ₜ − [5]ₒ
1 1
Solution: 𝑘(20 𝑚𝑖𝑛𝑠. ) = 0.5) − 0.10)
𝑘(20 𝑚𝑖𝑛𝑠. ) = 20𝑀 − 10𝑀
6 (78 .9:1.) 20)*10)
78 .9:1.
= 20 .9:1.
k = 0.5M/mins.

1 1
0.5𝑀/𝑚𝑖𝑛𝑠. (𝑡) = 0.5) − 0.2)
0.5𝑀/𝑚𝑖𝑛𝑠. (𝑡) = 20𝑀 − 5𝑀
0.5)/.9:1.(3) 20)*5)
0.5)/.9:1.
= 0.5)/.9:1.
t = 30 mins.
Answer: k = 0.5M/mins. t = 30 mins.

5. The decomposition of pure ozone into oxygen occurs according to the following reaction:
203(() → 302(()
This decomposition is a second order process with a rate constant of 0.835𝑀#1 𝑠 #1 . If
1.25 × 10#2 𝑀 of 𝑂3 is initially decomposed, what would be the half-life for this process?

Given: k = 0.835𝑀#1 𝑠 #1
Aₒ = 1.25 × 10#2 𝑀
1 1
Formula: 𝑡 2 = 𝐴ₒ 𝑘
1 1
Solution: 𝑡 2 =
(1.25×10!2 C)(0.835C !1 1 !1 )
1 1
𝑡 2 = 0.0104375C!1 1!1
Answer: 95.8 secs.