On 14 November 1804, Hanaoka Seishū, a Japanese doctor, became the

first person to successfully perform surgery using general anesthesia.[46]

Hanaoka learned traditional Japanese medicine as well as Dutch-
imported European surgery and Chinese medicine. After years of
research and experimentation, he finally developed a formula which he
named tsūsensan (also known as mafutsu-san), which combined Korean
morning glory and other herbs.[47]
Hanaoka's success in performing this painless operation soon became
widely known, and patients began to arrive from all parts of Japan.
Hanaoka went on to perform many operations using tsūsensan,
including resection of malignant tumors, extraction of bladder stones,
and extremity amputations.[48] Before his death in 1835, Hanaoka
performed more than 150 operations for breast cancer. However, this
finding did not benefit the rest of the world until 1854 as the national
isolation policy of the Tokugawa shogunate prevented Hanaoka's
achievements from being publicized until after the isolation ended.[49]
Nearly forty years would pass before Crawford Long, who is titled as
the inventor of modern anesthetics in the West, used general
anesthesia in Jefferson, Georgia.[50]