Curriculum Vitae of Saeed Emadi

Department of Biological Sciences

Biochemistry Group
Institute for Advanced Studies in Basic Sciences (IASBS)
Professor Yousef Sobouti Street
Zanjan, Zanjan 45138-70368
IRAN
Fax: +98-24-33413317
Tel. +98-24-33413006
Email: emadi@iasbs.ac.ir
URL: http://www.iasbs.ac.ir/chemistry/Faculty/Name=emadi

I. PERSONAL DETAILS
• Date of Birth: 7th August 1959.
• Place of Birth: Zanjan, Iran.
• Marital status: Married, 2 children.

II. EDUCATION
1. 1989- 1995:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran:
Ph.D in Biochemistry. Thesis title: “Study on the hemopoietic activity of human
placenta, in vitro, and effects of stimulators and inhibitors of transcription and
translation on it” Supervisor: Dr. Bahram Goliaie.

2. 1985-1988:
Medical College, Shiraz University of Medical Sciences, Shiraz, Iran: MS in
Biochemistry. Thesis title: “Abnormal hemoglobins in some patients from Fars
province (southern Iran).” Supervisor: Dr. Ahmad Merat.

3. 1977-1984:
Agricultural College, Shiraz University, Shiraz, Iran: BS in Food Technology and
Nutrition.

4. 1971 1977:
High school studies in Shiraz, Iran (Razi and Pahlavi University High School).

5. 1965-1971:
Elementary studies in Tehran (Mehran School) and Shiraz, Iran (Dr. Mahmoud Hesabi
School)

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 III. WORK EXPERIENCE
• Since October 2015:
Faculty Member (Associate Professor), Department of Biological
Sciences, IASBS, Zanjan, Iran

• September 2008-October 2015:

Faculty Member (Assistant Professor), Dept. of Biological Sciences,
IASBS, Zanjan, Iran.

• August 1996- September 2008:

Faculty Member (Assistant Professor), Dept. of Chemistry, IASBS,
Zanjan, Iran.

IV. Research Fields

❖ Protein Aggregation and Alzheimer's Disease (AD)
1. Inhibition of Protein Aggregation
2. Mechanisms of Protein Aggregation
3. Proteases and Protein Aggregation
4. Diabetes, Protein Aggregation and AD
5. Metal Ions, Oxidative Stress and Protein Aggregation
6. Crowding Agents and Protein Aggregation
❖ Bionanoscience
1. Immobilization of Proteins onto Synthetic Mesoporous Materials
❖ Computational Neuroscience
2. Computational Approach to Memory and Aβ Aggregation

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 V. ARTICLES
1. Botha A. E., Ansariara, M., Emadi S. and Kolahchi M. R. (2022) Chimera
Patterns of Synchrony in a Frustrated Array of Hebb Synapses. Front. Comput.
Neurosci. 16, Article 888019.
2. Kargar, F., Emadi, S., Fazli, H. (2020) Dimerization of Aβ40 inside
dipalmitoylphosphatidylcholine bilayer and its effect on bilayer integrity: Atomistic simulation
at three temperatures. Proteins 88, 1540-1552.
3. Ansariara, M., Emadi, S., Adami, V., Botha, A. E., Kolahchi, M. R. (2020) Signs
of memory in a plastic frustrated Kuramoto model of neurons. Nonlinear Dyn. 100,
3685-3694.
4. Nemati, S.S., Emadi, S., Ghiasvand Mohammadkhani, L., Kompany-Zareh, M.,
Hasanzadeh, Z. (2019) Multivariate spectrofluorimetric detection of lipase isolated from
Serratia marcescens in chromatographic fractions. Spectrochim. Acta A 222, 5 Nov.
117137.
)1396( ‫ سعید عمادي‬، ‫ مهرداد حمیدي‬، ‫ مجتبی صلوتی‬،‫ کاظم پریور‬،‫ محسن کالنتري‬.5
‫استفاده از نانومیله هاي طال در درمان سلول هاي سرطانی سینه به روش نورگرما درمانی‬
‫ فصلنامه علمی پژوهشی فیزیولوژي و تکوین‬،‫و بررسی توزیع بافتی آن در مدل موشی‬
.96 ‫ تا‬81 ‫ صص‬،4 ‫ شماره‬10 ‫ جلد‬،‫جانوري‬
6. Kalantari, M., Salouti, M., Parivar, K., Hamidi, M., Emadi, S. (2018) The use of
Gold nanorods conjugated with Herceptin in breast cancer treatment by photothermal therapy
method in mouse model, Int. J. Nano Dimens., 9, 123-133.
7. Ali K.M., Poulakchi Saber, S., Taite., D. R., Emadi, S., Irving, R. (2017) The
Protective Layer of Zebrafish Embryo Changes Continuously with Advancing Age of Embryo
Development (AGED), J. Toxicol. Pharmacol. 1, 009.
8. Kargar, F., Emadi, S., Fazli, H. (2017) The Molecular Behavior of a Single β-Amyloid
inside a Dipalmitoylphosphatidylcholine Bilayer at Three Different Temperatures: An
Atomistic Simulation Study, Proteins 85, 1298-1310.
9. Tahmasebinia, F., Emadi, S. (2017) Effect of metal chelators on the aggregation of beta-
amyloid peptides in the presence of copper and iron, Biometals 30, 285–293.
10. Emadi, S., Meskini, S., Maghbooli, M. (2016) The Blood Level of Leptin in
Alzheimer’s Patients and Healthy Individuals, J. Adv. Med. Sci. Appl. Tech.
(JAMSAT) 2, 262-267.

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11. Emadi, S., Aghababaee, L., Maghbooli, M., (2016) Serum concentration of beta
amyloid peptide and the activity of angiotensin converting enzyme in alzheimer's disease
patients: search for a potential biomarker, Int. J. Res. Med. Sci. 4, 421-427.
12. Emamyari, S., Kargar, F., Sheikh-hasani, V., Emadi, S., Fazli, H. (2015)
Mechanisms of the self-assembly of EAK16-family peptides into fibrillar and globular
structures: Molecular dynamics simulations from nano- to micro-seconds, Eur. Biophys. J.
44, 263-276.
13. Emadi, S., Behzadi, M. (2014) A comparative study on the aggregating effects of
guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation, Biochem.
Biophys. Res. Commun. 450, 1339-1344.
14. Karimi, B., Emadi, S., Safari, A. A., Kermanian, M. (2014) Immobilization, stability
and enzymatic activity of albumin and trypsin adsorbed onto nanostructured mesoporous SBA-
15 with compatible pore sizes. RSC Advances 4, 4387–4394.
15. Jabbari, S., Ali, M. K., Emadi, S. (2014) Electrophoretic analysis of phospho and non-
phosphoprotein mixtures extracted from zebrafish whole brain samples by immobilized metal
affinity electrophoresis. J. Iran. Chem. Soc. 11, 1165–1172.
16. Kaboudin, B., Emadi S, Faghihi M. R., Fallahi M., Sheikh-Hasani V. (2013)
Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most
potent derivative is bound to the peripheral site of acetylcholinesterase. J. Enz. Inhib. Med.
Chem. 27, 1-7.
17. Kaboudin, B., Emadi, S., Arefi, M., Sheikh-Hasani V. (2012) Synthesis and
inhibitory activity of ureidophosphonates, against acetylcholinesterase: Pharmacological assay
and molecular modeling. Bioorg. Chem. 41-42, 22-27.
18. Emadi, S., Khalaji, F., Valipour, M. (2011) Acetylcolinesterase (AChE) and
amyloidogenesis. J. Iran. Chem. Soc. 8, Suppl. 3, A72-A77.
19. Fazli, H., Emadi, S., Emamyari, S., Sheikh-Hasani, V., Kargar, F. (2011) Multi-
scale molecular dynamics simulations and experimental study of peptides self-assembly: A way
to a better understanding of peptides and proteins self-assembly and amyloid formation. J.
Iran. Chem. Soc., 8, Suppl. 3, A78-A81.
20. Kaboudin, B., Emadi, S., Hadizadeh-Esfahani, A. (2009) Synthesis of novel
phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
Bioorg. Chem. 37,101–105.

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21. Kaboudin, B., Emadi, S., Norouzi, H. (2004) A convenient method for the synthesis of
phosphorothioates and their anticholinesterase activities. Phosphorous, Sulfur and
Silicon 179, 585-590.
22. Goliaie, B., Emadi, S. ( 1996 )
A study on the hemopoietic activity of human placenta in vitro, in the presence and absence of
stimulators and inhibitors of transcription and translation. Med. J. Isl. Rep. Iran 9 (4):
319-325.

VI. ABSTRACTS
1. M. Mohajer, S. Emadi, M. Vasighi
A Bioinformatics Investigation on The Relationship between Aggregation Propensity of
Peptides and Proteins and Their Amino Acid Sequence, Extent of Beta Structure and
Intrinsically Disordered Regions in Their Structures. 6th IASBS Symposium in
Biological Sciences and 16th Conference of Iran Society of Biophysical
Chemistry (ISOBC), 4-5 February 2021, Zanjan, Iran.
2. P. Niazi, S. Emadi
Investigation of Amyloid Beta-42 Peptide Aggregation in The Presence of Insulin and
Amylin Peptides (IAPP). 6th IASBS Symposium in Biological Sciences and 16th
Conference of Iran Society of Biophysical Chemistry (ISOBC), 4-5 February
2021, Zanjan, Iran.
3. M. Ghoreishi, S. Emadi, P. Moradi
An Investigation on the Inhibitory Effects of Essential Oils, Extracted from Aerial Parts of
Salvia officinalis, on Protein Aggregation. 6th IASBS Symposium in Biological
Sciences and 16th Conference of Iran Society of Biophysical Chemistry
(ISOBC), 4-5 February 2021, Zanjan, Iran.
4. S. Alimohamadi Nafchi, S. Emadi
A Study on Inhibition of Aggregation: Inhibition of Amyloid Beta Peptide and Lysozyme
Aggregation by Sumoylation and Thymus daenensis Essence, Respectively. 6th IASBS
Symposium in Biological Sciences and 16th Conference of Iran Society of
Biophysical Chemistry (ISOBC), 4-5 February 2021, Zanjan, Iran.
5. A. Abolhassani and S. Emadi
An Investigation of the Effects of Different Crowding Agents on Lysozyme Aggregation in
the Presence and Absence of Di-Sulfide Bond Reduction Agents. 5th IASBS Symposium
in Biological sciences, January 15-17, 2020, Zanjan, Iran.

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 6. A. Aimiri, S. Emadi, F. Kazemi
Immobilization of Acetylcholinesterase Enzyme inside Carboxymethycellulose Hydrogels and
Comparing its Enzymatic Activity with Solubilized Acetylcholinesterase. 5th IASBS
Symposium in Biological sciences, January 15-17, 2020, Zanjan, Iran.
7. A. Javadi, S. Emadi, M. Pakpour
Aggregation of Aβ42 and Lysozyme in the Presence and Absence of the Natural Peptide
Fasciculin 2 and the Synthetic Peptide KLVFF. 15th CBC Conference on Biophysical
Chemistry, October 23-24, 2018, Gorgan, Iran.
8. M. Ahmadi, S. Emadi
Vitamin C Decreases the Toxicity of Aβ42 in SH-SY5Y Cell Culture Assay. 3rd IASBS
Symposium in Biological Sciences, International Symposium of Protein Folding
and Stability, November 2-4, 2017, IASBS, Zanjan, Iran.
9. S. Karimipasnd, S. Emadi
The toxicity of amyloid beta peptide on SH-SY5Y cells in the presence and absence of copper ions
and metal chelators. 3rd IASBS Symposium in Biological Sciences, International
Symposium of Protein Folding and Stability, November 2-4, 2017, IASBS, Zanjan,
Iran.
10. E. Heydari, S. Emadi
The Effects of Trypsin on the Aggregation of Lysozyme and its Aggregates. 3rd IASBS
Symposium in Biological Sciences, International Symposium of Protein Folding and
Stability, November 2-4, 2017, IASBS, Zanjan, Iran.
11. A. Javadi, S. Emadi
Study on the Aggregation of Amyloid Beta Peptide and Lysozyme in the Presence of a Short and
Natural Peptide, Fasciculin-II. 3rd IASBS Symposium in Biological Sciences,
International Symposium of Protein Folding and Stability, November 2-4, 2017,
IASBS, Zanjan, Iran.
12. S. Taslimi, S. Emadi
A Study on the Effect of Dithiothreitol and Beta-mercaptoethanol on the Production of Lysosomal
Aggregates. 3rd IASBS Symposium in Biological Sciences, International Symposium of
Protein Folding and Stability, November 2-4, 2017, IASBS, Zanjan, Iran.
13. E. Gheisari, S. Emadi
Investigation on the proteolytic effects of neprilysin and insulin degrading enzyme on the aggregation of
Aß40 peptide. 3rd IASBS Symposium in Biological Sciences, International Symposium of
Protein Folding and Stability, November 2-4, 2017, IASBS, Zanjan, Iran.

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14. S. Emadi, E. Gheisari
Investigation on the proteolytic effects of neprilysin on the aggregation of beta amyloid peptide. 19th and
7th National and International Congress of Biology, August 30– September 1, 2016,
Tabriz, Iran.
15. L. Ghiasvand Mohammadkhani, S. Emadi, S. S. Nemati, M. Kompany-Zareh
Production and purification of lipase from Serratia marcescens ATCC 13880 and multi-way
fluorescence based enzyme quantification. 23th Iranian Analytical Chemistry Seminar, August
31– September 3, 2016, Sharif University, Tehran, Iran.
16. S. Emadi, E. Heidari
Study on the effects of trypsin and α-chymotrypsin on lysozyme aggregation using SDS-PAGE. 19th
and 7th National and International Congress of Biology, August 30– September 1,
2016, Tabriz, Iran.
17. F. Tahmasebinia, S. Emadi
Effects of clioquinol on the aggregation of beta-amyloid peptides in the presence and absence of metal
ions and astrocyte-mediated inflammation. International Congress of Immunology, 21–26
August 2016, Melbourne, Australia.
18. S. Emadi, F. Tahmasebinia
Effect of metal chelators on the aggregation of beta amyloid peptides in the presence of metal ions. 12th
International Conference on Alzheimer's & Parkinson's Diseases, March 18 – 22,
2015, Nice, France.
19. S. Emadi, Z. Abbasskhani
Kinetics of metal ions-induced aggregation of lysozyme. The National Conference on Protein
and Peptide Sciences. "From Basic to Medical and Industrial Applications",
December 10 -11, 2014, Shiraz University, Shiraz, Iran.
20. S. Emadi, F. Hassanzadeh
Investigation on the cytotoxic effects of amyloid peptides on PC12 cultured cells. 18th National and
6th International Congress of Biology, August 26 -29, 2014, Kharazmi University, Karaj,
Iran.
21. S. Emadi, Z. Abbasskhani
Effect of metal ions (copper and iron) on the aggregation of beta amyloid peptide. 18th National and
6th International Congress of Biology, August 26 -29, 2014, Kharazmi University, Karaj,
Iran.
22. S. Emadi, L. Aghababaie, M. Maghbooli
Measurement of Aβ1-40 level in the peripheral blood of the Alzheimer's disease patients. 1st Tabriz
International Life Science and 12th Iran Biophysical Chemistry Conference, May 22 -
24, 2013, Tabriz University of Medical Sciences, Tabriz, Iran.

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23. M. Behzadi, S. Emadi
Effects of ionic strength and chaotropic agents on lysozyme aggregation. The First International &
11th Iran Biophysical Chemistry Conference, June 13-15, 2012, Ardabil University of
Medical Sciences, Ardabil, Iran.
24. F. Karimi Hafshejani, S. N. Seyyed Reihani, S. Emadi
Investigation on elasticity of intact and diabetic rbc membrane using optical tweezers . The First
International & 11th Iran Biophysical Chemistry Conference, June 13-15, 2012, Ardabil
University of Medical Sciences, Ardabil, Iran.
25. S. Zeinali Lathori, S. N. Seyed Reihani, S. Emadi
Investigation of mechano-chemical properties of lambda phage genome using optical tweezers . The
First International & 11th Iran Biophysical Chemistry Conference, June 13-15, 2012,
Ardabil University of Medical Sciences, Ardabil, Iran.
26. S. Davari, S. Emadi
A comparative study of non-hydrolytic activities of acetyl and butyrylcholinesterase enzymes and their
impact on the formation of beta-amyloid aggregation. The First International & 11th Iran
Biophysical Chemistry Conference, June 13-15, 2012, Ardabil University of Medical
Sciences, Ardabil, Iran.
27. O. B. Kruglova, H. Mehralitabar Firozja, S. Emadi
Investigation on the effect of salt concentration on the binding modes of doxorubicin to DNA with the
use of McGhee-von Hippel equation. The First International & 11th Iran Biophysical
Chemistry Conference, June 13-15, 2012, Ardabil University of Medical Sciences, Ardabil,
Iran.
28. S. Emamyari, H. Fazli, S. Emadi
Study on the dependency of the self-assembly of an ionic complementary peptide on environmental pH
conditions. 17th Conference on Condensed Matter Physics, May 26-27, 2012, Zanjan,
Iran.
29. S. N. Seyed Reyhani, S. Zeinali Lathory, S. Emadi
Investigation on the mechano-chemical specificities of lambda phage DNA with the use of optical
tweezer technique. 12th Iranian Genetics Congress, May 22-24, 2012, Tehran, Iran.
30. A. A. Safari, S. Emadi, B. Karimi
Bovine serum albumin adsorption on the Nano-engineered mesoporous silicate SBA-15; effects of
temperature, mixing time, pH and ionic strength. 4th International Conference on
Nanostructures (ICNS4), March 12-14, 2012, Kish Island, Iran.

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31. S. Emamyari, H. Fazli, S. Emadi
An experimental and molecular dynamics simulation study of the self-assembly of eak-16 peptides and
their resulting nanostructures. 10th Conference on Condensed Matter Physics, January 26-
27, 2011, Shiraz, Iran.
32. S. Emadi, T. Panahi, and A.A. Safari
A. study of trypsin behavior into functionalized nano-engineered SBA-15: Loading and stability of
enzyme. 3rd Conference on Nanostructures (NS2010), March 10-12, 2010, Kish Island,
Iran.
33. S. Emadi, B. Karimi, M. Kermanian
Adsorption of albumin and trypsin onto nanoporous sba-15 channels: activity, and thermal and
proteolytic stability. 15th Iranian Seminar of Organic Chemistry”, August 27-29, 2008,
University of Kermanshah, Iran.
34. S. Emadi, B. Kaboudin, D. Elhamifar
Synthesis of phosphrothioate compounds and the study of their inhibitory effects on acetylcholinesterase
(AChE) enzyme. 30th FEBS Congress & 9th IUBMB Conference, July 2005, Budapest,
Hungary, (The FEBS Journal, 272, Supplement 1).
35. S. Emadi, B. Kaboudin, H. Norouzi
Inhibitory effects of a number of synthetic phosphorothioate compounds on acetylcholinesterase. 7th
Iranian Congress of Biochemistry, January 2004, Ahvaz, Iran.
36. S. Emadi, F. Masdarolomour
Activity and kinetics of bovine pancreatic ribonuclease in organic-aqueous media. Abs. No. 324,
225th American Chemical Society National Meeting, March 2003, New Orleans, USA.

VIII. THESES SUPERVISED (PhD)

1. Kargar Haji-Abadi, Faezeh. Molecular Dynamics Study of Peptide Aggregation with the Use
of Model Peptides: Beta-Amyloid (Aβ) in Membrane, EAK16 in Solution. May 2017. (Co-
supervisor: Dr. H. Fazli, Dept. Physics, IASBS)

IX. THESES SUPERVISED (Master)

1. Mousavi, Hajar. A Study on the Roles of Proteolytic Enzymes on the Aggregation of Proteins and
Peptides: Role of Neprilysin and Angiotensin Converting Enzyme on the Aggregation of Lysozyme as
a Model Protein in Aggregation. November 2022.
2. Avizheh, Sara. Effect of Aggregated Lysozyme and Insulin on SH-SY5Y Cell Line and
Mesenchymal Stem Cells. September 2022.
3. Habashi, Mina. Investigation on The Effect of Divalent Copper Ion on the Aggregation and
Oxidative Effect of Amyloid Beta Peptide in the Presence and Absence of Chemical Chelator.
December 2021.

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4. Mohajer, Maryam. A Bioinformatic Investigation on the Relationship between Aggregation
Propensity of Peptides and Proteins and their Amino Acid Sequence, extent of Beta Structure and
Intrinsically Disordered Regions in their Structures. February 2021. (Advisor: Dr. Mahdi
Vasighi)
5. Alimohamadi Nafchi, Samaneh. Inhibition of Amyloid Beta Peptide and Lysozyme
Aggregation by SUMOylation and Thymus daenensis Essence, Respectively. January 2021.
(Advisors: Dr. Khosro Khajeh, Dr. Parviz Moradi)
6. Niazi, Parnaz. Investigation of Amyloid Beta 42 Peptide Aggregation in the Presence of Insulin
and IAPP (Amylin) Peptides. December 2020.
7. Ghoreishi, Mohammad. An Investigation on the Inhibitory Effects of Essential Oils,
Extracted from Aerial Parts of Salvia officinalis, on Protein Aggregation. October 2020.
(Advisor: Dr. Parviz Moradi)
8. Masiri, Mohammad. Transfer of Luciferase CP-RLUC8 Biosensor Gene to SH-SY5Y Cells,
to be Used as a Neuronal Model of Apoptosis and Differentiation. January 2020. (Co-
Supervisor: Dr. Shiva Akbari Birgani)
9. Abolhassani, Aghdas. Effect of Chemical and Natural Crowding Agents on the Aggregation of
Lysozyme. September 2019.
10. Amiri, Ahmad. Immobilization and Activity Assay of Acetyl-and Butyrylcholinesterase Enzymes
onto Hydrogel Supports. September 2019.
11. Omraie, Bahar. The Effect of Metal Ions (Copper, Iron and Zinc) on the Aggregation of Tau
Protein and their Resulted Aggregates on the SH-SY5Y Cell Line Viability. September 2019.
12. Javadi, Atefe. Aggregation of Amyloid Beta Peptide and Lysozyme in the Presence and Absence of
Natural Peptide Fasciculin-II and Synthetic Peptide KLVFF. June 2018.
13. Karimipasand, Sonia. A Cell Culture and an In Vitro Study on the Toxicity and Aggregation
of Amyloid Beta Peptide in the Presence and Absence of Metal Ions and Chelators. April 2018.
14. Ahmadi, Mina. A Study on Aβ42 Aggregation and Toxicity by Molecular and Cellular
Methods, in the Presence and Absence of Antuoxidants such as Vitamins E and C. April 2018.
15. Sherafati, Mandana. A Study on Visual Memory with the Use of Deep Learning Method.
March 2018. (Advisor: Prof. Mohammad Kolahchi, Dept. Physics, IASBS)
16. Seifi, Afsaneh. Effects of Crowding Agents on the Aggregation of Lysozyme Protein. August
2017.
17. Gheisari, Elham. Effect of Proteolytic Enzymes, Neprilysin and Insulin Degrading Enzyme, on
Aggregation Process and Aggregates of Beta Amyloid Peptides: Anticipation, Molecular Analysis and
Toxicity Assay. January 2017.
18. Heidari, Elahe. Study on the effect of lysozyme hydrolysis, by trypsin and α-chymotrypsin, on the
formation of lysozyme aggregates and also effect of these enzymes on the aggregated complexes of
lysozyme molecules. September 2016.

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19. Nemati, Saman. Separation of Lipase from Serratia marcescens, Enzyme Activity Measurement
by Fluorescent Spectroscopy, and Chemometrical Analysis of Results. August 2016. (Advisor:
Prof. M. Kompany-Zare, Dept. Chemistry, IASBS)
20. Yazdani, Sara. The effect of antioxidants (e.g., vitamin E) on the aggregation of Aβ 42. A cell
culture (PC12) study. May 2015.
21. Hassanzadeh, Fariba. A study on the effects of acethylcholinesterase enzyme on the promotion of
toxic effects of Aβ 42 in PC12 cell culture. March 2015.
22. Tahmasebinia, Foozhan. A comparative study on the effects of metal chelators on the formation
of amyloid-β aggregation, in the presence and absence of metal ions. March 2015.
23. Vahabi, Elham. Enzymatic degradation of beta- amyloid in health and disease. March 2015.
24. Abbasskhani, Zahra. Effect of metal ions on the aggregation of lysozyme and beta amyloid
peptide. January 2015.
25. Mokhtari, Robab (Dept. Physics). Scale-free networks in neuronal systems. June 2014. (Co-
supervisor: Dr. M. Kolahchi, Dept. Physics, IASBS)
26. Taslimi, Samaneh. A study on the effect of dithithreitol and beta mercaptoethanol on the
production of lysozomal aggregates. April 2014.
27. Meskini, Somayeh. Concentration of leptin hormone in the peripheral blood serum of
Alzheimer's disease patients in comparison with healthy individuals. April 2014. (Advisor: Dr.
Maghbooli, MD, Dept. Neurology, Zanjan University of Medical Sciences)
28. Yousefian, Sevda. A study on the proteolytic effect of trypsin and chymotrypsin enzymes on the
aggregates of lysozyme. March 2014.
29. Safargholizadeh, Elham. The concentration of insulin hormone in the peripheral blood serum of
Alzheimer's disease patients in comparison with healthy individuals. March 2014. (Advisor: Dr.
Maghbooli, MD, Dept. Neurology, Zanjan University of Medical Sciences)
30. Aghababaee Goorabjiri, Leyla. The measurement of the activity of angiotensin converting
enzyme (ACE) and the ratio of concentrations of Aβ1-42 to Aβ1-40 in the peripheral blood serum of
Alzheimer's disease patients. September 2013. (Advisor: Dr. Maghbooli, MD, Dept.
Neurology, Zanjan University of Medical Sciences)
31. Davari, Soheila. A comparative study on the effects of non-hydrolytic activities of acetyl- and
butyrylcholinesterase enzymes on the formation of beta amyloid aggregation, in the presence and absence
of enzymatic inhibitors. April 2013.
32. Behzadi, Maliheh (Mahsa). A study on the effect of different concentrations of salt, urea,
guanidine thiocyanate and guanidine hydrochloride on the aggregation of lysozyme. March 2013.
33. Karimi Hafshejani, Fatemeh. An investigation into elasticity of normal RBC membrane using
optical tweezers. March 2013. (Co-supervisor: Dr. S. N. Seyed-Reyhani, Dept. Physics,
IASBS)

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34. Arastou, Mohammad Reza. Study of miRNA presence in the plasma fractions of gastric cancer
patients. September 2012. (Co-supervicor: Dr. O. R. Faridani, Dept. Molecular Biology,
Karolinska Institute, Stockholm, Sweden)
35. Zeinali Lathori, Somayeh. Preparation of labeled DNA samples to be used in
mechanochemical studies using optical tweezers. September 2012. (Co-supervisor: Dr. S. N.
Seyed-Reyhani, Dept. Physics, IASBS)
36. Rezaie, Hedyeh (Dept. Physics). Investigation of synchronization and bursting in a triangular
array of Morrris-Lecar neurons. December 2011. (Co-supervisor: Dr. M. Kolahchi, Dept.
Physics, IASBS)
37. Valipour, Masoumeh. The effects of solution conditions such as temperature, pH, ionic strength
and chemical denaturants on lysozyme amyloid aggregation. July 2011.
38. Khalaji Farzaneh. The role of nonhydrolytic activity of acetylcholinesterase enzyme in the amyloid
aggregation of amyloid-β peptide. July 2011.
39. Shafeghat, Shima. Purification of protease inhibitor from human serum and its use in separation
of cellular protein complexes from erythrocyte membrane. February 2011. (Co-supervisor: Dr.
M. K. Ali, Dept. Biological Sciences, IASBS)
40. Jabbari, Safoura. Phosphoprotein purification by metal-ion affinity electrophoresis and its
application. February 2011. (Co-supervisor: Dr. M. K. Ali, Dept. Biological Sciences,
IASBS)
41. Panahi, Tahmineh (Dept. Chemistry). Immobilization of trypsin and lipase on regular and
functionalized nanoengineered mesoporous SBA-15. June 2010. (Advisor: Dr. B. Karimi, Dept.
Chemistry, IASBS)
42. Abdollahpour, Rokhsareh (Dept. Physics). A study on electrical activity of neurons (action
potential) on the basis of Hodgkin-Huxley model. June 2010. (Co-supervisor: Dr. M.
Kolahchi, Dept. Physics, IASBS)
43. Kermanian, Mehraneh (Dept. Chemistry). A study on immobilization of proteins on nano-
engineered sba-15 channels and their interactions with SBA-15 supports. September 2008.
(Advisor: Dr. B. Karimi, Dept. Chemistry, IASBS)
44. Hadizadeh-Esfahani, Atefeh (Dept. Chemistry). A structure–activity approach to the
interaction of acetyl and butyryl cholinesterases with synthetic phosphorothioates and
phosphorodithioates. July 2008. (Advisor: Dr. B. Kaboudin, Dept. Chemistry, IASBS)
45. Safari, Ali Asghar (Dept. Chemistry). Some new applications of silica-based scandium (iii)
interphase catalyst and the study of protein immobilization onto nanoengineered mesopores of SBA-
15. March 2006. (Co-supervisor: Dr. B. Karimi. Dept. Chemistry, IASBS)
46. Elhamifar, Davood (Dept. Chemistry). Synthesis of phosphorodithioates and study of their
inhibitory effects on activity and kinetics of acetylcholinesterase enzyme and novel methods for the
synthesis of thioamides from nitriles. December 2005. (Advisor: Dr. B. Kaboudin, Dept.
Chemistry, IASBS)

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47. Masdarolomour, Fatemeh (Dept. Chemistry). A study on activity and kinetics of bovine
pancreatic ribonuclease a in organic-aqueous medium by UV spectroscopy. December 2002.

X. THESES ADVISED (Master)

1. Mirzaiee, Meisam (Dept. Chemistry). Separation and purification of albumin and
immunoglobulins of human blood plasma by using ion exchange chromatography. November 2017.
(Supervisors: Dr. Mohsen Kompany, Dept. Chemistry at IASBS, and Dr. Ali
Ramezani, Dept. Medical Biotechnology, School of Pharmacy, Zanjan University of
Medicine).
2. Shahsavari, Mahvash (Dept. Chemistry). Study of separation of whey proteins using fractional
precipitation and three-way fluorescence spectra. June 2016. (Supervisor: Dr. Mohsen
Kompany, Dept. Chemistry, IASBS).
3. Khanbabaei-Meidani, Elmira (Dept. Chemistry). |Application of fluorescence spectroscopy
in evaluating the purity of separated proteins from whey using ultrafiltration combined with ion
exchange chromatography. May 2016. (Supervisor: Dr. Mohsen Kompany, Dept.
Chemistry, IASBS).
4. Shirdel, Arezoo. Immobilization of porcine pancreatic lipase onto periodic mesoporous
organosilicates (PMOs). December 2015. (Supervisors: Dr. Shekoufeh Zareian, Dept.
Biological Sciences, and Dr. Babak Karimi, Dept. Chemistry, IASBS).
5. Mousavi, Fatemeh (Dept. Chemistry). Voltametric Study of Chemical Reactions Coupled to
Electron Transfer in Adrenaline, Noradrenaline and Serotonin. October 2014. (Supervisor: Dr.
Mohammad Rafie, Dept. Chemistry, IASBS).
6. Aieni, Samira (Dept. Chemistry). A novel method for the synthesis of dexomedetomidine and
studies on the anti-cholinesterase activity of carbamoyl and thiocarbamoyl phosphinic acids. June
2014. (Supervisor: Dr. Babak Kaboudin, Dept. Chemistry, IASBS)
7. Tamimi, Faezeh. Comparative analysis of amino acids interactions network of hub and non-hub
proteins in yeast. October 2013. (Supervisors: Dr. Ali Masoudinejad, Institute of
Biochemistry and Biophysics (IBB), University of Tehran and Dr. Hossein Fazli, Dept.
Physics, IASBS).
8. Ahmadi, Soraya. Study on inhibitory effect of carbamoyl and thiocarbamoyl phosphinates on
aminopeptidase and effort toward synthesis of thiophosphate adenine nanlogues. August 2012,
(Supervisor: Dr. Babak Kaboudin, Dept. Chemistry).
9. Hasani Nia, Fatemeh. Investigation of multi-protein complexes of zebrafish brain before and
after treating with addictive drugs (alcohol and nicotine) through BN-PAGE. February 2012,
(Supervisor: Dr. Mohammad Kutub Ali, Dept. Biological Sciences).

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10. Fallahi, Maryam (Dept. Chemistry). A novel method for the Synthesis of α-carbamoyloxy
phosphonates and studying of their anti-cholinesterase activities. October 2011, (Supervisor: Dr.
Babak Kaboudin, Dept. Chemistry, IASBS).
11. Arefi, Marzban (Dept. Chemistry). Synthesis of novel α-ureidophosphate derivatives and study
of their inhibitory effects on activity of acetylcholinesterase enzyme. September 2011, (Supervisor:
Dr. Babak Kaboudin, Dept. Chemistry, IASBS).

XI. THESES ADVISED (PhD)

1. Tavaddod, Sharareh. Effect of active pumps, rotary hooks, and inactive flagella, on 3D
Brownian motion of Escherichia coli using single-particle tracking. May 2011, (Supervisor: Dr.
Ramin Golestanian, Dept. Physics, IASBS; Other Advisors: Dr. Hamid Reza
Khalesifard, Dept. Physics, IASBS; Dr. Conrad Woldringh, Dept. Physics, Univ.
Amsterdam, The Netherlands)
2. Godazgar, Tahmineh. Potential mapping of optical tweezers and using it to investigate elastic
properties of DNA. September 2011, (Supervisor: Dr. S. N. Seyed-Reihani, Dept.
Physics, IASBS)

XII. CURRENT STUDENTS (Master)

1. POUYA ALIMOHAMMADI: ? (2022)
2. SARA GHORESHI: Sleep, Melatonin and Aβ Aggregation. (2021)
3. FATEMEH MIRI: Anti-Aggregation Effect of Porphyrins (Co-Supervisor: Dr. Ali-
Akbar Meratan). (2021)
4. MASOUD ALIMORADI: Protein Aggregation and Apoptosis (Co-Supervisor: Dr.
Shiva Akbari-Birgani). (2020)
5. MOJGAN MIRZAZADEH: Drug Binding to Glycated Serum Albumin Aggregates (Co-
Supervisor: Dr. Mehran Habibi-Rezaie (Univ. of Tehran). (2020)
6. ZAHRA KALANTARI: Liquid-Liquid Phase Separation in the Aggregation Process of
Proteins (Co-Supervisor: Dr. Hossein Fazli) (2020)
7. RAMIN RASAIE: Amino Acid Sequence and Protein Aggregation (Co-Supervisor: Dr.
Mehdi Vasighi) (2020)
8. ZAHRA MAHMOUDI: Mitochondria, ROS and Amyloidogenesis (Co-Supervisor: Dr.
Ali Akbar Meratan). 2019

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 XIII. EXECUTIVE ACTIVITIES
• Head of the Education Affairs at IASBS: Since October 2016.
• Head of the Department of Biological Sciences: September 2008-September 2015.
• Head of the IASBS Central Library: April 2003-September 2008.

XIV. COURSES TAUGHT

❖ Graduate Courses:
• Biochemical Methods
• Biochemistry of the Nervous System
• Biochemistry of Hormones
• Enzymology
• Physical Biochemistry of Proteins and Nucleic Acids
• Regulation of Metabolism
• Biochemistry of Carbohydrates and Lipids
• Cell and Molecular Biology

XV. MEMBERSHIP IN PROFESSIONAL SOCIETIES

• Iranian Biochemical Society
• Iranian Nanotechnology Society
• Iran Society of Biophysical Chemistry
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End of Curriculum Vitae (Updated Dec 2022)

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