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The uncontrolled and abnormal proliferation of malignant cells causes the development of

cancer. During tumor progression, the availability of nutrients is continuously changing in an


equally demanding microenvironment. To support their onerous metabolic requirements, cancer
cells utilize a special reprogrammed metabolic machinery which allows them to alter or
dysregulate lipid metabolism in order to obtain energy, biological membrane components, and
signaling molecules which are all needed for rapid survival, proliferation, promotion, invasion,
metastasis, and response to the tumor microenvironment impact and cancer therapy.

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