ZOOM INTERNATIONAL SCHOOL

( Senior Secondary : Affiliated to CBSE, Delhi )

Session: 2022-23
Guidelines for Chemistry Practical & Project
Class: XII Subject: Chemistry (043)

1. Practical copy should be binding and covered with brown paper.

2. Details of student (Name, Stream, Class, Sec., Session, Roll no.)
must be written according to the Sample Project & Practical
uploaded in the Website / WhatsApp.
3. Students must write the index
4. Write experiments on the rule page (right page) and reactions on
the white page (left page)
5. Use only blue ink pen and write reactions in pencils.
6. Write all the experiments in tabular form, use pencil for making
table.
7. Printed format of the Project will be accepted.
8. Project should be submitted in channel file only.
9. A sample project and practical has been uploaded in School
website / WhatsApp for your reference.
 ZOOM INTERNATIONAL SCHOOL
Senior Secondary : (Affiliated to CBSE, Delhi)

CHEMISTRY
PRACTICAL FILE

NAME :
STREAM :
CLASS :
SECTION :
SESSION :
AISSCE ROLL NUMBER :
STUDENTS PARTICULARS

NAME:
STREAM: SCIENCE
CLASS:
SECTION:
SESSION: 2022-2023
AISSCE ROLL NUMBER:
TOPIC:
 CERTIFICATE
This is to certify that name of Master _________________

of Class ________ Section ________ Roll no. __________

has successfully completed the Chemistry Investigatory

project on

____________________________________________in the

academic year of 2022-2023 under the guidance of

________________________in particular fulfillment of the

curriculum of Central Board of Secondary Education

(CBSE).

External Examiner Internal Examiner

 ACKNOWLEDGEMENTS

I would like to thank my principal __________________________and

school for providing me the opportunity and with all the facilities
required to do my project.

I am highly indebted to my Chemistry teacher _________________for

his guidance which has sustained my efforts in this project.

I would also like to thank my parents for their continuous support

and encouragement.

It would have not been possible without the support and help of all
of them.

My thanks and appreciations also go to my classmates and the

laboratory assistant who had helped me throughout the project with
their abilities.
 Index
S.No. Content Page No.

1. Certificate

2. Acknowledgements

3. Aim/Objective

4. Introduction

5. Materials required

6. Content

7. Content

8. Content

9. Content

10. Conclusion

11. Bibliography
 TERM-I PORTION

ALREAY COMPLETED
 TERM-Ii PORTION

SYNTHESIS OF ASPIRIN

LABORATORY EXPERIMENT
Materials required
1. Graduated cylinder
2. Beakers
3. Spatula
4. Pasteur pipppets
5. Round bottom conical flask
6. Evaporating dish with sand
7. Vaccum filteration
8. 1g Salicylic acid
9. 2.5 ml acetyl chloride
10. Phosphoric acid
11. Deionized water
12. 3 ml ethanol
Theory
Aspirin, acetyl salicyclic acid, was first synthesized in 1893 by
Felix Holfmann, a chemist for the German firm of Bayer. This
compound had the medicinal properties of salicylic acid, an
extract of willow bark, without the unpleasant taste or the high
degree of irritation of the mucuous membranes lining the mouth.
Gullet and stomach. Aspirin is both an organic ester and organic
acid. It is used extensively in medicine as pain killer analgesic
and as fever reducing drug antipyretic. When ingested acetyl
salicyclic acid remains intact in the acidic stomach, but in the
basic medium of the upper intestinal tract, it hydrolyzes forming
the salicylate and acetate ions. However, it's additional
physiological effects and biomechemical reactions are still not
throughly understood. Aspirin (molar mass 180.2 g/mol) is
prepared by reacting salicylic acids (molar mass 138.1g/mol) with
acetic anhydride molar mass 120.1g/mol). Aspirin is a weak
monoprotic acid.
Procedures
 Take 1 gm Salicylic acid and add 2.5 ml of acetic
anhydride
 Add 5 drops of phosphoric acid in the mixture.
 Boil the mixture by placing hot water bath for 10
min
 Add 5 ml deionized water, and cool the mixture
upto room temperature
 Separate the crystals by vacuum filtration
 Dissolve crystals into 3 ml ethanol, warm to
dissolve solid and then place the flask in ice bath.
 Separate pure crystals by vacuum filtration.
 Observation table

Addition of compounds Observations

Addition of acetic anhydride,
White milky mixture
phosphoric acid and salicylic acid

Hot bath Clear yellow liquid

White cloudy solutions with

Ice bath
cloudy white precipitate

Isolation through filtration White sugar like crystals

Addition of ethanol warming,

Cloudy and crystal form
and placing in ice bath

Vacuum filtration Pure crystals obtained

Conclusion
In conclusion, aspirin was obtained by using phosphoric acid as a
catalyst and combining acetic anhydride and salicylic acid, which
resulted in a white/milky mixture. After heating a clear yellow
liquid was obtained. The solution was heated so that salicylic acid
would melt and react with acetic anhydride. The solution was
then cooled to room temperature and placed in ice bath as aspirin
is insoluble in cold water and would form crystals, which was
obtained through vacuum filtration. The crystals obtained at this
point is not pure and needs to purified through recrystallization. In
this purification process ethanol is added as it is used to dissolve
aspirin and any impurities present, and the ice bath is used to
recrystallize only pure aspirin, aspirin will not be recrystallized
from hot water since esters will hydrolyze in hot water.