LAB 13, 14 & 15

BIOPHARMACEUTICS & PHARMACOKINETICS

HOORIA ZIA
WOMEN INSTITUTE OF LEARNING ABBOTTABAD
 Lab-13
Advise Pharmaceutical Substitutes of the following prescribed drug products

S/No Prescribed Drug Products Pharmaceutical Substitutes Differences

Dosage form Product name Strength Route Dosage form Product name Strength Route
Tablet Quinidex 300mg P/O Capsule Qualaquin 324mg P/O
Generic(s) salt ester form Generic(s) salt ester form
1 Quinidine Sulphate Quinidine Sulphate
Dose: 200mg o.d Dose: 30mg/kg o.d
Dosage form Product name Strength Route Dosage form Product name Strength Route Dosage Form
Tablet Onset 8mg P/o
2 Generic(s) salt ester form Injection Onset 2mg/ml I/V
Ondansetron (HCl) Generic(s) salt ester form
Dose: 8mg t.i.d Ondansetron (HCl)
Dose: 2mg/ml sos
Dosage form Product name Strength Route Dosage form Product name Strength Route

1 Capsule Tetracycline 250mg P/O Tablet Tetracycline phosphate 250mg P/O

Generic(s) salt ester form
Tetracycline hydrochloride
Dose: 250mg q.i.d
Dosage form Product name Strength Route
Generic(s) salt ester form
Tetracycline phosphate complex
Dose: 500mg o.d
Salt form
Dosage form Product name Strength Route

2 Tablet Anac 50mg P/O Tablet Caflam 50mg P/O

Generic(s) salt ester form Generic(s) salt ester form
Diclofenac sodium Diclofenac potassium
Dose: 25mg b.d / 20mg o.d Dose: 50mg q.i.d
Dosage form Product name Strength Route Dosage form Product name Strength Route

1 Tablet Brufen 200mg P/O Tablet Brufen 400mg P/O

Generic(s) salt ester form Generic(s) salt ester form
Ibuprofen Ibuprofen
Dose: 100mg q.i.d Dose: 400mg o.d
Strength
Dosage form Product name Strength Route Dosage form Product name Strength Route

2 Injection Cefotax 250mg I/M Injection Cefotax 250mg I/M

Generic(s) salt ester form Generic(s) salt ester form
Cefotaxime Cefotaxime
Dose: 250mg b.i.d Dose: 500mg o.d
Dosage form Product name Strength Route Dosage form Product name Strength Route

Capsule Endocin 25mg P/O Tablet Methacil 25mg P/O

1 Generic(s) salt ester form Generic(s) salt ester form
Indomethacin Indomethacin
Release mechanism Release mechanism
Extended release Immediate release
Dose: 25mg (as recommended) Dose: 25mg (as recommended) Release
Dosage form Product name Strength Route Dosage form Product name Strength Route mechanism

Tablet Morphine ER 10mg P/O Capsule Magnus MR 10mg P/O

2 Generic(s) salt ester form Generic(s) salt ester form
Morphine Morphine Sulphate
Release mechanism Release mechanism
Extended release Immediate release
Dose: 10mg (as recommended) Dose: 10mg (as recommended)
S/ Therapeutic Class Prescribed Drug Products Therapeutic Substitutes
No
Dosage form Product name Strength Route Dosage form Product name Strength Route
Capsule Prozac 20mg P/O Tablet Zoloft 50mg P/O
Generic(s) salt ester form Generic(s) salt ester form
1
Anti-depressants Fluoxetine (HCl) Sertraline (HCl)
Prescribed Dose Recommended Dose
50mg 50mg

Dosage form Product name Strength Route Dosage form Product name Strength Route
Tablet Capoten 25mg P/O Tablet Lisna 20mg P/O
Generic(s) salt ester form Generic(s) salt ester form
Captopril Lisinopril
2 Anti-hypertensive
Prescribed Dose Recommended Dose
50mg o.d 20mg o.d

Dosage form Product name Strength Route Dosage form Product name Strength Route
Capsule Dilantin 100mg P/O Tablet Tegral 200mg P/O
Generic(s) salt ester form Generic(s) salt ester form
Phenytoin (Na) Carbamazepine
3 Anti-epileptics Prescribed Dose Recommended Dose
100mg b.i.d 100mg b.i.d

Dosage form Product name Strength Route Dosage form Product name Strength Route
Tablet Lozip 20mg P/O Capsule La Cap 30mg P/O
Generic(s) salt ester form Generic(s) salt ester form
Proton pump Omeprazole Lanasoprazole
4 Prescribed Dose Recommended Dose
Inhibitors
20mg b.d 30mg o.d

Dosage form Product name Strength Route Dosage form Product name Strength Route
Capsule Prozac 20mg P/O Tablet Cipramil 20mg P/O
Generic(s) salt ester form Generic(s) salt ester form
Fluoxetine (HCl) Citalopram (HBr)
Selective-Serotonin
5 Prescribed Dose Recommended Dose
Reuptake Inhibitors
20mg b.i.d 10mg b.i.d

Lab-14
Advise Therapeutic Substitutes of the following prescribed drug productss
S/No Prescribed Drug Products Generic Equivalent Drug Products

Dosage form Product name Strength Route of administration Dosage form Product name Strength Route
Tablet Disprin-Max 500mg P/O Tablet Ascard 300 mg P/O
Generic(s) salt ester form Strength Company
1 Aspirin 500mg Atco Laboratories Limited
Company Price Price
Reckitt benckiser Pak.LTD. Rs.111 Rs. 52

Dosage form Product name Strength Route of administration Dosage form Product name Strength Route
Capsule Azolib 250mg P/O Capsule Azomax 250mg P/O
Generic(s) salt ester form Strength Company
Azithromycin 250mg Novartis Pharma (PAK) LTD
2 Company Price Price
Stalwart Pharmaceuticals (PVT) Rs.180 Rs. 400
LTD

Dosage form Product name Strength Route of administration Dosage form Product name Strength Route
Tablet Lasix 20mg P/O Tablet Furine 40mg P/O
Generic(s) salt ester form Strength Company
Furosemide 20mg Murfy Pharmaceuticals (PVT) LTD
3 Company Price Price
Sanofi Aventis (PAK) LTD Rs.260 Rs.105

Dosage form Product name Strength Route of administration Dosage form Product name Strength Route
Injection Lanoxin 0.5mg/2ml I/V Tablet Digox 250mcg
Generic(s) salt ester form Strength Company
Digoxin 0.5mg/2ml Platinum Pharmaceuticals (PVT.) LTD
4 Company Price Price
Glaxosmithkline Rs.50 Rs.23

Dosage form Product name Strength Route of administration Dosage form Product name Strength Route
Tablet Leflox 250mg P/O Tablet Lefoxin 250mg P/O
Generic(s) salt ester form Strength Company
Levofloxacin 250mg Neutro Pharma (PVT) LTD
5 Company Price Price
Getz Pharma Pakistan (PVT) LTD Rs.416 Rs.700

Lab-15
Advise Generic Substitutes of the following prescribed drug products