1/21/23, 10:43 PM Gamma-glutamyltransferase (GGT), γ-Glutamyl Transpeptidase

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Gamma-glutamyltransferase (GGT), γ-Glutamyl Transpeptidase

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Table of Contents
1. Gamma-glutamyltransferase (GGT)
1.0.1. Sample for Gamma-glutamyl Transferase
1.0.2. Purpose of the test (Indications) for Gamma (γ) Glutamyl Transpeptidase
1.0.3. Precautions for Gamma-Glutamyl Transferase
1.0.4. Definition of Gamma-Glutamyl-transferase (GGT)
1.0.5. The biochemical function of the γ-glutamyl-transferase:
1.0.6. γ-glutamyl-transferase (GGT) concentration at different sites:
1.0.7. Importance of the gamma-glutamyl-transferase:
1.0.8. Functions of the gamma-glutamyl-transferase:
1.0.9. Normal Gamma- Glutamyl-Transferase
1.0.10. Raised levels of Gamma- Glutamyl-Transferase are seen in the following:
1.0.11. The decreased level of Gamma- Glutamyl Transferase is seen in the following:
1.0.12. γ-GT values are normal, seen in the following conditions:
1.0.13. Questions and answers:

Gamma-Glutamyltransferase (GGT)
Sample for Gamma-glutamyl Transferase
1. The venous blood is needed to prepare the serum.
2. The serum is stable for one month at 4 °C.
3. The serum can be stored for one year at -20 °C.
4. Heparinized samples interfere with various methods.

Purpose of the test (Indications) for Gamma (γ) Glutamyl Transpeptidase

1. This test is done for liver dysfunction.
2. This is also useful for detecting alcohol-induced liver cell injury and chronic alcoholics.
3. This test can detect the slightest degree of cholestasis.
4. GGT is very sensitive to biliary obstruction, cholangitis, and cholecystitis.
5. GGT is a good marker for pancreatic, prostatic, and liver cell carcinoma.
6. GGT level indicates remission and recurrence.

Precautions for Gamma-Glutamyl Transferase

1. Keep in mind that the value may be low in late pregnancy.
2. Drugs that decreased the value are Clofibrate and oral contraceptives.
3. Drugs that increase the value are Alcohol, Dilantin, and Phenobarbital.
4. GGT is raised in patients who are taking antiepileptic drugs.

Definition of Gamma-Glutamyl-transferase (GGT)

1. γ-glutamyl-transferase is a membrane-bound enzyme that is mainly present in the liver and cells lining the bile ductules and bile canaliculi.
2. γ-glutamyl-transferase was formerly called gamma-Glutamyltranspeptidase, which is mainly present in hepatocytes.
3. To a lesser extent is present in the kidneys, biliary tract epithelium, intestine, pancreas, brain, heart, and spleen.
4. GGT activity is also seen in the capillary endothelium.
5. GGT is responsible for the extracellular metabolism of glutathione, and it is the main antioxidant in the cells.
6. Serum GGT is raised in the newborn and comes to the adult level by 4 months of age.
7. GGT value may be higher in obese patients than in lean people.

The biochemical function of the γ-glutamyl-transferase:

1. γ-Glutamyl Transpeptidase is one of many peptidases cleaving terminal peptide bonds of proteins or peptides.
1. The C-terminal amino acid must be glutamic.
2. Specificity resides in the (γ) Glutamyl portion of the substrate.
3. Three different reactions have been attributed to this enzyme:
1. Hydrolysis.
2. Internal transpeptidation.
3. External transpeptidation.
4. Glutathione is the common substrate of this enzyme in the body.
1. This enzyme participates in amino acid transport by transferring the γ-Glutamyl portion of glutathione to other amino acids,
enabling them to cross cell membranes more easily.
2. GGT is present in the following:
1. Liver.
2. The proximal tubule of the kidney.
3. Brain.
4. Pancreas.
5. Intestine.
6. Prostate.
7. Capillary endothelial cell.

γ-glutamyl-transferase (GGT) concentration at different sites:

Privacy - Terms
1. The main concentration is present in the hepatocytes.

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1/21/23, 10:43 PM Gamma-glutamyltransferase (GGT), γ-Glutamyl Transpeptidase
2. GGT is found in the biliary tree’s epithelial cells, mostly in the interlobular bile ducts and bile ductules. This is the reason that it is susceptible to
biliary injury.
1. GGT is present in the kidney, pancreas, spleen, heart, intestine, brain, and prostate gland.
2. GGT level is higher in men because of the additional amount due to the prostate.
3. The kidney has a maximum amount, but the liver is considered the normal source of serum activity.
4. It is found throughout the hepatobiliary system and other tissues.
3. GGT is present in the microsomes of the cytoplasm and the cell membrane.

(https://labpedia.net/wp-content/uploads/2020/01/GGT-in-cell.jpg)
Gamma-glutamyltransferase (GGT): GGT distribution in the cell

4. The Minimal amount detected in the endothelium of capillaries.

5. GGT takes part in transferring amino acids and peptides across the cell membrane.

(https://labpedia.net/wp-content/uploads/2020/01/gamma-GT-enzyme.jpg)
Gamma-glutamyltransferase (GGT): Gamma GT enzyme distribution

Importance of the gamma-glutamyl-transferase:

1. This test has been useful in detecting a male in nearly-risk drinkers (Not in females).
1. This is most applicable as part of an alcoholic screening program.
2. It returns to normal after abstinence from alcohol for 3 weeks.
3. It can be used as a follow-up marker of alcohol intake.
2. It is a more sensitive indicator of liver disease in children than alkaline phosphatase.
3. This is a susceptible test for liver cell injury and its correlation with the alkaline phosphatase level.
4. GGT is raised in acute myocardial infarction, and the mechanism is unclear.
1. If it occurs in the first 7 days, it may be due to liver insult.
2. Otherwise, it is usually raised in 1 to 2 weeks.
5. However, its raised level is nonspecific because it is raised in cardiac, pulmonary, pancreatic, renal disorders, diabetes, and alcoholism.
6. GGT correlates with alkaline phosphatase in obstructive jaundice and metastatic liver infiltration.
1. In such a case, GGT is more sensitive and specific.
7. GGT is not raised in bone disease, while GGT and alkaline phosphatase will be raised in liver disease.
8. The overall clinical significance is limited.

Functions of the gamma-glutamyl-transferase:

1. GGT transports amino acids across the cell membrane.
2. GGT is a sensitive indicator of liver disease, especially hepatobiliary obstruction.
3. GGT is not raised in bone, muscle, and hemolytic anemia.

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1/21/23, 10:43 PM Gamma-glutamyltransferase (GGT), γ-Glutamyl Transpeptidase

(https://labpedia.net/wp-content/uploads/2020/01/gamma-GT-functions.jpg)
Gamma-glutamyltransferase (GGT): functions

GGT normal with raised alkaline phosphatase indicates skeletal muscle disease.
GGT raised with alkaline phosphatase indicates hepatobiliary disease.

Normal Gamma- Glutamyl-Transferase
Source 2

Male and female age 45 years and older = 8 to 38 units/L  (8 to 38 IU/L)

Female younger than 45 years = 5  to 27 units/L (5 to 27 IU/L)
Older people = Slightly higher than the adults
Newborn = 5 times higher than adults.
Child = Similar to adult level.

Another Source

Male = 7 to 47 U/L.
Female = 5 to 25 U/L.
Newborn = 5 times higher than an adult.
Another reference
Adult male = up to 55 U/L.
Adult female = 38 U/L.
The newborn is 6 to 7 times higher than the adults.
It is like an adult after 5 to 7 months.

Raised levels of Gamma- Glutamyl-Transferase are seen in the following:

1. Obstructive liver disease and posthepatic obstruction.
1. This may reach 5 to 30 times the normal value.
2. Infectious hepatitis, where the rise is 2 to 5 times the normal value. It is seen in 90% of the cases.
3. Liver diseases like cirrhosis have space-occupying lesions.
4. The mild increase in the fatty liver.
5. Infectious mononucleosis,
6. Renal transplant.
7. It may be increased in renal failure.
8. Hyperthyroidism.
9. Diabetes mellitus.
10. Pancreatitis.
1. The increase may be 5 to 15 times the normal value.
11. Myocardial infarction.
1. There is an increase in 50% of the cases of AMI.
2. The increase is mild and may occur after the fourth day of infarction, and the peak reaches in the next 4 days (another reference says 7 to
14 days after the infarction).
3. GGT rise in AMI is seen in 5% to 30% of the cases.
12. Alcohol ingestion. There is an average increase of >3.5 of the normal value.
1. In the case of alcohol abuse, there is GGT/Alkaline phosphatase ratio >2.5.
13. GGT is raised in EBV infection (Infectious mononucleosis), cytomegalic viral infection, and Reye syndrome.

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14. Drugs like Warfarin, Barbiturates, Valproic acid, Dilantin, and alcohol.

The decreased level of Gamma- Glutamyl Transferase is seen in the following:

Hypothyroidism.

γ-GT values are normal, seen in the following conditions:

1. Bone disorder and bone growth.
2. Pregnancy.
3. Skeletal muscle disease.
4. Renal failure.

GGT is the choice of enzyme in the case of Alcoholism.

Very good at monitoring liver disease. Its return to normal in liver disease is an excellent indicator.

Questions and answers:

Question 1: What is the significance of GGT in liver diseases?
Show answer
Question 2: What is the significance of GGT in alcoholics?
Show answer

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