Cancer develops due to the uncontrolled growth of malignant cells. As tumors progress, cancer cells encounter changing nutrient availability in the demanding tumor microenvironment. To support their high metabolic needs, cancer cells reprogram their metabolism to alter lipid processing to obtain energy, membranes, and signals needed for survival, growth, invasion, metastasis, and response to the microenvironment and therapies.
Original Description:
Original Title
The Uncontrolled and Abnormal Proliferation of Malignant Cells Causes the Development of Cancer
Cancer develops due to the uncontrolled growth of malignant cells. As tumors progress, cancer cells encounter changing nutrient availability in the demanding tumor microenvironment. To support their high metabolic needs, cancer cells reprogram their metabolism to alter lipid processing to obtain energy, membranes, and signals needed for survival, growth, invasion, metastasis, and response to the microenvironment and therapies.
Cancer develops due to the uncontrolled growth of malignant cells. As tumors progress, cancer cells encounter changing nutrient availability in the demanding tumor microenvironment. To support their high metabolic needs, cancer cells reprogram their metabolism to alter lipid processing to obtain energy, membranes, and signals needed for survival, growth, invasion, metastasis, and response to the microenvironment and therapies.
The uncontrolled and abnormal proliferation of malignant cells causes the development of
cancer. During tumor progression, the availability of nutrients is continuously changing in an
equally demanding microenvironment. To support their onerous metabolic requirements, cancer cells utilize a special reprogrammed metabolic machinery which allows them to alter or dysregulate lipid metabolism in order to obtain energy, biological membrane components, and signaling molecules which are all needed for rapid survival, proliferation, promotion, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy.