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'gut microbiota kidney transplant' OR (('gut'/exp OR gut) AND ('microbiota'/exp OR

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RECORD 1
TITLE
Clinical Significance of Gastrointestinal Carriage of Klebsiella
Pneumoniae-Producing Extended-Spectrum Beta-Lactamases in
Kidney Graft Recipients
AUTHOR NAMES
Wilkowski P.; Gajko K.; Marczak M.; Hryniewiecka E.; Wojtowicz M.; Dobrzaniecka
K.; Mlynarczyk G.; Paczek L.; Ciszek M.
AUTHOR ADDRESSES
(Wilkowski P.; Gajko K.; Marczak M.; Hryniewiecka E.; Wojtowicz M.; Paczek L.;
Ciszek M., mciszek@onet.pl) Department of Immunology, Transplant Medicine and
Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
(Hryniewiecka E.) Department of Clinical Nursing, Medical University of Warsaw,
Warsaw, Poland.
(Dobrzaniecka K.; Mlynarczyk G.) Chair and Department of Medical Microbiology,
Medical University of Warsaw, Warsaw, Poland.
(Paczek L.) Department of Bioinformatics, Institute of Biochemistry and Biophysics,
Polish Academy of Sciences, Warsaw, Poland.
CORRESPONDENCE ADDRESS
M. Ciszek, Department of Immunology, Transplant Medicine and Internal Diseases,
Medical University of Warsaw, 59 Nowogrodzka St, Warsaw, Poland. Email:
mciszek@onet.pl
AiP/IP ENTRY DATE
2018-07-31
FULL RECORD ENTRY DATE
2018-11-05
SOURCE
Transplantation Proceedings (2018) 50:6 (1874-1877). Date of Publication: 1 Jul 2018
SOURCE TITLE
Transplantation Proceedings
PUBLICATION YEAR
2018
VOLUME
50
ISSUE

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 6
FIRST PAGE
1874
LAST PAGE
1877
DATE OF PUBLICATION
1 Jul 2018
PUBLICATION TYPE
Article
ISSN
1873-2623 (electronic)
0041-1345
BOOK PUBLISHER
Elsevier USA
ABSTRACT
The burden of Klebsiella pneumoniae (KP) producing extended-spectrum beta-
lactamases (ESBL+) urinary tract infections (UTIs) is a growing problem after kidney
transplantation (KTX). The study was aimed at evaluating the incidence of KP ESBL+
gut colonization in KTX recipients and its correlation with clinical outcomes with special
regard to UTIs. The study included all KTX patients hospitalized in our department
between January 2014 and December 2016. During this period 2018 KTX patients were
admitted: 605 in 2014, 750 in 2015, and 663 in 2016, respectively. Screening for drug-
multiresistant Enterobacteriaceae gut carriage was performed in 104 patients (2014),
122 (2015), and 166 (2016). In 2014, 2015, and 2016, 18 (17.3%), 26 (21.3%), and 30
(18.1%) patients had positive test results, and 44 (42.3%), 36 (29.5%), and 45 (27.4%)
KTX patients were diagnosed with KP ESBL+ UTI. In 2014, KP ESBL+ UTI was
diagnosed in 30 (34.9%) cases with negative anal swab and in 14 patients (77.8%) with
positive test result (P =.0008). In 2015, KP ESBL+ UTI was diagnosed in 21 patients
(21.9%) with negative anal swab and in 15 (57.7%) with positive test result (P =.0004).
In 2016, KP ESBL+ UTI was diagnosed in 24 patients (17.8%) with negative anal swab
and in 21 (72.4%) with positive test result (P =.000001). In conclusion, we have
revealed a strong association between gut K. pneumoniae colonization, female sex, and
MPA intake and KP ESBL+ urinary tract infections in kidney transplant recipients. Our
results indicate the very important role of KP ESBL+ screening, while strategies of
identified carriers require further research.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
extended spectrum beta lactamase producing Klebsiella pneumoniae; graft recipient;
intestine flora; kidney graft
EMTREE MEDICAL INDEX TERMS
adult; article; bacterial colonization; clinical outcome; correlational study; female;

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gender; human; incidence; major clinical study; male; middle aged; multidrug
resistance; priority journal; trend study; urinary tract infection
EMBASE CLASSIFICATIONS
Urology and Nephrology (28)
Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
LANGUAGE OF ARTICLE
English
LANGUAGE OF SUMMARY
English
EMBASE ACCESSION NUMBER
20180518609
MEDLINE PMID
30056919 (http://www.ncbi.nlm.nih.gov/pubmed/30056919)
PUI
L2000979369
DOI
10.1016/j.transproceed.2018.03.114
FULL TEXT LINK
http://dx.doi.org/10.1016/j.transproceed.2018.03.114
EMBASE LINK
https://www.embase.com/search/results?subaction=viewrecord&id=L2000979369&from
=export
COPYRIGHT
Copyright 2018 Elsevier B.V., All rights reserved.

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