1 - Adrenaline

( 'oncentTiirinr img/ I ml

Dilution Dexirtise 5%

Precautions * Central line is required for administration

• Stable fcn24h
* Sensitive to light and ait; prmeciion from light is recoinmended
• OxidatiM turns drug pink, then hrtmu
• Solutions should not he used if they are discolored or contain a precipitate
• Inactivated in alkaline media, st) don't mix with sodium bicarbonate

Dow 0.04- J nx’g'kgmin

Infusion into Sunp X SO ml ► 2 tml/'h (0JQ5 rncglcjj/minj

2 - Noradrenaline
( ’< inccjilriilion 4 mg /4ml (8 mg iaitrale)
Dilution. Dcxtiùse 5%

Precautions * Solution is stable for 24h

«keep away from light don't use if brown coloration (oxidized)
* Inactivated in uikaline media, so don’t mix with sodium bicarbonate

Dose O.2-1.3 mcg/kg/min

Infusion, rate samp X 50 ml ► 10 ml/h (0.4 mcg/kg/mi n)

3 - Dopamine
Concentration 200 mg /5ml
Dilution Dextrose 544

Precautions • Stable for 24h

• keep away from light, don’t use if brown coloration (oxidized)
• Inactivated in alkaline media, so don't mix with sodium bicarbonate
• High risk of precipitating arrhythmia
• Renal dose is rarely used

Dose Renal dose: 1 -3mcg/kg/min

Beta dose: 4- lOmcg/kg min
Alfa dose: > lOmcgkg/min (max dose 20 mcg/kg/min)

Infusion rate 2amp X 50 ml ►S mhh ( 10 mcg/kg/min)

4 - Dobutamine
Concentration 250 mg / 5 ml
Dilution Dextrose 5%

Precautions • Stable for 24h

• keep away from light .don't use if brown coloration (oxidized)
• Inactivated in alkaline media, so don't mix with sodium bicarbonate

Dose 3-15mcgkg min (max dose 20 mcg’kg/min)

Infusion rate 2amp X 50 ml >2 ml/h (5 meg kg/min)

 1- Heparin
Concentration 5000IU amp
Dilution Normal saline

Precautions • Stable for 24h

• Slight yellow coloration does not affect potency

Dose ACS
& 60 units kg lamp bolus
Infusion rate Then IS unitkgh (max 1000 uh) 5amp X 50ml ► 2 inlh

VTE
80 units'kg lamp bolus then
Then 18 unitskgh 5amp X 50ml >2.7 mUh

IV anticttagulution
10,000 units lamp bolus
Then 50-70 units'kg 1 -2amp '4-6h
(5000-10,000 units) every 4-6h

2- Streptokinase
Concentration 1.5 million units

Dilution Normal saline or dextrose 5%

Precautions • Reconstituted solutions should be refrigerated and arc stable for 24h
• At room temperature used within 8h

Dose STEMI
& 1.5 million If over 1 h 1.5 million IIX 50ml ► over Ih
Infusion rate
PE
250,000 U over 30 min 1.5 million U X 50ml ► 8 ml over 30 min
then then
100,000 Uh for 24-72h 3.3 tnl/h for 24-72h

1- Furosemide
Concentration 40 mg /4 ml
Dilution Normal saline

Precautions Stable for 24h

Dose Start wilh SO mg

Then 10 mg.'Ti, increased to 40 me. ti according to disease

Infusion rate Samp X 50ml ► start with 2,5ntl/ti

2- Torsemide
Concentration 10 iiig /I ml

Dilution Normal saline

Precautions Stable for 24b

Do>e Start wilh 20 mg

Then 5-40 mg/h

Infusion rate 5amp X 50ml ► 5-40mPh

1- Aminophylline
Concentration 125 mg /5 ml
Dilution Normal saline or dextrose 5%
Precautions • Stable for 24h
• Adults 16-60 years max daily dose: aminophylline 1139 mg/day
(equivalent to theophylline 900 mg/day)
• Age > 60 years decrease dose to half
• High risk of tachycardia and arrhythmia
Dose Loading: 5.6 mg/kg over 30 min
Then 0.6 mg /kg/h
Infusion rate 3 amp X 250ml over 30 min
Then 4amp X 50 ml ► 4 ml/h

1- Nitroglycerin
; Concentration 50 mg/50mI
Dilution Normal saline or dextrose 5% or thick
Precautions • Tolerance occur after 24h, to avoid this give interval free of drug at least 6h
within 24h
• Should not be used in patients who have taken a phosphodiesterase
inhibitor within the past 24h because of the high risk of hypotension when
these agents are combined
Dose Venodilator (<50 mcg/min)
Arteriodilator (>200 mcg/min)
Mixed dose (5O-2OOmcg/min)
Infusion rate 1 vial ►O.é ml/h (10 mcg/ min)
1- Midazolam
Concentration 5 nig .'ml

Dilution Normal saline Cf dextrose 5*

Precautions ■ Subic fur 2uti
■ In staina eptlepucus withdraw gradually tn prevent recurrence
Duse Sedation
<fc Loading: 0.5 to 4 mg repeat every 5­ lamp X 10 ml ► l-ft ml
Infusion rue 15 mln until adequate ladidoa
achieved
Maintenance. O.tJI-tll I mg/kg/h Samp X50ml ► 3-14ml.h

Srultu epilepUcits
Loading: 0.2 irig'ig 3atnp bulus over 5 iriin
Maintenance: Ü.05-2 mg-'kg.'li 5amp X 50ml ► 7-290 ml'b

2- Propofol
Cnncrniniilinn 200 mgïllhnl
Diluiion Usually uscdl thick, if need, dilution use dextrose 5%

Frecautiocis • Avoid exposure io sir

* After transferred to a syringe or other container, use within fih
» Withdraw gradually to preveni recntrenl statua cjiilepticus
• Using high dosea > 5 mg.'Tfg/h nray pmcipilste "Propofol infusion
syndrome' (heart failure, bradycardia, lactic acidosis, hyperlipidemia and
rhabdomyolysis)

Dose Jet/tir™
& Loading: 0.15-1 mg/ltț lamp thick ► 2-itHl
[jifuaioa r«e Maintenance: 0.01-tWÎ mgdtg/min lamp thick >8-30 mlrti

Scutul epileptteiit
Loading: 1-5 mg.'kj lamp thick ► 7-35mJ
Maintenance: I -15 mg^glh 2amp thick >8-40 mL'h
3- Fentanyl
ConœnlnitHjfi IO0 rrrcg .'2ml
Dituiicm Normal saline <x <fcxtrg«c .5%

PrtcaullMR • Stable for 24h

■ Muy muse respimttiry dcprrxxicin even if used in IhempEutir dost

[X:w Shoals: 0.35 Ma 0.5 mcgftg IV every 1X2-Ih

Ccxidnuex Infusion: 0.7 io 10 meg/kg/h

[infusion ffiic 1 ump X 1 Ûrii 1 k 3^1 ml over 2 min e'very 1/2-1 h

5nnip X 50ni ►S-7ümâfli

4- Mor )hin©
Concent [Mien 2U m-ș /îmi
Diln.cit.Mi Normal saline <x <J?xinjsç 5%

Praaulirms Stable ftir 24h

Do*e SJirHlIS: Û.Ü I IPÙ.15 mù.'kt tv evtr-j1 ]-2n

Coatiiius infualoa: IltH u> Cl.5 iqg/Kgfli

Infusioo rale J snip X 20tnJ H-IOoiJtvery 1. - 2h over 5 jnin

5mapX 50ml ►1.5-I8ml.1i '

5- Phenytoin
CrmLertralirin JS(lirtgZ5ml

DildtirM Vinfial Hite

Pft'CàuLiüilS * Stable for 4h only

■ Nd! rrEngcraLc
• Injeci; into □ large peripheral or central vein
• hluisJ) line with saline before and after each IV dose loavotdl local venoua
irriLiuon eauiied by alkalinity of solution

Dow kteiag : I3-IS mg'kg

Then 5-K mg ■Uli

Infusion rale 4-5nmj <T3mi) X 100 nV over 30 min

Then 2.S-3 ml X 7 ml Sh over 3 min.
1- Amiodarone
ISOmg/Amp
Str ength
OSW
Com|□atibility
Dose Infusion rate
AF loading 5-7 mg/kg IV over 10-60 1 amp *250 ml -lover 30 60mm
minutai, then 12—18 g/day Then
cardioversion continuous IV OR then 1.2-18 g/ day continuous IV or
Uses divided oral doses until 10 g. divided oral doses until 10 g

Maintenance 200-400 mg/day PO

-100 mg/oay for the elderly or tow
body mass

AF rate 300 mg over 1 hr then 10 50mg/hr 2 amp" 150 ml -lover Ihr

over 24 hrs Then 6 amp’SOOml -> 5.5 ml 27ml
control Followed by lOO-TOOmg/day as
(unlabeled)
Stable VT or first 24 hours 1050 mg accordvsg to 1 amp'lOOnd -lover 10 mln Then
following regimen :• 6 amp"500ml -1 34 ml/hr for 6 hrs
SVT ■150 mg’lOOmIDSW over first 10 Then
minutes 17 nd/hr for 18 hrs
■Then 360 mg "200ml D5W over nest
6 hours >1 mg/mlnute
Then 540 mg ■ 100ml D5W over
next 18 hours = 0.5 mg/mmute
-Then SOOrng /day for 1 month then

24 hr
St;ability
4 High dru* concentration > lmg/ml associated with win phlebitis.
Prec autions
* For infusion >lhr do not exceed 2mg/ml