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AJR Radiologic Signs in Thoracic Imaging 2008
AJR Radiologic Signs in Thoracic Imaging 2008
AJR Radiologic Signs in Thoracic Imaging 2008
Keywords: “head cheese sign,” “hilum convergence sign,” “hilum overlay sign,” “hogs head cheese sign,” “incomplete border sign,” luftsichel sign, thoracic imaging, “walking
man sign,” “water bottle sign”
DOI:10.2214/AJR.07.7081
Received March 9, 2008; accepted after revision July 11, 2008.
M. S. Parker is a design consultant for Worldwide Innovations and Technologies, Inc., Overland Park, KS.
1
Department of Radiology, Medical College of Virginia Hospitals–VCU Health System, Main Hospital, 3rd Floor, 1250 E Marshall St., PO Box 980615, Richmond, VA 23298-0615. Address
correspondence to M. S. Parker (msparker@vcu.edu).
Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
2
Department of Medical Imaging, Thoracic Imaging, University of Toronto, Toronto, ON, Canada.
3
Question 2 Question 3
Where is this lesion MOST LIKELY located? What is the MOST LIKELY diagnosis?
A. Lung parenchyma. A. Primary lung cancer.
B. Mediastinum. B. Chest wall chondrosarcoma.
C. Pleura. C. Pseudotumor or vanishing tumor of the pleura.
D. Chest wall. D. Localized fibrous tumor of the pleura.
A B
Fig. 2—68-year-old asymptomatic nonsmoking woman who underwent preoperative screening chest radiography in preparation for total knee arthroplasty.
Radiographic findings prompted subsequent chest CT.
A, Frontal chest radiograph reveals vague opacity in right midthorax overlying fourth and fifth anterior ribs. Ribs appear intact. Inferior margin of this mass is well
delineated; however, superior margin is ill-defined or incomplete.
B, On lateral chest radiograph, lesion appears better defined and is lentiform in morphology. Long axis of this mass parallels long axis of right oblique fissure.
Anterior, superior, and inferior borders appear better defined than posterior border.
(Fig. 2 continues on next page)
C D
pleura of the chest wall, thus forming an incompletely visu- fluid collections is usually oriented along the long axis of
alized border on radiography (Figs. 2A and 2B) and creating the interlobar fissure [21]. Fluid has a tendency to accumu-
the so-called incomplete border sign [15–17]. late in the interlobar fissure in the setting of cardiac decom-
Mediastinum- and chest wall–based masses may also pensation and to localize in the horizontal fissure in partic-
show an incomplete border sign [15]. However, the location ular [21]. The fluid collections tend to be spontaneously
of this lesion on the frontal radiograph (Fig. 2A) would ar- absorbed when the heart failure has been relieved and are
gue against a mediastinal or chest wall cause. Options B therefore referred to as either pseudotumors or vanishing
and D are not the best responses. Localization of the lesion tumors of the pleura [21]. Option C is not the best response.
to the oblique fissure on the lateral chest radiograph (Fig. Invariably, concomitant radiographic evidence of cardiac
2B) supports a pleural cause, which is subsequently con- decompensation is seen or an ipsilateral pleural effusion is
firmed on CT (Figs. 2C–2E). Option C is the best response. present [21].
The most common extrapulmonary lesions include, but Localized or solitary fibrous tumor of the pleura is a rare
are not limited to, loculated pleural effusions, various rib pleural neoplasm but is the second most common primary
lesions (e.g., fractures, primary and secondary tumors), pleural neoplasm after malignant mesothelioma [22–24].
mesenchymal tumors, neural tumors, hematomas, lipomas, Option D is the best response. Although most of these tu-
and various cutaneous lesions (e.g., neurofibromas) [15]. mors are related to the pleura, they have also been described
in other intra- and extrathoracic locations. These tumors
Solution to Question 3 typically occur in adult men and women in the fifth through
The incomplete border sign supports a conclusion that eighth decades of life. Many patients are asymptomatic
the lesion in question is extrapulmonary. Option A is not and are diagnosed incidentally because of abnormal chest
the best response. radiographic findings, as in our patient (Figs. 2A and 2B).
Although chest wall metastases are the most common ma- Symptoms typically relate to tumor size and include cough,
lignant chest wall neoplasm in adults, chondrosarcoma is the chest pain, and dyspnea. Hypertrophic pulmonary osteoar-
most common primary malignant tumor of the adult chest thropathy is seen in 20–25% of patients. Symptomatic hy-
wall [18–20]. Chondrosarcomas are malignant neoplasms poglycemia occurs in less than 5% of patients [22–24]. Ra-
with cartilaginous differentiation. Option B is not the best diographically, localized fibrous tumors of the pleura
response. This neoplasm typically arises in the anterior chest present as well-defined, variably sized, lobular extrapulmo-
wall and involves the sternum or costochondral cartilages. nary nodules or masses (i.e., incomplete border sign) and
Less frequently, chondrosarcomas arise in the ribs (17%) and typically abut the pleura [23, 24] (Figs. 2A and 2B). CT re-
scapulae [18–20]. Chondrosarcomas occur across a wide age veals a noninvasive lobular soft-tissue mass of variable size
range but typically affect patients between the ages of 30 that abuts at least one pleural surface or may exhibit an
and 60 years. Most tumors manifest as palpable chest wall interlobar fissure location (Figs. 2C–2E). Smaller lesions are
masses that may grow rapidly and become painful [18–20]. more homogeneous in attenuation, whereas larger lesions
Males are affected slightly more frequently than females, in a may appear heterogeneous. Foci of calcification and en-
ratio of 1.3:1.0 [18–20]. On radiologic imaging, variable hancing vessels may be observed in the lesion [23, 24] (Fig.
intratumoral calcifications (e.g., rings, arches, flocculent, or 2C). These tumors are not related to mesothelioma, asbes-
stippled) can be identified, and osseous destruction is often tos exposure, or tobacco abuse. Benign and malignant vari-
present [18–20]. Surgical resection is the treatment of choice. ants have been described. Prognosis is related more to resec-
The 5-year survival rate is more than 60% and may approach tability than to histologic features [22–24].
80% in patients without metastases. Poor prognosis is associ-
ated with incomplete tumor resection, metastases, local re- Treatment
currence, and patient age older than 50 years [18–20]. The tumor was successfully resected in its entirety at
Interlobar pleural fluid collections are typically ovoid or open thoracotomy. The patient remained disease-free at the
lentiform when viewed in tangent and may simulate a mass time of the last follow-up CT examination 12 months before
on conventional radiography [21]. The long axis of such this writing.
A B
Fig. 3—33-year-old man with 3- to 4-day history of dyspnea and nonproductive
cough. Chest radiograph (not shown) revealed bilateral perihilar air-space opaci-
ties with intervening normal aerated lung. Patient was admitted to general
medicine ward with presumptive diagnosis of community-acquired pneumonia
and began taking levofloxacin. Over next 3 days he developed progressive
hypoxia and was subsequently transferred to intensive care unit for mechanical
ventilation and nitric oxide therapy. Follow-up chest radiograph (not shown)
before intubation revealed progressive bilateral perihilar air-space disease.
A–C, Selected chest CT pulmonary angiography images using lung window
setting through upper (A), mid (B), and lower (C) lung zones reveal patchy
pattern of variable attenuation characterized by combination of ground-glass
opacities, consolidations, reduced lung attenuation resulting from mosaic
perfusion, and intervening normal lung.
bolus but did reveal an interesting pattern of air-space attenuation characterized by a combination of ground-
disease (Fig. 3). glass opacities, consolidations, reduced lung attenuation
resulting from mosaic perfusion, and intervening normal
Description of Images lung. Note the “head cheese sign.”
The selected CT images (Fig. 3) through the upper, mid,
and lower lung zones reveal a patchy pattern of variable Diagnosis
The diagnosis is Mycoplasma pneumonia with associated
bronchiolitis, as indicated by the head cheese sign.
Question 4 Solution to Question 4
Which diagnosis would be LEAST LIKELY? The combination of mixed densities in the lung parenchy-
ma created by ground-glass opacities, air-space consolida-
A. Sarcoidosis. tions, reduced lung attenuation from mosaic perfusion, and
B. Atypical infection with associated bronchiolitis. intervening normal lung give the lung a geographic appear-
C. Hypersensitivity pneumonitis. ance on CT [25, 26] (Fig. 3). This pattern of mixed parenchy-
D. Multiple septic pulmonary emboli. mal lung densities has been likened to the morphologic ap-
pearance of the mixture of boiled pork scraps and pigs’ feet
in a gelatinous background known and marketed as head ple septic pulmonary emboli, would be the least likely diag-
cheese or hog’s head cheese and is therefore known as the nosis; therefore, option D is the best response.
“head cheese sign” or “hog’s head cheese sign” [25, 26]. How Mycoplasmas are bacteria that lack a cell wall, adhere to
does this particular imaging sign help radiologists in their di- ciliated respiratory epithelium, and produce hydrogen per-
agnostic interpretation? CT must clearly show areas of oxide, which damages epithelial cells and interferes with
ground-glass opacity and consolidation with concomitant ciliary function. M. pneumoniae are one of three human
mosaic perfusion (rather than one or the other) (Fig. 3). When pathogenic Mycoplasma species [29]. Bacteria are transmit-
these findings are present, they indicate a mixed infiltrative ted from person to person thorough aerosolized droplets.
disease characterized by ground-glass or consolidation and Infection may occur the year round but usually occurs dur-
an obstructive disease (usually associated with bronchiolitis) ing fall and winter [29, 30]. Patients may present with fever,
characterized by mosaic perfusion, with a decrease in vessel chills, malaise, anorexia, sore throat, dry cough, and head-
caliber and side branches in the hypoattenuating regions of ache. As the disease progresses, nearly all patients develop
lung parenchyma. The latter will often reveal air trapping on an intractable hacking cough, but only 3% of such patients
expiratory images [25–27]. The most common clinical causes develop pneumonia. Extrapulmonary features are common
of this CT pattern of disease include hypersensitivity pneu- and may include cervical lymphadenopathy, skin rash,
monitis, sarcoidosis, atypical infections (e.g., those caused by aseptic meningitis, nausea, vomiting, and diarrhea. Rarely,
Mycoplasma pneumoniae) with associated bronchiolitis, and patients present with or develop acute respiratory distress
acute interstitial pneumonia [25–27]. Options A, B, and C, syndrome [29–31]. Such patients have higher morbidity
which are likely diagnoses, are not the best responses. Addi- and mortality rates. In these latter cases, supportive me-
tional clinical and laboratory data would be necessary to fur- chanical ventilation is necessary in addition to corticoster-
ther narrow the differential diagnosis. In this particular case, oids and antibiotic therapy (e.g., erythromycin, azithromy-
the diagnosis was an atypical infection with associated bron- cin, tetracycline, clarithromycin, and so forth) [29–31].
chiolitis secondary to Mycoplasma pneumonia. After infection, patients may fully recover; or interstitial
The CT pattern of multiple septic pulmonary emboli is fibrosis, bronchiectasis, Swyer-James syndrome, and im-
much different. The latter disease process may be charac- paired pulmonary function may develop as sequelae of the
terized by unilateral or bilateral areas of juxtapleural and infection [29, 30].
wedge-shaped consolidation; diffuse, often angiocentric,
nodules ranging from 0.5 to 3.5 cm in diameter, many of Treatment
which show various stages of cavitation; and a peripheral Treatment is support with a mechanical ventilator and
rimlike pattern of enhancement after the administration of nitric oxide therapy, corticosteroids, and clarithromycin.
IV contrast media. Pleural effusions may also be identified The patient was maintained on mechanical ventilation
in two thirds of patients, and 27% have identifiable hilar or for 5 days and then was successfully extubated. Eight
mediastinal lymphadenopathy [28]. On the basis of the days later, he was discharged and was subsequently lost
clinical presentation and the CT findings, Option D, multi- to follow-up.
Scenario 4
Clinical History
A 35-year-old woman presented with fatigue, chest pain,
and weight loss over the past several months (Fig. 4).
Description of Images
A posteroanterior (Fig. 4A) chest radiograph shows a mas-
sively enlarged cardiomediastinal silhouette. Lateral chest
radiography (not shown) showed complete obliteration of
the retrosternal clear space. On closer inspection, the normal
right and left pulmonary arteries and their respective interlo-
Fig. 4—35-year-old woman with fatigue, chest pain, and weight loss over past
several months.
A, Posteroanterior chest radiograph shows massively enlarged cardiomediasti-
nal silhouette. Lateral chest radiograph (not shown) showed complete obliteration
of retrosternal clear space. On closer inspection, normal right and left pulmonary
arteries and their respective interlobar divisions can be identified well in what
appears to be lateral or peripheral margin of cardiomediastinal silhouette.
A (Fig. 4 continues on next page)
bar divisions can be identified well in what appears to be the the myocardium (Fig. 4C) show a large aggressive anterior
lateral or peripheral margin of the cardiomediastinal silhou- mediastinal mass intimately related to the ascending aorta
ette. Contrast-enhanced CT images (mediastinal window set- and main pulmonary artery with invasion of the myocardi-
ting) through the main pulmonary artery level (Fig. 4B) and um proper. A small pericardial effusion is present.
Diagnosis
Question 5 The diagnosis is malignant peripheral nerve sheath tu-
mor of the vagus nerve with mediastinal invasion, the hi-
What is the MOST LIKELY diagnosis? lum overlay sign.
A. Cardiomyopathy.
B. Pericardial effusion. Solution to Question 5
C. Anterior mediastinal mass. The proximal segment of the visible left or right pulmo-
D. Pleural effusion. nary artery lies laterally to the cardiac silhouette or just
within its edge on normal frontal chest radiography. As
Question 6 the myocardium enlarges in the setting of a cardio-
All of the following are TRUE statements myopathy or cardiomegaly or as the pericardial sac dis-
regarding the “hilum convergence sign” EXCEPT: tends with fluid from pericardial effusion, the pulmonary
artery segments are simply displaced outward but con-
A. It differentiates a potential hilar mass from an tinue this same relationship to the cardiac silhouette [32,
enlarged pulmonary artery. 33]. Options A and B are not the best responses. Alterna-
B. If the pulmonary arteries converge into the lateral tively, if either the left or right pulmonary artery can be
border of the apparent hilar mass, the mass seen 1.0 cm or more within the lateral edge of an opacity
represents an enlarged pulmonary artery. that appears to represent the cardiac silhouette, that opac-
C. If the pulmonary arteries converge behind the ity does not represent the cardiac silhouette and therefore
apparent hilar mass, the mass represents an cannot be the result of cardiomyopathy, cardiomegaly, or
enlarged pulmonary artery. pericardial effusion, but is related instead to the presence
D. If the convergence of the pulmonary arteries of an anterior mediastinal mass [32, 33]. Option C is the
arises from the cardiac silhouette, a mediastinal best response. This is referred to as the hilum overlay sign,
which can be used to determine that a lesion is extracar-
mass is likely present.
diac and localized to the anterior mediastinal compart-
B C
Fig. 4 (continued)—35-year-old woman with fatigue, chest pain, and weight loss over past several months.
B and C, Contrast-enhanced chest CT scans using mediastinal window setting through main pulmonary artery level (B) and myocardium proper (C) show large
aggressive anterior mediastinal mass intimately related to ascending aorta and main pulmonary artery as well as invasion of myocardium proper. Small pericardial
effusion is present. DA = descending thoracic aorta, LLPA = left lower lobe pulmonary artery, PA = pulmonary artery, PV = pulmonary vein, RLPA = right lower lobe
pulmonary artery, RA = right atrium, RV = right ventricle.
ment, thus steering the differential diagnosis in the appro- Solution to Question 6
priate direction [32, 33]. Because the lesion of concern is Felson’s hilum convergence sign should be differentiated
mediastinum-based, option D, pleural effusion, is not the from the hilum overlay sign discussed in the solution to ques-
best response. It likewise would be quite unusual for pleu- tion 5 [32]. The hilum convergence sign is useful in distinguish-
ral effusion to present as perihilar ground-glass opacity. ing between a large pulmonary artery and a hilar mass [32].
Additionally, the costophrenic angles are preserved. The Because the pulmonary artery branches arise from the main
mediastinal mass in this particular patient proved to be a pulmonary artery trunk, an enlarged pulmonary artery will
malignant peripheral nerve sheath tumor (MPNST) aris- have branches that arise from its lateral margin, and its vessels
ing from the intrathoracic vagus nerve in the mediasti- will appear to converge toward the main pulmonary artery
num. MPNSTs are rare but aggressive sarcomas that arise [32]. Option B is the best response. A true hilar mass may have
from the nerve sheath or show features of nerve sheath the appearance of an enlarged pulmonary artery, but the ves-
differentiation; they more often involve the extremities, sels will not arise from its lateral margin but rather seem to
the head, and the neck. Intrathoracic MPNST is uncom- pass through the margin as they converge on the true pulmo-
mon [34]. Although such tumors may occur in patients nary artery [32]. Therefore, if the convergence of the pulmo-
with neurofibromatosis 1 (von Recklinghausen’s disease) nary arteries appears behind the apparent hilar mass or ap-
with an incidence of 0.16%, these tumors may also occur in pears to arise from the heart, a mediastinal mass is more likely
patients with no signs of such (incidence of 0.001%), as in [32]. Options A, C, and D are not the best responses.
our patient [34–36]. Successful treatment requires complete
surgical excision of the MPNST. Radiotherapy may delay Treatment
recurrence but has little impact on patient survival. Con- The treatment, which was unsuccessful, was surgical de-
ventional advanced soft-tissue sarcoma single-agent chemo- bulking of the tumor and palliative radiotherapy. The pa-
therapy with doxorubicin has a poor response rate [34]. tient died over the next several weeks.
A B
Fig. 5—47-year-old man with chronic renal failure and dyspnea.
A, Posteroanterior chest radiograph shows globular enlargement of
cardiomediastinal silhouette. Note increase in transverse diameter of
cardiomediastinal silhouette but no increase in its height. Proximal segment of
visible left and right pulmonary artery lies lateral to cardiac silhouette.
B, Coned-down lateral chest radiograph reveals separation of black retrosternal
fat stripe (single arrow) from black epicardial fat stripe (double arrows) by
opaque interface. No pleural effusion or interstitial edema is present.
C, Contrast-enhanced coronal maximum-intensity-projection chest CT scan at
mediastinal window setting shows separation of visceral and parietal
pericardial layers by large fluid collection surrounding myocardium.
sac itself normally contains 20–50 mL of fluid [37]. An ex- 250 mL [37–39]. The cardiomediastinal silhouette may then
cess of pericardial fluid may accumulate in a number of set- show symmetric enlargement and preservation of the nor-
tings. Option E is the best response. The most common cause mal hilar relationships, resulting in the water bottle–shaped
is myocardial infarction with left ventricular failure [37]. morphology [37–39] (Fig. 5A). A well-penetrating lateral
Fifty percent of patients with chronic renal failure develop chest radiograph is even more sensitive in the early detec-
uremic pericardial effusions [37]. Other causes of peri- tion of pericardial effusion and may reveal separation of
cardial effusion may include hypoalbuminemia, myxedema, the retrosternal and epicardial fat stripe by more than 2
infection, drug reactions, trauma, neoplasia, and autoim- mm, which is sometimes referred to as the “Oreo [Nabisco]
mune disease [37]. The chest radiograph may appear rela- cookie sign,” “sandwich sign,” or “bun sign” [37–39] (Fig.
tively normal until the volume of pericardial fluid exceeds 5B). The black epicardial and retrosternal fat stripes consti-
tute the outer dark cookie layers or slices of bread in the propriate considerations in this patient. Options A and B
sandwich or bun, and the opaque intervening pericardial are not the best responses.
fluid, the white fluff of the cookie or the meat in the sand- Uremic pericardial effusion commonly improves with inten-
wich or bun. Although the cardiac silhouette is enlarged, sified or increased frequency of peritoneal or hemodialysis
the pulmonary vasculature appears normal, and signs of [41]. More aggressive management may be needed if the peri-
heart failure (e.g., vascular redistribution, Kerley B lines, cardial effusion is larger than 250 mL, if it continues to in-
and so forth) are absent (Fig. 5A). Option C is not the best crease despite intensive dialysis for 10–14 days, or if the pa-
response. CT is more sensitive in the detection of small peri- tient develops tamponade [41, 42]. In these latter instances,
cardial effusions. Small effusions first collect dorsally to the pericardiocentesis, pericardial window, subxiphoid pericar-
left ventricle and along the left atrium. Larger effusions col- diotomy, or pericardiectomy may be necessary [41, 42].
lect ventrally and laterally to the right ventricle. Very large
effusions may envelop the myocardium, forming the “halo Treatment
sign” [37, 40] (Fig. 5C). Lobar pneumonia and primary lung The patient was successfully treated with a combination
cancer are both air-space disease processes and are not ap- of increased hemodialysis and subxiphoid pericardiotomy.
Scenario 6 put. A convex bulge is present along the left heart border re-
lated to left atrial chamber enlargement. Midline median ster-
Clinical History notomy wires can be delineated. A lateral chest radiograph
A 62-year-old woman presented with a long-standing his- (Fig. 6B) reveals a convex bulge in the superoposterior cardiac
tory of chronic atrial fibrillation; she had undergone cardiac border below the carina, with posterior displacement of the
surgery 7 days earlier (Fig. 6). left lower lobe bronchus and opacification of the retrocardiac
Description of Images clear space. Right ventricular enlargement encroaches on the
A posteroanterior chest radiograph (Fig. 6A) shows an in- retrosternal clear space. Foci of residual pneumomediastinum
creased cardiothoracic ratio. The pulmonary artery segment and a retained subxiphoid pacer lead can be seen in the retro
is enlarged, suggesting precapillary pulmonary hypertension. sternum. A newly placed mitral valve prosthesis is present.
The aorta appears small from decreased forward cardiac out- Thin curvilinear calcifications can also be seen paralleling the
A B
Fig. 6—62-year-old woman with long-standing history of chronic atrial fibrillation. Patient had undergone cardiac surgery 7 days earlier.
A, Posteroanterior chest radiograph shows increased cardiothoracic ratio. Pulmonary artery segment is enlarged, suggesting precapillary pulmonary hyperten-
sion. Aorta appears small from decreased forward cardiac output. Convex bulge is present along left heart border related to left atrial chamber enlargement.
Midline median sternotomy wires can be delineated.
B, Lateral chest radiograph shows relative posterior displacement of left upper and lower lobe bronchus relative to right (arrows), forming “walking man sign.”
Right ventricular enlargement encroaches on retrosternal clear space. Foci of residual pneumomediastinum and retained subxiphoid pacer lead can be seen in
retrosternum. Newly placed mitral valve prosthesis is present. Thin curvilinear calcifications can also be seen paralleling posterior wall of enlarged left atrium. No
radiographic evidence of acute cardiac decompensation is seen.
cardiac region (Fig. 6A). The interface represents the inferior Balloon valvotomy is usually the initial procedure of choice
margin of the enlarged left atrium as it pushes into the adja- for symptomatic patients with moderate to severe mitral
cent lung [52]. On frontal radiographs of adult patients, a left stenosis. Valvotomy can double the mean valve area, with a
atrial dimension—defined as the distance from the midpoint 50–60% decrease in the transmitral gradient, which provides
of the double density to the inner margin of the left main- symptomatic improvement. Surgical commissurotomy has a
stem bronchus—greater than 7 cm suggests left atrial en- similar efficacy to that of balloon valvotomy but is usually
largement is present [52]. However, this sign and these dimen- reserved for patients with left atrial thrombus despite antico-
sions are not reliable in pediatric patients [52]. The double agulation or a nonpliable or calcified valve. Mitral valve re-
density sign is often associated with splaying of the normal placement is reserved for patients who are not candidates for
carinal angle of 60–90° and divergence of the caudal main- either percutaneous balloon mitral valvotomy or surgical
stem bronchi, creating a somewhat “wishbone” morphology commissurotomy [58, 59]. Lifelong endocarditis antibiotic
in severe cases [52]. These latter two signs are best appreciat- prophylaxis is recommended for procedures that may be as-
ed on well-exposed or well-penetrating frontal examinations. sociated with transient bacteremia (e.g., dental procedures,
The “doughnut sign” is an imaging sign seen on lateral chest bronchoscopy, colonoscopy, cystoscopy, and so forth) [58–60].
radiography; however, it suggests the presence of mediastinal
Treatment
lymphadenopathy, not cardiac valvular disease [53, 54]. Op-
The treatment is mitral valve replacement. The patient
tion D is not the best response. On normal chest radiography,
was discharged on postoperative day 7. We have no addi-
the aortic arch and the right and left pulmonary arteries cre-
tional information on her current clinical status.
ate an inverted horseshoe appearance [53, 54]. Subcarinal
lymphadenopathy obliterates the notch in the horseshoe, Conclusion
forming a rounded circle likened to the morphology of a bagel This case-based self-assessment module describes several
or doughnut [53, 54]. important radiologic signs that are useful in diagnosing vari-
The normal trachea, right and left upper lobe bronchi, and ous diseases affecting the chest, including the luftsichel sign of
lower lobe bronchi are vertically aligned on a normal lateral left upper lobe collapse; the incomplete border sign of pleural
chest radiograph. The walking man sign is a lateral chest radi- and chest wall-based lesions; the head cheese sign or hog’s head
ography sign that is seen with posterior displacement of the cheese sign of atypical infection with associated bronchiolitis,
left upper or lower lobe bronchus relative to the right bronchi, sarcoidosis, acute interstitial pneumonitis, and hypersensitivi-
so that the bronchial relationship resembles the legs of a man ty pneumonitis; the hilum overlay sign, which is useful in local-
in midstride [55]. Option B is the best response. Posterior dis- izing lesions to the anterior mediastinum; the hilum conver-
placement of the left bronchi is typically the result of mass gence sign that distinguishes an enlarged pulmonary artery
effect on the bronchi by a markedly enlarged left atrium but is from a true hilar mass; the water bottle sign and the Oreo
not pathognomic of an enlarged atrium [55]. The walking man cookie sign of pericardial effusion; and the walking man sign
sign may also occur in the setting of subcarinal lymphadenop- of left atrial enlargement. Future articles will continue this
athy, mediastinal masses, left lower lobe volume loss, large hi- discussion of additional useful signs in thoracic imaging that
atal hernias, and thoracolumbar scoliosis. can be applied to assist the radiologist in establishing the cor-
rect diagnosis or differential diagnosis in applicable cases.
Solution to Question 10
Although it is rare today, mitral stenosis is still most com- References
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