SGH Protocol for N-acetylcysteine (NAC) for paracetamol overdose HUS/NSG/BOR-23

Paracetamol Overdose
Patient’s Actual body
IC No:
name: weight (kg):

BW ≥ 40 kg without fluid restriction

Start date &
IV NAC 200 mg/kg over 4 hours time

STEP 200 mg × _______ (kg) BW = ______________ (mg) NAC

1 Dilute _________ (ml) in 500 ml D5% and infuse over 4 hours.
Infusion rate:125 ml/hour (Signature)

Start date &

IV NAC 50 mg/kg over 8 hours time

STEP 50 mg × _______ (kg) BW = _______________ (mg) NAC

2 Dilute _________ (ml) in 500 ml D5% and infuse over 8 hours.
Infusion rate: 63 ml/hour (Signature)

Start date &

IV NAC 50 mg/kg over 8 hours time

STEP 50 mg × _______ (kg) BW = _______________ (mg) NAC

3 Dilute _________ (ml) in 500 ml D5% and infuse over 8 hours.
Infusion rate: 63 ml/hour (Signature)

××××××××××××××××××××××××××××××××××××××××××××
BW < 40 kg and/or fluid restriction
Start date &
IV NAC 200 mg/kg over 4 hours time

STEP 200 mg × _______ (kg) BW = _____________ (mg) NAC

1 Dilute _________ (ml) in 250 ml D5% and infuse over 4 hours.
Infusion rate:63 ml/hour (Signature)

Start date &

IV NAC 100 mg/kg over 16 hours time

STEP 100 mg × _______ (kg) BW = ______________ (mg) NAC

2-3 Dilute _________ (ml) in 500 ml D5% and infuse over 16 hours.
Infusion rate: 32 ml/hour (Signature)

NOTE: Alternative diluent: Normal Saline (NaCl 0.9%)

Stability of diluted solution: 24 hours
Strength of NAC available: 5g/25mL

Ordered by: Date:

(Signature & stamp)