ABASYN UNIVERSITY

Islamabad Campus
Mid Term Examination, Fall 2022

Course Code: PD304 Course Title: Pharmaceutical Chemistry-IIIA

(Pharmaceutical Analysis)
Teacher’s Name: Muhammad Junaid Total Marks: 30
Date & Time:16/11/2022 (11:30 AM to 1:00 Total Time: 90 minutes
PM)
Student’s Name: Reg. No:
1. Follow all the instructions written on answer booklet.
2. Write your Registration Number and other relevant information on the front page of the answer booklet & sign it.
3. Ask for clarifications by the Course Instructor only within the first 15 minutes of the start of the paper.
4. The marks for each question/part are written in parentheses [ ].
QUESTION 1 [10 Marks]

PART A [6 Marks]
Provide a brief account of UV-Vis spectra. Deliberate upon the Principle and Instrumentation of UV-
Vis Spectrometer. How would you discern a compound and throw some light on measurement of
reaction rate.

PART B – Select the correct answer/choice for the following. [1x4=4 Marks]
1. NMR spectra is obtained when the sample is irradiated with_________ at frequency
complementary to Precession frequency.

a. Microwaves c. Radio-waves
b. Visible light d. Ultraviolet waves
2. A wave exhibits the distance between two troughs as 500m. This wave would be identified as,

a. Microwaves c. Radio-waves
b. Visible light d. Ultraviolet waves
3. Cyano- group contains Non-bonding electrons is associated with absorption in the region of___.

a. 275-295 nm c. 3250-3290
b. 2300-2100 d. 1250-1550

4. Bathochromic shift: A shift of λmax to a ___________.

a. Shorter wavelength c. Increase in intensity of

absorption.
b. Longer wavelength d. Decrease in intensity of
absorption.

QUESTION 2 [10 Marks]

PART A [6 Marks]
Define, classify and describe principle of Chromatography. Briefly discuss Mass spectroscopy
(instrumentation).

PART B – Select the correct answer/choice for the following. [1x4=4 Marks]
1. C-18 column is______.

a. Polar c. Hydrophilic
b. Lipophilic d. lipophobic

2. Correct order for Eluting power (decreasing order) is________?

a. Water, Acetic acid, Pyridine, c. Ethanol, Pyridine, water, acetic

Ethanol acid
b. Water, Ethanol, pyridine, Acetic d. Acetic acid, Ethanol, Pyridine,
acid Water

3. Correct order for adsorption strength (least to most strongly adsorbed) is________.

a. Esters, ethers, alcohols, carbonyls c. Ethers, Esters, Carbonyls,

b. Carbonyl compounds, Ethers, Alcohols.
Esters, Alcohols, d. Alcohols, Ethers, carbonyls, esters

4. Eluite is synonymous with __________.

a. Mobile Phase c. Solvent
b. Stationary Phase d. Analyte

QUESTION 3 [10 Marks]

PART A [2+4=6 Marks]

What is the significance of atomic Emission spectroscopy. Expand its instrumentation, with due
diligence to the sources.

PART B – Select the correct answer/choice for the following. [1x4=4 Marks]
1. In IR spec: the Fingerprint region ranges from________.

a. 4000-1600 /cm c. 2500-16000 cm-1

b. 1600-650 /cm d. 650-1450 /cm

2. =C-H (33 %-S character) bond vibration lies in region of_____.

a. 3250 c. 3100
b. 2250 d. 2100

3. C-O group in the alcohols lie in region of_______.

a. 1500-1700 b. 1000-1300
 c. 2250-2450 d. 750-950
4. Methoxy group Pi-Star transition occurs at ______cm -1.
a. 190 c. 220
b. 150 d. 450
1.3=B
1.4=B
3.4=A
3.2=C
3.3=B
3.1=D