There are quite a few functionalities that have changed in SAP S/4 HANA from ECC.

I will try and

list down the most important ones to give you an idea on the transformation, the article does
not cover all that has changed in SAP MM or IM to S/4 HANA

 Restructuring of back-end tables and transactions - Few transactions are made obsolete
such as MB01, MB02...MB05, MB0A, MB11, 1A....MBSU. They have been replaced by
Fiori apps for the better user experience and improved performance and less load on
data bases. Tables MKPF and MSEG have been made obsolete and stored in the table
MATDOC (Simple table). Here are few transactions which are replaced with the Fiori
apps

 Vendor Master Transactions : In S/4 HANA we maintain business partner through the
the SAP Fiori app. Transactions related to Vendor Master transactions like XK01, XK03,
MK01, FX01 are made obsolete in S/4 HANA
 Overview of Inventory Analytics (A separate business catalog role is needed to activate
this) and it brings

1. Stock Value by Stock Type (Pie Chart)

2. Stock Value by special stock type
3. Warehouse Throughput History
4. Monitor Purchase Order Items
5. Recent Material Documents

 Stock Transfer between Storage Locations (One step transfer) - IN ECC while doing the
one step transfer the transaction code used is MIGO with movement type 311. In Fiori it
is the "Transfer Stock- In Plant". This app will pull in information such as material details
and shows the material stock overview.

Summary - These are just some of the examples on some of the key functionalities that have
changed from ECC to S/4 HANA, in details there are hundreds of apps now being used in IM and
MM alone, for example Display Inbound Delivery, Expected Goods Receipt, General Inbound
Delivery List, etc. etc.