Fenmoccaing hea padnea 20.412005 Phabiera 44. Dados dose = 5y6 mg/kg AME Man nel = 4136, 44.0 mecca comtet= 68) MILOTF) = 180,125 manca dente 8 = ¥3%9 Regnesaa Iincon: ya, 0/1842 (y= 0% +b) Pade que Inc = InG ~ kext, vem qe wen mnFa-0130t m= Ke ce b=lnCe 3 C= 9.988-0,134+ C = 61676" ekesawat' Inco< aa¢a (eda hora € eliminads 45,4 dr frm €aCo = 46,4613 m/l. cet. 90 omgprusmo |! tie = Ine ke tie = nz = 516 W > A conamdnago € nedirida a 01384 mmtiade a coda. 5,16 fi btm v 2 dieculas Keonhien ~ tendteautar avinoplind. st oes ‘each VS Belmgmt d= 19.81% 034 6 = 286 LK Cavoume axptundo ot unidade de tempo) uC? = Go. ep (AUC = s6,193 ety > FOES = 120 mg.h LY, ke 104" Ttéledso _independenk do wedelo (riCede dos trape.sios - us0-se valoues. naa nena; jacks: ) (peut, uitsdine) ucS = nucle ave Fara 8-025 Pregl aeila, + Avene mele mist auc» auch mck + nace + Ade bene + aes! Aue (2. fous) OAS = 16,1913 161 «OBS = 4,03 mail + ° we « AUC = 409,1 mg hl” y AUC, = WATENSA = tat my hly newiluat 1. eioumese > Mn = Sie) = nat ngit 211,94 mg hl? 4 cencanictadt! kK an34 a!ie BIR mg! 48 = 3 daingnt! nk by = = BGHX of8%+ aa4Jqus = ¥ O18 299 a148 a = ws 26d L At <= ® Je Probiema 1.2. Dados. m= 500mg Pevclor a coder de gnondesa mistake) forts « Deemed £2 Smn a= 5,8330 Regnestao linear b= -0,0369 Yy = 8,833 - Cons R= -o\me Inc + bnGe - kext j= le «3,58 + oral 4) onduireg ene Inco! = 3.633 os ke = 0,033 ft ce = 46,20 ng/L te = Ina Ke tae Ina ae | bia = |ajo0 & oak £ b) som D= 309 mq— 500 mg Mole oye 2 ost eng’ We.20 enfll m v= 1022 f, 9 néledo dependenle do medtio AS = fo > atotae 4 a , Ag = 4e.p0m9 AS = bon mg KL 0.08 h nie do Ae it pom lant bats | baie | et at tet ta | ig tt alee ale wis sar al eas a AS 4 AL AB a nib ALG ATK + Ade = 606,03 mp hk Ao” = (4eane ts a) Ob - 2asas Aoi > (sraetans ) 0, ery 21,925Terr Mg Gates AL, 1405 hg tt ke opath® AS | pansion h CP App ad le Lae 614,04 mg he”! Tape ld pendent! dp. cracalo ha haky oh ef =| ote, 1.galh @_=|.0,800Lh? @) ak guns Regnesso. linear ya ou be 10,2885 a= -onsaa saberde que InC= \nGa =a, Ince = 2.4853 eo Co = 11,9809 99 kok, com tabOe eI 1) ke : thal hel [ot foe oh la, hal + AT Co + mepepatante co modelo, sae ng ht! AS! = (024) + Andependie me » ea wks u co =) aso anil > es tus = Sain én ven arab * pon toda hone Sao climinades 99.2) t= —= C= ny, 1] | Feliminadia |=) Cebimpos 3) tFeim= 11,4 [aj2) Fetemmaa = (Qeeagees) To abedadatelgsleal Sich + boda 61,6" zoey tht 28a bo2s20% thelgde, ingtependen we do modster p20 | vem que ke = 0,2220h'¢ ec) enol v=o Da) 10mg Ya cos ed b= S00 my v= 200 arse bt! Vie aiask =s TAS | = eaer| cane) pl ebm ofs reo come: 1.980) eal sane PM aysa5h mail jain tees mgt 09 -9,2854 = Cone Qrseaigsces) cestimada ta | ayaa 16 °F74 4.9098 mall. =e ag ne FE 3,098.4 moll. | tag | 2. aye se FES 3 as amo oe, e02 OPP Pree eeBEE a | Eo | | | Ee oe Sees EE eee CEE ee aa eae ace eeeeeee a Aaa Pt BCE ata ae see ee = » se a a ‘ 2 ge esr EAL —— fel LPT fe f | Re | |b. FL a8 Oi {he | Leas Taal loaas Pea 0,908 | O28, Lt oy a “A S| Cet cry iste sae a # BH ERE EE BEEEEES faGge “28 eRe EEE eekProblema 1.4 - Dodas > | 50. mg hx “peso (hg) = 1B4Ingy Dose = ABAmg- (50mg, /K9-) peo we alg = |3,68) SUyItE- a) a= 4.9416 Regnesso linear Y= 4.9416 -0,0353 2 b= -o(0a53 Oy ¢ bobe-se que InC = InCo - ke xt 3 InC=aaane - \ hy In Cor 4,966 po} te Co = 439,49 mg/L. : | ke = o,oasaht € 4 © Binal © indica dacad blz = Ing de. concaninagdo, ke } ttz =_Inz_ tila = 932aph 60253 b) a auch + AUCE™ Ave tua) Greleperdeme) Jaucy = Co (dependone ) my) Aucs= ( mes sai} * (enwe)as , ( elie + (rain) 412 + (texio)xfa + 2 ; 2 ( tara2)so + (aaa) a4 (10a a4 L ° ot] 2 14a AUC, | = 128,495 + 642.9 +669 \+1034 +408 + 180 + 490 +/376,6 = 4808 5 Nude = a | Ae lag, asm At | 0,0053.N? | AUCS = 4e0B 795 + 146,24s = 4455,0H0 mg hl* | 9) AUCS = 434,99 = 5.535, 901mg htt | 0,033, t | 9,033.x10. mL ——~ Bamin 3 Cle 9 6 min ae & 0,616 mL) mio cls 1eany = 0,03L/h 49 25,040 oy pL" | ay Vos Do > Va = 18 4n%— M |e aladal |= 0,953.1) joo} | 159,99 pyle m. B62 kg. | Me 4314le) Adulto Recémn:natscidta 21-0, Lg Fe. 6,299 Le J tn = 85h Th ta = 09,40 1 - domt fia {1 ete 0,65.en tenia fe=o.6n frotcdio eee ease fle} sot-butt 4 Ake Papell = 1= 16 pasar tO) Pe: Ainda uae} frocsdo live }-eun=1-€ ~? saberros como, O medebarsino |.db.aytmdxane es4_compnometide deride a \maluridade hepato. cares dnd. (cele confines pho 12, ¢) CL, isha eo vaturre| de meico. elimnada por unidade Keehpo € |sutstancialy. mena. , ruglechinds ro verge nesta. pl 0.40 conctohingc sea nethsich 6 merade. que. ethand’ ass umes Prcblema 1.5. Daclot Mitene = 60 by. 2 = Ging th a) O=0, 148 Regnessidd linear y= @,149+-0,1303% b=0,1h03 y be-se ue Inc! = 9,\483-o,n08t , Jobo InCo = 9,14 ke =0,1303 hy. B59 gl L 200 mY D=_emgitg x 2064 = scomy 8,593) pg lib £ 3499L, tvs + Ins ke tia + Ind = 4,03 h, R03 « : : s £ s ne oO 2 4 : ; d d i 4b) C< amgil Quando ¢ deg Inc = 3,148 —0, 03% In(a.o) < 9,1483 0, 1903¢ t = Into) = 9, 148% 4 1AO3 4h — 600 ks @5ahy ost aan A ponria das gh33min 0 fanmaco deiza de ten acovrdade ov sep , a cctividade do férmco dna Th32min ro Co= 8,5133mglL — jou 6, SoM hg ie (lavas), { u th ec ln (2,5339007) = 911497 -0,n03t o oseh — 3 {n.( 5383410") — 9, 148% = 0,108 t= 40,56, > Ad fimde axe axCo= 90 = e-OFRE rales = scomg- eerreet _ oer 84.98 Info.n63) = -0,ro3t C= Y%leiemg/L £=13,6h, In Go = aac Quesriondeio 1 w. = 09904 -%39@e => InC= 0.9301- o,a56F Ay 1% oedem a) Ke = rojaseh! 3) \w.Co: 0,9.308 G3 ik =4h @) G5 0.53 mg/L D = 750mg. 4) Cehe? In Cah = 0.91201-0,936.06 ae te = 4R, seh Represe In CeR = |-0.6059 4n2ammidas — faaccdo eliminada Con = 95456 mlb 420% 0,345 = 303, 1951 Qa. D= 49 = 10@mg- 2 top em Ya8 owdern apm 2) Gaus lasele Sans 9.4033 m/b. 3) GOp.= Kex¥ V=2 @ V= loom ALC = 2 . G Re Cpe 9.82% 49,480 #2 mg/L 2 0th = G3,enBb Avuc= g2maft ; alee? ee 2omiu — 033k Cosh o034x@ 1" Cb = 1D c= G= Ai smg C= 0,031S ugll, ¥ 413,48 L, Cox Olnae cool7 Modtio de. 2 compartimentos apos adm. bieus Problema dt. ala apllbokaa a) e Admihnde que a paniia. dé ponla + =3h as conc). se dspdem alyolonia mente em toero. | deuma linha naa. veo que Peggestin Cneap. + _|yn s,nn6-10,36 49%. INC = |InGo — kext Do qual, se tea. que 3uu1e e B= 0,2649h! 4 pgiml, ¥ tja\=| lod i? Go !! tila © Ling =| 4,40h) (-seerivida de eliminogao !! ) 03643. A panrie da neck arferonen) de finida |! ao Bs he e £ (h) cond. (4ugimL) cone _{ jagimL) R (Cots 0/166 ae | 29,40 5 03333 a0 PENT 9934 os 02,0. 20.02. ysar 4,0 3,6 94,64 1,91 fa et 8,0 td fa 2455 eempeee Nad=|3)96 =| C= 94,40 polmL eo Recadts| eesidues tn (A) Mt Regnessio linea ya sae aan © 47 ce InAs saa oe 4\ubtg h ee A= 2165, gimb tt, " aya +oiseas ) C2 s2.65xe dy dane Toe a Y1s 10 AB “ 5, niga = 5a, 65 inguil + 34,004 mngeil LONOAAAEPARAANANANANENNANAAANAAANANATTTETTTLLAAAAAAA Te= Aaslag mph LL Vokes 500 mbes 2 acl rea 941,96 9h KIL Wes Ker 7 Krz xv Kare 8 Kee a vi Man he Vcewo Kits ate ke Kel ‘ 4 Kits 2,a5ht4 0364 -0,3h-0,61h" = 0,264 4 Vos = (a2era36\ x 3,4r = eral, Oe % @s\ szeoke ‘componenie A —s distnibuigdo t=a9b (inetuida do roan ) beak ( eetucde na ceca) -hasxab ee Cah = 52.65 xe Can> saerxe Cat = aga ygiat Gah = 0,044 ght. Gen 9 100 = g89 4j00= Jee! x 100 = 0,644 x 100= 6,047 obs 0 ata A contnibui gda db pono t= 2h € ainda. Aconinibuigio uo ponte t=3h nave signipicaciva. (>> 97.) aa distribus'edd Significativa paca a fax de damibuigad Noo clive see exciricla (52) peloque bern inctui- ter na, chimigagé.aod + bo0.010 ug e | Adinitindo. |. que) o| pantie | ca _penb © br, arcond. se. dixpeemn atsolora nent |e Ware duced aba abciO,, veri gut Raga essio) Linear y= 4.6098 0,000 £ Ro quatse cika que In@. = 4,608. ' i q 6 4.100,08 yg | ele p,papth x (he) e (ug/l) ace-e) a5 146,07 44.8 aad hea tdah e 36 60,28 di 93,48 1,53 Joo 438 13,68 Regaentaa._Cineck y= 9,3620- O24 1 ob quallad Had gle Ina 23,5628 o=o,eeah 1 Ax 060,63 pal qeqt oyozert C= 040,6n¥€ + J00,6.4€ ») e vi = 2 ane V4 2.200.000 = sokuel, 260 46 + 100,06 pigll Vaerd »| aL pt aA) pao ot Wc! = 260, 6%. pg + Apooe pale = (4463, 19 pooh) " ota 890% Vguee, =| 9001 00 j49 2 AIAG, 0, 0909” & 460,10 ,ye HL Vb Kat sz |e v4 Keil = PFE hey k Kees e LEAN AAA AKHATIATOTTTTTT TLEi i : : ie ram a 7 is w e a. Tee a at reel 4 =o 4 a Pe 4 SEE ECE ECR F + coD= 100. ny. Adnritiedo. ued arene do.7ord> t=! ahh | as conc_| se dispaem. eleatoriamente em tomo de uma. Ginhhmsca , Vern que Regnessao. neds: Yet dass = 09,0346 « Pogqua se riece In = 4,132 in —_|_| 63,1530 mgt |p Metco dos | residios: t € (g/t) é (ng/L) @ (c-2) c L m3 0,5 2.4 2,08 482. 1,0 6.4 3,03 3,23 1,5 3.98 9,48 3,00, a 93 2,84 3 483 2.44 4 - 2,33 aan é 55 Oy; Regnessdohineas:| ly = 4.6451 = 0, 0182 De quae se dina In Al = 4.6052 A= 5,168.14 mg] L «= /0,312h* HOB IER =posaet Ce 5 181uxe +/3,1320xe Vie De vie 100 ome = 12, oa ALB SPN iy)L +3, 13st IL Aue S 2 Al +t Be i: Aug) = S.ABIamgiL | +) 2340 mg = 106/95 mg h/ L c O,3182h* 9, p3ueht Vaden |= | 100 im = 27,03 00346" x 106,915 Mp /L vss | tee le Keae |va Res 4 BL 2 ox Wal PNHONKOKPRRERAOHOHOHHEKHHHHHHHH HHH ON HA AAA HHHKe = | oondeh x 2024. 0,088 hi soak Kae o,arezh"' x ooueh = 9,14 ho! 01088 kia + 0,3188h'!+ oauch*|— 0,14 -0,0748 = Wss= O42 0) > tipi = a0,48L, 0,4 fle gpl e dos |= 0/446 vance ba)02 torr = Ine 8) loo dma t= In Cobre ocrae) + 4,e2h, a-B 0,3 182k 9,083.46 h” 4) Varo > Vss > V4 Vi > Ao toh Jado © fanmact. s¢ encontia na. comp. ceninal Grondo dem inico 6 pnocessd de distmbuigdo , ha decawmenb da cone de fdemaco\no cs anteae e aumenlo. significative. da cone. ¥_ ¢aarbeo 10 p26. / Aedes { Vs > comzesporde ao vetume manana de dist ~ abnge-se a cone. emdinmia de fetamade- nos feces. Veen * 0 faneraco saido peniférice yoo central paRe compensod- © que € feliminades.,.atinge-se den eq iui ¢elmio( e lndéncic_powa denqiibee)Peobiema 2.5. Dodo: De 100 mg a) Admilindo que o paanin do ponds += 4,540 cone. oe dispiem leatoeiamente em Jomo. de oma. linha eect Regnesstio| Vineoo 6,366 —O,us16% Da qual se hea In B= 6.366% P= Oan6h™ B= 5¥2,)2y91L Meictlo dos gesfdvos - c (uci), @ Cuigtt), (ct) 345 963,64 340 546,65 eae 913,08 50a 422,03 eal 46a, G4 Regnestag_tinene. ys S.9281- 4 416be Bo pal sk Hea, eran As 2890p gl nigah! =jurert $026 = asaazxe ME 4 ser rare Wil = 1100000 wae | = ya,asl, agaazpolt + s22saygll x Vere) = | 100 cho fee Ls apa,ake,, p Aus bp, 254Gb") x 449,94 pg hl 3 Als Bob AUS & asana + onz 12 | = 9.407,94 pgill up ane? 02316 Kany Riz AVI @> Ves Ke = 0,9916n'» 19,45 2 0,a201h"! W995 KL = 4,016} x t1ayibe = t,06ash~ Vora 108,48 6 | ka} ke or ikie & uineri' + 9,29 10h! = 1,063 1'= we iKizs 0, agaeehhPlt pxivdeda led Leder = | toe bere in iuier+ 0.9546) = yugn! 2+ 0,9546 ) = juan! ag 16. 4) Ces toll tnin| =» aA5x 10.1 Imin ne 6b Ih eb leaute ent cat = 40,2 6A = 33,24 Uh w 25h, eliimnacio —_ Cdomicente!) +-0,URA ctarabyicho -o, 41x t = In o,03) = In(o03) U=)o/aghy yee CUCU ULAR eef pees a em tetad cb minutos |x a -dure 20Cle Vx Ke Gls 13,76. x.0ja009)"= 4,aB Ui? & b) = ko CPx Css (stndy stale) a = Lobo mgih | | | oy a,nogshr" k 144L tt. CO ac ¥ = | 444.8362 2 145 ¢miL =Qnal Lengo denora.o..ahiqge 4 abledal ellehiolddln 2 ? Considena'se , na pedtica dinca, Q que eslamas ne _estade eoticondiio pacsackas [SSS temindas~ gsando 907. do. ¢eerdacs. Gey TA. faced da conc.de estado eslaciondaio depende de Ke (cle ae cheminagao), que Ao fim de toh , dem-ce 637 da Se. mantem inalterada. cancenlnagdo do'estade tslocardta. tooo, a farcaio sera igual , sadependent 2 de lke Clownde pengusas) | Lscampln ou €.s30mglh) Crh = Smgil xa.63=2,19mgt-O tempo necessciaio poeoalingsa o estado orc at eve pe ee ter ictal. akingda € ditemente. Goce diger queao pm de 10h i forarn ahingides 657 de core. do doelm le {siemacd no etade eslaciondno, Kev qveconeespondem a a somal Se tke Tf €s3 Quien? semwidas necessdeos para alingin 627 da concenlaacda da eslada eStacionamia ? 4 E10, ne 1.46 x eae Aazich, A, 9216 semi-vidas \ G27. fernaco se ae 40h. Kot dese eazga Koz - doce manylengao Néo se consegue T UIle do (aemaco, psa, ein cexros siloagces , admmistea-se uma dase de cea Teal, pewando segucorm/ a peafusio neta taxa < ‘mantendo Koz W smalProblema 4.2. , Dados t=th Te € Qa) Ha diferentes colheilos no decukso da’ pearusda. (t=, t- 0,90h) 4= 49h] t=3,0h, t=3,0h) ineluiedo 9 ponte &= 4th Repnesentando geagicom/ MC ve t comsesponde ap féamino dé perfusao sue ‘a per Y= 4,0698 ~ 0,39334% Ince InCec —kext Donde ce hea que ke =o,0204 h! In Cert = 4,0628 Cext = 58,12 61 mg/L, cext # CT In cr = 4,0628- 0,3334%5% Cert — ordenada na omge ia Crs 9,499 Cr > cone maxima ating) de Cre 14,3495 % 11,39 malty firm oe 1B D = 3.2716 mg Wx TH © QD = #3041 mg/L = Co wy v b) : a Css = 4 a 8, 2976 mg WL 0, assay" 4 4, 1028 44,10. mall, Css = c) tea,sh ry Inc = 4.0628 - 0,3334x4,5b InC = 1,8495kor = _(Koe/v) {=e-RT e For = | |3,:29% mo detente lye Je eon SA, Kol = #,4temglhil Quaute! @ 2dpido Vv se pnetende aback o estado estacondaia, G) 3,24 mg/h) L kko_,@ veloadade de. 41g ORB persladn Fol £ | js. gomg/hiL e) ko = a5m9.h7* M217 @ ko = 5.2916 mgt" v Vel ikd | aly : 3.2916. rghit! 22816 mp HL Vs qsnsil¥ +.6l, koae ? Kors koa Thee Teoh a>e” dmg) L bl Kol = 2,87 | ogh 4-e ue koi= 26,23 rglh ov | UO, 96 $mg/0,Sh Crekoy Daeea sta administeacos 0, 365 my dueant kexv SOminues Foo = |C/ 2 Ke XV | F (0,93340"x 3) f |8, hme gy} z h Koa gly x (0.93340 "x 6 Y) Read ngfh © 2\2F mol itp.coon ‘yplnk 1 | 8 Coo | | | 7 | h H LI r | f eee } | t T ramen : 0,24 cee eee eee “kos 3 9, 3232 4 | faPrebiema 4 Dados rv Fo + o,a(mgltg)h = 4 1 (mg/h) 0.29 x 70Kg = oerg Indust | ah helg stig o§ re laden a) Cpe Kexv Comaderands o> dad do administ por bi wv y= Hol adoee Donde se hea InC= InCo - Ket InCo = 9,2033 ke = 0, 900 sgiinl b Cox 10,003 1g) boca Vv ve ao Vatde! Kol (ytere | z o {+e | Kev. - — aren Aa Ces _Mmgth |x (1-€ } ah | Odooel Gre 48209 mall Tkalte = j oid on TR =4 te ore ett) 2) C+ 464 mgll. xe s( ) G: ‘at ngly ¢) Cox ker! V. Aomaly x.0,3006 h''x 4£ Wu, 0uz.ng h* ) CT = Con (btn fy) + |Coh(pexfuldaL} = 3,6¢ + 6.81 2962 ngll hd I, +0 900% BE Coy (Souity} |=) a O.mg|x!e . r Jp 800685 ) ; Sh (pou ") DP Ce AG alte } + 63 malt 9.006% t