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BIOCHEMISTRY
PLASMA GLUCOSE (FASTING) 86 mg/dl 70 - 110
Hexokinase
Interpretation (In accordance with the American Diabetes Association guidelines):
. A fasting plasma glucose level below 100 mg/dl is considered normal.
. A fasting plasma glucose between 100-126 mg/dl is considered as glucose intolerant or pre diabetic. A fasting and postprandial blood sugar
test (after consumption of 75 gm of glucose) is recommended for all such patients.
. A fasting plasma glucose above 126 mg/dl is highly suggestive of a diabetic state. A repeat fasting test is strongly recommended for all such
patients. A fasting plasma glucose level in excess of 126 mg/dl on both the occasions is confirmatory of a diabetic state.
SEROLOGY
INSULIN FASTING 17.5 mIU/L 5.0 - 25.0
CLIA
INTERPRETATION-
Insulin is a peptide hormone with a molecular weight of approximately 6000 daltons. It is secreted by the B-cells of the pancreas and passes
into circulation via the portal vein and the liver. Insulin is generally released in pulses, with the parallel glucose cycle normally about 2 minutes
ahead of the insulin cycle.
The Insulin molecule consists of two polypeptide chains, the alpha-chain with 21 and the beta-chain with 30 amino acids. Biosynthesis of the
hormone takes place in the beta-cells of the islets of Langerhans in the form of single-chain preproinsulin, which is immediately cleaved to
give proinsulin. Specific proteases cleave proinsulin to insulin and C-peptide which pass into the bloodstream simultaneously. Circulating
insulin has a half-life of 3-5 minutes and is preferentially degraded in the liver, whereas inactivation or excertion of proinsulin and C-peptide
mainly takes place in the kidneys.Serum Insulin determinations are mainly performed on patients with symptoms of hypoglycemia.
A disorder in insulin metabolism leads to massive infuencing of a number of metabolic processes. A too low concentration of free, biologically
active insulin can lead to the development of diabetes mellitus. Possible causes of this include destruction of the beta-cells (type I diabetes),
reduced activity of the insulin, or reduced pancreatic synthesis (type II), circulating antibodies to insulin, delayed release of insulin or the
absence (or inadequacy) of insulin receptors.
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